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Nano Research 2021年第6期14卷 1937-1954页

作者： liyun zhao Qiuyu Shang Meili Li Yin Liang Chun Li Qing Zhang Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Two-dimensional(2D)transition metal dichalcogenide(TMDC)semiconductors not only hold great promises for the development of ultra-thin optoelectronic devices with low-energy consumption,but also provide ideal platforms to explore and tailor light-matter interaction,e.g.,the exciton-photon interaction,at the atomic level,due to their atomic thickness,large exciton binding energy,and unique valley *** recent years,the exciton-photon interactions in TMDC semiconductor microcavities,including the strong exciton-photon coupling and lasing,have drawn increasing attention,which may open up new application prospects for transparent,on-chip coherent,and quantum light ***,we review the research progresses of strong exciton-photon interaction and lasing of TMDC ***,we introduce the electronic structure,exciton,and emission properties of semiconducting TMDCs in the weak exciton-photon coupling ***,the progresses on strong exciton-photon interaction and exciton-polaritons of these TMDCs are discussed from the aspects of photophysics,materials and fabrications,spectroscopies,and ***,the progresses on TMDC lasers are introduced in the aspects of cavity types and materials,and finally,the challenges and prospects for these fields are discussed.

关键词： transition metal dichalcogenides light-matter interaction strong exciton-photon interaction lasing

Analysis of photoluminescence behavior of high-quality single-layer MoS2

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Nano Research 2019年第7期12卷 1619-1624页

作者： Lu Xu liyun zhao Yunsong Wang Mingchu Zou Qing Zhang Anyuan Cao Department of Materials Science and Engineering College of Engineering Peking UniversityBeijing 100871China

The ability to tailor and enhance photoluminescence (PL) behavior in two-dimensional (2D) transition metal dichalcogenides (TMDCs) such as molybdenum disulfide (MoS2) is significant for pursuing optoelectronic *** achieve this,it has been essential to obtain high-quality single-layer MoS2 and fully explore its intrinsic PL ***,we fabricate single-layer MoS2 by a thermal vapor sulfurization method in which a pre-deposited molybdenum trioxide (MoO3) thin film is sulfurized over a short period (for several minutes) to turn into *** as-grown MoS2 crystals show quite strong PL,which is about one order of magnitude higher than that of chemical-vapor-deposited ***- and power-dependent spectroscopy measurements disclose the apparent influence of sulfur (S) vacancies on the PL behavior and the noticeable free-to-bound exciton recombinations in the luminescence *** fact that PL intensity of the sample in vacuum sharply lowered down relative to in air reveals that the high PL is facilitated by molecular adsorption on S vacancies in *** multi-channel decay processes coupled with S vacancies are revealed in the time-resolved PL *** our work,single-layer MoS2 with high PL is synthesized and its defect-induced PL features are analyzed,which is of great importance for developing advanced nano-electronics and optoelectronics based on 2D structures.

关键词： MoS2 photoluminescence thermal vapor sulfurization S vacancy

Impulsive Containment Control in Networked Harmonic Oscillators 36

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Impulsive Containment Control in Networked Harmonic Oscillat...

Synthesis of carbon quantum dots decorating Bi_(2)MoO_(6) microspherical heterostructure and its efficient photocatalytic degradation of antibiotic norfloxacin

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作者： zhaoyan Wang Jun Liu liyun zhao Department of Mathematics Jining University School of Mathematics Physics and Biological EngineeringInner Mongolia University of Science and Technology

ISBN: (纸本)9781538629185

In this paper,impulsive containment control problem for networked harmonic oscillators is investigated with multiple leaders under directed network *** on the graphic theory,matrix analysis theory and impulsive differential equation stable theory,a distributed impulsive containment control law is proposed,and the sufficient conditions which guarantee the convergence of the proposed control law are also ***,the theoretical results are illustrated by numerical simulations.

关键词： Impulsive control containment control networked harmonic oscillators directed networks

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Chinese Chemical Letters 2024年第8期35卷 373-378页

作者： Meijuan Chen liyun zhao Xianjin Shi Wei Wang Yu Huang Lijuan Fu Lijun Ma School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China Key Lab of Aerosol Chemistry and Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China

In this study,three-dimensional microspherical CQDs/Bi_(2)MoO_(6)heterostructures were synthesized using a simple alcohol-thermal *** was found that the CQDs/Bi_(2)MoO_(6)had a large specific surface area of 56.0 m^(2)/g,and the introduction of CQDs extended the light absorption spectrum from 480 nm to 496 *** utilizing the synthesized CQDs/Bi_(2)MoO_(6)composite for photocatalytic degradation of antibiotic nor-floxacin in a water environment,complete decay of norfloxacin and effective removal of total organic car-bon(TOC)were achieved within 30 *** the optimization of material synthesis and experimen-tal conditions,the optimal CQDs loading amount was determined as 200μL,the optimal CQDs/Bi_(2)MoO_(6)dosage was 0.8 g/***,the CQDs/Bi_(2)MoO_(6)worked well under a wide pH range of *** co-existence of HCO_(3)−enhanced the norfloxacin decay,while the presence of Cl^(−),NO_(3)^(−),and SO_(4)^(2−)slightly retarded *** synthesized CQDs/Bi_(2)MoO_(6)had the great potential in removing and mineralizing nor-floxacin in real aquatic environments.

关键词： Bi_(2)MoO_(6) CQDs Heterojunction Norfloxacin Photocatalysis

Recent research and development of DYRK1A inhibitors

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Chinese Chemical Letters 2022年第4期33卷 1841-1849页

作者： liyun zhao Xuan Xiong Li Liu Qi Liang Rongsheng Tong Xuanlin Feng Lan Bai Jianyou Shi Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China College of Medicine Southwest Jiaotong UniversityChengdu 610031China Emergency Intensive Care Unit Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Dual specificity tyrosine phosphorylation regulated kinase 1 A(DYRK1 A) is an evolutionarily conserved protein kinase belonging to the CMGC kinase family, which is closely related to Down syndrome(DS)and Alzheimer’s disease(AD). In recent years, not only the treatment of diabetes, but also the treatment of cancer gradually focuses on targeting DYRK1 A. Therefore, a series of DYRK1 A inhibitors have been developed to treat relevant diseases and clarify their treatment mechanism furtherly. DYRK1 A inhibitors are mainly divided into natural products and synthetic compounds. Among them, harmine is an excellent DYRK1 A inhibitor. Therefore, the synthetic DYRK1 A inhibitors are mainly based on harmine, which greatly enriches the structure and quantity of DYRK1 A inhibitors. The interaction between the inhibitors and the DYRK1 A protein has a guiding significance in predicting the activity of the inhibitors, and plays an irreplaceable role in the design of the compounds. This paper mainly reviews DYRK1 A inhibitors found in recent years and their structure-activity relationship, looking forward to providing a theoretical basis for the development of DYRK1 A inhibitors.

关键词： DYRK1A inhibitor Natural product Synthetic compound Alzheimer’s disease Down syndrome

A small molecule inhibitor targeting SHP2 mutations for the lung carcinoma

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Chinese Chemical Letters 2021年第5期32卷 1645-1652页

作者： Qing Niana Jinhao Zenga Li He Yu Chen Zhiqiang Zhang Fernando Rodrigues-Lima liyun zhao Xuanlin Feng Jianyou Shi Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072China School of Clinical Medicine Chengdu University ofTCMChengdu 610072China Department of Emergency Binzhou Medical University HospitalBinzhou 256603China Unite de Biologie Fonctionnelle et Adaptative Universite de ParisParis 75013France Department of Pharmacy Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalPersonalized Drug Therapy Key Laboratory of Sichuan ProvinceSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of EICU Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalChengdu 610072China

The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine phosphatase SHP2 dysfunction has been reported in many lung cancer ***,the Src homology region 2(SH2)-containing protein tyrosine phosphatase 2(SHP2)mutation or deletion triggers multiple signaling pathway dysfunctions including RAS/MAPK,RAS/extracellular-signal-regulated kinase(ERK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT),Janus kinase/signal transducers and activators of transcription(JAK/STAT)and Hippo/yes-associated protein(YAP)which affect the expression of growth factors,cytokines and *** recent years,the developing of the small molecule SHP2 inhibitors received a lot of *** this review,we summarize the recent years'progresses of the SHP2 inhibitors development for the lung cancer treatment.

关键词： Lung carcinoma Small molecule inhibitor SHP2 Targeted therapy Gene mutation

Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6−17 Years—China,2016−2017

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China CDC weekly 2021年第9期3卷 189-192页

作者： Rui Wang Huidi Zhang Yi-chun Hu Jing Chen Zhenyu Yang liyun zhao Lichen Yang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known on this topic?Vitamin A deficiency(VAD)in children is still a global public health problem,which needs continuous monitoring and timely *** is added by this report?Using surveillance data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016−2017,the prevalence of VAD and marginal deficiency was 0.96%and 14.71%,respectively.

关键词： Serum prevalence Vitamin

Salt-assisted growth and ultrafast photocarrier dynamics of large-sized monolayer ReSe2

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Nano Research 2020年第3期13卷 667-675页

作者： Shaolong Jiang Jin Yang Yuping Shi Jing zhao Chunyu Xie liyun zhao Jiatian Fu Pengfei Yang Yahuan Huan Qin Xie Huachao Jiang Qing Zhang Xianlong Wang Fuhai Su Yanfeng Zhang Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China Center for Nanochemistry(CNC) Beijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

Owing to its anisotropic optical and electrical properties,rhenium diselenide(ReSe2)has garnered considerable attention recently as a candidate material for polarization-sensitive ***,the direct and controllable synthesis of large-sized ReSe2 with a uniform thickness is still a great ***,we have refined the synthesis method to obtain uniform monolayer ReSe2 flakes with a size of up to^106μm on sapphire via an ambient-pressure chemical vapor deposition technique using Na promoter from sodium ***,optical pump-probe spectroscopy revealed a fast switching from saturable absorption(SA)to absorption enhancement(AE)in subpicosecond time scale,followed by a slower decay induced by exciton ***,both AE and SA signals exhibited clear angular dependence with a periodicity of 180°,which reflected the dichroism in nonlinear absorption *** addition,the photocarrier dynamics including free-carrier transport and subpicosecond relaxation due to exciton formation or surface trapping was probed using time resolved terahertz *** believe that our study serves as a reference for atomically controlled synthesis of large-sized ReSe2 and provides useful insights on its optoelectronic properties for novel device applications.

关键词： ReSe2 chemical vapor deposition sodium chloride large size ultrafast photocarrier dynamics

Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

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Protein & Cell 2023年第6期14卷 398-415页

作者： Qian zhao Yandong Zheng Dongxin zhao liyun zhao Lingling Geng Shuai Ma Yusheng Cai Chengyu Liu Yupeng Yan Juan Carlos Izpisua Belmonte Si Wang Weiqi Zhang Guang-Hui Liu Jing Qu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China The Fifth People's Hospital of Chongqing Chongqing 400062China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Altos Labs Inc.San DiegoCA 94022USA

Hair loss affects millions of people at some time in their life,and safe and efficient treatments for hair loss are a significant unmet medical *** report that topical delivery of quercetin(Que)stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in *** construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1αin endothelial *** administration of a HIF-1αagonist partially recapitulates the pro-angiogenesis and hair-growing effects of ***,these findings provide a molecular understanding for the efficacy of Que in hair regrowth,which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine,and suggest a route of pharmacological intervention that may promote hair regrowth.

关键词： single-cell RNA-sequencing Que hair follicle regeneration endothelial cells HIF-1α