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Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy

Neuroscience Bulletin 2019年第4期35卷 743-755页

作者： Fulong Xiao Chao Lu Dianjiang Zhao Qihong Zou liyue xu Jing Li Jun Zhang Fang Han Sleep Medicine Center Department of Respiratory and Critical Care Medicine Peking University People's Hospital Beijing 100044 China Department of Radiology Peking University International Hospital Beijing 102206 China Center for MRI Research Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China PKU-UPenn Sleep Center Peking University International Hospital Beijing 102206 China Department of Neurology Peking University People's Hospital Beijing 100044 China

The present study was aimed to evaluate restingstate functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls.Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls.MRI data were first analyzed by group independent component analysis,then a graph theoretical method was applied to evaluate the topological properties in the whole brain.Small-world network parameters and nodal topological properties were measured.Altered topological properties in brain areas between groups were selected as regionof-interest seeds,then the functional connectivity among these seeds was compared between groups.Partial correlation analysis was performed to evaluate the relationship between the severity of sleepiness and functional connectivity or topological properties in the narcolepsy patients.Twenty-one independent components out of 48 were obtained.Compared with healthy controls,the narcolepsy patients exhibited significantly decreased functional connectivity within the executive and salience networks,along with increased functional connectivity in the bilateral frontal lobes within the executive network.There were no differences in small-world network properties between patients and controls.The altered brain areas in nodal topological properties between groups were mainly in the inferior frontal cortex,basal ganglia,anterior cingulate,sensory cortex,supplementary motor cortex,and visual cortex.In the partial correlation analysis,nodal topological properties in the putamen,anterior cingulate,and sensory cortex as well as functional connectivity between these regions were correlated with the severity of sleepiness(sleep latency,REM sleep latency,and Epworth sleepiness score)among narcolepsy patients.Altered connectivity within the executive and salience networks was found in narcolepsy patients.Functional connection changes between the left frontal cortex and left caudate nucleus may be one of the parameters describing the sev

关键词： Narcolepsy Functional connectivity Independent component analysis Graph theory

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杀虫剂对脊胸露尾甲生物活性的测定方法筛选

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农药 2024年第4期63卷 300-303页

作者：许丽月吴忠华朱国渊张永科王进强贺熙勇云南省热带作物科学研究所云南省澳洲坚果农业工程研究中心云南景洪666100

[目的]为筛选出对澳洲坚果新害虫——脊胸露尾甲成虫和幼虫灵敏的生物活性测定方法。[方法]以甲氨基阿维菌素苯甲酸盐为供试药剂,分别采用浸虫法、饲喂法和药膜法开展了生物活性测定试验。[结果]处理24 h后,浸虫法对成虫的生物活性最高(... 详细信息

[目的]为筛选出对澳洲坚果新害虫——脊胸露尾甲成虫和幼虫灵敏的生物活性测定方法。[方法]以甲氨基阿维菌素苯甲酸盐为供试药剂,分别采用浸虫法、饲喂法和药膜法开展了生物活性测定试验。[结果]处理24 h后,浸虫法对成虫的生物活性最高(LC_(50)值为28.48 mg/L),显著高于药膜法(LC_(50)值为206.81 mg/L)和饲喂法(LC_(50)值为343.80 mg/L);饲喂法对2龄幼虫的生物活性最高(LC_(50)值为44.30 mg/L),显著高于药膜法(LC_(50)值为144.81 mg/L)和浸虫法(LC_(50)值为142.27 mg/L)。[结论]浸虫法可用于成虫的生物活性测定、饲喂法可用于幼虫的生物活性测定,该结论可为脊胸露尾甲成虫及幼虫的生物活性测定方法的选择提供参考。

关键词：澳洲坚果脊胸露尾甲生物活性测定甲氨基阿维菌素苯甲酸盐

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基于辅导员工作室建设提升辅导员职业能力研究

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创新创业理论研究与实践 2024年第8期7卷 97-100页

作者：张宏敏周松周建平徐黎悦同济大学浙江学院浙江嘉兴314000

高校辅导员工作室是提升辅导员职业化、专业化程度的重要举措之一,也是为学生提供更加优质服务的有效载体。该文进一步理清建设辅导员工作室与提升辅导员职业能力之间的辩证关系,构建基于辅导员工作室建设提升辅导员职业能力发展新模式... 详细信息

高校辅导员工作室是提升辅导员职业化、专业化程度的重要举措之一,也是为学生提供更加优质服务的有效载体。该文进一步理清建设辅导员工作室与提升辅导员职业能力之间的辩证关系,构建基于辅导员工作室建设提升辅导员职业能力发展新模式,形成工作室建设和辅导员队伍建设协同发展、互促互融的良性循环系统,最终助力学生成长。

关键词：辅导员辅导员工作室建设提升职业能力模式

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澳洲坚果新害虫——脊胸露尾甲生物学习性观察

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中国南方果树 2024年第2期53卷 117-122页

作者：许丽月王进强孔祥东张永科朱国渊吴忠华贺熙勇云南省热带作物科学研究所/云南省澳洲坚果农业工程研究中心云南景洪666100

在云南省西双版纳澳洲坚果种植区发现为害澳洲坚果的新害虫——脊胸露尾甲,为准确掌握其生物学习性,在室内以澳洲坚果果仁为食料饲养该虫,观察各虫态形态、成虫交配习性、产卵习性,测定卵孵化率及各虫态存活率。结果表明,脊胸露尾甲发... 详细信息

在云南省西双版纳澳洲坚果种植区发现为害澳洲坚果的新害虫——脊胸露尾甲,为准确掌握其生物学习性,在室内以澳洲坚果果仁为食料饲养该虫,观察各虫态形态、成虫交配习性、产卵习性,测定卵孵化率及各虫态存活率。结果表明,脊胸露尾甲发育经历卵、幼虫、蛹、成虫4个虫态,其中幼虫分为3个龄期,随着龄期增长,幼虫体长、体宽和头壳宽度逐渐增加。成虫羽化后不会立即交配,交配前期(4.65±0.04)d,交配时长不等,初次交配时长(13.78±0.29)min,雄成虫存在争夺交配权行为。雌成虫产卵前期(8.65±0.03)d,初次产卵量(1.94±0.06)粒,一天中15:00—18:00产卵量/h最高;雌成虫对产卵位置具有选择性,背光面着卵率极显著高于向光面。卵孵化率随着相对湿度增加而不断提高。常规饲养条件下,卵、1龄幼虫、2龄幼虫、3龄幼虫、蛹的存活率分别为(86.50±0.69)%、(83.31±2.99)%、(94.85±0.71)%、(97.09±1.46)%、(98.77±1.23)%。

关键词：云南澳洲坚果新害虫脊胸露尾甲虫态产卵

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无创通气治疗OSA顺应性管理:基于真实世界的研究（英文）

无创通气治疗OSA顺应性管理:基于真实世界的研究（英文）

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中国睡眠研究会第十四届全国学术年会

作者：衣荟洁 Shaomei Shang Yuan Zhang Chi Zhang liyue xu Jingyu Wang Xiaojun He Xiaosong Dong Fang Han 北京大学人民医院

Obstructive Sleep Apnea(OSA) is a disorder that is characterized by obstructive apneas and hypopneas/respiratory effort-related arousals caused by upper airway collapse during sleep. Positive Airway Pressure(PAP) is the first-line treatment for moderate to severe OSA. However, the effectiveness of PAP therapies is contingent on treatment adherence. With the implementation of the wireless transmission for PAP treatment, it is possible to evaluate the objective adherence to PAP use. The purpose of this study is to assess the adherence to PAP therapy of Chinese OSA patients in a telemedicine management system which could fulfill automatic transmission of PAP treatment data. First, we use the telemedicine management system to extract PAP adherence information of OSA adult patients in one week, one month, three months, six months and 12 months. Second, we describe the general profile of PAP therapy adherence. Third, the latent class growth modeling and growth mixture modeling was conducted using Mplus 8.0 to identify the trajectories of adherence over time. Of all the 662 patients involved in our study, PAP adherence declined over time. After one year, the proportion of days compliant was 53.7%, the proportion of good compliance was 45.2%, the daily usage(all days) was 3.9 hours/night, slightly lower than subjective adherence reported in the previous literatures. In addition, we identified three patterns of adherence over time: great users(39.9%;high mean value and level, negative slope, slow decline), good users(34.8%;moderate mean value and level, negative slope, rapid decline) and low users(25.3%;low mean value and level, negative slope, rapid decline). In brief, telemedicine management system provides a convenient platform for monitoring the treatment compliance of OSA patients powerfully and accurately. To improve the low PAP adherence in China, we should make good use of the PAP therapy telemedicine management platform to detect patients with poor adherence and provide timely intervention. Besides, our research

关键词： Telemedicine management system PAP adherence Real-world data

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Study on Adherence to Positive Airway Pressure Treatment for Patients with Obstructive Sleep Apnea Using Real-world Big Data in a Telemedicine Management System

Study on Adherence to Positive Airway Pressure Treatment for...

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中国睡眠研究会第十四届全国学术年会

作者： Huijie Yi Shaomei Shang Yuan Zhang Chi Zhang liyue xu Jingyu Wang Xiaojun He Xiaosong Dong Fang Han 北京大学人民医院北京大学护理学院西南大学电子信息工程学院苏州凯迪泰医学科技有限公司

关键词： Telemedicine management system PAP adherence Real-world data

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Establishment of a Refined Brain Model for Evaluating Implantation Behavior of Neural Electrode and Research of its Simulated Behavior

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上海交通大学学报:英文版 2023年第4期28卷 401-410页

作者：贺雨欣张文光胥浩天徐倚帆许李悦 State Key Laboratory of Mechanical Systems and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

The long-term reliability of the neural electrode is closely related to its implantation behavior.In orderto realize the quantitative research of the implantation behavior in a low-cost and accurate way,a refined brainmodel containing meninges is proposed.First,the expected simulation material was selected through measuringthe elastic modulus based on the method of atomic force microscope indentation technique.As a result,the 2%(mass fraction)agarose gel simulated the gray and white matter,the 7:1(volume ratio)polydimethylsiloxane(PDMS)sheet simulated the pia mater,and the polyvinyl chloride(PVC)film simulated the dura mater.Second,based on designing a three-layer structure mold,the brain model was prepared by inverted pouring to realizea flat implantation surface.Finally,the simulation behavior of the brain model was investigated with the ratbrain as a reference.For mechanical behavior of implantation,the implantation force experienced two peaks bothin the brain model and the rat brain,maximum values of which were 10.17 mN and 7.69 mN respectively.Thelarger implantation force in the brain model will increase the strength requirement for the electrode,but reducethe risk of buckling of that in practical application.For humoral dissolution behavior,the dissolution rates ofthe polyethylene glycol(PEG)coating of the electrode in the brain model and rat brain were 7000μm3/s and5600μm3/s,respectively.The faster dissolution rate in the brain model will cause the larger thickness of thecoating design but provide sufficient implantable time in practical application.The establishment of the brainmodel and the research of its simulated behavior are beneficial to the size design of the electrode substrate andcoating,and research of the implantation mechanism,and further increase the functional life of the electrode.

关键词： neural electrode brain model implantation behavior

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Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue xu Shurui Song Huiying Wang Xilong Cao Xinran Zhao Wenli Wang liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan Shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and taste.However,the industrial development of pear fruit is significantly limited by its short shelf life.Salicylic acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf life.However,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly understood.In this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide analysis.These COL genes were divided into three subgroups according to the structural domains of the COL protein.Pp COL8,with two B-box motifs and one CCT domain,belonged to the first subgroup.In contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third subgroup.The four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit development.Moreover,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp COL9b.Interestingly,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its expression.While the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit senescence.In contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit senescence.The co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit senescence.The results of this study revealed that Pp COL8 can pl

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS

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柔性神经电极植入工具的振动植入参数研究

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华中科技大学学报（自然科学版） 2022年第12期50卷 89-97页

作者：胥浩天张文光贺雨欣许李悦上海交通大学机械与动力工程学院上海200240

为了分析振动植入中各振动参数对柔性神经电极辅助植入工具植入过程的影响,基于受迫振动及黏弹性材料的理论基础,通过运动学和黏弹性力学方法分析了振动中频率、振幅、振动波形对植入过程的影响;提出了穿刺能量这一植入过程评价指标,其... 详细信息

为了分析振动植入中各振动参数对柔性神经电极辅助植入工具植入过程的影响,基于受迫振动及黏弹性材料的理论基础,通过运动学和黏弹性力学方法分析了振动中频率、振幅、振动波形对植入过程的影响;提出了穿刺能量这一植入过程评价指标,其更加直观反映被植入组织的损伤情况;最后,通过体外脑组织模型植入实验对理论分析结果进行了验证.实验结果表明:对各个振动参数影响的理论分析与实验结果基本相符,振动植入能降低植入中的穿刺力及穿刺能量,并且通过提高振幅及采用锯齿波进行触发,进一步降低植入过程的穿刺力及穿刺能量.

关键词：柔性神经电极振动穿刺力穿刺能量组织切割

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用于辅助柔性神经电极深度植入的槽形截面硅针的设计

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上海交通大学学报 2022年第5期56卷 648-655页

作者：贺雨欣张文光许李悦周旭晖上海交通大学机械系统与振动国家重点实验室上海200240

针对柔性神经电极的深度植入屈曲问题,设计一种槽形截面硅针作为辅助植入工具,为电极植入提供暂时刚度.为定量化评价辅助工具的综合性能,结合临界屈曲力和截面积,综合考虑力学性能及生物性能,提出辅助工具的性能评价指数.基于该评价指... 详细信息

针对柔性神经电极的深度植入屈曲问题,设计一种槽形截面硅针作为辅助植入工具,为电极植入提供暂时刚度.为定量化评价辅助工具的综合性能,结合临界屈曲力和截面积,综合考虑力学性能及生物性能,提出辅助工具的性能评价指数.基于该评价指数研究槽形截面硅针的最佳槽深比及槽宽比,其中最佳槽深比为工艺要求内的极大值,最佳槽宽比随着硅针厚度的增大而增大;利用性能评价指数定量证明相对于传统的圆形截面和矩形截面硅针,槽形截面硅针具有明显的性能优势.槽形截面硅针的仿真设计有利于筛选出截面最佳参数组合,减少加工数量,降低实验成本.

关键词：柔性神经电极植入策略槽形截面硅针

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