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光缆监测系统在电力通信网中的应用

通信电源技术 2023年第17期40卷 196-198页

作者：高丽媛赵丹阳国网天津市电力公司东丽供电分公司天津301900 国网天津市电力公司蓟州供电分公司天津301900

对于电力通信网的基本组成结构而言,光缆监测系统属于关键性的通信网络部分。要想发挥电力通信网络全方位网络传输和安全保障的作用,离不开光缆监测设备的支撑。电力通信网具有较为复杂的网络设计架构,优化设计光缆监测的系统结构形式... 详细信息

对于电力通信网的基本组成结构而言,光缆监测系统属于关键性的通信网络部分。要想发挥电力通信网络全方位网络传输和安全保障的作用,离不开光缆监测设备的支撑。电力通信网具有较为复杂的网络设计架构,优化设计光缆监测的系统结构形式就是要智能化解决光缆安全风险,从而保障电力通信网的正常效能得以实现。因此,探讨电力通信网中的光缆监测系统设计实现思路,合理完善光缆监测的设备体系架构。

关键词：光缆监测系统电力通信网运用实践要点

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浙江省蜉蝣目昆虫的种类

贵州农业科学 2018年第8期46卷 46-50页

作者：高亚杰项丽雅许丽媛高欣艳叶启梦张加勇胡一中浙江师范大学化学与生命科学学院浙江金华321004 浙江师范大学野生动物生物技术与保护利用浙江省重点实验室浙江金华321004

为蜉蝣目昆虫在水域水质监控中的研究利用提供参考,2016年7月至2017年9月采用实地考察与标本采集相结合的方法,对浙江省42个县(市、区)102个样点的蜉蝣目昆虫资源进行调查,并对其分布进行统计,体视解剖镜观察结合文献资料对其种类进行... 详细信息

为蜉蝣目昆虫在水域水质监控中的研究利用提供参考,2016年7月至2017年9月采用实地考察与标本采集相结合的方法,对浙江省42个县(市、区)102个样点的蜉蝣目昆虫资源进行调查,并对其分布进行统计,体视解剖镜观察结合文献资料对其种类进行鉴定。结果表明:在浙江省42个县(市、区)的102个样点中,共采集到蜉蝣目昆虫稚虫标本13 300个,分属13科24属46种;包括古丝蜉科(Siphluriscidae)、短丝蜉科(Siphlonuridae)和等蜉科(Isonychidae)等13科,古丝蜉属(Siphluriscus)、短丝蜉属(Siphlonurus)和等蜉属(Isonychia)等24属,中国古丝蜉(Siphluriscus chinensis)、二点短丝蜉(Siphlonurus binotatus)和江西等蜉(Isonychia kiangsinensis)等46种;其中,浙江省新记录科1科(新蜉科Neoephemeridae),新记录种19种(含未定名的8种),分隶属于8科(包括新记录科)12属。结合文献报道,浙江省现有蜉蝣目昆虫总计13科34属62种(含未定名的8种)。

关键词：蜉蝣目稚虫名录浙江

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通信电源远程监控系统的应用研究分析

通信电源技术 2023年第17期40卷 47-49页

作者：赵丹阳高丽媛国网天津市电力公司蓟州供电分公司天津301900 国网天津市电力公司东丽供电分公司天津301900

为切实保障电力通信系统的稳定运行,须对系统的通信电源采取统一的集中监控管理。而通信电源监控系统自身属于多级分布式网络架构,根据各网络层级功能的划分,其系统组成通常划分为监控中心、监控站以及监控单元3个层级。通过在监控单元... 详细信息

为切实保障电力通信系统的稳定运行,须对系统的通信电源采取统一的集中监控管理。而通信电源监控系统自身属于多级分布式网络架构,根据各网络层级功能的划分,其系统组成通常划分为监控中心、监控站以及监控单元3个层级。通过在监控单元中设置多元传感器,能够获取系统运行数据和异常信息,并将数据信息上传至监控站进行数据解析与处理,而后将处理过的数据信息传输至监控中心进行可视化显示,反映出电力通信系统运行的实际状态,同时实时反馈异常问题,并提出问题处理建议,这对提高系统运行效率与质量,减少运行故障发生十分有利。

关键词：通信电源远程监控系统可视化显示

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宁夏枸杞蓟马研究进展

宁夏农林科技 2020年第3期61卷 46-47页

作者：何嘉高立原张蓉宁夏农林科学院植物保护研究所宁夏银川750002 宁夏植物病虫害防治重点实验室宁夏银川750002

本文综述了枸杞园蓟马的种类、发生规律和防治技术,为进一步开展枸杞园蓟马的防治技术研究提供参考。

关键词：枸杞蓟马发生规律防治技术

Broken electron transfer pathway in enzyme:Gold clusters inhibiting TrxR1/Trx via cell studies and theory simulations

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Chinese Chemical Letters 2022年第7期33卷 3488-3491页

作者： Wenchao Niu Zhongying Du Chunyu Zhang Deting Xu Jiaojiao Li Minghui Sun liyuan Wu Haodong Yao Lina Zhao Xueyun gao Department of Chemistry and Biology Beijing University of TechnologyBeijing 100124China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Thioredoxin reductase 1(TrxR1)is over activity in tumor cell to maintain their redox *** gold clusters have great potential in antitumor drug as they could well inhibit TrxR1,the molecular mechanism has not been disclosed *** this work,we revealed gold clusters can well inhibit the activity of TrxR1 in lung tumor cells and further disclosed the inhibition mechanism by using computational simulation *** firstly inferred the binding sites of gold in the hydrophobic cavities on *** simulation results show that the gold ion(released from Au cluster)interact with–SH of Cys189 in TrxR1,this greatly increase the distance between the C-terminal redox center of TrxR1 and the Trx redox center,thereby destroy the electron transfer pathway between *** electron transfer destroying mechanism is different from the previous hypothesis that gold binds to the Sec498 of TrxR1 which has never been proved by experimental and theory *** work provides a new understanding of the gold clusters to inhibit TrxR1 activity.

关键词： Enzyme inhibition Electron transfer Thioredoxin reductase 1 Gold clusters Molecular dynamics Density functional theory

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

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药学学报:英文版 2023年第6期13卷 2680-2700页

作者： Kezheng Peng Chenye Zeng Yuqi gao Binliang Liu liyuan Li Kang Xu Yuemiao Yin Ying Qiu Mingkui Zhang Fei Ma Zhao Wang The Ministry of Education Key Laboratory of Protein Science School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Medicine Tsinghua UniversityBeijing 100084China Department of Cardiac Surgery First Hospital of Tsinghua UniversityBeijing 100016China

Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein, histone deacetylase SIRT6 expression was reduced in plasma of patients treated with anthracyclines-based chemotherapy regimens. Furthermore,overexpression of SIRT6 alleviated doxorubicin-induced cytotoxicity in cardiomyocytes, and potentiated cytotoxicity of doxorubicin in multiple cancer cell lines. Moreover, SIRT6 overexpression ameliorated doxorubicin-induced cardiotoxicity and potentiated antitumor efficacy of doxorubicin in mice, suggesting that SIRT6 overexpression could be an adjunctive therapeutic strategy during doxorubicin ***, doxorubicin-impaired mitochondria led to decreased mitochondrial respiration and ATP production. And SIRT6 enhanced mitochondrial biogenesis and mitophagy by deacetylating and inhibiting Sgk1. Thus, SIRT6 overexpression coordinated metabolic remodeling from glycolysis to mitochondrial respiration during doxorubicin treatment, which was more conducive to cardiomyocyte metabolism, thus protecting cardiomyocytes but not cancer cells against doxorubicin-induced energy deficiency. In addition, ellagic acid, a natural compound that activates SIRT6, alleviated doxorubicininduced cardiotoxicity and enhanced doxorubicin-mediated tumor regression in tumor-bearing *** findings provide a preclinical rationale for preventing cardiotoxicity by activating SIRT6 in cancer patients undergoing chemotherapy, but also advancing the understanding of the crucial role of SIRT6 in mitochondrial homeostasis.

关键词： SIRT6 Doxorubicin Cardiotoxicity Antitumor efficacy Ellagic acid Mitochondrial homeostasis Glycolysis SGK1

Microcarriers promote the through interface movement of mouse trophoblast stem cells by regulating stiffness

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Bioactive Materials 2023年第10期28卷 196-205页

作者： Zili gao Jia Guo Bo Gou Zhen Gu Tan Jia Sinan Ma liyuan Jiang Wenli Liu Lixun Zhou Qi Gu State Key Laboratory of Membrane Biology The State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing100101PR China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101PR China University of Chinese Academy of Sciences Beijing100049PR China Department of Chemistry and Biological Engineering University of Science and TechnologyBeijing100083PR China School of Life Sciences Northeast Agricultural UniversityHarbin150030PR China

Mechanical force is crucial in the whole process of embryonic ***,the role of trophoblast mechanics during embryo implantation has rarely been *** this study,we constructed a model to explore the effect of stiffness changes in mouse trophoblast stem cells(mTSCs)on implantation:microcarrier was prepared by sodium alginate using a droplet microfluidics system,and mTSCs were attached to the microcarrier surface with laminin modifications,called T(micro).Compared with the spheroid,formed by the self-assembly of mTSCs(T(sph)),we could regulate the stiffness of the microcarrier,making the Young’s modulus of mTSCs(367.70±79.81 Pa)similar to that of the blastocyst trophoblast ectoderm(432.49±151.90 Pa).Moreover,T(micro)contributes to improve the adhesion rate,expansion area and invasion depth of ***,T(micro)was highly expressed in tissue migration-related genes due to the activation of the Rho-associated coiled-coil containing protein kinase(ROCK)pathway at relatively similar modulus of ***,our study explores the embryo implantation process with a new perspective,and provides theoretical support for understanding the effect of mechanics on embryo implantation.

关键词： Biomechanics Microcarriers Embryo implantation Cell migration

High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2

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Food Science and Human Wellness 2023年第4期12卷 1081-1101页

作者： Yuqi gao Rui Hua Kezheng Peng Yuemiao Yin Chenye Zeng Yannan Guo Yida Wang liyuan Li Xue Li Ying Qiu Zhao Wang MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China School of Medicine Tsinghua UniversityBeijing 100084China

Nonalcoholic fatty liver disease(NAFLD)is a high-incidence lipid disorder that affects more than a quarter of the population worldwide,and dietary intervention is the recognized *** is the main component of staple foods that are consumed daily,and the effects,metabolic pathway,and molecular mechanism of starch in the context of NAFLD remain *** study showed that a high-starch carbohydrate diet(HCD)led to the occurrence and exacerbation of NAFLD in *** and metabonomic analyses showed that the increased fatty acid influx mediated by NADPH oxidase 2(NOX2)exacerbated *** down NOX2 specifically alleviated HCD-induced NAFLD in vivo and in ***,the large amounts of ROS produced by NOX2 further exacerbated insulin resistance and increased lipolysis in perirenal white adipose tissue(periWAT),thereby providing fatty acids for hepatic lipid *** addition,the interaction between AMPKα1 and p47phox was the pathway that mediated the high expression of NOX2 induced by a *** study systematically demonstrated the effect of a HCD on *** fatty acid influx is a unique molecular regulatory pathway that mediates HCD-induced NAFLD exacerbation,which is different from the effect of simple ***,NOX2 was suggested to be a specific and effective drug target for NAFLD.

关键词： Starchy carbohydrates Nonalcoholic fatty liver disease NADPH oxidase 2 Fatty acid influx

基于普洱茶中重金属成分检测标准物质长期稳定性的研究

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计量与测试技术 2024年第3期51卷 39-41,44页

作者：杨春凤李志娟段凤敏孙力元高林春云南省计量测试技术研究院

本文对所研发的普洱茶中重金属成分检测标准物质的长期稳定性进行了研究,阐述了该标准物质长期稳定性的研究理论及方法。该研究引用经典稳定性评估方案,采用电感耦合等离子体质谱方法,应用标准曲线分析规则(内标法),对普洱茶中Cr、Cu、C... 详细信息

本文对所研发的普洱茶中重金属成分检测标准物质的长期稳定性进行了研究,阐述了该标准物质长期稳定性的研究理论及方法。该研究引用经典稳定性评估方案,采用电感耦合等离子体质谱方法,应用标准曲线分析规则(内标法),对普洱茶中Cr、Cu、Cd等重金属元素成分检测标准物质的长期稳定性进行了考察。结果表明:该实验可用于检验普洱茶中重金属成分检测标准物质的性能与品质。

关键词：普洱茶重金属标准物质长期稳定性检验