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Spatial heterogeneity and compositional profiles of dissolved organic matter in farmland soils across China' Mainland

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Journal of Environmental Sciences 2024年第3期137卷 593-603页

作者： Bingjun Han liyuan Chen kang Xiao Yang Liu Dong Cao Lu Yu Yujun Li Shu Tao Wenxin Liu Key Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Beijing Yanshan Earth Critical Zone National Research Station College of Resources and EnvironmentUniversity of Chinese Academy of SciencesBeijing 101408China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental ScienceChinese Academy of SciencesBeijing 100085China

Dissolved organic matter(DOM) plays an essential role in many geochemical processes,however its complexity, chemical diversity, and molecular composition are poorly understood. Soil samples were collected from 500 vegetable fields in administrative regions of China' Mainland, of which 122 were selected for further investigation. DOM properties were characterized by three-dimensional excitation-emission matrix(3D-EEM) fuorescence spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry(FTICRMS)(field intensity is 15 Tesla). Our results indicated that the main constituents were UVA humic-like substances, humic-like substances, fulvic acid-like substances, and tyrosine-like substances. A total of 10,989 molecular formulae with a mass range of 100.04 to 799.59 Da were detected, covering the mass spectrometric information of the soil samples from 27 different regions. CHO and CHON molecules were dominant in DOM, whereas lignin, tannins,and aromatic substances served as the main components. The results of cluster analysis revealed that the soil properties in Jiangxi Province were considerably different from those in other regions. The key backgrounds of the DOM molecular characteristics in the vegetablefield soil samples across China' Mainland were provided at the molecular level, with large abundance and great variability.

关键词： Dissolved organic matter(DOM) Fourier transform ion cyclotron resonance mass(FTICR-MS) Excitation-emission matrix(EEM) Vegetable-field soils China' Mainland

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GPP(composition of Ganoderma lucidum polysaccharides and Polyporus umbellatus polysaccharides) protects against DSS-induced murine colitis by enhancing immune function and regulating intestinal flora

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Food Science and Human Wellness 2022年第4期11卷 795-805页

作者： liyuan Li Yannan Guo Qing Huang Xiaojin Shi Qingqing Liu Fang Wang Qingfei Liu kang Yu Zhao Wang MOE Key Laboratory of Protein Science School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China Tianjin Research Institute for Advanced Equipment Tianjin 300300China Department of Clinical Nutrition and Department of Health Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides(GLP)and Polyporus umbellatus polysaccharides(PUP)in a ratio of 3:1 named GPP enhances innate immune function in mice through enhancing the function of macrophage cells and activity of natural killer(NK)*** in our research,we further investigated the effect of GPP on the diversity and composition of intestinal flora,and explored its effect on colitis model *** immunoregulatory verification experiments of GPP were conducted in both normal and DSS-induced mice *** research showed that GPP increased the diversity of intestinal microorganisms in mice with the extension of administration *** GPP intake attenuated DSS-induced colon injury,protected the splenic lymphocyte proliferation ability,enhanced the serum hemolysin synthesis,and increased peripheral phagocytes and NK cell activity in model *** of the predominant gene pathways of the bacterial microbiota showed that DNA repair and recombination,base mismatch repair pathways was stronger in GPP-treatment group than in control group,indicating the possible molecular mechanisms of immune function *** study showed that GPP regulated immune function in both health and colitis model,and had a positive effect on maintaining intestinal flora homeostasis.

关键词： Ganoderma lucidum polysaccharides Polyporus umbellatus polysaccharides Immune function Intestinal flora Colitis

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犬舌体传热与中医舌诊机制的实验研究

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天津中医学院学报 2002年第4期21卷 35-36页

作者：王怡李玉红康立源商洪才诸凯邹瑾李艳高秀梅张伯礼天津中医学院天津大学天津中医学院 300193 300072

目的:从中医舌诊客观化角度出发,结合中医舌诊机理进行生物传热学研究。方法:在测定全舌血液灌注率等参数的条件下,研究犬舌动脉血液温度与血管面积的分布对舌横截面积温度场的影响,并用有限元法数值模拟计算出犬舌不同横截面积的温度场... 详细信息

目的:从中医舌诊客观化角度出发,结合中医舌诊机理进行生物传热学研究。方法:在测定全舌血液灌注率等参数的条件下,研究犬舌动脉血液温度与血管面积的分布对舌横截面积温度场的影响,并用有限元法数值模拟计算出犬舌不同横截面积的温度场,并计算出不同血流量、不同血液温度时的舌断面温度场,探明舌面温度场与横截面温度场、舌血流灌注率之间的关系。结果:在全舌血液灌注率一定时,舌体内部温度分布主要受血管面积和分布的控制,动脉血液温度的高低将主要引起温度分布值的变化。结论:研究舌血流与舌温度场的关系对中医舌诊机制和生物传热研究有重要意义。

关键词：犬舌温度场舌动脉血液灌注率

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Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2680-2700页

作者： Kezheng Peng Chenye Zeng Yuqi Gao Binliang Liu liyuan Li kang Xu Yuemiao Yin Ying Qiu Mingkui Zhang Fei Ma Zhao Wang The Ministry of Education Key Laboratory of Protein Science School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Medicine Tsinghua UniversityBeijing 100084China Department of Cardiac Surgery First Hospital of Tsinghua UniversityBeijing 100016China

Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein, histone deacetylase SIRT6 expression was reduced in plasma of patients treated with anthracyclines-based chemotherapy regimens. Furthermore,overexpression of SIRT6 alleviated doxorubicin-induced cytotoxicity in cardiomyocytes, and potentiated cytotoxicity of doxorubicin in multiple cancer cell lines. Moreover, SIRT6 overexpression ameliorated doxorubicin-induced cardiotoxicity and potentiated antitumor efficacy of doxorubicin in mice, suggesting that SIRT6 overexpression could be an adjunctive therapeutic strategy during doxorubicin ***, doxorubicin-impaired mitochondria led to decreased mitochondrial respiration and ATP production. And SIRT6 enhanced mitochondrial biogenesis and mitophagy by deacetylating and inhibiting Sgk1. Thus, SIRT6 overexpression coordinated metabolic remodeling from glycolysis to mitochondrial respiration during doxorubicin treatment, which was more conducive to cardiomyocyte metabolism, thus protecting cardiomyocytes but not cancer cells against doxorubicin-induced energy deficiency. In addition, ellagic acid, a natural compound that activates SIRT6, alleviated doxorubicininduced cardiotoxicity and enhanced doxorubicin-mediated tumor regression in tumor-bearing *** findings provide a preclinical rationale for preventing cardiotoxicity by activating SIRT6 in cancer patients undergoing chemotherapy, but also advancing the understanding of the crucial role of SIRT6 in mitochondrial homeostasis.

关键词： SIRT6 Doxorubicin Cardiotoxicity Antitumor efficacy Ellagic acid Mitochondrial homeostasis Glycolysis SGK1

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π-Extension of Isoindigos(IIDs)through C—H/N—H Activation and Alkyne Annulation

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Chinese Journal of Chemistry 2023年第20期41卷 2589-2596页

作者： kang Wang Liangliang Chen Yan-Ying Huang liyuan Qin Cheng Li Xi-Sha Zhang Feixian Luo Zheng Duan Guanxin Zhang Deqing Zhang College of Chemistry Green Catalysis CenterZhengzhou UniversityZhengzhouHenan450000 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGansu730000 China Key Laboratory of Ecology and Environment in Minority Areas Minzu University of ChinaNational Ethnic Affairs CommissionBeijing100081 China

Isoindigo(IID)is widely used as organic dye and conjugated unit in opto-electronic *** of IID to increase its structural complexity is demanding for obtaining diversity ***,we developed a direct C-H/N-H activation method of IIDs via double alkyne annulations and synthesizedπ-extended IIDs with two pairs of 5/7 membered *** structure of theπ-extended IIDs was characterized and confirmed by^(1)H NMR,^(13)C NMR,HRMS and X ray crystal *** physical properties were characterized by UV-vis absorption,cyclic voltammetry and thermogravimetric *** absorption coefficient of the annulated products enhanced significantly compared with the non-annulated analogue.

关键词： Isoindigo C-H N-H activation Alkyne annulation Opto-electronic function Synthetic methods Functionalized Units

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Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice

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Acta Pharmaceutica Sinica B 2022年第2期12卷 747-758页

作者： Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng kang Xu Xiaojin Shi liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Urology Department Peking Union Medical College HospitalBeijing 100730China School of Medicine Tsinghua UniversityBeijing 100084China

Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains *** this study,we established a novel primary vesical calculi model with D,L-choline tartrate in *** with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney *** studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is *** assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat *** changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical *** fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological *** analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological *** expression of CXCL14 significantly increased in the bladder in the high-fat diet ***14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of *** human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of *** fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,whic

关键词： Primary vesical calculi Diet High-fat D,L-Choline tartrate Macrophage CXCL14 Fatty acid Urothelium

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Petal-assisted artificial pollination method enhanced the fruit setting ratios in tea plant(Camellia sinensis)

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Beverage Plant Research 2023年第1期3卷 64-69页

作者： liyuan Wang Liyi Xu Shirin Aktar Mengdi He Liyun Wu Zhuozhuo Mao Hao Cheng kang Wei National Centre for Tea Improvement Tea Research Institute of the Chinese Academy of Agricultural Sciences(TRICAAS)Hangzhou 310008China College of Life Sciences Ningde Normal UniversityNingde 352100China

Pollination methods play an important role in developing F1 *** study presents an improved method of petal-assisted artificial pollination in tea *** field operation using this method exhibited high efficiency in which more than 500 pistillate flowers per day can be pollinated per capita,and the pollen amount from only one staminate flower was sufficient to pollinate more than five pistillate ***,we surveyed the fruit-setting ratio in three F1 groups,which were established using this method and the influence of rainfall on the fruit-setting *** results indicate that the fruit-setting ratio was superior among the tested F1 population with an average value of 12.90%,and a significant negative correlation was observed between rainfall and fruit-setting *** analyzing the growth states of each F1 population,both a high germination rate and survival rate were ***,the purity for 184 individuals in the F1 population of'Jiaming 1'×'Longjing 43'(J×L)were analyzed with 32 selected simple sequence repeats(SSRs).The purposes of this paper are(1)to demonstrate that this method is beneficial to establish high purity F1 populations and(2)to identify the number of SSR markers that are suitable for *** parentage analysis detected nine false-hybrid individuals,and the rate of false-hybrid was only 4.89%at 95%confidence,demonstrating that a low false-hybrid rate can be achieved using the ***,one to two SSR markers randomly selected from each linkage group or chromosome were recommended as a sufficient quantity for SSR identification.

关键词： artificial false flowers

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基于深度学习的下行大规模MIMO OFDM系统的1比特预编码算法

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电子与信息学报 2024年第3期46卷 886-894页

作者：周宸颢温利嫄钱骅康凯中国科学院上海高等研究院上海201210 中国科学院大学北京100049 上海科技大学信息科学与技术学院上海201210

大规模多输入多输出(MIMO)系统中通过在基站端配备数百根天线,在提高频谱利用效率的同时,也带来了系统成本的增加。本课题组之前提出了一种适用于下行大规模MIMO正交频分复用(OFDM)系统的收敛保证的多载波1比特预编码算法(CG-MC1bit),... 详细信息

大规模多输入多输出(MIMO)系统中通过在基站端配备数百根天线,在提高频谱利用效率的同时,也带来了系统成本的增加。本课题组之前提出了一种适用于下行大规模MIMO正交频分复用(OFDM)系统的收敛保证的多载波1比特预编码算法(CG-MC1bit),能够获得较优的系统性能,但相应的计算复杂度较高,阻碍了其在实时系统中的应用。为进一步解决大规模MIMO系统中的成本和功耗问题,该文提出了一个模型驱动的神经网络,在CG-MC1bit算法的基础上迭代展开(Unfolding)得到了一种更加高效的CG-MC1bit-Net算法。具体而言,将迭代算法展开为一个神经网络,并引入可训练的参数来替代前向传播中的高复杂性操作。实验结果表明,该方法能够自动更新参数,与传统的预编码算法相比,收敛速度更快,计算复杂度更低。

关键词：大规模多输入多输出预编码正交频分复用(OFDM) 迭代展开神经网络

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An integrative analysis of metabolomics,DNA methylation and RNASeq data reveals key genes involved in albino tea'Haishun 2'

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Beverage Plant Research 2022年第1期2卷 10-18页

作者： kang Wei Shuping Yu Qili Quan Shirin Aktar Mengdi He Yazhen Zhang Huihan Fang Rongmei Wu Li Ruan Peng Mao Peixian Bai Liyun Wu Hao Cheng liyuan Wang Key Laboratory of Tea Biology and Resources Utilization Ministry of AgricultureNational Center for Tea ImprovementTea Research Institute Chinese Academy of Agricultural Sciences(TRICAAS)Hangzhou 310008China Agricultural Technology Extension Center Kaihua Special Local Product(Tea)BureauQuzhou 324000China Jiande Agricultural and Rural Bureau Jiande 311699China

Albino tea,a type of tea closely associated with the chlorophyll-deficient phenotype is of great interest due to its multiple benefits to human *** explore the potential mechanisms involved in albino tea,we performed metabolomics,DNA methylation and RNA-Seq analysis of green and albino leaves in a special tea mutant'Haishun 2'.The albino leaves accumulated significantly less catechins compared with the green leaves,which is closely associated with their difference in chlorophyll formation.A total of 385 candidate genes were identified by the integrative *** NAC transcription factors were less methylated and highly up regulated in the albino leaves of'Haishun 2',which was the first identification of the key roles of NAC transcription factors in albino tea and worth further *** genes involved in catechin biosynthesis were down regulated in albino leaves,such as 4-coumarate-CoA ligase,flavonol synthase and leucoanthocyanidin reductase genes,suggesting chlorophyll formation is important for catechin ***,CsMYB5 and CsGSTF11 were found to be differentially methylated and expressed in albino and green leaves,indicating their potential roles in catechin *** was the first report of the integrative analysis of transcriptome and DNA methylation data in tea plants and the results suggest that the integrative analysis is useful for exploring key genes associated with epigenetic changes in tea plants.

关键词： analysis analysis integrative

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民航协同创新网络的集群特性分析

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科技管理研究 2015年第17期35卷 119-124页

作者：党亚茹史丽媛康馨艺中国民航大学民航科教评估中心经济与管理学院天津300300

通过收集分析103例民航协同创新案例,以机构类型分布为研究视角,建立创新集群和协作网络的结构模型对比进行分析。采用复杂网络的研究方法建立民航协同创新协作网络,分析网络的整体特征,进一步运用聚类分析找出协同创新网络中协作关系... 详细信息

通过收集分析103例民航协同创新案例,以机构类型分布为研究视角,建立创新集群和协作网络的结构模型对比进行分析。采用复杂网络的研究方法建立民航协同创新协作网络,分析网络的整体特征,进一步运用聚类分析找出协同创新网络中协作关系较为紧密的集群类型,重点研究民航协同创新网络中的主要集群结构特征,找出网络中重点机构类型并研究其在网络中的作用,探讨与其他机构类型形成的集群现象,论证政产学研协作关系在民航协同创新发展中的重要作用。

关键词：民航协同创新网络创新集群聚类分析

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