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A meta-analysis of Chinese herbal medicines for vascular dementia

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Neural Regeneration Research 2013年第18期8卷 1685-1692页

作者： Xiude Qin Yu Liu Yanqing Wu Shuo Wang Dandan Wang Jinqiang Zhu Qiaofeng Ye Wei Mou liyuan kang Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Department of Encephalopathy the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine GCP Center the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine

OBJECTIVE： To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL： We retrieved publications from Cochrane Library （2004 to July 2011）, PubMed （1966 to July 2011）, the Chinese Science and Technique Journals Database （1977 to July 2011）, the China National Knowledge Infrastructure （1979 to July 2011）, Google Scholar （July 2011）, and the Chinese Biomedical Database （1977 to July 2011） using the key words ＂Chinese medicine OR Chinese herbal medicine＂ and ＂vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia＂. SELECTION CRITERIA： Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et I＇Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers＇ Handbook 5.0. MAIN OUTCOME MEASURES： Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS： We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants （1 605 patients took Chinese medicine decoctions （treatment group）; 1 263 patients took western medicine or placebo）. The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention （relative risk （RR） = 1.27; 95%

关键词： neural regeneration Chinese herbal medicine meta-analysis vascular dementia mild cognitiveimpairment decoction efficacy Mini-Mental State Examination Hasegawa Dementia Scale adverse reaction neurodegenerative disease grants-supported paper neuroregeneration

Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

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Journal of Traditional Chinese Medicine 2015年第1期35卷 69-76页

作者： Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian kang liyuan Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Department of Neurology the Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Institute of Clinical Foundational Chinese Medicine China Academy of Chinese Medical Sciences

OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 ***: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation ***: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and ***: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis.

关键词： Neural stem cells Glial fibrillary acidicprotein Cell differentiation Janus kinase 2 STAT3transcription factor Qingnaoyizhi decoction

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小儿中医体质分型研究现状与展望

中医儿科杂志 2012年第1期8卷 59-61页

作者：康立媛北海市中医院广西北海536000

综述了小儿中医体质分型及与发病倾向、证型、预防、治疗、康复相互关系的研究现状,肯定中医体质分型研究对临床防治起到了重要的指导意义,并指出目前存在的不足之处。

关键词：儿童中医体质分型综述

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加味玉屏风散治疗儿童哮喘缓解期25例

中医儿科杂志 2012年第3期8卷 23-25页

作者：康立媛北海市中医院儿科广西北海536000

目的:观察加味玉屏风散治疗儿童哮喘缓解期的疗效。方法:将50例哮喘缓解期儿童按随机数字表法分为治疗组和对照组各25例,治疗组给予加味玉屏风散口服,对照组给予布地奈德气雾剂吸入,2组均治疗3月,随访1年。结果:治疗组总有效率92%,对照... 详细信息

目的:观察加味玉屏风散治疗儿童哮喘缓解期的疗效。方法:将50例哮喘缓解期儿童按随机数字表法分为治疗组和对照组各25例,治疗组给予加味玉屏风散口服,对照组给予布地奈德气雾剂吸入,2组均治疗3月,随访1年。结果:治疗组总有效率92%,对照组总有效率72%,治疗组疗效优于对照组(P<0.05);2组治疗后随访1年内哮喘发作次数分别为:治疗组(1.8±1.4)次,对照组(3.6±1.2)次,2组比较差异有统计意义(P<0.05)。结论:加味玉屏风散治疗儿童哮喘缓解期,可显著改善哮喘症状,明显减少哮喘反复发作的次数,提高哮喘患儿生活质量,安全简便,值得临床推广应用。

关键词：儿童哮喘缓解期加味玉屏风散疗效观察

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品质管理探究——以上海慧高为例

价值工程 2012年第12期31卷 110-111页

作者：康立元江苏科技大学经济管理学院镇江212003

伴随目前经济增速放缓的趋势,产品质量的保证是企业在竞争激烈的市场环境中保持竞争优势的关键。本文通过对上海慧高品质管理问题的现状,对影响产品质量的关键因素进行了分析,并在此基础上提出了产品质量管理改善的相关对策。

关键词：供应商管理质量管理制程改善 6S 客户服务

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中药多糖的药理学研究进展

世界科学技术-中医药现代化 2008年第3期10卷 82-86页

作者：王超康立源天津中医药大学省部共建方剂学重点实验室天津300193

多糖广泛存在于植物、动物中,现代研究证实多糖具有多方面的药理活性。本文从免疫调节、抗肿瘤、降血糖等几个方面综述了中药中多糖的最新研究进展,为多糖研究提供科学依据。

关键词：中药多糖药理作用

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饮食结构与冠心病痰湿证关系的探讨

中华中医药学刊 2014年第5期32卷 1019-1020页

作者：李霖王硕康立源天津中医药大学天津300193 天津中医药大学中医药研究院天津300193

冠心病是危害人类健康的多发病之一,现代医学研究表明饮食结构不合理是冠心病发病的重要原因之一。中医学认为冠心病病机属于本虚(心肾阳虚、心肾阴虚、气阴两虚)标实(气滞、寒凝、痰浊、瘀血),而痰湿证又是冠心病标实中之常发者。探讨... 详细信息

冠心病是危害人类健康的多发病之一,现代医学研究表明饮食结构不合理是冠心病发病的重要原因之一。中医学认为冠心病病机属于本虚(心肾阳虚、心肾阴虚、气阴两虚)标实(气滞、寒凝、痰浊、瘀血),而痰湿证又是冠心病标实中之常发者。探讨饮食结构与冠心病痰湿证的关系对于防治冠心病有重要意义。但是目前关于饮食结构与冠心病痰湿证关系研究的报告不多。从饮食结构与冠心病危险因素、饮食结构与冠心病痰湿证形成、冠心病痰湿证的现代研究及预防等几个方面,探讨饮食结构与冠心病痰湿证的关系以及在预防冠心病发病中的作用等,为冠心病的防治提供依据。

关键词：冠心病痰湿证饮食结构发病率