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Protein & Cell 2015年第3期6卷 221-224页

作者： Kunlin Zhang Suhua Chang liyuan guo Jing Wang Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China.

Dear Editor, The standard data analysis of genome-wide association study （GWAS） is based on single SNP （single nucleotide polymorphism）, thus it ignores combined effect of modest SNPs/genes. To solve this problem, pathway-based analysis （PBA） has been introduced to GWAS data analysis. PBA aims to identify biological functions and mechanisms associated with complex trait （Wang et al., 2007; Wang et al., 2010）. By now it has been one of the key ways to interpret GWAS data （Wang et al., 2010）.

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Identification of key genes and pathways for Alzheimer's disease via combined analysis of genome-wide expression profiling in the hippocampus

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Biophysics Reports 2019年第2期5卷 98-109页

作者： Mengsi Wu Kechi Fang Weixiao Wang Wei Lin liyuan guo Jing Wang CAS Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Department of Psychology University of Chinese Academy of Sciences

In this study, combined analysis of expression profiling in the hippocampus of 76 patients with Alzheimer’s disease(AD) and 40 healthy controls was performed. The effects of covariates(including age,gender, postmortem interval, and batch effect) were controlled, and differentially expressed genes(DEGs) were identified using a linear mixed-effects model. To explore the biological processes, functional pathway enrichment and protein–protein interaction(PPI) network analyses were performed on the DEGs. The extended genes with PPI to the DEGs were obtained. Finally, the DEGs and the extended genes were ranked using the convergent functional genomics method. Eighty DEGs with q <0.1,including 67 downregulated and 13 upregulated genes, were identified. In the pathway enrichment analysis, the 80 DEGs were significantly enriched in one Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway, GABAergic synapses, and 22 Gene Ontology terms. These genes were mainly involved in neuron, synaptic signaling and transmission, and vesicle metabolism. These processes are all linked to the pathological features of AD, demonstrating that the GABAergic system, neurons, and synaptic function might be affected in AD. In the PPI network, 180 extended genes were obtained, and the hub gene occupied in the most central position was CDC42. After prioritizing the candidate genes, 12 genes,including five DEGs(ITGB5, RPH3A, GNAS, THY1, and SEPT6) and seven extended genes(JUN, GDI1,GNAI2, NEK6, UBE2D3, CDC42EP4, and ERCC3), were found highly relevant to the progression of AD and recognized as promising biomarkers for its early diagnosis.

关键词： Alzheimer’s disease Combined analysis Hippocampus Gene expression Differentially expressed genes Microarray

The Status of Organochlorine Pesticides Pollution in Hubei Section of the Yangtze River

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地学前缘 2009年第S1期16卷 81-82页

作者： Chen Liu,liyuan guo School of the Earth Sciences and Resources,China University of Geosciences(Beijing),Beijing 100083,China.

The Organochlorine Pesticides(OCPs),such as hexachlorocyclohexane(HCH)and dichlorodiphenyltrichloro ethane(DDT),are well known as typical persistent organic pollutions(POPs).They were worldwide used several decades ago,even today in some *** the water resource is very important in natural environments and essential to agriculture,the pollution of OCPs in water has emerged as worldwide environmental problem. Wuhan section of the Yangtze River is the drinking water source of Wuhan area in Hubei *** addition,Hubei province is an important production base of grain,cotton,oil and *** the rapid development of industry and mass-use of OCPs

关键词： organochlorine pesticides Yangtze River water residues

Bibliometric Analysis of Patient Navigation Model Applied in Colorectal Cancer Care Based on Web of Science

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Journal of Biosciences and Medicines 2019年第3期7卷 1-11页

作者： Wenwen Cao Xiaoli Chen liyuan guo Xianbo Pei School of Health Sciences Wuhan University Wuhan China Malden Catholic High School Malden MA USA

Background: The mortality rate of colorectal cancer in China is on the rise, which has exceeded the global average rate, thus making the care of colorectal cancer widely concerned. As a comprehensive nursing model, the patient navigation model has shown its effectiveness in improving the quality of life among patients with chronic diseases and reducing the shortage of current healthcare resources in some area. This study aims to identify the current status and dilemma of the patient navigation model applied in colorectal cancer care in China. Methods: Bibliometric method was used to analyze published articles regarding the application of patient navigation model in colorectal cancer care retrieved from the Web of Science database. Statistics were presented using visualization method processed by the Bibliographic Items Co-occurrence Matrix Builder (BICOMB) software. Results: 124 articles, from 2006 to 2018, covering 14 countries, involving 931 researchers, 356 institutions and 60 publications were obtained;American research papers are the largest components of the aforementioned articles;only one of them is written by Chinese authors. The 3 leading institutions in this domain are University OF Rochester, Ohio State University, Icahn School of Medicine at Mount Sinai, yet the distribution of authors is relatively decentralized. “Cancer” is the main journal that publishes the researches in this domain. Research hotspots are on “cancer prevention and screening”, “health disparities”, “economic evaluation”, “patient navigators”, and “ethnicity”. Conclusion: In China, the research on the patient navigation is still in its infancy. Therefore, the Chinese government should provide more endorsement to this particular area and encourage the cooperation with other countries. China, having a long way to go, should further explore patient navigation on colorectal cancer care and establish a model that matches its cultural backgrounds.

关键词： Bibliometric Analysis Patient Navigation Colorectal Cancer Web of Science

Chemical Sterilization with Compound Phenol Paste(Report of 1167 Cases)

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大连医科大学学报 1986年第2期 19-23页

作者： Department of Obstet Gynecol,Chu liyuan,guo Yuxian

It had been over 100 years since Froriep in 1849 first reported usingsilver nitrate cauterization of the fallopian tubes for *** al first reported the action of atebrine in tubal occlusion and itsclinical application(1).Animal experiments in chemical tubal sterilizationand clinical researches were begun with good results in China in theearly part of the 1970’s.(2,3).The present paper is a report of theclinical research work on 1167 cases and a collective review of the Chinese

关键词： rate Report of 1167 Cases Chemical Sterilization with Compound Phenol Paste

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苛意匜銘文新解

文史 2022年第3期 259-263页

作者：郭理遠中國美術學院漢字文化研究所

苛意匜銘文中舊多釋爲从人、鑄聲之字,應改釋爲“(遺)”,全銘“蔡倀遺苛意”意爲此器是蔡倀送給苛意的。周羽劍銘“遺周羽”、余壺銘“余”、李徛壺銘“李徛”都是同格式銘文的簡省。這些銘文應係賵贈時書刻,其格式比較少見,豐富了我們... 详细信息

苛意匜銘文中舊多釋爲从人、鑄聲之字,應改釋爲“(遺)”,全銘“蔡倀遺苛意”意爲此器是蔡倀送給苛意的。周羽劍銘“遺周羽”、余壺銘“余”、李徛壺銘“李徛”都是同格式銘文的簡省。這些銘文應係賵贈時書刻,其格式比較少見,豐富了我們對先秦時期賵贈類銘文的認識。

关键词：苛意匜賵贈楚國金文

“双重发展”维度中健全人民文化权益保障制度的基本逻辑

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江西师范大学学报（哲学社会科学版） 2021年第2期54卷 43-51页

作者：郭力源上海师范大学马克思主义学院上海200234

党的十九届四中全会首次提出“健全人民文化权益保障制度”,相较之前“保障人民的基本文化权益”的工作部署,此次对人民文化权益的保障在内容上由“基本文化权益”扩展至“文化权益”,在力度上作出了“系统性”和“全局性”的制度安排,... 详细信息

党的十九届四中全会首次提出“健全人民文化权益保障制度”,相较之前“保障人民的基本文化权益”的工作部署,此次对人民文化权益的保障在内容上由“基本文化权益”扩展至“文化权益”,在力度上作出了“系统性”和“全局性”的制度安排,体现出“保障内容”和“保障力度”的“双重发展”。因此,在明晰“双重发展”具体意涵的基础上,从实践维度分析我国文化权益保障工作中的三大问题以明确实现“双重发展”所面临的挑战,并从马克思主义文化理论维度剖析当前文化权益保障体制机制中的三大短板以把握“双重发展”的实现方向,就成为新时代健全人民文化权益保障制度的基本逻辑。

关键词：双重发展文化权益制度

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论赫勒个性发展理论及其现实价值

河南社会科学 2018年第3期26卷 106-112页

作者：郭力源上海师范大学马克思主义学院上海200030

作为东欧新马克思主义的代表人物之一,赫勒在保有对马克思精神忠诚的同时,扬弃传统马克思主义的宏观经济分析和阶级分析,她通过何为个性,个性发展何以可能,个性发展何以实现的逻辑理路清晰地论述了作为微观领域的个性发展对社会变革的意... 详细信息

作为东欧新马克思主义的代表人物之一,赫勒在保有对马克思精神忠诚的同时,扬弃传统马克思主义的宏观经济分析和阶级分析,她通过何为个性,个性发展何以可能,个性发展何以实现的逻辑理路清晰地论述了作为微观领域的个性发展对社会变革的意义,但与历史唯物主义主要传统的决裂注定赫勒个性发展理论具有忽视物质生产和政治经济变革价值,而过度重视道德力量的局限。因此,从正反两个方面对赫勒个性发展理论进行考察能够客观认知个性发展的内核,从理论上为深入研究马克思人的发展理论提供辩证思维方式;从实践上为个性发展假象的解决及国家政策的解读提供新的视角和思想酵素。

关键词：赫勒个性发展理论现实价值

Diversity X chromosome inactivation and higher copy number in parthengenetic stem cells

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Diversity X chromosome inactivation and higher copy number i...

以胡承珙《小尔雅义证》“键谓之籥”条为例谈谈古籍整理中的点校问题

中华医学会第六次全国生殖医学学术会议

作者： Xiaofang Sun Weiqiang Liu liyuan guo Wenzhi He Experimental Department of Institute of Gynecology and Obstetrics the Third Affiliated Hospital of Guangzhou Medical UniversityGuangdong Key Laboratory of Obstetric Critical Disease

Background Human parthenogenetic embryonic stem cells(phESC) play important roles in the study of gene function,epigenetic *** and Epigenetic stability is critical to ensure the safety of these cells in regenerative *...

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中国典籍与文化 2019年第1期 156-159页

作者：郭理远复旦大学出土文献与古文字研究中心

《小尔雅》是增补《尔雅》的一部训诂专书,在《小尔雅》的注本中,胡承珙的《小尔雅义证》成就较高,最为世人推重。以《小尔雅义证》"键谓之籥"条为例来看,今人对此书的整理、引用存在不少点校问题,主要有标点问题、文字的错讹脱衍、没... 详细信息

《小尔雅》是增补《尔雅》的一部训诂专书,在《小尔雅》的注本中,胡承珙的《小尔雅义证》成就较高,最为世人推重。以《小尔雅义证》"键谓之籥"条为例来看,今人对此书的整理、引用存在不少点校问题,主要有标点问题、文字的错讹脱衍、没有指出原书引文方面的错误等。在古籍整理工作中,整理者和出版者都应该细心审校,尽量减少或避免此类问题的出现。

关键词：小尔雅义证键谓之籥古籍整理点校