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Combined application of organic fertilizer and chemical fertilizer alleviates the kernel position effect in summer maize by promoting post-silking nitrogen uptake and dry matter accumulation

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Journal of Integrative Agriculture 2024年第4期23卷 1179-1194页

作者： Lichao Zhai Lihua Zhang Yongzeng Cui Lifang Zhai Mengjing Zheng Yanrong Yao Jingting Zhang Wanbin Hou liyong wu Xiuling Jia Institute of Cereal and Oil Crops Hebei Academy of Agriculture and Forestry Sciences/Key Laboratory of Crop Cultivation Physiology and Green Production of Hebei ProvinceShijiazhuang 050035China Hebei Science and Technology Innovation Service Center Shijiazhuang 050051China Yongnian Agricultural Technology Extension Center Handan 057150China Ningjin Agricultural Technology Extension Center Xingtai 055550China

Adjusting agronomic measures to alleviate the kernel position effect in maize is important for ensuring high *** order to clarify whether the combined application of organic fertilizer and chemical fertilizer(CAOFCF)can alleviate the kernel position effect of summer maize,field experiments were conducted during the 2019 and 2020 growing seasons,and five treatments were assessed:CF,100%chemical fertilizer;OFCF1,15%organic fertilizer+85%chemical fertilizer;OFCF2,30%organic fertilizer+70%chemical fertilizer;OFCF3,45%organic fertilizer+55%chemical fertilizer;and OFCF4,60%organic fertilizer+40%chemical *** with the CF treatment,the OFCF1 and OFCF2 treatments significantly alleviated the kernel position effect by increasing the weight ratio of inferior kernels to superior kernels and reducing the weight gap between the superior and inferior *** effects were largely due to the improved filling and starch accumulation of inferior ***,there were no obvious differences in the kernel position effect among plants treated with CF,OFCF3,or OFCF4 in most *** area indexes,post-silking photosynthetic rates,and net assimilation rates were higher in plants treated with OFCF1 or OFCF2 than in those treated with CF,reflecting an enhanced photosynthetic capacity and improved postsilking dry matter accumulation(DMA)in the plants treated with OFCF1 or *** with the CF treatment,the OFCF1 and OFCF2 treatments increased post-silking N uptake by 66.3 and 75.5%,respectively,which was the major factor driving post-silking photosynthetic capacity and ***,the increases in root DMA and zeatin riboside content observed following the OFCF1 and OFCF2 treatments resulted in reduced root senescence,which is associated with an increased post-silking N *** showed that post-silking N uptake,DMA,and grain yield in summer maize were negatively correlated with the kernel position *** conclusion,the combined application of

关键词： chemical fertilizer dry mater accumulation kernel position effect N uptake organic fertilizer

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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额颞叶痴呆治疗进展

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重庆医科大学学报 2024年第5期49卷 531-535页

作者：岳爱玲褚敏武力勇首都医科大学宣武医院神经内科北京100053

额颞叶痴呆(frontotemporal dementia,FTD)是一组临床表型多样,遗传因素复杂,神经病理高度异质的以进行性人格行为改变,执行功能障碍及言语障碍为特征的神经退行性疾病。目前尚无有效治疗方法可以治愈或者逆转FTD进展,临床常采用对症治... 详细信息

额颞叶痴呆(frontotemporal dementia,FTD)是一组临床表型多样,遗传因素复杂,神经病理高度异质的以进行性人格行为改变,执行功能障碍及言语障碍为特征的神经退行性疾病。目前尚无有效治疗方法可以治愈或者逆转FTD进展,临床常采用对症治疗策略改善FTD患者神经精神、运动及认知症状。随着FTD发病机制的深入研究,越来越多靶向FTD突变基因及神经病理的药物正进入临床试验,以实现疾病的早期管理,精准治疗。本文主要就FTD治疗进展进行综述,有助于临床医师了解FTD最新治疗信息,提高FTD疾病管理。

关键词：额颞叶痴呆治疗基因靶向 Tau病理神经调控

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携带GRN基因突变致语义变异型原发性进行性失语患者1例:突触囊泡蛋白2A正电子发射体层摄影特点

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中华神经科杂志 2024年第4期57卷 383-386页

作者：岳爱玲褚敏刘疏影陈彪武力勇首都医科大学宣武医院神经内科北京100053

额颞叶痴呆(FTD)早期存在突触功能障碍等病理生理改变,不同基因型的FTD突触损伤模式存在差异。GRN基因突变在中国人群中较少见,目前尚未见关于GRN基因突变或语义变异型原发性进行性失语(svPPA)突触损伤模式的报道。文中报道了1例携带GR... 详细信息

额颞叶痴呆(FTD)早期存在突触功能障碍等病理生理改变,不同基因型的FTD突触损伤模式存在差异。GRN基因突变在中国人群中较少见,目前尚未见关于GRN基因突变或语义变异型原发性进行性失语(svPPA)突触损伤模式的报道。文中报道了1例携带GRN基因突变的svPPA患者的突触损伤特征,表现为偏侧额、颞、顶叶及对侧小脑突触密度降低,提示突触功能障碍参与疾病发生过程,为未来的临床干预提供了潜在的靶点。

关键词：额颞叶痴呆失语,原发进行性突触囊泡蛋白正电子发射断层显像术 GRN基因

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电力系统阵列传感开关柜局放在线监测定位技术研究

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电力设备管理 2024年第9期 262-264页

作者：吴立勇牛森李博瑶国网河南省电力公司镇平县供电公司

局放是高压电器装备绝缘性能退化的一个主要特征,也是导致其最终失效的关键因素。本文采用同轴电缆连接多个传感器构成直线阵,采用包络法对UHF局放进行频率下压,通过互相关法时延估算分析确定局放的来源,从而达到两路对多侧开关柜局放... 详细信息

局放是高压电器装备绝缘性能退化的一个主要特征,也是导致其最终失效的关键因素。本文采用同轴电缆连接多个传感器构成直线阵,采用包络法对UHF局放进行频率下压,通过互相关法时延估算分析确定局放的来源,从而达到两路对多侧开关柜局放的探测和定位。

关键词：开关柜局部放电定位特高频电磁波

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经皮椎弓根螺钉固定术联合PVP治疗老年胸腰椎骨质疏松爆裂性骨折患者的效果分析

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中外医疗 2024年第17期43卷 46-49页

作者：郭志坂许清玫吴李勇安溪县医院脊柱外科福建泉州362400

目的探讨经皮椎弓根螺钉固定术联合经皮椎体成形术(Percutaneous Vertebro Plasty,PVP)治疗老年胸腰椎骨质疏松爆裂性骨折患者的效果。方法回顾性选取2021年1月—2023年12月安溪县医院脊柱外科收治的118例老年胸腰椎骨质疏松爆裂性骨... 详细信息

目的探讨经皮椎弓根螺钉固定术联合经皮椎体成形术(Percutaneous Vertebro Plasty,PVP)治疗老年胸腰椎骨质疏松爆裂性骨折患者的效果。方法回顾性选取2021年1月—2023年12月安溪县医院脊柱外科收治的118例老年胸腰椎骨质疏松爆裂性骨折患者的临床资料,根据治疗方式分为PVP组与观察组。PVP组接受单纯PVP治疗,观察组接受经皮椎弓根螺钉固定术联合PVP治疗。比较两组手术指标、视觉模拟评分法(Visual Analogue Scale,VAS)得分、日本骨科协会评估治疗分数(Japanese Orthopaedic Association Scores,JOA)评分、Cobb角与椎体前缘高度、并发症发生情况。结果观察组手术时间为(71.50±6.36)min,术后住院时间为(5.50±1.38)d,长于PVP组,差异有统计学意义(t=27.311、10.935,P均<0.05)。观察组术中出血量为多于PVP组,差异有统计学意义(P<0.05)。术后,观察组VAS评分低于PVP组,Cobb角小于PVP组,JOA评分与椎体前缘高度高于PVP组,差异有统计学意义(P均<0.05)。观察组并发症总发生率低于PVP组,差异有统计学意义(P<0.05)。结论经皮椎弓根螺钉固定术联合PVP虽然会在一定程度上延长手术与住院时间,增加出血量,但其可提升老年胸腰椎骨质疏松爆裂性骨折治疗效果,减轻术后疼痛感,提升腰椎功能,降低并发症发生风险。

关键词：胸腰椎骨折骨质疏松老年人经皮椎弓根螺钉固定术经皮椎体成形术

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A Certified Cubic B-Spline Interpolation Method with Tangential Direction Constraints

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Journal of Systems Science & Complexity 2024年第3期37卷 1271-1294页

作者： HE Shitao SHEN liyong wu Qin YUAN Chunming School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

Curve interpolation with B-spline is widely used in various areas. This problem is classic and recently raised in application scenario with new requirements such as path planning following the tangential vector field under certified error in CNC machining. This paper proposes an algorithm framework to solve Hausdorff distance certified cubic B-spline interpolation problem with or without tangential direction constraints. The algorithm has two stages: The first stage is to find the initial cubic B-spine fitting curve which satisfies the Hausdorff distance constraint;the second stage is to set up and solve the optimization models with certain constraints. Especially, the sufficient conditions of the global Hausdorff distance control for any error bound are discussed, which can be expressed as a series of linear and quadratic constraints. A simple numerical algorithm to compute the Hausdorff distance between a polyline and its B-spline interpolation curve is proposed to reduce our *** results are presented to show the advantages of the proposed algorithms.

关键词： Cubic B-spline Hausdorff distance interpolation tangential direction

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Clusterin transduces Alzheimer-risk signals to amyloidogenesis

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3658-3661页

作者： Xi Liu Rongbo Che Wenping Liang Yun Zhang liyong wu Chao Han Hong Lu Weihong Song Yili wu Zhe Wang The National Clinical Research Center for Geriatric Disease Department of NeurologyAdvanced Innovation Center for Human Brain ProtectionXuanwu HospitalCapital Medical UniversityBeijingPR China Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanPR China Department of Psychiatry Shandong Collaborative Innovation Center for DiagnosisTreatment&Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandongPR China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and The Affiliated Wenzhou Kangning HospitalWenzhou Medical UniversityWenzhouZhejiangPR China

Dear Editor,Deposition of amyloid-β(Aβ)to form neuritic plaque(NP)is the hallmark of Alzheimer’s Disease(AD).Major non-genetic risk factors such as ageing,stroke,diabetes and other conditions facilitate AD pathogenesis via unclear ***,the mechanism underlying NP formation is *** Aβcauses NP in familial AD patients and in transgenic AD mice robustly expressing Aβ,but the NP formation requires long-term Aβaccumulation.

关键词： Alzheimer Aβ Clusterin

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Advances in longitudinal studies of amnestic mild cognitive impairment and Alzheimer's disease based on multi-modal MRI techniques

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Neuroscience Bulletin 2014年第2期30卷 198-206页

作者： Zhongjie Hu liyong wu Jianping Jia Ying Han Department of Neurology Xuan Wu Hospital Capital Medical University Postgraduates Institute Capital Medical University Alzheimer's Disease Center Beijing Institute for Brain Disorders

Amnestic mild cognitive impairment （aMCI） is a prodromal stage of Alzheimer＇s disease （AD）, and 75%-80% of aMCI patients finally develop AD. So, early identification of patients with aMCI or AD is of great significance for prevention and intervention. According to cross-sectional studies, it is known that the hippocampus, posterior cingulate cortex, and corpus callosum are key areas in studies based on structural MRI （sMRI）, functional MRI （fMRI）, and diffusion tensor imaging （DTI） respectively. Recently, longitudinal studies using each MRI modality have demonstrated that the neuroimaging abnormalities generally involve the posterior brain regions at the very beginning and then gradually affect the anterior areas during the progression of aMCI to AD. However, it is not known whether follow-up studies based on multi-modal neuroimaging techniques （e.g., sMRI, fMRI, and DTI） can help build effective MRI models that can be directly applied to the screening and diagnosis of aMCI and AD. Thus, in the future, large-scale multi-center follow-up studies are urgently needed, not only to build an MRI diagnostic model that can be used on a single person, but also to evaluate the variability and stability of the model in the general population. In this review, we present longitudinal studies using each MRI modality separately, and then discuss the future directions in this field.

关键词： magnetic resonance imaging amnestic mild cognitive impairment Alzheimer's disease multi-modality longitudinal studies

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Short-Term Household Load Forecasting Based on Attention Mechanism and CNN-ICPSO-LSTM

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Energy Engineering 2024年第6期121卷 1473-1493页

作者： Lin Ma liyong Wang Shuang Zeng Yutong Zhao Chang Liu Heng Zhang Qiong wu Hongbo Ren New Energy Technology Center State Grid Beijing Electric Power Research InstituteBeijing100075China College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai200090China

Accurate load forecasting forms a crucial foundation for implementing household demand response plans andoptimizing load scheduling. When dealing with short-term load data characterized by substantial fluctuations,a single prediction model is hard to capture temporal features effectively, resulting in diminished predictionaccuracy. In this study, a hybrid deep learning framework that integrates attention mechanism, convolution neuralnetwork (CNN), improved chaotic particle swarm optimization (ICPSO), and long short-term memory (LSTM), isproposed for short-term household load forecasting. Firstly, the CNN model is employed to extract features fromthe original data, enhancing the quality of data features. Subsequently, the moving average method is used for datapreprocessing, followed by the application of the LSTM network to predict the processed data. Moreover, the ICPSOalgorithm is introduced to optimize the parameters of LSTM, aimed at boosting the model’s running speed andaccuracy. Finally, the attention mechanism is employed to optimize the output value of LSTM, effectively addressinginformation loss in LSTM induced by lengthy sequences and further elevating prediction accuracy. According tothe numerical analysis, the accuracy and effectiveness of the proposed hybrid model have been verified. It canexplore data features adeptly, achieving superior prediction accuracy compared to other forecasting methods forthe household load exhibiting significant fluctuations across different seasons.

关键词： Short-term household load forecasting long short-term memory network attention mechanism hybrid deep learning framework

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