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Analysis of ethoxyquin and its oxidation products in swine tissues by gas chromatography-tandem mass spectrometry for evaluating the feed-toanimal tissue transfer of ethoxyquin and its metabolites

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Journal of Animal Science and Biotechnology 2021年第2期12卷 806-814页

作者： Chi zhang Xiangrong Gai Ying Tian Jiayi Wang Dongting He Wenjun Yang liying zhang Yiqiang Chen State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background:Ethoxyquin(EQ)is a common antioxidant which is widely used in animal *** the supplement of EQ in animal feed may lead to the residues of EQ and its major oxidation products:ethoxyquin quinone imine(EQI)and ethoxyquin dimer(EQDM)in animal ***,it would pose potential health hazards to ***,the method for the simultaneous determination of EQ,EQI and EQDM in animal tissues is currently not available,and the accumulation extend of these chemicals in animal tissues after EQ administration remains to be ***:A gas chromatography-tandem mass spectrometry method was successfully developed for the simultaneous determination of EQ,EQI and EQDM in swine *** quantitative limits of EQ,EQI and EQDM can achieve to 0.5,5.0 and 5.0μg/kg in swine tissues,*** spiked-recovery ratios of the three analytes(5–2000μg/kg)were in the range of 64.7%–100.7%with relative standard deviations below 11.6%.Moreover,the utilization of this method for the analysis of actual swine tissue samples revealed that the application of commercial EQ additive in swine diet would produce the residues of all the three chemicals(EQ,EQI and EQDM)in fat,kidney,liver and ***:The assay accuracy and precision of this GC-MS/MS method can meet the requirement of quantitative ***,the safety of EQ as a feed additive should be seriously considered with regard to food safety concerns since the oxidation product of EQ may have potential carcinogenicity.

关键词： Ethoxyquin Ethoxyquin dimer Ethoxyquin quinone imine Gas chromatography-tandem mass spectrometry Safety evaluation Swine tissues

Sdr4 dominates pre-harvest sprouting and facilitates adaptation to local climatic condition in Asian cultivated rice

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Journal of Integrative Plant Biology 2022年第6期64卷 1246-1263页

作者： Bo Zhao Hui zhang Tianxiao Chen Ling Ding liying zhang Xiali Ding Jun zhang Qian Qian Yong Xiang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Shanxi Key Laboratory of Minor Crop Germplasm Innovation and Molecular Breeding College of Life SciencesShanxi Agricultural UniversityTaigu 030801China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China

Pre-harvest sprouting(PHS),which reduces grain yield and quality,is controlled by seed dormancy *** few dormancy-related genes have been cloned,the genetic basis of seed dormancy in rice(Oryza sativa L.)remains ***,we performed a genome-wide association study and linkage mapping to dissect the genetic basis of seed dormancy in *** findings suggest that Seed Dormancy4(Sdr4),a central modulator of seed dormancy,integrates the abscisic acid and gibberellic acid signaling pathways at the transcriptional *** analysis revealed that three Sdr4 alleles in rice cultivars already existed in ancestral Oryza rufipogon ***,like the semi-dwarf 1(SD1)and Rc loci,Sdr4 underwent selection during the domestication and improvement of Asian cultivated *** distribution frequency of the Sdr4-n allele in different locations in Asia is negatively associated with local annual temperature and ***,we developed functional molecular markers for Sdr4,SD1,and Rc for use in molecular *** results provide clues about the molecular basis of Sdr4-regulated seed ***,these findings provide guidance for utilizing the favorable alleles of Sdr4 and Rc to synergistically boost PHS resistance,yield,and quality in modern rice varieties.

关键词： climatic adaptation pre-harvest sprouting Rc rice SD1 Sdr4 seed dormancy

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核燃料筒体部件焊缝的承载性能研究

电焊机 2024年第7期54卷 110-115页

作者：秦国鹏张丽英李金魁李冬中核建中核燃料元件有限公司四川宜宾644000

不锈钢电子束焊通常被认为是手工GTAW焊的最佳升级方案,然而在某些有剪切强度要求的焊接结构中,电子束焊缝较窄的特性可能会影响其承载性能。为保证堆芯产品焊接结构可靠性,首先对比分析了电子束(EB)焊和手工GTAW焊缝的几何尺寸和承载面... 详细信息

不锈钢电子束焊通常被认为是手工GTAW焊的最佳升级方案,然而在某些有剪切强度要求的焊接结构中,电子束焊缝较窄的特性可能会影响其承载性能。为保证堆芯产品焊接结构可靠性,首先对比分析了电子束(EB)焊和手工GTAW焊缝的几何尺寸和承载面积,发现EB焊缝的宽度仅为GTAW焊缝的53.5%,承载面积仅为GTAW焊缝的48.8%。然后通过理论计算和工况分析,得出筒体部件焊缝的最大承载力为134765 N,而EB焊缝和GTAW焊缝的理论承载力均远大于这一值。最后,通过实物试验验证,EB焊缝和GTAW焊缝的承载性能相当,且均大于筒体部件本身结构的承载能力。最终证明EB焊缝可满足正常工况及事故工况下产品承载性能的设计要求,为核燃料国产化研究的顺利推进提供了支持。

关键词：核燃料筒体部件焊接结构低钴奥氏体不锈钢焊缝承载性能

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高等量子力学研究生课程教学改革

物理通报 2024年第8期 2-5页

作者：张丽莹罗艳伟王书杰河南大学纳米科学与材料工程学院河南开封475004 河南工业大学理学院河南郑州475001

根据新工科及双一流对理工科研究生高等量子力学的课程要求,结合课程自身特点,深入探讨教学要求、知识内容、教学方法、思政元素等方面,构建学科专业所需的高等量子力学课程体系.从量子力学的课程体系改革探讨新工科育人新模式,发挥量... 详细信息

根据新工科及双一流对理工科研究生高等量子力学的课程要求,结合课程自身特点,深入探讨教学要求、知识内容、教学方法、思政元素等方面,构建学科专业所需的高等量子力学课程体系.从量子力学的课程体系改革探讨新工科育人新模式,发挥量子力学在培养理工科材料专业创新型人才的理论认知度、创新实践能力等方面的积极作用,促进理论、科研实践及课程思政的有机融合,深化量子力学课程体系改革,提升学生探物究理的科学素养.

关键词：高等量子力学研究生课程教学改革

The effects of dietary fiber level on nutrient digestibility in growing pigs

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Journal of Animal Science and Biotechnology 2013年第4期4卷 309-315页

作者： Wenjuan zhang Defa Li Ling Liu Jianjun Zang Qiwu Duan Wenjun Yang liying zhang State Key Laboratory of Animal Nutrition China Agricultural University

The objective of this study was to investigate the effects of total dietary fiber level on nutrient digestibility and the relationship between apparent total tract digestibility of total dietary fiber, and soluble dietary fiber, insoluble dietary fiber and available energy. Sugar beet pulp was as the only fiber source. The experiment was designed as a 6 x 6 Latin square with an adaptation period of 7 d followed by a 5-d total collection of feces and urine. Feed intake tended to decrease （P =0.] O） as total dietary fiber level increased. The apparent total tract digestibility of dry matter, crude protein and gross energy decreased （P 〈0.0]） when total dietary fiber increased but the digestibility of soluble dietary fiber and insoluble dietary fiber increased （P 〈0.01）. The digestible energy and metabolizable energy content of diets decreased （P 〈0.01） as the total dietary fiber increased.

关键词： Growing pigs Insoluble dietary fiber Nutrient digestibility Soluble dietary fiber Total dietary fiber

甲状腺癌冰冻切片病理不能明确诊断的临床因素分析

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中国现代医生 2024年第18期62卷 38-42页

作者：刘建张立英贾兴东冯艳玉北京市大兴区人民医院乳甲外科北京102600 北京市大兴区人民医院病理科北京102600

目的探讨术中冰冻切片(frozen section,FS)病理检查不能明确诊断甲状腺癌的发生情况,探寻影响FS病理检查准确率的临床因素。方法回顾性分析2016年8月至2019年12月在北京市大兴区人民医院行手术治疗的甲状腺癌患者。根据FS与石蜡切片病... 详细信息

目的探讨术中冰冻切片(frozen section,FS)病理检查不能明确诊断甲状腺癌的发生情况,探寻影响FS病理检查准确率的临床因素。方法回顾性分析2016年8月至2019年12月在北京市大兴区人民医院行手术治疗的甲状腺癌患者。根据FS与石蜡切片病理检查结果,将目标结节分为FS明确诊断组与不能明确诊断组(包括延迟诊断组、误诊断组、意外诊断组)。比较FS明确诊断组与不能明确诊断组之间患者的一般情况、实验室检查、彩超、病理类型。结果共纳入癌结节336个,其中明确诊断组、延迟诊断组、误诊断组、意外诊断组癌结节数量及占比分别为266个(79.17%)、28个(8.33%)、21个(6.25%)、21个(6.25%)。延迟诊断组中,“不除外”甲状腺癌使用频率最高。与明确诊断组相比,延迟诊断组、误诊断组、意外诊断组癌结节最大径均更小(P1的比例更多(P=0.017)、微钙化比例更低(P=0.002);误诊断组甲状腺过氧化物酶抗体水平更高(P=0.002)。结论临床医生应熟悉延迟诊断、误诊断常用的诊断用语。在治疗决策时应充分考虑难以明确诊断的可能,尤其是较小结节、合并慢性淋巴细胞性甲状腺炎患者。

关键词：甲状腺结节甲状腺癌冰冻切片病理延迟诊断误诊断意外诊断

Enhancing Breast Cancer Diagnosis with Channel-Wise Attention Mechanisms in Deep Learning

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Computers, Materials & Continua 2023年第12期77卷 2699-2714页

作者： Muhammad Mumtaz Ali Faiqa Maqsood Shiqi Liu Weiyan Hou liying zhang Zhenfei Wang School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou450001China

Breast cancer,particularly Invasive Ductal Carcinoma(IDC),is a primary global health concern predominantly affecting *** and precise diagnosis is crucial for effective treatment *** AI-based tech-niques for IDC-level classification have been proposed in recent *** speed,memory size,and accuracy can still be improved for better *** study presents ECAM,an Enhanced Channel-Wise Attention Mechanism,using deep learning to analyze histopathological images of Breast Invasive Ductal Carcinoma(BIDC).The main objectives of our study are to enhance computational efficiency using a Separable CNN architecture,improve data representation through hierarchical feature aggregation,and increase accuracy and interpretability with channel-wise attention *** publicly available datasets,DataBioX IDC and the BreakHis,we benchmarked the proposed ECAM model against existing state-of-the-art models:DenseNet121,VGG16,and *** the IDC dataset,the model based on AlexNet achieved an accuracy rate of 86.81%and an F1 score of 86.94%.On the other hand,DenseNet121 outperformed with an accuracy of 95.60%and an F1 score of 95.75%.Meanwhile,the VGG16 model achieved an accuracy rate of 91.20%and an F1 score of 90%.Our proposed ECAM model outperformed the state-of-the-art,achieving an impressive F1 score of 96.65%and an accuracy rate of 96.70%.The BreakHis dataset,the AlexNet-based model,achieved an accuracy rate of 90.82%and an F1 score of 90.77%.DenseNet121 achieved a higher accuracy rate of 92.66%with an F1 score of 92.72%,while the VGG16 model achieved an accuracy of 92.60%and an F1 score of 91.31%.The proposed ECAM model again outperformed,achieving an F1 score of 96.37%and an accuracy rate of 96.33%.Our model is a significant advancement in breast cancer diagnosis,with high accuracy and potential as an automated grading,especially for IDC.

关键词： Invasive ductal carcinoma breast cancer artificial intelligence deep learning

Application of halide vapor phase epitaxy for the growth of ultrawide band gap Ga_2O_3

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Journal of Semiconductors 2019年第1期40卷 57-62页

作者： Xiangqian Xiu liying zhang Yuewen Li Zening Xiong Rong zhang Youdou Zheng Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and Engineering Nanjing University

Halide vapor phase epitaxy(HVPE) is widely used in the semiconductor industry for the growth of Si, GaAs, GaN, *** is a non-organic chemical vapor deposition(CVD) technique, characterized by high quality growth of epitaxial layers with fast growth rate, which is versatile for the fabrication of both substrates and devices with wide applications. In this paper, we review the usage of HVPE for the growth and device applications of Ga_2O_3, with detailed discussions on a variety of technological aspects of HVPE. It is concluded that HVPE is a promising candidate for the epitaxy of large-area Ga_2O_3 substrates and for the fabrication of high power β-Ga_2O_3 devices.

关键词： halide vapor phase epitaxy Ga2O3 Schottky barrier diodes epitaxy growth

Controllable Synthesis of Fluorescent Carbon Dots and Their Detection Application as Nanoprobes

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Nano-Micro Letters 2013年第4期5卷 247-259页

作者： Zhi Yang Zhaohui Li Minghan Xu Yujie Ma Jing zhang Yanjie Su Feng Gao Hao Wei liying zhang Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University

Carbon dots(CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because of their outstanding water solubility, high sensitivity and selectivity to target analytes, low toxicity, favorable biocompatibility, and excellent photostability, researchers from diverse disciplines have come together to further develop the fundamental properties of CDs. Many methods for the production of CDs have been reported, therein, hydrothermal and solvothermal technology needs simple equipments, and microwave synthesis needs less reaction time, hence these methods become current common synthesis methods, in which many precursors have been applied to produce CDs. Due to their excellent fluorescence, CDs have made impressive strides in sensitivity and selectivity to a diverse array of salt ions,organic/biological molecules and target gases. The development of CDs as nanoprobes is still in its infancy, but continued progress may lead to their integration into environmental and biological applications. Hydrothermal,solvothermal, and microwave synthesis of fluorescent carbon dots and their detection applications as nanoprobes in salt ions, organic/biological molecules, and target gases will be reviewed.

关键词： Carbon dots Hydrothermal Solvothermal Microwave Nanoprobe