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120A列车照明设计仿真分析

今日自动化 2024年第1期 146-148页

作者：何英彪汤诚马丽英中车株洲电力机车有限公司湖南株洲412000

文章对客室照明设计方案和灯具选型进行了阐述,利用DIALux软件对120 A客室照明强度进行仿真,并通过装车验证分析对客室照明方案进行验证,为轨道车辆客室照明设计提供了指导性意见.

关键词：客室照明 LightTools DIALux 照度试验

Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B

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Virologica Sinica 2020年第2期35卷 181-190页

作者： Zheng Wang Xiaolin Ji Yanling Hao Kunxue Hong liying ma Dan Li Yiming Shao State Key Laboratory of Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeijing 102206China Division of Research of Virology and Immunology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation,stabilization,and translation of the viral *** of HIV-1 clade BC often shows a truncation of 16 AAs due to a premature stop codon at residue *** stop codon presents the highest frequency in clade BC and the lowest frequency in clade *** order to discover the potential biological effect of this truncation on Rev activity and virus replication of clade BC,we constructed Rev expression vectors of clade BC with or without 16 AAs within C-terminal separately,and replaced the stop codon by Q in a CRF07_BC infectious *** found that 16 AAs truncation had no effect on expression and activity of Rev in clade ***,the mutation from the stop codon to Q had no effect on virus replication of clade ***,to investigate the effect of this truncation on Rev activity and replication capacity of clade B,Rev expression vectors of clade B carrying or lacking 16 AAs in C-terminal were constructed respectively,and residue Q at position 101 within Rev was substituted by the stop codon in a clade B infectious *** was found that 16 AAs truncation significantly down-regulated Rev expression and impaired clade B Rev ***,a Q-to-stop codon substitution within Rev significantly reduced viral replication fitness of clade *** results indicate that the premature stop codon at residue 101 within Rev exerts diverse impact on viral replication among different HIV-1 clades.

关键词： HIV-1 CRF_BC Rev Premature stop codon Replication

面部注射美容术致视力障碍眼部并发症的MRI表现

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分子影像学杂志 2024年第6期47卷 587-592页

作者：杨淑辉沈海洋张鹏举钟燕邢新博刘文潇马丽颖李天然中国人民解放军总医院第四医学中心放射诊断科北京100048 首都医科大学附属北京同仁医院放射科北京100005 中国人民解放军总医院第四医学中心介入科北京100048

目的总结面部美容注射术后致视力障碍患者眼部并发症的MRI影像表现。方法回顾性分析2015年12月~2023年5月因在外院行面部美容注射术后出现单眼视力急剧下降于解放军总医院第四医学中心就诊的73例患者的眼眶高分辨MRI表现。左眼视力障碍3... 详细信息

目的总结面部美容注射术后致视力障碍患者眼部并发症的MRI影像表现。方法回顾性分析2015年12月~2023年5月因在外院行面部美容注射术后出现单眼视力急剧下降于解放军总医院第四医学中心就诊的73例患者的眼眶高分辨MRI表现。左眼视力障碍38例,右眼视力障碍35例。MRI的观察内容包括有无缺血性视神经病变、视网膜缺血损伤、眼外肌缺血水肿、上眼睑缺血水肿、球后渗出、眼球萎缩、眼球突出及MRI表现。结果73例(100%)均在MRI上出现缺血性视神经病变;38例表现为视神经眶内段局灶性病变,其中2例表现为多节段;35例累及视神经眶内段全程;73例在高清弥散Resolve序列上均表现为明显高信号,ADC图上信号减低;在T1WI上呈等信号,在T2WI上呈等或稍高信号。52例(71.2%)出现视网膜缺血损伤,在高清弥散Resolve序列上表现为视网膜弧形高信号影。45例(61.6%)出现眼外肌缺血水肿,表现为受累眼外肌增粗、肿胀,在T2WI上呈稍高信号。21例(28.8%)出现球后渗出,表现为在横轴位T2WI-FS上眼球后方肌锥内斑片状稍高信号影。33例(45.2%)出现上眼睑缺血水肿,表现为上眼睑肿胀,在横轴位T2WI-FS上呈稍高信号。7例(9.6%)出现眼球萎缩变形。4例(5.5%)出现眼球突出。结论面部注射美容术致视力障碍患者眼部并发症在MRI上可表现为急性缺血性视神经病变、视网膜缺血损伤、眼外肌缺血水肿、上眼睑缺血水肿、球后渗出、眼球萎缩及眼球突出。

关键词：面部注射美容术视力障碍磁共振成像

A novel thermomechanically stable LaF_3–CsH_5(PO_4)_2 composite electrolyte with high proton conductivity at elevated temperatures over 150 °C

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Journal of Energy Chemistry 2019年第3期28卷 114-120页

作者： Jie Xiong Yunjie Huang Jing Li liying ma Guoxiao Xu Zhao Liu Weiwei Cai Hansong Cheng Sustainable Energy Laboratory Faculty of Materials Science and Chemistry China University of Geosciences (Wuhan) College of Chemistry Chemical Engineering and Material Science Zaozhuang University

A facile strategy is introduced to upgrade thermomechanical stability of the cesium pentahydrogen diphosphate(CPD), which is the most efficient inorganic electrolyte among all solid proton conductors,by constructing P–OH···F hydrogen bonds with lanthanum fluoride(LaF_3). The optimal combination of the LaF_3–CPD composite electrolyte is found to be 1:2 in a molar ratio(LaF_3–CPD-2). LaF_3–CPD-2 composite maintains robust solid state, even at a temperature up to 200 °C, which is 50 °C higher than the melting temperature of CPD. Meanwhile, the considerable proton conductivity of CPD is achieved in the LaF_3–CPD-2 composite electrolyte due to the synergistic effect of the P–OH···F hydrogen bonds and the intrinsic proton conductive property of CPD. Last but not least, the LaF_3–CPD-2 composite manifests excellent conductivity durability at 150 °C and low humidity condition with sizeable proton conductivity of0.0262 S cm^(-1) after 60 h operation, implying that the LaF_3–CPD composite could be a promising candidate for intermediate temperature proton conductors.

关键词： Intermediate temperature fuel cell Hydrogen bond Cesium pentahydrogen diphosphate Lanthanum fluoride Thermomechanical stability

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1658-1668页

作者： liying may Haojie Wangy Yinghua You Chaoya ma Yuejiao Liu Feifei Yang Yichao Zheng Hongmin Liu Collaborative Innovation Center of New Drug Research and Safety Evaluation Henan ProvinceKey Laboratory of Technology of Drug Preparation(Zhengzhou University)Ministry of Education of ChinaKey Laboratory of Henan Province for Drug Quality and EvaluationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Histone lysine specific demethylase 1(LSD1)has become a potential therapeutic target for the treatment of *** and develop novel and potent LSD1 inhibitors is a challenge,although several of them have already entered into clinical ***,for the first time,we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide(FAD)similarity-based designing strategy,of which compound 14 q was finally identified to repress LSD1 with IC50=183 nmol/*** analysis suggested that compound 14 q fitted well into the FAD-binding *** mechanism studies showed that compound 14 q may inhibit LSD1 activity competitively by occupying the FAD binding sites of LSD1 and inhibit cell migration and invasion by reversing epithelial to mesenchymal transition(EMT).Overall,these findings showed that compound14 q is a suitable candidate for further development of novel FAD similarity-based LSD1 inhibitors.

关键词： LSD1 inhibitors Pyrimidine Anticancer Flavin adenine dinucleotide(FAD) Gastric cancer

Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety

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Chinese Journal of Chemistry 2014年第5期32卷 443-447页

作者： Kunpeng Shao Xuyao Zhang Xiaosong Zhang Dengqi Xue liying ma Qiurong Zhang Hongmin Liu School of Pharmaceutical Sciences and New Drug Research&Development Center Zhengzhou UniversityZhengzhouHenan 450001China

A series of 4-anilino-6-phenylpyrimidines containing urea moiety were synthesized and the structures of all products were confirmed by^(1)H NMR,^(13)C NMR and *** antiproliferative activities of these compounds were evaluated against three human tumor cell lines(MGC-803,MCF-7 and EC-109)by applying the MTT assay *** 4a,4b and 6a showed the most effective activity,among which,6a was more cytotoxic than 5-fluorouracil against all tested human cancer cell lines with IC_(50) values ranging from 1.80 to 2.72μmol·L^(-1).

关键词： synthesis pyrimidine urea antitumor

不同途径给药恩诺沙星对豚鼠体质量和血液生理生化指标的影响

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实验动物科学 2024年第3期41卷 40-45页

作者：董浩刘志国刘金生武卫国王学文张乐颖董青花朱婉月马丽颖左琴中国食品药品检定研究院国家啮齿类实验动物资源库北京102629

目的测定不同途径进行恩诺沙星给药,对豚鼠体质量变化和血液生理生化指标的影响。方法分别测定不同途径进行恩诺沙星给药对豚鼠体质量、血液生理指标和血液生化指标的影响,利用统计学方法分析组间差异。结果高剂量恩诺沙星饮水给药会显... 详细信息

目的测定不同途径进行恩诺沙星给药,对豚鼠体质量变化和血液生理生化指标的影响。方法分别测定不同途径进行恩诺沙星给药对豚鼠体质量、血液生理指标和血液生化指标的影响,利用统计学方法分析组间差异。结果高剂量恩诺沙星饮水给药会显著影响豚鼠的饮水量,高剂量恩诺沙星和低剂量恩诺沙星饮水给药都会显著影响豚鼠的体质量增长。在血液生理指标方面,不同给药处理组中的白细胞计数WBC、单核细胞绝对值MON、中性粒细胞绝对值GRAN、平均红细胞血红蛋白浓度MCHC、红细胞分布宽度变异系数RDW-CV、血小板分布宽度PDW等6项指标与对照组相比具有统计学意义(P<0.05)。在血液生化指标方面,与对照组相比,不同给药处理组中的钙Ca、丙氨酸氨基转移酶ALT、碱性磷酸酶ALP、γ-谷氨酰转肽酶γ-GT、三酰甘油TG等5项指标具有统计学意义。结论不同途径恩诺沙星给药对豚鼠多项生物学指标影响的测定,为豚鼠的科学用药提供了基础数据。

关键词：恩诺沙星豚鼠血液生理指标血液生化指标

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HIV-1潜伏储存库检测方法的研究进展

中华实验和临床病毒学杂志 2022年第4期36卷 488-493页

作者：何林马丽英中国疾病预防控制中心性病艾滋病预防控制中心北京102206

HIV-1的感染引起艾滋病,抗逆转录病毒治疗能有效地抑制病毒复制,由于HIV-1潜伏储存库的存在使得艾滋病无法治愈。有复制能力HIV-1潜伏在细胞内、逃脱免疫系统监视,从而形成HIV-1潜伏储存库。如何准确检测HIV-1潜伏储存库,可为今后艾滋... 详细信息

HIV-1的感染引起艾滋病,抗逆转录病毒治疗能有效地抑制病毒复制,由于HIV-1潜伏储存库的存在使得艾滋病无法治愈。有复制能力HIV-1潜伏在细胞内、逃脱免疫系统监视,从而形成HIV-1潜伏储存库。如何准确检测HIV-1潜伏储存库,可为今后艾滋病治愈提供思路。本文就目前HIV-1潜伏储存库的检测方法和特点进行概述。

关键词：艾滋病 Ⅰ型艾滋病病毒潜伏储存库检测

Cu nanoparticle-decorated two-dimensional carbon nanosheets with superior photothermal conversion efficiency of 65 % for highly efficient disinfection under near-infrared light

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Journal of materials Science & Technology 2021年第28期87卷 83-94页

作者： Jie Song Jun Li Xiangren Bai Liang Kang liying ma Naiqin Zhao Shuilin Wu Yuan Xue Jiajun Li Xiaojian Ji Junwei Sha School of materials Science and Engineering and Tianjin Key Laboratory of Composites and Functional materials Tianjin UniversityTianjin300350China Department of Orthopaedic Surgery Tianjin Medical University General HospitalTianjin300052China Department of Rheumatology Chinese PLA General HospitalBeijing100853China

Low photothermal conversion efficiency restricts the antibacterial application of photothermal *** this work,two-dimensional carbon nanosheets(2D C)were prepared and decorated with Cu nanoparticles(2D C/Cu)by using a simple soluble salt template method combined with ultrasonic *** photothermal conversion efficiency of 2 D C/Cu system can be optimized by changing the content of Cu nanoparticles,where the 2D C/Cu2 showed the best photothermal conversion efficiency(á)of 65.05%under 808 nm near-infrared light *** addition,the photothermal performance can affect the release behavior of Cu *** superior photothermal property combined with released Cu ions can endow this 2D hybrid material with highly efficient antibacterial efficacy of 99.97%±0.01%,99.96%±0.01%,99.97%±0.01%against Escherichia coli,Staphylococcus aureus,and methicillin-resistant Staphylococcus aureus,respectively,because of the synergetic effect of photothermy and ion *** addition,this 2D hybrid system exhibited good ***,this study provides a novel strategy to enhance the photothermal performance of 2D materials and thus will be beneficial for development of antibiotics-free antibacterial materials with safe and highly efficient bactericidal activity.

关键词： Photothermal conversion Antibacterial Two-dimensional carbon nanosheet Cu nanoparticle Near-infrared light