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集成电路应用 2024年第8期41卷 400-401页

作者：石丽姚广州华商职业学院广东511300

阐述RPA技术在智能财务系统中的应用,包括在数据录入、报表生成、账单管理、税务处理方面的应用。分析RPA技术在智能财务系统中的优势和效益,对智能财务系统效益评估的作用。

关键词：机器人流程自动化RPA 智能财务系统效益评估

Exploring the mechanism of Fu-Zi Decoction in treatment of chronic heart failure based on network pharmacology and molecular docking technology

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Journal of Chinese Pharmaceutical Sciences 2021年第9期30卷 705-715页

作者： Taixiang Gao Feng Zhao liyao shi Rui Wang School of Traditional Chinese Materia Medical Shanxi University of Traditional Chinese MedicineJinzhong 030619China

In the present study, we aimed to explore the mechanism of Fu-Zi Decoction in the treatment of chronic heart failure(CHF) using network pharmacology. Sym Map database was used to analyze the modern medical(MM) symptoms of various medicines. The chemical components of Fu-Zi Decoction were obtained through TCMSP, ETCM database, and previous results. The targets of Fu-Zi Decoction were obtained through STITCH, Swiss Target Prediction, Target NET database, and literature. The targets for the treatment of CHF were obtained from the Dis Ge NET, GEO, and Drug Bank databases, and the common parts of the Fu-Zi Decoction targets were screened out to construct the PPI network. The PPI network was decomposed modularly, its functions were analyzed, and the KEGG pathway enrichment analysis was performed. The key target was verified by Swiss Dock for molecular docking. A total of 205 chemical components of Fu-Zi Decoction, 551 drug targets, and 521 disease targets were collected. Functional enrichment analysis revealed that it was mainly involved in biological processes, such as negative regulation of cell death, oxidative stress, and G protein-coupled receptor regulation. KEGG enrichment findings mainly involved fluid shear stress and atherosclerosis, IL-17 signaling pathway, and so on. The results of molecular docking showed that benzoylaconitine, aconitine, mesaconitine, paeoniflorin, and atractylodes Ⅲ all had a strong affinity with the core target CXCL8, suggesting that Fu-Zi Decoction could negatively regulate cell apoptosis and oxidative stress through fluid shear stress and atherosclerosis, IL-17 signaling pathway, and so on. Collectively, our data showed that Fu-Zi Decoction had a good effect on the treatment of CHF.

关键词： Fu-Zi Decoction Chronic heart failure Network pharmacology Molecular docking

Qualitation of Chuanxiong Rhizome essential oil and determination of 3-butylidenephthalide and ligustilide by GC-MS

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Journal of Chinese Pharmaceutical Sciences 2021年第5期30卷 434-445页

作者： Ximei Yan Taixiang Gao liyao shi Rui Wang School of Traditional Chinese Materia Medical Shanxi University of Traditional Chinese MedicineJinzhong 030619China

Chuanxiong Rhizoma(rhizomes of Ligusticumchuanxiong Hort)is a classical Chinese medicine,and it is usually used for the treatment of cardiovascular *** essential oil is the main active constituent of *** this study,a GC-MS quantitative method based on the SIM scanning mode and batch processing analysis was established,and the total contents of 3-butylidenephthalide and ligustilide were used as the indicators to optimize three extraction methods,including hydro-distillation extraction(HDE),ultrasound-assisted extraction(UAE)and supercritical fluid extraction(SFE).Then the volatile oil obtained by three extraction methods was analyzed *** results showed that the volatile oil obtained by the UAE had the highest contents of 3-butylidenephthalide and ligustilide,the volatile oil extracted by HDE had the most types of chemical components,and the SFE volatile oil had the highest oil yield.

关键词： Ligusticumchuanxiong Hort 3-Butylidenephthalide Ligustilide GC-MS SIM scanning

越婢加术汤的HPLC指纹图谱建立、含量测定及化学模式识别分析

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中国药房 2021年第22期32卷 2724-2730页

作者：赵峰高太祥石莉尧王瑞山西中医药大学中药与食品工程学院山西晋中030619

目的:建立越婢加术汤的高效液相色谱(HPLC)指纹图谱,测定其中盐酸麻黄碱和盐酸伪麻黄碱的含量,同时进行化学模式识别分析。方法:以甘草酸铵为参照,使用《中药色谱指纹图谱相似度评价系统(2012版)》建立10批越婢加术汤的HPLC指纹图谱并... 详细信息

目的:建立越婢加术汤的高效液相色谱(HPLC)指纹图谱,测定其中盐酸麻黄碱和盐酸伪麻黄碱的含量,同时进行化学模式识别分析。方法:以甘草酸铵为参照,使用《中药色谱指纹图谱相似度评价系统(2012版)》建立10批越婢加术汤的HPLC指纹图谱并进行相似度评价,结合混合对照品指认共有峰;采用HPLC法测定盐酸麻黄碱和盐酸伪麻黄碱的含量;采用SPSS 26.0软件进行聚类分析,采用SIMCA 13.0软件进行主成分分析和偏最小二乘法-判别分析,并筛选影响越婢加术汤质量的差异性成分。结果:越婢加术汤指纹图谱中共有20个共有峰,与对照指纹图谱的相似度均大于0.92;共指认了2个色谱峰,分别为甘草苷(峰11)和甘草酸铵(峰18)。盐酸麻黄碱、盐酸伪麻黄碱检测质量浓度的线性范围分别为0.98~48μg/mL(r=0.9999)、1.02~51μg/mL(r=0.9992);精密度、重复性、稳定性(24 h)试验的RSD均小于2%;平均加样回收率分别为105.67%(RSD=2.88%,n=9)、104.15%(RSD=2.02%,n=9);含量分别为0.0081~0.0143、0.0025~0.0118 mg/mL。聚类分析结果显示,10批越婢加术汤可聚为3类,S1聚为一类,S3聚为一类,S2、S4~S10聚为一类。主成分分析结果显示,S3位于得分图的最右侧,S1位于得分图的右侧,S2、S4~S10位于得分图的中部。偏最小二乘法-判别分析结果与聚类分析、主成分分析基本一致,且峰9、峰3、峰12、峰8、峰19、峰18(甘草酸铵)、峰13、峰20、峰11(甘草苷)的重要性投影值均大于1。结论:所建HPLC指纹图谱和含量测定方法操作简便、准确,结合化学模式识别可用于越婢加术汤的质量控制。峰9等9个成分为影响越婢加术汤质量的差异性成分。

关键词：越婢加术汤高效液相色谱法指纹图谱含量测定化学模式识别

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少腹逐瘀丸质控方法研究

河北科技大学学报 2019年第3期40卷 208-214页

作者：史利瑶李建晨田蜜河北科技大学化学与制药工程学院

为了解决现行《中华人民共和国药典》中关于少腹逐瘀丸的鉴别存在项目单一、不同剂型之间质控标准不统一等问题,通过对处方中主要药效成分进行定性和定量研究,建立了一种更为全面的少腹逐瘀丸质控方法。采用薄层色谱法定性鉴别处方中的... 详细信息

为了解决现行《中华人民共和国药典》中关于少腹逐瘀丸的鉴别存在项目单一、不同剂型之间质控标准不统一等问题,通过对处方中主要药效成分进行定性和定量研究,建立了一种更为全面的少腹逐瘀丸质控方法。采用薄层色谱法定性鉴别处方中的蒲黄、延胡索、肉桂3味药材,通过高效液相色谱法测定芍药苷的含量。结果表明:在薄层色谱图中观察到蒲黄、延胡索、肉桂药材的特征斑点,芍药苷进样量在0.128~1.28μg范围内线性关系良好,精密度、稳定性、重复性试验的RSD值均小于2.0%,平均回收率为92.10%,RSD值为1.40%(n=9),芍药苷含量的建议值不低于1.20mg/g。所建立的方法准确可靠,可行性高,重复性良好,可以作为完善少腹逐瘀丸质量标准的参考依据。

关键词：色谱分析薄层色谱法高效液相色谱法少腹逐瘀丸质量控制

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正庚烷/甲烷混合燃烧特性数值分析

航空动力学报 2024年第2期39卷 24-31页

作者：石云姣孙继昊徐宏昊庞历瑶赵宁波郑洪涛哈尔滨工程大学动力与能源工程学院哈尔滨150001

针对燃气轮机的双燃料混合燃烧问题,采用直接关系图法对NUI(National University of Ireland)机理进行简化(含204组分,902步反应),在此基础上数值研究了甲烷质量分数和体积分数对正庚烷/甲烷混合燃烧特性的影响。结果表明:提高甲烷体积... 详细信息

针对燃气轮机的双燃料混合燃烧问题,采用直接关系图法对NUI(National University of Ireland)机理进行简化(含204组分,902步反应),在此基础上数值研究了甲烷质量分数和体积分数对正庚烷/甲烷混合燃烧特性的影响。结果表明:提高甲烷体积分数会使混合燃料的着火延迟时间非线性增加,层流火焰速度、绝热火焰温度、一氧化碳排放下降;当甲烷体积分数超过70%时,混合燃料的层流火焰速度和着火延迟时间对甲烷体积分数较为敏感。此外,对于采用正庚烷/甲烷的环形燃烧室,在保持混合燃料热值不变的条件下,两种燃料的火焰锋面位置基本相同,且随着甲烷质量分数的升高,火焰长度和托举高度逐渐增加,燃烧效率、总压损失、一氧化碳和氮氧化物排放逐渐下降;当甲烷质量分数低于30%时,火焰呈“V”型,高于30%时火焰呈“M”型。

关键词：燃气轮机正庚烷甲烷机理简化燃烧室

A DEEP LEARNING BASED DISCONTINUOUS GALERKIN METHOD FOR HYPERBOLIC EQUATIONS WITH DISCONTINUOUS SOLUTIONS AND RANDOM UNCERTAINTIES

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Journal of Computational Mathematics 2023年第6期41卷 1281-1304页

作者： Jingrun Chen shi Jin liyao Lyu School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China School of Mathematical Sciences Institute of Natural Sciencesand MOE-LSCShanghai Jiao Tong UniversityShanghai200240China Department of Computational Mathematics Scienceand EngineeringMichigan State UniversityEast LansingMI48824USA

We propose a deep learning based discontinuous Galerkin method(D2GM)to solve hyperbolic equations with discontinuous solutions and random *** main computational challenges for such problems include discontinuities of the solutions and the curse of dimensionality due to *** learning techniques have been favored for high-dimensional problems but face difficulties when the solution is not smooth,thus have so far been mainly used for viscous hyperbolic system that admits only smooth *** alleviate this difficulty by setting up the loss function using discrete shock capturing schemes–the discontinous Galerkin method as an example–since the solutions are smooth in the discrete *** convergence of D2GM is established via the Lax equivalence theorem kind of *** high-dimensional random space is handled by the Monte-Carlo *** a setup makes the D2GM approximate high-dimensional functions over the random space with satisfactory accuracy at reasonable *** D2GM is found numerically to be first-order and second-order accurate for(stochastic)linear conservation law with smooth solutions using piecewise constant and piecewise linear basis functions,*** examples are given to verify the efficiency and the robustness of D2GM with the dimensionality of random variables up to 200 for(stochastic)linear conservation law and(stochastic)Burgers’equation.

关键词： Discontinuous Galerkin method Loss function Convergence analysis Deep learning Hyperbolic equation

盐析辅助水蒸气蒸馏法对川芎挥发油提取的影响研究

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山西中医药大学学报 2021年第1期22卷 41-44页

作者：闫玺镁石莉尧高太祥王瑞山西中医药大学山西晋中030619

目的:探讨盐析辅助水蒸气蒸馏法对川芎挥发油提取的影响。方法:采用气相色谱-质谱联用(GC-MS)仪对氯化钠、磷酸氢二钠辅助水蒸气蒸馏法和传统水蒸气蒸馏法提取的川芎挥发油成分进行分析,同时以丁烯基苯酞和藁本内酯的总含量为指标进行... 详细信息

目的:探讨盐析辅助水蒸气蒸馏法对川芎挥发油提取的影响。方法:采用气相色谱-质谱联用(GC-MS)仪对氯化钠、磷酸氢二钠辅助水蒸气蒸馏法和传统水蒸气蒸馏法提取的川芎挥发油成分进行分析,同时以丁烯基苯酞和藁本内酯的总含量为指标进行定量比较。结果:水蒸气蒸馏所得挥发油中得到17种化合物,挥发油提取率为0.15%,丁烯基苯酞和藁本内酯的平均总含量为4.09 mg/g;氯化钠辅助水蒸气蒸馏法得到15种化合物,挥发油取率为0.29%,丁烯基苯酞和藁本内酯的平均总含量为4.15 mg/g;磷酸氢二钠辅助水蒸气蒸馏法得到15种化合物,挥发油提取率为0.11%,丁烯基苯酞和藁本内酯的平均总含量为3.31 mg/g。结论:盐析辅助水蒸气蒸馏法与传统水蒸气蒸馏法相比,所提川芎挥发油成分差别不大,氯化钠辅助可提高出油率,但对丁烯基苯酞和藁本内酯含量无明显影响;磷酸氢二钠辅助会降低出油率,丁烯基苯酞和藁本内酯含量也稍有降低。

关键词：川芎挥发油盐析辅助水蒸气蒸馏 GC-MS 丁烯基苯酞藁本内酯

A Consensus-Based Global Optimization Method with Adaptive Momentum Estimation

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Communications in Computational Physics 2022年第4期31卷 1296-1316页

作者： Jingrun Chen shi Jin liyao Lyu School of Mathematical Sciences University of Science and Technology of ChinaHefeiAnhui 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhouJiangsu 215123China School of Mathematical Sciences Institute of Natural SciencesMOE-LSCShanghai Jiao Tong UniversityShanghai200240China Department of Computational Mathematics Scienceand EngineeringMichigan State UniversityEast LansingMI48824USA

Objective functions in large-scalemachine-learning and artificial intelligence applications often live in high dimensions with strong non-convexity and massive local ***-based methods,such as the stochastic gradient method and Adam[15],and gradient-freemethods,such as the consensus-based optimization(CBO)method,can be employed to find *** this work,based on the CBO method and Adam,we propose a consensus-based global optimization method with adaptive momentum estimation(Adam-CBO).Advantages of the Adam-CBO method include:It is capable of finding global minima of non-convex objective functions with high success rates and low *** is verified by finding the global minimizer of the 1000 dimensional Rastrigin function with 100%success rate at a cost only growing linearly with respect to the *** can handle non-differentiable activation functions and thus approximate lowregularity functions with better *** is confirmed by solving a machine learning task for partial differential equations with low-regularity solutions where the Adam-CBO method provides better results than *** is robust in the sense that its convergence is insensitive to the learning rate by a linear stability *** is confirmed by finding theminimizer of a quadratic function.

关键词： Consensus-based optimization global optimization machine learning curse of dimensionality

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地下煤气化合成气的脱碳提氢耦合工艺探讨

低碳化学与化工 2024年第1期49卷 125-132页

作者：王涛史世杰曾丽瑶罗珊周振华丁锋王召民高继峰中石化中原石油工程设计有限公司河南郑州451000 中石化石油工程建设有限公司北京100020

针对煤炭地下气化(UCG)技术制备的合成气具有温度高(>200℃)、压力大(3.35 MPa)、饱和含水量大及组分复杂(含CH_(4)、H_(2)、CO_(2)和CO等)的特点,设计并采用膜分离+溶剂吸收耦合的处理方法以实现地下煤合成气中CO_(2)的脱除和H_(2)的... 详细信息

针对煤炭地下气化(UCG)技术制备的合成气具有温度高(>200℃)、压力大(3.35 MPa)、饱和含水量大及组分复杂(含CH_(4)、H_(2)、CO_(2)和CO等)的特点,设计并采用膜分离+溶剂吸收耦合的处理方法以实现地下煤合成气中CO_(2)的脱除和H_(2)的提纯。地下煤合成气经过二级膜分离单元的处理,实现了CO_(2)/H_(2)与CH_(4)的分离并得到了脱碳净化气,其中CO_(2)含量(物质的量分数)≤3%,该膜分离工艺所需能耗为0.297 k W·h/m^(3)。使用醇胺吸收法处理CO_(2)/H_(2)混合气,并通过配方溶液筛选、工艺流程优化和校验分析等方法开展了研究,最终得到了H_(2)纯度(物质的量分数)≥99%的产品,该醇胺吸收法的能耗为0.341 k W·h/m^(3)。使用膜分离+溶剂吸收耦合处理复杂工况的地下煤合成气,可得到脱碳净化气、纯CO_(2)和工业级H_(2),提高了项目的经济价值,具有较大的应用潜力。

关键词：地下煤气化膜分离溶液吸收法脱碳提氢