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The Application of Artificial Intelligence in Alzheimer’s Research

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Tsinghua Science and Technology 2024年第1期29卷 13-33页

作者： Qing Zhao Hanrui Xu Jianqiang Li Faheem Akhtar Rajput liyan qiao Faculty of Information Technology Beijing University of TechnologyBeijing 100124China School of Medicine Tsinghua UniversityBeijing 100084China Department of Computer Science Sukkur IBA UniversitySukkur 65200Pakistan Department of Neurology Tsinghua University Yuquan HospitalBeijing 100040China

Alzheimer's disease(AD)is an irreversible and neurodegenerative disease that slowly impairs memory and neurocognitive function,but the etiology of AD is still *** the explosive growth of electronic health data,the application of artificial inteligence(Al)in the healthcare setting provides excellent potential for exploring etiology and personalized treatment approaches,and improving the disease's diagnostic and prognostic *** paper first briefly introduces Al technologies and applications in medicine,and then presents a comprehensive review of Al in *** simple,it includes etiology discovery based on genetic data,computer-aided diagnosis(CAD),computer-aided prognosis(CAP)of AD using multi-modality data(genetic,neuroimaging and linguistic data),and pharmacological or non-pharmacological approaches for treating ***,some popular publicly available AD datasets are introduced,which are important for advancing Al technologies in AD ***,core research challenges and future research directions are discussed.

关键词： Alzheimer's disease artificial intelligence etiology discovery computer-aided diagnosis computer-aided prognosis treatment

A Computer-Aided System for Ocular Myasthenia Gravis Diagnosis

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Tsinghua Science and Technology 2021年第5期26卷 749-758页

作者： Guanjie Liu Yan Wei Yunshen Xie Jianqiang Li liyan qiao Ji-jiang Yang the Faculty of Information Technology Beijing University of TechnologyBeijing 100124China the Neurology Department The Second Affiliated Hospital of Tsinghua UniversityBeijing 100040China the Department of Automation Tsinghua UniversityBeijing 100084China

The current mode of clinical aided diagnosis of Ocular Myasthenia Gravis(OMG)is time-consuming and laborious,and it lacks quantitative *** aided diagnostic system for OMG is proposed to solve this *** values calculated by the system include three clinical indicators:eyelid distance,sclera distance,and palpebra superior fatigability test *** the first two indicators,the semantic segmentation method was used to extract the pathological features of the patient's eye image and a semantic segmentation model was *** patient eye image was divided into three regions:iris,sclera,and *** indicators were calculated based on the position of the pixels in the segmentation *** the last indicator,a calculation method based on the Eyelid Aspect Ratio(EAR)is proposed;this method can better reflect the change of eyelid distance over *** system was evaluated based on the collected patient *** results show that the segmentation model achieves a mean Intersection-Over-Union(mIoU)value of 86.05%.The paired-sample T-test was used to compare the results obtained by the system and doctors,and the p values were all greater than ***,the system can reduce the cost of clinical diagnosis and has high application value.

关键词： ocular myasthenia gravis computer-aided system semantic segmentation eyelid aspect ratio

Cell-based therapy in Alzheimer's disease: Current knowledge and perspective

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Translational Neuroscience and Clinics 2016年第1期2卷 50-58页

作者： liyan qiao Hongyun Huang Lin Chen Department of Neurology Tsinghua University Yuquan Hospital Institute of Neurorestoratology General Hospital of Armed Police Forces Beijing Hongtianji Neuroscience Academy Lingxiu Building Department of Neurosurgery Tsinghua University Yuquan Hospital

Alzheimer’s disease(AD)is the most prevalent type of dementia,and its neuropathology is characterized by the deposition of insolubleβ‐amyloid(Aβ)peptides,intracellular neurofibrillary tangles,amyloid angiopathy,age‐related brain atrophy,synaptic pathology,white matter rarefaction,granulovacuolar degeneration,neuron loss,and *** much is known about the neurobiology of AD,very few conventional therapies are available to arrest or slow the *** is an urgent need for novel therapeutic approaches for *** subjects have significantly fewer viable precursor cells in the hippocampus compared with age‐matched healthy control ***,the viable precursor cells that remain in AD and age‐matched healthy control brain specimens can be induced to *** facilitate or mimic the natural compensatory effect in AD,cell therapy,including endogenous and exogenous stem cells,has been considered in *** this review,we focus on the history and development of cell therapy in AD,and consider the role of cell therapy as a potential treatment for AD.

关键词： Alzheimer’s disease cell therapy stem cells neurogenesis

Parameter Estimation of Multi-component Chirp Signal Based on Differential Evolution

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Instrumentation 2017年第2期4卷 34-43页

作者： ZHAO Haoran MENG Fankuo qiao liyan Department of Automatic Test and Control Harbin Institute of Technology

Chirp signals show energy aggregation in the fractional Fourier domain(FrFD) w hich can be used to estimate the parameter of the signals. In this paper,a parameter estimation method for multi-component chirp signal w hich corrupted by w hite Gaussian noise is proposed based on the discrete fractional Fourier transform(DFrFT) and the differential evolution( DE) algorithm. The proposed algorithm uses the DE algorithm instead of the conventional fine search algorithm to detect the peak of the signals in the FrFD. The paper simulated the influence of the noise and the resolution of the proposed algorithm. The results of the simulation show the proposed method does not only improve the estimation accuracy of the peak coordinate,but also reduces time consuming.

关键词： Chirp Signal Fractional Fourier Transform Parameter Estimation Differential Evolution

移动互联网视域下移动图书馆数字资源版权管理探究

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图书馆工作与研究 2021年第7期 18-24页

作者：乔丽彦南阳市图书馆

移动图书馆对数字版权资源的利用呈现出组织碎片化、来源多元化和传播广域化等特征。在移动服务模式下,图书馆无论是对自有馆藏资源,还是对第三方资源,抑或对用户生成资源的组织和传播都存在直接侵权,或者间接侵权与责任承担等法律问题... 详细信息

移动图书馆对数字版权资源的利用呈现出组织碎片化、来源多元化和传播广域化等特征。在移动服务模式下,图书馆无论是对自有馆藏资源,还是对第三方资源,抑或对用户生成资源的组织和传播都存在直接侵权,或者间接侵权与责任承担等法律问题。图书馆防范和化解移动服务的版权风险,一方面,要严格遵循版权限制与例外制度和"通知—删除"程序等免责规范,不触碰"红旗标准"的底线,积极完善综合性版权管理对策;另一方面,第三方权利人和用户要增强版权保护意识和能力,为移动图书馆提供无权利瑕疵的版权资源。同时要健全版权立法,为移动图书馆发展提供宽松的法律条件,政府还要加大对侵权违法行为的查处力度,并对图书馆版权管理工作进行经常化的监督、指导。

关键词：图书馆移动互联网移动图书馆版权管理

Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Peripheral Nerve Injury:A Case Report

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Journal of Advances in Medicine Science 2020年第2期3卷 12-16页

作者： Fangjie Huang Shimei Zhou Mangsuo Zhao Jing Wang Jingfen Huang HongzhiGuan liyan qiao Department of Neurology Yuquan Hospital of Tsinghua UniversityBeijing100040China Department of Neurology Peking Union Medical College HospitalBeijing100005China

A patient with Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis presented with quadriplegia and multiple peripheral neuropathy with axonal lesion,confirmed by electrophysiological *** muscle strength in the limbs of the patient gradually recovered almost completely,accompanied by the reversal of neuroelectrophysiological symptoms,and the improvement of clinical manifestations,including consciousness,respiration and cognitive *** was revealed that the neuropathy in NMDAR encephalitis involved motor or sensorimotor nerves more than pure sensory *** autoantibodies were detectable,in contrast to other anti-NMDAR overlapping *** the underlying mechanism remains unclear,it may be associated with autoimmune *** conclusion,when patients with NMDAR encephalitis present with severe limb paralysis,the possibility of peripheral nerve damage should be considered.

关键词： Anti-NMDAR encephalitis Peripheral nerve disease Multiple peripheral neuropathy Autoimmune generalization Overlapping syndrome

基于频域时延-多普勒二维聚焦的欠采样雷达信号参数估方法

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电子与信息学报 2021年第11期43卷 3228-3236页

作者：尉志良付宁乔立岩哈尔滨工业大学电子与信息工程学院自动化测试与控制研究所哈尔滨150001

针对欠采样脉冲多普勒雷达信号参数估计中已有方法抗噪性差、顺序参数估计方法中后续参数估计受前面参数估计精度影响严重等问题,该文提出一种基于有限新息率(Finite Rate of Innovation,FRI)采样的频域时延-多普勒2维聚焦(FD2TF)算法... 详细信息

针对欠采样脉冲多普勒雷达信号参数估计中已有方法抗噪性差、顺序参数估计方法中后续参数估计受前面参数估计精度影响严重等问题,该文提出一种基于有限新息率(Finite Rate of Innovation,FRI)采样的频域时延-多普勒2维聚焦(FD2TF)算法。在该算法中,利用FRI采样结构能够以低于奈奎斯特采样频率的速率获得信号的一系列傅里叶系数,通过频域2维聚焦过程能够同时估计时延和多普勒参数,避免了参数顺序估计中误差累积的问题,理论分析证明了该算法能够大幅提升采样信号的信噪比,提高算法抗噪性和鲁棒性。在2维聚焦算法的基础上该文还提出了基于逆傅里叶变换的2维聚焦简化算法,在提高参数估计网格密度的同时,大大减低了2维聚焦算法的计算量。仿真和对比实验结果证明了该方法的有效性和良好的抗噪性。

关键词：脉冲多普勒雷达有限新息率采样欠采样参数估计

Reconfigurable Test Software

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Reconfigurable Test Software

2007 8th International Conference on Electronic Measurement & Instruments（ICEMI’2007）

作者： Chen Chun qiao liyan Peng Xiyuan Harbin Institute of Technology Harbin 150001 China

The general test system developed in recent years has solved the generality problem of test ***,the software for test systems still does not meet the demand of generality nowadays,so that we have to change its code or totally reprogram it when that is applied from one Unit Under Test （UUT） to *** order to solve this problem,we propose a Reconfigurable Test Software （RTS） based on Automatic Test Markup Language （ATML） and *** uses the virtual instrument modules and some other functional components which already exist to implement the dynamic reorganization of test system or test *** the test requirements or the instruments are changed,RTS doesn’t need to *** this paper,the framework of RTS is introduced at first,and then the behavior model and extensibility of RTS is *** last,it has been demonstrated how to use ATML to describe test procedures.

关键词： automatic test software reconfigurable component ATML IVI-COM

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基于带宽匹配思想的SoC测试结构设计

仪器仪表学报 2012年第8期33卷 1819-1825页

作者：邓立宝乔立岩俞洋彭喜元哈尔滨工业大学自动化测试与控制系哈尔滨150080

IP(intellectual property)核复用的设计思想使得SoC(system-on-a-chip)成为当今集成电路设计的主流,但对其进行测试变得异常困难,这就是需要为SoC设计测试结构的主要原因。传统的测试结构功能是:根据自动测试设备(automatic test equip... 详细信息

IP(intellectual property)核复用的设计思想使得SoC(system-on-a-chip)成为当今集成电路设计的主流,但对其进行测试变得异常困难,这就是需要为SoC设计测试结构的主要原因。传统的测试结构功能是:根据自动测试设备(automatic test equip-ment,ATE)提供的某一频率,将测试数据通过测试结构依次施加到SoC内部的IP核,并获取测试响应传输到ATE中,以分析其功能正常与否。但是这种测试结构存在很多缺点,其中最主要的是未考虑测试设备提供的测试访问机制(test access mecha-nism,TAM)的宽度与SoC内各IP核的最佳测试带宽是否一致。对这一系列问题进行研究,提出一种基于带宽匹配思想的SoC测试结构设计方法,该方法主要通过一个带宽匹配转换模块,实现测试数据的宽度调整和施加频率的调整,在牺牲了芯片部分额外面积的前提下,很好地实现了测试带宽和测试频率的匹配,缩短了SoC的测试时间。最后将这种方法应用在ITC’02标准测试集上,实验结果验证了该方法的有效性。

关键词： IP核复用测试结构测试访问机制带宽匹配