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Effect of Y substitution on the microstructure,magneto-optical,and thermal properties of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)transparent ceramics

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Journal of Advanced Ceramics 2024年第4期13卷 529-538页

作者： lixuan zhang Dianjun Hu Xiao Li Ziyu Liu Chen Hu Lexiang Wu Tingsong Li Dariusz Hreniak Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China Institute of Low Temperature and Structure Research Polish Academy of SciencesWroclaw 50-422Poland

Faraday isolators can prevent the front-end system from disturbance and damage caused by a back-reflected beam,so they are important elements in laser *** magneto-optical materials are the most important component in Faraday isolators,the studies on magneto-optical materials have attracted much attention these ***_(3)Al_(5)O_(12)(TAG)ceramics are considered to be one of the most promising magneto-optical materials for visible to near-infrared wavelength band application because of their outstanding comprehensive magneto-optical ***,the optical quality of TAG ceramics needs further optimization to meet the application *** this work,high optical quality(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)(x=0,0.05,0.1,0.2,and 0.3)magneto-optical ceramics were fabricated successfully by solid-state reaction sintering combined with hot isostatic pressing(HIP)*** the ceramics obtained showed a single garnet phase for different values of x in the range *** addition of Y_(2)O_(3) was found to suppress the secondary phase and improve optical quality *** ceramic samples obtained had clear grain boundaries and possessed the in-line transmittance values of 82.9%at 1064 nm and 82.2%at 633 nm,*** Verdet constants of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics with x=0,0.05,0.1,0.2,and 0.3 were−188.1,−175.4,−168.5,−143.0,and−119.9 rad/(T·m),*** thermal conductivity of TAG ceramics was found to be 5.23 W/(m·K)at 25℃,and when 20%Y was substituted in place of Tb,the thermal conductivity decreased by only 9.4%.

关键词： (Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics magneto-optical materials optical quality thermal properties

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基于动量源与精细多孔介质的堆芯特征组件域CFD计算分析技术研究

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核技术 2024年第7期47卷 135-147页

作者：张历轩陈广亮田兆斐殷新立钱浩孙大彬哈尔滨工程大学核科学与技术学院哈尔滨150001 武汉第二船舶设计研究所武汉430205

堆芯计算流体力学(Computational Fluid Dynamics,CFD)对确定堆芯薄弱环节、优化特征结构、提升安全及经济性等具有重大意义。典型压水堆燃料组件存在大量带交混翼片格架,导致存在网格数量激增、网格划分困难、求解难以收敛等问题。目... 详细信息

堆芯计算流体力学(Computational Fluid Dynamics,CFD)对确定堆芯薄弱环节、优化特征结构、提升安全及经济性等具有重大意义。典型压水堆燃料组件存在大量带交混翼片格架,导致存在网格数量激增、网格划分困难、求解难以收敛等问题。目前基于流固作用机理所建立的动量源模型未考虑交混翼背流侧低压区对流体的影响,预测交混翼下游域轴流分布误差较大,此外在识别交混翼片固体域、添加动量源项时较为困难。为此本文提出了一种基于精细化多孔介质和动量源的联合仿真方案来模拟5×5带交混翼片棒束通道冷却剂流动,该方案中的域识别技术可以精确定位流体域中交混翼片所在位置,并基于格架前端及交混翼片迎流与背流侧的流固作用机理,建立多孔介质和动量源模型。该方案在格架域,采用精细化多孔介质模型,提高原格架固体所在流域局部阻力系数,相较于在格架域施加动量源项,其数值稳定性更好。而在交混翼域,对动量源方案进行了优化,优化后的动量源模型考虑到了交混翼片背流侧低压区对流体的作用,其仿真交混翼下游的速度分布和传热更准确。该方案可以在网格生成的过程中无须考虑格架、交混翼片的几何特征,从而实现全结构化网格建模、CFD求解耗时短、对网格数量不敏感,鲁棒性较优。通过与实验及贴体网格仿真结果对比,验证了该方案仿真阻流、流动、交混、涡流、传热的有效性。同时仿真5×5棒束通道时可减少90%的网格数量和60%的计算耗时。此外,由于棒束通道交混翼在轴向和周向都是规则排列,因此本文开发的动量源方案通过调整坐标即可适用于更大流体域的燃料组件。

关键词：棒束通道交混翼域识别动量源多孔介质

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部分泛素特异性蛋白酶生物学功能的研究进展

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中国医学创新 2024年第1期21卷 149-154页

作者：杨静张丽璇张晨钰安康河北北方学院基础医学院河北张家口075000 河北医科大学附属石家庄市第五医院检验科河北石家庄050023 河北北方学院医学检验学院河北张家口075000

泛素特异性蛋白酶(ubiquitin-specific proteases,USPs)家族是去泛素化酶家族中成员最多的一种,主要存在于骨骼肌、心脏、肝脏、脑、胰腺等组织中,且在不同物种间有表达差异性。目前的研究表明,虽然USPs特异性选择水解的泛素链的机制还... 详细信息

泛素特异性蛋白酶(ubiquitin-specific proteases,USPs)家族是去泛素化酶家族中成员最多的一种,主要存在于骨骼肌、心脏、肝脏、脑、胰腺等组织中,且在不同物种间有表达差异性。目前的研究表明,虽然USPs特异性选择水解的泛素链的机制还不清楚,但USPs在机体生命过程中有极大作用,USPs在调控肿瘤发生及转移、免疫调节、炎症反应、能量代谢、病毒感染等方面具有重要临床意义。本文综述了近年来部分USPs生物学功能的研究进展,期望能够对相关疾病的诊断及治疗提供新的思路。

关键词：泛素特异性蛋白酶肿瘤治疗靶点

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A review on magneto-optical ceramics for Faraday isolators

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Journal of Advanced Ceramics 2023年第5期12卷 873-915页

作者： lixuan zhang Dianjun Hu Ilya LSnetkov Stanislav Balabanov Oleg Palashov Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Institute of Applied Physics of the Russian Academy of Sciences Nizhny Novgorod 603950Russia Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod 603950Russia G.G.Devyatykh Institute of Chemistry of High-Purity Substances Russian Academy of SciencesNizhny Novgorod 603951Russia

As a promising magneto-optical(MO)material applied in Faraday isolators,magneto-optical ceramics possess excellent comprehensive properties and have attracted much attention these ***,we review the fabrication and properties of magneto-optical ceramics including garnet,sesquioxide,and A_(2)B_(2)O_(7) *** of the ceramics have been proved to possess applicable performance,while further studies are still needed for most of the magneto-optical *** at the application for isolators,the research status,existing problems,and development trends of magneto-optical ceramics are shown and discussed in this review.

关键词： magneto-optical(MO)ceramics Faraday isolators optical quality thermo-optical effects

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术前下肢肌肉锻炼对改善闭合性胫骨干骨折预后的影响及患者腓肠肌平均肌电值变化

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创伤外科杂志 2024年第3期26卷 205-211页

作者：王家梁张理选钟少文李燕珍汕头大学医学院广东汕头515000 惠州市中心人民医院骨科广东惠州516000

目的探索术前下肢肌肉锻炼对改善闭合性胫骨干骨折预后的效果并同时基于可穿戴式表面肌电技术(sEMG)监测患者平均肌电值(AEMG)变化。方法前瞻性选择2021年5月—2023年1月因胫骨干骨折于惠州市中心人民医院行髓内钉内固定手术治疗的60例... 详细信息

目的探索术前下肢肌肉锻炼对改善闭合性胫骨干骨折预后的效果并同时基于可穿戴式表面肌电技术(sEMG)监测患者平均肌电值(AEMG)变化。方法前瞻性选择2021年5月—2023年1月因胫骨干骨折于惠州市中心人民医院行髓内钉内固定手术治疗的60例患者作为研究对象。随机分为研究组(n=30)和对照组(n=30)。研究组男性22例,女性8例;年龄38~59岁,平均45.8岁;对照组患者男性21例,女性9例;年龄40~58岁,平均44.9岁。道路交通伤35例,重物砸伤17例,高处坠落伤8例。两组患者在入院后均接受可穿戴式sEMG测量术前术后小腿肌群等长收缩时腓肠肌的AEMG,研究组患者进行术前踝泵运动,对照组不进行术前锻炼。对比两组患者术前,术后1、3、7 d VAS;术后住院期间下肢静脉血栓形成风险;远期功能恢复情况,包括完全负重活动时间、膝关节伸屈活动度(ROM)、踝关节伸-跖屈ROM、Johner-Wruhs评分、胫骨对位情况及两侧胫骨长度差;同时根据患者的可穿戴式sEMG的记录情况,记录骨折后(术前)1、3、5 d,以及术后1、3d、1周、1、3、6个月时腓肠肌的AEMG水平。结果随着治疗的进行,两组患者VAS呈显著下降趋势(P<0.05),术后1、3、7d两组患者VAS差异无统计学意义(P<0.05);术后3~7 d内两组患者均有不同程度的D-二聚体升高,但研究组升高的比例显著低于对照组(16.7%vs.43.3%,P<0.05);研究组患者完全负重活动时间显著短于对照组[(55.90±8.85)d vs.(60.28±9.33)d,P<0.05],研究组术后1、3个月的膝关节伸-屈ROM显著大于对照组(P<0.05);在骨折后5d,研究组患者腓肠肌AEMG水平显著高于对照组(P<0.05),在术后1、3 d、1周、1、3个月时,研究组患者的腓肠肌AEMG水平均显著高于对照组(P<0.05)。结论术前下肢肌肉锻炼可以加快闭合性胫骨干骨折患者术后康复进程,其在sEMG所记录到的AMEG变化具有更加明确的影响。这也表明基于可穿戴式sEMG技术监测患者AEMG并对其进行量化,以期在指导闭合性胫骨干骨折患者的下肢肌肉锻炼以改善预后具有较好的应用价值。

关键词：胫骨干骨折可穿戴式表面肌电技术下肢肌肉锻炼

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Bowen’s disease with multiple lesions of the penis and scrotum:A case report

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第2期4卷 79-81页

作者： lixuan zhang Wei Han Guoliang Shen Plastic Surgery Department The First Affiliated Hospital of Soochow UniversitySuzhou 215001JiangsuChina Group Regenerative Biology and Medicine Institute of Regenerative Biology and MedicineHelmholtz Zentrum MünchenNeuherberg D-85764Germany Department of Burns The First Affiliated Hospital of Soochow UniversitySuzhou 215001JiangsuChina

Bowen’s disease is a rare squamous cell carcinoma in situ of the skin,the etiology and pathogenesis of which remain unclear.A 57-year-old man presented with the penis and scrotum erythema,with indistinct boundaries with the surrounding *** and histopathology of the biopsy specimen revealed Bowen’s *** are many clinical treatments for Bowen’s disease,including surgical excision,liquid nitrogen freezing,electrocautery,laser therapy,topical application of 5-fluorouracil ointment,and photodynamic ***’s disease mostly involves solitary *** case involved multiple lesions,and its scope was extensive;therefore,surgical resection was performed.

关键词： Bowen’s disease Squamous cell cancer in situ Multiple lesions

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Fabrication and properties of non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)magneto-optical ceramics

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Journal of Advanced Ceramics 2022年第5期11卷 784-793页

作者： lixuan zhang Xiaoying LI Dianjun HU Ziyu LIU Tengfei XIE Lexiang WU Zhaoxiang YANG Jiang LI Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBejing 100049China

Non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)(x=-0.07-0.45)magneto-optical ceramics were fabricated by solid-state reactive sintering in vacuum combined with hot isostatic pressing(HIP)posttreatment without any sintering *** phase composition,densification process,microstructure,optical transmittance,and Verdet constant of Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics were *** in-line transmittance of(Tb_(0.93)Hf_(0.04))_(2)Hf_(2)O_(7.07)ceramics with a thickness of 2.0 mm reaches 74.6%at 1064 *** Verdet constant of Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics is-153.4,-155.8,and-181.2 rad/(T-m)at the wavelength of 633 nm when x=-0.07,0,and 0.1,*** Verdet constant increases with the increase of Tb content,and these values are higher than that of the commercial Tb_(3)Ga_(5)O_(12) crystal,indicating that non-stoichiometric Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics have a great potential for the application in Faraday isolators.

关键词： magneto-optical ceramics Tb_(2)(Hf_(1-x)Tb_(x))_(2)O_(7-x)ceramics reactive sintering Verdet constant

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Multilevel Attention Unet Segmentation Algorithmfor Lung Cancer Based on CT Images

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Computers, Materials & Continua 2024年第2期78卷 1569-1589页

作者： Huan Wang Shi Qiu Benyue zhang lixuan Xiao Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’anChina School of Biomedical Engineering Fourth Military Medical UniversityXi’anChina University of Illinois at Urbana Champion ChampaignUSA

Lung cancer is a malady of the lungs that gravely jeopardizes human ***,early detection and treatment are paramount for the preservation of human *** computed tomography(CT)image sequences can explicitly delineate the pathological condition of the *** meet the imperative for accurate diagnosis by physicians,expeditious segmentation of the region harboring lung cancer is of utmost *** utilize computer-aided methods to emulate the diagnostic process in which physicians concentrate on lung cancer in a sequential manner,erect an interpretable model,and attain segmentation of lung *** specific advancements can be encapsulated as follows:1)Concentration on the lung parenchyma region:Based on 16-bit CT image capturing and the luminance characteristics of lung cancer,we proffer an intercept histogram algorithm.2)Focus on the specific locus of lung malignancy:Utilizing the spatial interrelation of lung cancer,we propose a memory-based Unet architecture and incorporate skip connections.3)Data Imbalance:In accordance with the prevalent situation of an overabundance of negative samples and a paucity of positive samples,we scrutinize the existing loss function and suggest a mixed loss *** results with pre-existing publicly available datasets and assembled datasets demonstrate that the segmentation efficacy,measured as Area Overlap Measure(AOM)is superior to 0.81,which markedly ameliorates in comparison with conventional algorithms,thereby facilitating physicians in diagnosis.

关键词： Lung cancer computed tomography computer-aided diagnosis Unet segmentation

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Mg,Ti-base surface integrated layer and bulk doping to suppress lattice oxygen evolution of Ni-rich cathode material at a high cut-off voltage

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Journal of Energy Chemistry 2022年第8期31卷 434-444,I0012页

作者： Fan Peng Youqi Chu Yu Li Qichang Pan Guangchang Yang lixuan zhang Sijiang Hu Fenghua Zheng Hongqiang Wang Qingyu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004GuangxiChina Guangxi New Energy Ship Battery Engineering Technology Research Center Guangxi Normal UniversityGuilin 541004GuangxiChina

The Nickel-rich layered cathode materials charged to 4.5 V can obtain a specific capacity of more than 200 m Ah g^(-1).However,the nickel-rich layered cathode materials suffer from the severe capacity fade during high-voltage cycling,which is related to the phase transformation and the surface sides reactions caused by the lattice oxygen ***,the simultaneous construction of a Mg,Ti-based surface integrated layer and bulk doping through Mg,Ti surface treatment could suppress the lattice oxygen evolution of Nirich material at deep *** importantly,Mg and Ti are co-doped into the particles surface to form an Mg_(2)TiO_(4) and Mg_(0.5–x)Ti_(2–y)(PO_(4))_(3) outer layer with Mg and Ti *** the constructed surface integrated layer,the reverse electric field in the Mg_(2)TiO_(4) effectively suppressed the outward migration of the lattice oxygen anions,while Mg_(0.5–x)Ti_(2–y)(PO_(4))_(3) outer layer with high electronic conductivity and good lithium ion conductor could effectively maintained the stability of the reaction interface during highvoltage ***,bulk Mg and Ti co-doping can mitigate the migration of Ni ions in the bulk to keep the stability of transition metal–oxygen(M-O)bond at deep *** a result,the NCM@MTP cathode shows excellent long cycle stability at high-voltage charging,which keep high capacity retention of 89.3%and 84.3%at 1 C after 200 and 100 cycles under room and elevated temperature of 25 and 55°C,*** work provides new insights for manipulating the surface chemistry of electrode materials to suppress the lattice oxygen evolution at high charging voltage.

关键词： Ni-rich layered oxide Mg Ti-base surface integrated layer Bulk doping Lattice oxygen evolution

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基于KANO模型的国际形势与政策专题课程质量提升关键要素研究

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中医教育 2024年第4期43卷 87-92页

作者：周益桢赵宏扬甘秀伦安家宜杨凤唐仁鹏张丽璇赵海滨北京中医药大学北京102488 中国中医科学院中医药信息研究所中医药知识组织与标准研究中心北京100700 兰州大学化学化工学院兰州730000

基于KANO模型理论,以提升国际形势与政策专题课程质量为目标,通过对北京中医药大学国际形势与政策专题课程现状进行调查,探究提升国际形势与政策专题课程质量的关键要素,并结合中医理论对课程质量提升提出对策建议。问卷调查发现,“课... 详细信息

基于KANO模型理论,以提升国际形势与政策专题课程质量为目标,通过对北京中医药大学国际形势与政策专题课程现状进行调查,探究提升国际形势与政策专题课程质量的关键要素,并结合中医理论对课程质量提升提出对策建议。问卷调查发现,“课程内容涉及学科专业知识”质量指标与学生满意度提升高度相关,“课前为学生提供学习资料”等质量指标落点于“满意度高关联区”。在思政内容与专业学习衔接度、课程环节设置等方面仍有改进空间。研究结果表明,国际形势与政策专题课程质量提升应把握好“课程内容涉及学科专业知识”“课前为学生提供学习资料”两个关键要素,注重课程内容及考核方式两方面。基于中医药高等院校相关课程建设现状,提出“学为中心,三因制宜”教学创新路径:因时制宜—探明全周期培养需求,打造分阶段课程体系;因地制宜—发挥中医药学科优势,实现多维度课程目标;因人制宜—凝聚师生集体智慧,合力构建高质量课程。

关键词：形势与政策思想政治理论课 KANO模型课程质量满意度

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