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动态导航技术在无牙颌种植中的应用进展

中华口腔医学杂志 2022年第10期57卷 1079-1083页

作者：张馨月王柏翔萧立萱王慧明浙江大学医学院附属口腔医院种植科·浙江大学口腔医学院浙江省口腔疾病临床医学研究中心浙江省口腔生物医学研究重点实验室浙江大学癌症研究院杭州310006

无牙颌种植一直是种植领域的难点,动态导航技术在无牙颌种植中的应用可解决传统无牙颌种植修复中的诸多问题。动态导航技术的优势在于,精确定位引导,修复引导外科,美学效果好;方案设计与种植实时引导可以同时进行;术中将"盲视"变为"直... 详细信息

无牙颌种植一直是种植领域的难点,动态导航技术在无牙颌种植中的应用可解决传统无牙颌种植修复中的诸多问题。动态导航技术的优势在于,精确定位引导,修复引导外科,美学效果好;方案设计与种植实时引导可以同时进行;术中将"盲视"变为"直视",可实时引导医师种植及调整方案;全程提高医、技、患三者沟通效率等。本文对动态导航技术在无牙颌的工作流程、临床应用现状和挑战、精度分析及其局限性进行探讨,并对其未来发展提出展望,以期为临床开展动态导航技术引导的无牙颌种植提供参考。

关键词：颌,无牙牙种植数字化技术动态导航修复导向

基于空洞单流ViT网络的灵活模态人脸呈现攻击检测方法

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计算机应用研究 2024年第3期41卷 916-922页

作者：肖立轩封筠高宇豪贺晶晶石家庄铁道大学信息科学与技术学院石家庄050043

灵活模态人脸呈现攻击检测突破传统多模态方法对于模型训练与部署的模态一致性限制,可将统一模型按需灵活部署到多样模态的现实场景,但仍存在模型性能有待提升、计算资源需求高的问题。为此,提出一种以视觉Transformer(ViT)结构为基础... 详细信息

灵活模态人脸呈现攻击检测突破传统多模态方法对于模型训练与部署的模态一致性限制,可将统一模型按需灵活部署到多样模态的现实场景,但仍存在模型性能有待提升、计算资源需求高的问题。为此,提出一种以视觉Transformer(ViT)结构为基础的单流灵活模态人脸呈现攻击检测网络。提出空洞块嵌入模块以减少运算冗余,降低输入向量维度;为区分不同模态特征,设计模态编码标记;采用非补齐策略处理模态缺失问题。在公开多模态数据集上的实验结果表明,该方法在域内和跨域评估中分别获得2.69%和33.81%的最佳平均ACER值,相较于现有的三种方法,具有更优的域内和域外泛化性能,在不同子协议上的性能表现较为均衡,且其模型计算量与参数量均远低于多流方法,更加适合模态缺失场景下的灵活、高效部署。

关键词：人脸呈现攻击检测灵活模态多模态视觉Transformer

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领域外人脸活体检测综述

计算机科学与探索 2022年第11期16卷 2471-2486页

作者：史屹琛封筠肖立轩贺晶晶胡晶晶石家庄铁道大学信息科学与技术学院石家庄050043 北京理工大学计算机科学与技术学院北京100081

人脸活体检测(FAS)作为保护人脸识别模型的重要手段,能够确保系统在面对各种呈现攻击时仍然安全、可靠。当前基于深度学习的人脸活体检测模型在测试数据与训练数据服从同一分布时结果令人满意,但当训练好的模型在领域外场景进行推理时,... 详细信息

人脸活体检测(FAS)作为保护人脸识别模型的重要手段,能够确保系统在面对各种呈现攻击时仍然安全、可靠。当前基于深度学习的人脸活体检测模型在测试数据与训练数据服从同一分布时结果令人满意,但当训练好的模型在领域外场景进行推理时,如遇到跨域迁移、分布外场景时,模型的准确性会出现较大的下降。主要阐述了静默型人脸活体检测模型在真实场景中会遇到的问题,即模型遇到未知环境和未知攻击方式。将相应的解决方案分为四类:基于领域自适应的方法、基于领域泛化的方法、基于零样本/小样本学习的方法以及基于异常检测的方法。对各解决方案及其包含的深度学习模型方法进行总结、比较,归纳了主要方法的机制、模型结构、优势、局限性以及适用场景。介绍了领域外场景下人脸活体检测常用的公共数据集、评价指标、测评协议以及在部分测评协议下当前先进方法的测试结果。最后讨论了人脸活体检测在实际应用中存在的难点与挑战,总结了未来的研究方向。

关键词：人脸活体检测(FAS) 领域自适应领域泛化零样本/小样本学习异常检测深度学习

Effect of Sc substitution on the phase composition,microstructure,and properties of(Tb_(1−x)Sc_(x))_(3)(Al_(1−y)Sc_(y))_(2)Al_(3)O_(12) transparent ceramics

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Journal of Advanced Ceramics 2024年第9期13卷 1442-1452页

作者： lixuan Zhang Chen Hu xiao Li Zhenzhen Zhou Tingsong Li Yiyang Liu Lexiang Wu Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

Terbium aluminum garnet(Tb_(3)Al_(5)O_(12);TAG)ceramics are among the most promising magneto–optical materials owing to their outstanding comprehensive *** works have focused on improving the optical quality of TAG ceramics.A key point for improving optical quality is ensuring the accuracy of the stoichiometric ratio and avoiding secondary *** this work,0,2,4,or 6 wt%Sc2O3 was added to the TAG ceramics to increase the solid *** effects of Sc substitution on the crystal structure,sintering process,microstructure,optical transmittance,and magneto–optical properties of(Tb_(1−x)Sc_(x))_(3)(Al_(1−y)Sc_(y))_(2)Al_(3)O_(12)(TSAG)ceramics are studied in detail.4 wt%Sc2O3:TAG ceramics with an in-line transmittance of 82.2%at 1064 nm and 81.2%at 633 nm were successfully fabricated,and the Verdet constant was 164.4 rad·T^(−1)·m^(−1) at 633 ***-site defects(ADs)and Sc replacement in TAG are further studied via first-principles calculations to determine the working mechanism of *** the experimental and calculation results show that the introduction of Sc can effectively increase the solid solubility of TAG ceramics,suppress secondary phases,and hence improve the optical transmittance.

关键词： terbium aluminum garnet ceramics magneto-optical materials microstructures anti-site defects(ADs) firstprinciples calculations

Effect of Y substitution on the microstructure,magneto-optical,and thermal properties of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)transparent ceramics

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Journal of Advanced Ceramics 2024年第4期13卷 529-538页

作者： lixuan Zhang Dianjun Hu xiao Li Ziyu Liu Chen Hu Lexiang Wu Tingsong Li Dariusz Hreniak Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China Institute of Low Temperature and Structure Research Polish Academy of SciencesWroclaw 50-422Poland

Faraday isolators can prevent the front-end system from disturbance and damage caused by a back-reflected beam,so they are important elements in laser *** magneto-optical materials are the most important component in Faraday isolators,the studies on magneto-optical materials have attracted much attention these ***_(3)Al_(5)O_(12)(TAG)ceramics are considered to be one of the most promising magneto-optical materials for visible to near-infrared wavelength band application because of their outstanding comprehensive magneto-optical ***,the optical quality of TAG ceramics needs further optimization to meet the application *** this work,high optical quality(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)(x=0,0.05,0.1,0.2,and 0.3)magneto-optical ceramics were fabricated successfully by solid-state reaction sintering combined with hot isostatic pressing(HIP)*** the ceramics obtained showed a single garnet phase for different values of x in the range *** addition of Y_(2)O_(3) was found to suppress the secondary phase and improve optical quality *** ceramic samples obtained had clear grain boundaries and possessed the in-line transmittance values of 82.9%at 1064 nm and 82.2%at 633 nm,*** Verdet constants of(Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics with x=0,0.05,0.1,0.2,and 0.3 were−188.1,−175.4,−168.5,−143.0,and−119.9 rad/(T·m),*** thermal conductivity of TAG ceramics was found to be 5.23 W/(m·K)at 25℃,and when 20%Y was substituted in place of Tb,the thermal conductivity decreased by only 9.4%.

关键词： (Tb_(1−x)Y_(x))_(3)Al_(5)O_(12)ceramics magneto-optical materials optical quality thermal properties

Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses

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Molecular Plant 2024年第3期17卷 438-459页

作者： Xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang xiaoyu Zhang xiaomin Bie lixuan Gui Zhongxu Chen Yiliang Ding Long Mao Xueyong Zhang Fei Lu Xiansheng Zhang Cristobal Uauyo Xiangdong Fu Jun xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Nanjing Agricultural University NanjingJiangsu 210095China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China Department of Life Science Tcuni Inc.ChengduSichuan 610000China John Innes Centre Norwich Research ParkNorwich NR47UHUK Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyCASBeijing 100101China

The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding *** this study,we used a multi-omic approach to analyze the transcriptome and epigenome profiles of the young spike at eight developmental stages,revealing co-ordinated changes in chromatin accessibility and H3K27me3 abundance during the flowering *** constructed a core transcriptional regulatory network(TRN)that drives wheat spike formation and experimentally validated a multi-layer regulatorymodule involving TaSPL15,TaAGLG1,and *** integrating the TRN with genome-wide association studies,we identified 227 transcription factors,including 42 with known functions and 185 with unknown *** investigation of 61 novel transcription factors using multiple homozygous mutant lines revealed 36 transcription factors that regulate spike architecture or flowering time,such as TaMYC2-A1,TaMYB30-A1,and *** particular interest,TaMYB30-A1,downstream of and repressed by WFzP,was found to regulate fertile spikelet ***,the excellent haplotype of TaMYB30-A1,which contains a C allele at the WFzP binding site,was enriched during wheat breeding improvement in China,leading to improved agronomic ***,we constructed a free and open access Wheat Spike Multi-Omic Database(http://39.***.48.156:8800/#/).Our study identifies novel and high-confidence regulators and offers an effective strategy for dissecting the genetic basis of wheat spike development,with practical value forwheat breeding.

关键词： wheat spike development epigenome TRN TaMYB30-A1 breeding selection

TNP-ATP is Beneficial for Treatment of Neonatal HypoxiaInduced Hypomyelination and Cognitive Decline

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Neuroscience Bulletin 2016年第1期32卷 99-107页

作者： Jie xiao Yilong Huang Xia Li Longjun Li Ting Yang lixuan Huang Ling Yang Hong Jiang Hongchun Li Fan Li Department of Pathology and Pathophysiology School of Basic Medical Science Kunming Medical University

Our previous study together with other inves- tigations have reported that neonatal hypoxia or ischemia induces long-term cognitive through brain inflammation impairment, at least in part and hypomyelination. How- ever, the detailed mechanisms are not fully understood. Here, we used a rodent model of neonatal hypoxia by subjecting postnatal day 0 （P0） rat pups to systemic hypoxia （3.5 h）. We found that neonatal hypoxia increased the glutamate content and initiated inflammatory responses at 4 h and 1 day after hypoxia, caused hypomyelination in the corpus callosum, and impaired hippocampus-dependent learning and memory when assessed 30-60 days after hypoxia. Interestingly, much of the hypoxia-induced brain damage was ameliorated by treatment with the ATP ana- logue 21,3-0-（2,4,6-trinitrophenyl）-adenosine 5^-triphos- phate （TNP-ATP; blocks all ionotropic P2Xl-7 receptors）, whereas treatment with pyridoxalphosphate-6-azophenyl- 2＇,4＇-disulphonic acid （PPADS; inhibits P2X1-3 and P2X5- 7 receptors） was less neuroprotective. Our data indicated that activation of ionotropic ATP receptors might be par- tially, if not fully, involved in glutamate deregulation, neuroinflammation, hypomyelination, and cognitive dys- function after neonatal hypoxia.

关键词： Neonatal hypoxia. Inflammation. IonotropicATP receptors - Glutamate Memory deficit

Gene expression profile of cancer stem-like cells in the SW480 colon adenocarcinoma cell line

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Gene expression profile of cancer stem-like cells in the SW4...

改进稠密块轻量化神经网络的管道泄漏孔径识别

第三十一届全国中西医结合消化系统疾病学术会议

作者： WANG YUANYUAN ZHOU LING QING QING LI YINGFEI LI lixuan DONG xiaoYING xiao BING Guangdong Provincial Key Laboratory of Gastroenterology Department of GastroenterologyNanfang HospitalSouthern Medical University

Cancer stem cells (CSCs) serve an important role in tumorigenesis,tolerance to treatment,relapse and *** the signaling pathways involved in cancer are well known,the molecular mechanisms underlying CSC actions require further *** the present study,a population of colon CSCs with a cluster of differentiation 133 (CD133)surface-expression phenotype from the human SW480 colon adenocarcinoma cell line were isolated by flow *** CD133+cells exhibited increased tumor sphere-forming efficiency in vitro and increased tumorigenic potential in ***,the gene expression profile of colon CSCs was investigated using gene chip *** results demon?strated differential gene expression between the CD133+and CD133-subpopulations,including inrelation to a number of important genes with functions in transcription control,cell cycle,karyomitosis and protein phosphorylation,including cyclin dependent kinase inhibitor 1A,cyclin B1,checkpoint kinase 1,cyclin dependent kinase 1 and transforming growth factorβreceptor *** analysis revealed that the mitogen-activated protein kinase,p53 and calcium signaling pathways,as well as other important signaling pathways,were differentially activated between CD133+and *** the best of our knowledge,these results provide the first evidence for the gene expression profile of colon CSCs in the SW480 colon adenocarcinoma cell *** further studies will be required to identify the functional roles of these genes in the CSC phenotype,these observations provide the basis for future studies to elucidate the pathogenesis of colorectal cancer and to develop novel tumor-targeting therapies.

关键词： cancer stem cell cluster of differentiation 133 colorectal cancer mitogen-activated protein kinase signaling pathway p53 signaling pathway

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仪器仪表学报 2022年第3期43卷 98-108页

作者：孙洁娣王利轩温江涛肖启阳燕山大学信息科学与工程学院秦皇岛066004 燕山大学河北省信息传输与信号处理重点实验室秦皇岛066004 燕山大学河北省测试计量技术及仪器重点实验室秦皇岛066004 河南大学人工智能学院郑州450046

深度神经网络的管道泄漏孔径识别方法虽然识别率高,但因结构复杂造成参数量大、内存占用大,极大地限制了其在资源有限的工业环境及实时处理中的应用。提出一种优化卷积改进稠密块的轻量化神经网络用于管道泄漏孔径识别。首先将深度可分... 详细信息

深度神经网络的管道泄漏孔径识别方法虽然识别率高,但因结构复杂造成参数量大、内存占用大,极大地限制了其在资源有限的工业环境及实时处理中的应用。提出一种优化卷积改进稠密块的轻量化神经网络用于管道泄漏孔径识别。首先将深度可分离卷积与异构卷积结合,构造了新的多卷积稠密块实现泄漏信号的特征提取;之后采用卷积注意力机制对特征进行权重划分,实现特征的重要性区分;最后通过分类器获取结果。实验结果表明,本文方法识别准确率达到了96.59%,参数量仅为781 KB。本文方法在保证高识别准确率的同时,参数量及浮点数大幅下降,训练时间也有所减少,改善了实时响应能力,对于实际工业监测应用有指导意义。

关键词：管道泄漏孔径识别轻量级网络深度可分离卷积异构卷积多卷积稠密块