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A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis

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Bioactive Materials 2023年第8期26卷 264-278页

作者： Ye Yuan Zhaowenbin Zhang Fandi Mo Chen Yang Yiren Jiao Enci wang Yuchong Zhang Peng Lin Chengkai Hu Weiguo Fu Jiang Chang lixin wang Department of Vascular Surgery Zhongshan HospitalFudan University180 Fenglin RoadShanghai200032China Department of Vascular Surgery Zhongshan Xiamen HospitalFudan University668 JinhuRoadXiamen361015China Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou325000China Shanghai Institute of Ceramics Chinese Academy of Sciences1295 Dingxi RoadShanghai200050China

Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic *** this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic *** particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 *** importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 *** biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in *** results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood *** addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting *** results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.

关键词： Hindlimb ischemic diseases Strontium carbonate and calcium silicate bioceramic Bioactive hydrogel Muscle necrosis Angiogenesis

Development of a large-scale remote sensing ecological index in arid areas and its application in the Aral Sea Basin

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Journal of Arid Land 2021年第1期13卷 40-55页

作者： wang Jie LIU Dongwei MA Jiali CHENG Yingnan wang lixin School of Ecology and Environment Inner Mongolia UniversityHohhot 010021China

The Aral Sea Basin in Central Asia is an important geographical environment unit in the center of *** is of great significance to the ecological protection and sustainable development of Central Asia to carry out dynamic monitoring and effective evaluation of the eco-environmental quality of the Aral Sea *** this study,the arid remote sensing ecological index(ARSEI)for large-scale arid areas was developed,which coupled the information of the greenness index,the salinity index,the humidity index,the heat index,and the land degradation index of arid *** ARSEI was used to monitor and evaluate the eco-environmental quality of the Aral Sea Basin from 2000 to *** results show that the greenness index,the humidity index and the land degradation index had a positive impact on the quality of the ecological environment in the Aral Sea Basin,while the salinity index and the heat index exerted a negative impact on the quality of the ecological *** eco-environmental quality of the Aral Sea Basin demonstrated a trend of initial improvement,followed by deterioration,and finally further *** spatial variation of these changes was *** 2000 to 2019,grassland and wasteland(saline alkali land and sandy land)in the central and western parts of the basin had the worst ecological environment *** areas with poor ecological environment quality are mainly distributed in rivers,wetlands,and cultivated land around *** the period from 2000 to 2019,except for the surrounding areas of the Aral Sea,the ecological environment quality in other areas of the Aral Sea Basin has been improved in *** correlation coefficients between the change in the eco-environmental quality and the heat index and between the change in the eco-environmental quality and the humidity index were–0.593 and 0.524,*** conditions and human activities have led to different combinations of heat and humidity changes in the eco-env

关键词： eco-environmental quality arid remote sensing ecological index Moderate Resolution Imaging Spectroradiometer(MODIS) landscape changes remote sensing monitoring Central Asia

Spatial changes and driving factors of lake water quality in Inner Mongolia, China

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Journal of Arid Land 2023年第2期15卷 164-179页

作者： REN Xiaohui YU Ruihong LIU Xinyu SUN Heyang GENG Yue QI Zhen ZHANG Zhuangzhuang LI Xiangwei wang Jun ZHU Penghang GUO Zhiwei wang lixin XU Jifei Inner Mongolia Key Laboratory of River and Lake Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Key Laboratory of Mongolian Plateau Ecology and Resource Utilization Ministry of EducationHohhot 010021China

Lakes play important roles in sustaining the ecosystem and economic development in Inner Mongolia Autonomous Region of China,but the spatial patterns and driving mechanisms of water quality in lakes so far remain *** study aimed to identify the spatial changes in water quality and the driving factors of seven lakes(Juyanhai Lake,Ulansuhai Lake,Hongjiannao Lake,Daihai Lake,Chagannaoer Lake,Hulun Lake,and Wulannuoer Lake)across the longitudinal axis(from the west to the east)of Inner ***-scale research was conducted using the comprehensive trophic level index(TLI(Σ)),multivariate statistics,and spatial analysis *** results showed that most lakes in Inner Mongolia were weakly *** dissolved solids and salinity of lake water showed obvious zonation *** and phosphorus were identified as the main pollutants in lakes,with high average concentrations of total nitrogen and total phosphorus being of 4.05 and 0.21 mg/L,*** values of TLI(Σ)ranged from 49.14 to 71.77,indicating varying degrees of lake eutrophication,and phosphorus was the main driver of lake *** lakes of Inner Mongolia could be categorized into lakes to the west of Daihai Lake and lakes to the east of Daihai Lake in terms of salinity and TLI(Σ).The salinity levels of lakes to the west of Daihai Lake exceeded those of lakes to the east of Daihai Lake,whereas the opposite trend was observed for lake trophic *** intensity and mode of anthropogenic activities were the driving factors of the spatial patterns of lake water *** is recommended to control the impact of anthropogenic activities on the water quality of lakes in Inner Mongolia to improve lake ecological *** findings provide a more thorough understanding of the driving mechanism of the spatial patterns of water quality in lakes of Inner Mongolia,which can be used to develop strategies for lake ecosystem protection and water resources management i

关键词： salinity lake eutrophication lake water quality comprehensive trophic level index anthropogenic activities Daihai Lake Inner Mongolia

Composite structure and properties of the pitcher surface of the carnivorous plant Nepenthes and its influence on the insect attachment system

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Progress in Natural Science:Materials International 2009年第12期19卷 1657-1664页

作者： lixin wang,Qiang Zhou~*,Yongjun Zheng,Shuyan Xu Department of Mechatronic Engineering,China Agricultural University,Beijing 100083,China [a]Department of Mechatronic Engineering China Agricultural University Beijing 100083 China

Pitchers of the carnivorous plant Nepenthes have evolved specialized organs serving the purpose of attracting,capturing,retaining and digesting small animals,mostly *** consist of several well distinguishable zones,including a leaf-like lid,a collar-like peristome, a slippery zone and a digestive zone,differing in morphology,microstructure,chemical composition and physical *** zones display different functions,and the combined effects of several zones result in great trapping *** principal aim of this review is to introduce the structure and physiochemical properties of the pitcher surface,as well as the interaction between the pitcher surface and the insect attachment *** with our present study,the potential application of the pitcher surface being utilized in bionics to manufacture insect slippery trapping plates is discussed,and the original research direction of the pitcher surface and its application on agricultural pest control is highlighted.

关键词： Pitcher surface Nepenthes Composite structure Insect Attachment system

Anti-attachment Function and Biomimetic Application of Slippery Zone in Nepenthes Pitcher

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Journal of Agricultural Science and Technology(A) 2015年第2期5卷 106-113页

作者： lixin wang Qiang Zhou College of Mechanical Engineering Hebei University of Science and Technology Shijiazhuang 050018 China Department of Mechatronie Engineering China Agricultural University Beijing 100083 China

Carnivorous plants of Nepenthes species have evolved particular organs named pitchers at the tips of their conspicuous leaves, allowing slippery trapping and effective digesting prey to acquire sufficient growing nutrients. Nepenthes pitchers are generally distinguished by several morphological regions exhibiting distinct functions in prey capturing, and combined effect of the several zones results in great trapping efficiency. Depending on specific micro-structures, slippery zone performs an important role in efficiently preying arthropods, and this prey ability inspires an idea for biomimetic development of slippery trapping plate used in controlling agricultural pests. In this paper, combined with our latest results, the authors introduced the recent studies of the slippery zone, including surface structures and anti-attachment functions. They also highlighted the biomimetic application of slippery zone in developing slippery trapping plate for controlling agricultural pest.

关键词： Agricultural bionic engineering agricultural pest slippery trapping plate Nepenthes pitchers slippery surface,anti-attachment mechanism.

Geographically driven shifts in land use influence phytoplankton community patterns in the Inner Mongolian Plateau lakes

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Journal of Plant Ecology 2024年第5期17卷 157-175页

作者： Yue Geng Xue Lei Ruihong Yu Xiangwei Li Heyang Sun Xingyu Liu Yuan Li Xiangyu Zhang Zhuangzhuang Zhang Jifei Xu Changwei Lü lixin wang Jianfeng wang Inner Mongolia Key Laboratory of River and Lake Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Key Laboratory of Mongolian Plateau Ecology and Resource Utilization Ministry of EducationHohhot 010021China Autonomous Region Collaborative Innovation Center for Integrated Management of Water Resources and Water Environment in the Inner Mongolia Reaches of the Yellow River Hohhot 010018China Inner Mongolia Hetao Irrigation District Water Conservancy Development Center Urat Branch Center Nine Drainage Ditch DrainageBayannur 015000China

Phytoplankton play an irreplaceable role as producers in maintaining lake ***,scant attention has been given to investigating the dispersion of phytoplankton communities and the factors influencing them across expansive *** this study,we present the results of a survey on the distribution of phytoplankton community and the effects of different driving factors in 11 lakes along Inner Mongolia in July–August ***-metric multidimensional scaling analysis and variance decomposition(VPA)were used to elucidate the distribution of phytoplankton communities and the response of drivers.A total of 169 species of phytoplankton from 8 phyla were *** the abundance and diversity of phytoplankton in the Inner Mongolia lakes showed a trend of high in the east and low in the west(with Daihai Lake as the boundary).The Margalef index of phytoplankton significantly negatively correlated with salinity(r=−0.707,P<0.05)and total dissolved solids(r=−0.720,P<0.05),and both density and biomass highly significantly positively correlated with the suspended solids,Chlorophyll a and trophic level *** VPA explained 38.9%of the changes in the phytoplankton community with the highest rate of explanation of land ***,preventing anthropogenic impacts,as well as reducing nutrient loads,can effectively ensure the ecological diversity of lake phytoplankton in lake populations with large geographical spans and varying levels of nutrients.

关键词： phytoplankton driving factor water quality land use community distribution Inner Mongolian Plateau

Morphological and phylogenetical analysis reveals that a new tapeworm species (Cestoda: Hymenolepididae) from whooper swan belongs to Cloacotaenia not Hymenolepis

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Journal of Forestry Research 2020年第6期31卷 2581-2587页

作者： Zhijun Hou Lei Han Ying Sun Dongdong Shen Zhiwei Peng lixin wang Qian Zhai Yanqiang Zhou Yaxian Lu Liwei Teng Hongliang Chai College of Wildlife Resource Northeast Forestry UniversityHarbin 150040People’s Republic of China

During a helminthological study of waterfowl in China,a new species(Cloacotaenia cygnimorbus ***.)of hymenolepidid cestodes(tapeworm)was found in the small intestine of whooper swan(Cygnus cygnus,Linnaeus,1758).The rudimentary rostellum and four unarmed muscular suckers,proglottids with distinct craspedote and three spherical testes were coincident with the characters of Cloacotaenia or Hymenolepis,but phylogenetic analysis of 28S rRNA and cox1 gene revealed that the new species is Cloacotaenia rather than *** morphology was also clearly diff erentiated from *** in the arrangement of its testes in a triangle instead of in line and the cirrus unarmed rather than *** with ***,the new species has more elongated neck,much larger mature proglottids and much smaller testes,cirrus sac,ovary,vitellarium and uterine *** addition,it infected the host intestine not the *** analysis of cox1 gene of the new species shows that it had a level of sequence variation(10.52–23.06%)with the sequences of *** considerable morphological and molecular diff erences between those two parasites support *** *** a new species.

关键词： Cloacotaenia Hymenolepididae Hymenolepis Whooper swan 28S rRNA cox1

With the dragon as a foil： American imagining of China and the construction of America＇s national identity

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Social Sciences in China 2008年第4期29卷 98-112页

作者： wang lixin Department of History Peking University

Throughout the period from the late eighteenth to the mid-twentieth century, China was invariably ＂the other＂ contrasted with the US in the latter＇s imagination. Imagining this ＂other＂ reflected the fears, aspirations and yearnings of Americans, and helped define American identity and its position in the world in different historical periods. It was a w^iy for the US to reflect on and conceive of itself, and was therefore profoundly autobiographical. Americans should give up their manner of understanding and imagining China within the framework of their own values and interests and obtain a clear understanding of the feelings, desires and aspirations of the Chinese people, so as to lay a sound emotional foundation for the stable development of Sino-US relations.

关键词： national identity image of China other missionary

＂Who Are We？＂ Woodrow Wilson, the First World War and the Reshaping of America＇s National Identity

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Social Sciences in China 2010年第2期31卷 111-129页

作者： wang lixin Department of History Peking University

In the new context of the rise of United States as a world power, Woodrow Wilson seized the exceptional opportunity offered by American involvement in the First World War and wartime mobilization to reinterpret America＇s traditions and characteristics, contrasting the US with Germany, the ＂other.＂ He successfully transformed America＇s self-image and international role from the ＂model republic＂ and ＂example of freedom＂ of the nineteenth century to ＂champion of liberty＂ and ＂world leader.＂ Wilson＇s reshaping of the national identity not only facilitated wartime mobilization but also resolved America＇s identity crisis and its confusion about the role it was to play after it came on the world stage. In so doing, he identified the long-term direction of national policy for an America that had risen to be a world power. His creative interpretation of America＇s ideals, role and destiny guided his countrymen in their understanding of the meaning of their country＇s existence and its relations with the world and became the most influential foreign policy discourse of twentieth century America. This had a far-reaching influence on American foreign policy.

关键词： Woodrow Wilson national identity international role champion of liberty American diplomacy