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The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs

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Science China Chemistry 2014年第6期57卷 833-841页

作者： LI JingYuan shi lixin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei State Key Laboratory of Bioelectronics (Chien-shiung Wu Laboratory) Southeast University Laboratory Animal Center Institute of Comparative MedicineNantong University Department of Chemistry and Biochemistry California State University Department of Hematology Zhongda HospitalSoutheast University

As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/***,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 *** important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer *** enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 ***-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real *** addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce *** a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine.

关键词： celastrol cysteamine-modified CdTe QDs leukemia cancer cells labeling drug delivery

Lipschitz functions on Banach spaces which are actually on Asplund spaces

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Chinese Science Bulletin 1997年第24期42卷 2051-2054页

作者： CHENG lixin shi ShuzhongNankai Institute of Mathematics, Nankai University, Tianjin 300071, China Nankai Institute of Mathematics Nankai University Tianjin China

SINCE Namioka and Phelps, starting with Asplund’s pioneering work, introduced the no-tion of Asplund spaces (those are Banach spaces on which every continuous convex function isFrechet differentiable on a dense G_δ subset) and proved that the dual of an Asplund space hasthe Radon-Nikodym property (RNP), the study of differentiability properties of functions oninfinite dimensional spaces has continued widely and deeply (see, for instance, Phelps andGiles). The research attained a great achievment after Stegall’s theorem: If the dualspace E~* has the RNP, then E is an Asplund space. Because of the N-Ph-S theorem, we

关键词： mathematics Lipschitz function Radon-Nikodym property subdifferential Banach space.

Every Banach space with a w*-separable dual hasa 1+ε-equivalent norm with the ball covering property

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Science China Mathematics 2009年第9期52卷 1869-1874页

作者： CHENG lixin, shi HuiHua & ZHANG Wen School of Mathematical Sciences, Xiamen University, Xiamen 361005, China 1. School of Mathematical Sciences Xiamen University Xiamen 361005 China

A normed space is said to have ball-covering property if its unit sphere can be contained in the union of countably many open balls off the origin. This paper shows that for every ε>0 every Banach space with a w*-sep... 详细信息

关键词： ball-covering property renorming Banach space

Comparative Analysis on Juvenile Moral Education between China and America

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International Journal of Technology Management 2013年第6期 78-80页

作者： lixin shi Extramural Education Guidance Centre of Baicheng City in Jilin Province Baicheng City Jinlin Province

In the 21st Century of the increasing living standards, the social demand for talents with various aspects of ability is becoming higher and higher. The families, study and society of generations after 70s and 80s pay more attention to cultivating their own children＇s comprehensive development. Juvenile moral education is an important part of the contemporary juvenile education. Juvenile moral education is worthy of being paid attention to. On one hand, it is because the juvenile education is in the most basic and critical stage of the whole education stage, which is in the stage of the biggest influence of education development; on the other hand, it is because the young people are active and curious by nature, which will cause the difficulty of moral education to increase in the education process. Various countries and regions in the world have their own unique cultures and adjustments,and these different cultures affect the residents of different countries and regions with different living habits, ways of thinking and behaviors; thus forming different cultural differences. This paper, by taking the juvenile moral education between China and America as the research object, aims at analyzing the Chinese and Western cultural difference in juvenile moral education representation and transmission, aiming at from point to area,promoting the communication and development of juvenile moral education.

关键词： parenting style juvenile education moral education relationship

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糖尿病神经病变的机制与药物治疗

中华糖尿病杂志 2021年第4期13卷 446-448页

作者：时立新贵州医科大学附属医院内分泌代谢病科贵阳550004

糖尿病神经病变是糖尿病最常见的慢性并发症。在高血糖状态下,多元醇通路、糖基化终末产物、氧化应激与细胞因子等因素独立或相互作用,直接或间接参与糖尿病神经病变的发生与发展。醛糖还原酶特异性抑制剂通过阻断多元醇通路发挥作用,... 详细信息

糖尿病神经病变是糖尿病最常见的慢性并发症。在高血糖状态下,多元醇通路、糖基化终末产物、氧化应激与细胞因子等因素独立或相互作用,直接或间接参与糖尿病神经病变的发生与发展。醛糖还原酶特异性抑制剂通过阻断多元醇通路发挥作用,同时减轻糖尿病个体的氧化应激,并抑制蛋白非酶糖化,还可与α-硫辛酸、甲钴胺等药物联用治疗糖尿病神经病变,可有效改善其神经功能。

关键词：糖尿病神经病变多元醇通路醛糖还原酶特异性抑制剂

从蛋白尿到特征组学：糖尿病肾病的个体化防治——第52届欧洲糖尿病研究协会年会述评

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中华内分泌代谢杂志 2017年第3期33卷 263-265页

作者：时立新贵州医科大学附属医院内分泌科贵阳550004

本文围绕第52届欧洲糖尿病研究协会（European Association for the Study of Diabetes，EASD）大会***教授的Golgi奖获奖演说“糖尿病肾病的个体化防治：从蛋白尿到特征组学”，结合其他学者关于糖尿病肾病组学研究进展的报告进行述评... 详细信息

本文围绕第52届欧洲糖尿病研究协会（European Association for the Study of Diabetes，EASD）大会***教授的Golgi奖获奖演说“糖尿病肾病的个体化防治：从蛋白尿到特征组学”，结合其他学者关于糖尿病肾病组学研究进展的报告进行述评,以飨读者。

关键词：欧洲糖尿病研究协会糖尿病肾病蛋白尿防治个体年会 Golgi

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吸烟和糖尿病对心血管疾病相互影响的研究进展

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中华糖尿病杂志 2022年第8期14卷 841-844页

作者：杨洋时立新贵州医科大学附属医院内分泌代谢病科贵阳550004 贵黔国际总医院内分泌代谢病科贵阳550018

吸烟是糖尿病患者患心血管疾病的主要危险因素,吸烟还可能增加糖尿病的患病风险,危险因素管理在糖尿病病程中起着重要作用。该文综述了吸烟、糖尿病、危险因素管理与心血管疾病相互作用的研究证据,为今后制定精确的临床防治策略,从而减... 详细信息

吸烟是糖尿病患者患心血管疾病的主要危险因素,吸烟还可能增加糖尿病的患病风险,危险因素管理在糖尿病病程中起着重要作用。该文综述了吸烟、糖尿病、危险因素管理与心血管疾病相互作用的研究证据,为今后制定精确的临床防治策略,从而减轻糖尿病患者心血管疾病负担提供更合理的参考。

关键词：糖尿病吸烟心血管疾病危险因素管理

《糖尿病神经病变诊治专家共识(2021年版)》要点说明

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中华糖尿病杂志 2021年第6期13卷 535-539页

作者：吴静时立新中南大学湘雅医院内分泌科长沙410008 贵州医科大学附属医院内分泌代谢病科贵阳550004

糖尿病神经病变是糖尿病最常见的慢性并发症,国际上有关糖尿病神经病变的共识和指南也在更新。基于此,中华医学会糖尿病学分会神经并发症学组发布了《糖尿病神经病变诊治专家共识(2021年版)》(后简称共识)。共识中有关糖尿病神经病变分... 详细信息

糖尿病神经病变是糖尿病最常见的慢性并发症,国际上有关糖尿病神经病变的共识和指南也在更新。基于此,中华医学会糖尿病学分会神经并发症学组发布了《糖尿病神经病变诊治专家共识(2021年版)》(后简称共识)。共识中有关糖尿病神经病变分型较以往有了较大变化,而诊断筛查作为重点内容,也有部分更新,治疗则针对痛性神经病变做了重点介绍。因此,本文针对共识中有关糖尿病神经病变的分型、诊断筛查和治疗进行介绍。

关键词：糖尿病神经病变筛查诊断治疗

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论元明善和他的《清河集》

民族文学研究 2006年第4期24卷 143-149页

作者：史礼心北方工业大学文法学院

元代鲜卑人后裔元明善的诗文成就在当时享有盛誉,但在现代却鲜为人提及。其原因主要在于其《清河集》的绝大部分作品佚失,现存清人辑集的诗文作品仅及原集的十分之一二。首先介绍元明善其人其事,次叙其文集版本流传经过及后来的辑集情况... 详细信息

元代鲜卑人后裔元明善的诗文成就在当时享有盛誉,但在现代却鲜为人提及。其原因主要在于其《清河集》的绝大部分作品佚失,现存清人辑集的诗文作品仅及原集的十分之一二。首先介绍元明善其人其事,次叙其文集版本流传经过及后来的辑集情况,最后对其有代表性的诗文作品进行评析。

关键词：元明善《清河集》元诗文