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Nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang Xiaohan Guo Yi Wu Xingyu Chen lixiang feng Na Xie Guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

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Numerical Analysis of Perforation during Hydraulic Fracture Initiation Based on Continuous-Discontinuous Element Method

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2103-2129页

作者： Rui Zhang lixiang Wang Jing Li Chun feng Yiming Zhang School of Civil and Transportation Engineering Hebei University of TechnologyTianjin300401China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou310018China Jinyun Institute Zhejiang Sci-Tech UniversityLishui321400China

Perforation is a pivotal technique employed to establish main flow channels within the reservoir formation at the outset of hydraulic fracturing *** perforation designs is critical for augmenting the efficacy of hydraulic fracturing and boosting oil or gas *** this study,we employ a hybrid finite-discrete element method,known as the continuous–discontinuous element method(CDEM),to simulate the initiation of post-perforation hydraulic fractures and to derive enhanced design *** model incorporates the four most prevalent perforation geometries,as delineated in an engineering technical ***-world perforations deviate from the ideal cylindrical shape,exhibiting variable cross-sectional profiles that typically manifest as an initial constriction followed by an expansion,a feature consistent across all four perforation *** simulations take into account variations in perforation hole geometries,cross-sectional diameters,and perforation *** findings show that perforations generated by the 39g DP3 HMX perforating bullet yield the lowest breakdown pressure,which inversely correlates with increases in sectional diameter and perforation ***,this study reveals the relationship between breakdown pressure and fracture degree,providing valuable insights for engineers and designers to refine perforation strategies.

关键词： Hydraulic fracturing real perforation shape breakdown pressure perforation layout design CDEM

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Regulating interfacial chemistry and kinetic behaviors of F/Mo co-doping Ni-rich layered oxide cathode for long-cycling lithium-ion batteries over-20°C-60°C

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Journal of Energy Chemistry 2024年第7期94卷 449-457页

作者： Siqi Guan Lin Tao Pei Tang Ruopian Fang Huize Wu Nan Piao Huicong Yang Guangjian Hu Xin Geng lixiang Li Baigang An feng Li Institute of Energy Materials and Electrochemistry Research University of Science and Technology LiaoningAnshan 114051LiaoningChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Shenyang King Power Tech.Co. Ltd.Shenyang 110016LiaoningChina School of Chemical Engineering The University of New South WalesSydney 2052NSWAustralia

Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature conditions(below0°C and above 50 °C).Here,we report the design of F/Mo co-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(FMNCM)cathode for high-performance LIBs from-20 to 60°C.F^(-) doping with high electronegativity into the cathode surface is found to enhance the stability of surface lattice structure and protect the interface from side reactions with the electrolyte by generating a LiF-rich surface ***,the Mo^(6+) doping suppresses phase transition,which blocks Li^(+)/Ni^(2+) mixing,and stabilizes lithium-ion diffusion ***,the FMNCM cathode demonstrates excellent cycling stability at a high cutoff voltage of 4.4 V,even at 60°C,maintaining 90.6%capacity retention at 3 C after 150 ***,at temperatures as low as-20°C,it retains 77.1%of its room temperature capacity,achieving an impressive 97.5%capacity retention after 500 *** stable operation under wide temperatures has been further validated in practical Ah-level *** study sheds light on both fundamental mechanisms and practical implications for the design of advanced cathode materials for wide-temperature LIBs,presenting a promising path towards high-energy and long-cycling LIBs with temperatureadaptability.

关键词： Anion-cation co-doping Wide temperature operation Ni-richlayered cathode Phase transition Surface/interface

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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

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Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao Ye Man feng Changhua Ji Wenzhong Zhou Fei Wang lixiang Yu Shuya Huang Zhigang Yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is ***: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to ***: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft ***: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

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Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B

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Animal Models and Experimental Medicine 2024年第3期7卷 324-336页

作者： Bowen Niu Lingling Liu Qian Gao Meng-Min Zhu lixiang Chen Xiu-Hua Peng Boying Qin Xiaohui Zhou feng Li Department of Laboratory Animal Science Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Biology College of Life SciencesShanghai Normal UniversityShanghaiPeople's Republic of China

Background:Bitter taste receptors(Tas2rs)are generally considered to sense various bitter compounds to escape the intake of toxic *** taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in ***:To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues,multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique.A mixture containing Cas9 and sgRNA mRNAs for Tas2rs and Gnat3 gene was microinjected into the cytoplasm of the ***,T7EN1 assays and sequencing were used to screen genetic mutation at the target sites in founder *** real-time polymerase chain reaction(qRT-PCR)and immunostaining were used to study the expression level of taste signaling cascade and bitter taste receptor in taste *** to taste substance was also studied using twobottle preference ***:We successfully produced several Tas2rs and Gnat3 mutant mice using the CRISPR/Cas9 *** results showed that the expression of GNAT3 and PLCB2 was not altered in Tas2rs mutant *** qRT-PCR results revealed the changed expression profile of m Tas2rs gene in taste buds of these mutant *** two-bottle preference tests,these mutant mice eliminate responses to cycloheximide due to genetic mutation of *** addition,these mutant mice showed a loss of taste perception to quinine dihydrochloride,denatonium benzoate,and cucurbitacin B(CuB).Gnat3-mediated taste receptor and its signal pathway contribute to CuB ***:These findings implied that these mutant mice would be a valuable means to understand the biological functions of TAS2Rs in extraoral tissues and investigate bitter compound-induced responses mediated by these TAS2Rs in many extraoral tissues.

关键词： bitter taste receptor CRISPR/Cas9 genetic mutation two-bottle preference test type 2 taste receptors(Tas2rs)

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具有隔离和不完全治疗的传染病模型的全局稳定性

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数学物理学报（A辑） 2021年第4期41卷 1235-1248页

作者：丰利香王德芬宁夏理工学院宁夏石嘴山753000

该文建立了一类具有隔离和不完全治疗的传染病模型.在模型中考虑了无意识和有意识的易感人群,通过基本再生数确定了模型的传播动力学,当R_(0)≤1时,无病平衡点是全局渐近稳定的,当R_(0)>1时,地方病平衡点是全局渐近稳定的,并通过数值模... 详细信息

该文建立了一类具有隔离和不完全治疗的传染病模型.在模型中考虑了无意识和有意识的易感人群,通过基本再生数确定了模型的传播动力学,当R_(0)≤1时,无病平衡点是全局渐近稳定的,当R_(0)>1时,地方病平衡点是全局渐近稳定的,并通过数值模拟说明了理论分析的正确性.

关键词：传染病模型基本再生数全局稳定性 Lyapunov泛函

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煤矿轮式无轨运输机械事故的研究与分析

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机械管理开发 2021年第7期36卷 303-304页

作者：冯利翔山西宁武大运华盛南沟煤业有限公司山西忻州036700

煤矿开采中应用了大量的移动开采设备,由于这些设备在操作过程中因为各种原因在造成了严重事故。因此,根据对某煤矿的历史事故数据分析,并提出了煤矿事故的成因,并进一步对无轨运输机械事故展开分析,基于现有调查程序中的主要差距,提出... 详细信息

煤矿开采中应用了大量的移动开采设备,由于这些设备在操作过程中因为各种原因在造成了严重事故。因此,根据对某煤矿的历史事故数据分析,并提出了煤矿事故的成因,并进一步对无轨运输机械事故展开分析,基于现有调查程序中的主要差距,提出了相应的措施,以确保煤矿的安全开采,提高煤矿生产运输的工作效率。

关键词：轮式无轨运输机械煤矿事故研究

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柔性无机矿物绝缘电缆在某公建项目的应用

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建筑电气 2011年第4期30卷 50-52页

作者：冯立祥南方兵器装备产业有限公司北京市100089

以某公建项目为例,介绍柔性无机矿物绝缘电缆与氧化镁矿物绝缘电缆的区别,柔性无机矿物绝缘电缆的选型、订货和安装注意事项。

关键词：柔性无机矿物绝缘电缆氧化镁矿物绝缘电缆电缆选型安装

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吊环超声波探伤的声程计算

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无损检测 2000年第1期22卷 35-37页

作者：冯礼祥宝鸡石油机械厂宝鸡721002

吊环是钻井中承受钻柱重量的可卸构件,既要安全承载,又不能体大笨重,而构件内部又不允许存在有害缺陷,故必须采用超声波探伤.根据超声波从探头发射后在吊环传播中自身的反射回波特性,就能判别缺陷的位置和判定缺陷大小.

关键词：钻井吊环超声波探伤声程计算

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北京市住宅小区配电室及楼内配电相关要求

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建筑电气 2017年第7期36卷 8-12页

作者：冯立祥佟利北京世纪鸿城置业有限公司北京市100012 国网北京市电力公司朝阳供电公司北京市100124

北京市住宅小区配电室及其楼内配电系统的设计除应满足国家规范、标准之外,还应满足北京市的地方标准和当地供电部门的要求,针对在住宅小区的建设和参与供电部门图纸审查中发现的设计与供电部门要求不相符的问题,结合北京市地方标准DB11... 详细信息

北京市住宅小区配电室及其楼内配电系统的设计除应满足国家规范、标准之外,还应满足北京市的地方标准和当地供电部门的要求,针对在住宅小区的建设和参与供电部门图纸审查中发现的设计与供电部门要求不相符的问题,结合北京市地方标准DB11/T 1147-2015《10k V及以下配电网建设技术规范》,提出北京市住宅小区配电室及楼内配电系统设计应注意的问题和解决办法。

关键词：住宅小区公用配电室用户配电室楼内配电系统地方标准供电部门要求需用系数供电半径

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