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An Improved Training Algorithm Based on Ensemble Penalized Cox Regression for Predicting Absolute Cancer Risk

China CDC weekly 2023年第9期5卷 206-212,I0009-I0014页

作者： Liyuan Liu Fu Yang Yeye Fan Chunyu Kao Fei Wang lixiang yu Yong He Jiadong Ji Zhigang yu Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinan CityShandong ProvinceChina School of Mathematics Shandong UniversityJinan CityShandong ProvinceChina Zhongtai Securities Institute for Financial Studies Shandong UniversityJinan CityShandong ProvinceChina Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan CityShandong ProvinceChina.

Introduction:Biases in cancer incidence characteristics have led to significant imbalances in databases constructed by prospective cohort *** they use imbalanced databases,many traditional algorithms for training cancer risk prediction models perform ***:To improve prediction performance,we introduced a Bagging ensemble framework to an absolute risk model based on ensemble penalized Cox regression(EPCR).We then tested whether the EPCR model outperformed other traditional regression models by varying the censoring rate of the simulated ***:Six different simulation studies were performed with 100 *** assess model performance,we calculated mean false discovery rate,false omission rate,true positive rate,true negative rate,and the areas under the receiver operating characteristic curve(AUC)*** found that the EPCR procedure could reduce the false discovery rate(FDR)for important variables at the same true positive rate(TPR),thereby achieving more accurate variable *** addition,we used the EPCR procedure to build a breast cancer risk prediction model based on the Breast Cancer Cohort Study in Chinese Women *** for 3-and 5-year predictions were 0.691 and 0.642,representing improvements of 0.189 and 0.117 over the classical Gail model,***:We conclude that the EPCR procedure can overcome challenges posed by imbalanced data and improve the performance of cancer risk assessment tools.

关键词： Cancer false prediction

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Breast Cancer Awareness and Association with Frequency of Screening Among Women—China,2020

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China CDC weekly 2023年第15期5卷 327-332页

作者： Heling Bao Liyuan Liu Shu Cong Fei Wang lixiang yu Liwen Fang Xuening Duan Feng Tan Zhigang yu Linhong Wang Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina The Second Hospital of Shandong University Jinan CityShandong ProvinceChina Peking University First Hospital BeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?Breast cancer awareness plays a crucial role in promoting screening attendance,enabling early detection,and improving survival rates associated with breast ***,a persiste... 详细信息

关键词： Breast Cancer awareness

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Rice productivity and profitability with slow-release urea containing organic-inorganic matrix materials

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Pedosphere 2021年第4期31卷 511-520页

作者： Yang YANG Binmei LIU Xiaoyu NI Liangzhi TAO lixiang yu Ye YANG Mengxi FENG Wenjin ZHONG yuejin WU Engineering Laboratory of Environment-friendly High-effciency Fertilizers and Pesticides of Anhui Province Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031(China) The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100101(China) Henan Xinlianxin Fertilizer Co. Ltd.Xinxiang 453700(China)

Applying slow-release fertilizers is possible means for reducing nitrogen(N) loss in rice production. Matrix-based fertilizers represent novel slow-release fertilizers. To date, there is little consensus about the effect of combined addition of organic and inorganic matrix materials on rice production. We developed a slow-release urea fertilizer with selected organic and inorganic matrix materials. The study aimed to: i) determine the effect of the slow-release urea on rice yield, profit, and agronomic efficiency and ii) elucidate its possible mechanisms. A two-year field experiment was conducted during 2015–2016. Besides,laboratory experiments were conducted to determine the potential N loss risk. Three treatments were set up: control without N application(CK), regular urea treatment(RU, 150 kg N ha^(-1)), and slow-release urea treatment(SU, 150 kg N ha^(-1)). The results showed that rice biomass and grain yield were significantly higher in SU than in RU(P < 0.05). The higher panicle density in SU was largely responsible for the greater grain yield. Net profit in SU was US$450 ha^(-1), higher than in RU. Agronomic efficiency was significantly greater in SU than in RU(P < 0.05). Rice height, root area, leaf chlorophyll, leaf nitrate reductase activity, and leaf glutamine synthetase activity were larger in SU than in RU. Less N loss and greater soil N availability were partly responsible for the improvements in rice growth traits and physiological parameters in SU. Overall, the slow-release urea is a promising fertilizer for rice production.

关键词： ammonia emission ferric sulfate matrix-based fertilizer montmorillonite nitrogen leaching path analysis

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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

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Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao Ye Man Feng Changhua Ji Wenzhong Zhou Fei Wang lixiang yu Shuya Huang Zhigang yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is ***: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to ***: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft ***: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

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Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer—China,2020

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China CDC weekly 2023年第15期5卷 333-339页

作者： Liyuan Liu Heling Bao Fei Wang lixiang yu Shu Cong Fei Zhou yujuan Xiang Shuya Huang Chao Zheng Liwen Fang Linhong Wang Zhigang yu Department of Breast Surgery The Second Hospital of Shandong UniversityJinan CityShandong ProvinceChina Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan CityShandong ProvinceChina Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Psychological and lifestyle factors are known to potentially play a significant role in the development of breast ***,current evidence-based studies present controversial... 详细信息

关键词： breast Breast Cancer

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Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways

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Chinese Journal of Cancer Research 2020年第3期32卷 347-360页

作者： Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang lixiang yu Fei Zhou yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang yu School of Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Department of Breast Surgery the Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China

Objective:Obesity is closely associated with metastasis in breast cancer *** frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with *** study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying ***:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 *** and epithelialmesenchymal transition(EMT)signal pathways were investigated by western *** SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further *** databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and ***:Reduced SFRP5 level was detected in the hypertrophic adipocyte *** SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of ***,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer *** circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer *** SFRP5 level was associated with favorable predicted ***-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer ***:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast *** of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis.

关键词： Obesity adipocytes breast cancer metastasis SFRP5 EMT

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Establishment of novel rat models for premalignant breast disease

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Chinese Medical Journal 2014年第11期127卷 2147-2152页

作者： Wang Feng Ma Zhongbing Wang Fei Fu Qinye Fang yunzhi Zhang Qiang Gao Dezong Li yuyang Li Liang yu lixiang yu Zhigang Department of Breast Disease the Second Hospital of ShandongUniversity Jinan Shandong 250033 China Department of General Surgery the Sixth People's Hospital of JinanCity Jinan Shandong 250200 China

Background Breast cancer has become one of the most common malignant tumors among females over the past several *** carcinogenesis is a continuous process,which is featured by the normal epithelium progressing to premalignant lesions and then to invasive breast cancer （IBC）.Targeting premalignant lesions is an effective strategy to prevent breast *** establishment of animal models is critical to study the mechanisms of breast carcinogenesis,which will facilitate research on breast cancer prevention and drug *** this study,we established a feasible chemically-induced rat model of premalignant breast *** Following the administration of the drugs （carcinogen,estrogen,and progestogen） to Sprague-Dawley （SD） rats,tumors or suspicious tumors were identified by palpation or ultrasound imaging,and were surgically excised for pathological evaluation.A series of four consecutive steps were carried out in order to determine the carcinogen：7,12-dimethylbenzaanthracene （DMBA） or 1-methyl-1-nitrosourea,the route of carcinogen administration,the administration period of estrogen and progestogen,and the DMBA *** Stable premalignant lesions can be induced in SD rats on administration of DMBA （15 mg/kg,administered three times） followed by administration of female hormones 5-day *** were confirmed by ultrasound and *** Under the premise of drug dose and cycle,DMBA combined with estrogen and progestogen can be used as a SD rat model for breast premalignant lesions.

关键词： animal model premalignant breast cancer rats 7,12-dimethylbenza anthracene 1-methyl-1-nitrosourea

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低能氮离子注入固态羧酸钠的光谱分析

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光谱学与光谱分析 1999年第5期19卷 697-699页

作者：王相勤姚建铭余立祥余增亮中国科学院等离子体物理研究所生物工程中心合肥230031

对２５ｋｅＶＮ＋离子束辐照羧酸钠（苯甲酸钠和乙酸钠）引起其分子结构的变化进行了研究，通过紫外光谱的分析，得到了离子注入后苯甲酸钠的残存剂量效应曲线，辐照后乙酸钠样品产生了新的具有紫外吸收的物质。傅里叶红外光谱分析证... 详细信息

对２５ｋｅＶＮ＋离子束辐照羧酸钠（苯甲酸钠和乙酸钠）引起其分子结构的变化进行了研究，通过紫外光谱的分析，得到了离子注入后苯甲酸钠的残存剂量效应曲线，辐照后乙酸钠样品产生了新的具有紫外吸收的物质。傅里叶红外光谱分析证明，两种羧酸钠样品辐照后的产物中含有新的化学基团氰基。

关键词：羧酸钠损伤氮离子注入辐照苯甲酸钠乙酸钠

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我国中老年人群童年期居住社区质量与认知功能的关联研究

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中华预防医学杂志 2023年第3期57卷 371-377页

作者：于丽香羊柳赵敏席波山东大学齐鲁医学院公共卫生学院流行病学系济南250012 山东大学齐鲁医学院公共卫生学院毒理与营养学系济南250012

目的探讨我国中老年人童年期居住社区质量与中老年认知功能的关联。方法基于2011年中国健康与养老追踪调查调查数据,纳入符合标准的≥45岁人群10940名,采用标准化调查问卷收集调查对象的一般人口学特征、生活方式、个人疾病史、社区质... 详细信息

目的探讨我国中老年人童年期居住社区质量与中老年认知功能的关联。方法基于2011年中国健康与养老追踪调查调查数据,纳入符合标准的≥45岁人群10940名,采用标准化调查问卷收集调查对象的一般人口学特征、生活方式、个人疾病史、社区质量和认知功能等信息。社区质量包括社区安全、社区热情及邻里关系,认知功能评价包括认知完整性和情景记忆能力。采用多因素logistic回归模型分析童年期居住社区质量与中老年期认知功能的关联。结果10940名研究对象年龄为(58.3±9.1)岁,女性占51.5%(5635名),认知功能良好者占47.3%(5174名)。多因素logistic回归模型分析结果显示,与童年期居住社区很不安全、童年期居住社区很不热情、童年期居住社区邻里关系很不融洽者相比,童年期居住社区比较安全(OR=0.75,95%CI:0.57~1.00)和非常安全(OR=0.72,95%CI:0.55~0.95)、居住社区比较热情(OR=0.69,95%CI:0.56~0.85)和非常热情(OR=0.70,95%CI:0.57~0.87)、邻里关系不太融洽(OR=0.57,95%CI:0.34~0.94)、比较融洽(OR=0.52,95%CI:0.33~0.83)和非常融洽(OR=0.49,95%CI:0.31~0.79)者的中老年认知状态均较好。结论童年期社区质量与我国中老年人群认知功能存在正向关联。

关键词：认知回顾性队列研究社区质量童年期

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An advanced machine learning method for simultaneous breast cancer risk prediction and risk ranking in Chinese population:A prospective cohort and modeling study

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Chinese Medical Journal 2024年第17期137卷 2084-2091页

作者： Liyuan Liu Yong He Chunyu Kao Yeye Fan Fu Yang Fei Wang lixiang yu Fei Zhou yujuan Xiang Shuya Huang Chao Zheng Han Cai Heling Bao Liwen Fang Linhong Wang Zengjing Chen Zhigang yu Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China School of Mathematics Shandong UniversityJinanShandong 250100China Zhongtai Securities Institute for Financial Studies Shandong UniversityJinanShandong 250100China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinanShandong 250033China Department of Maternal and Child Health School of Public HealthPeking UniversityHaidian DistrictBeijing 100191China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

Background:Breast cancer(BC)risk-stratification tools for Asian women that are highly accurate and can provide improved interpretation ability are *** aimed to develop risk-stratification models to predict long-and short-term BC risk among Chinese women and to simultaneously rank potential non-experimental risk ***:The Breast Cancer Cohort Study in Chinese Women,a large ongoing prospective dynamic cohort study,includes 122,058 women aged 25-70 years old from the eastern part of *** developed multiple machine-learning risk prediction models using parametric models(penalized logistic regression,bootstrap,and ensemble learning),which were the short-term ensemble penalized logistic regression(EPLR)risk prediction model and the ensemble penalized long-term(EPLT)risk prediction model to estimate BC *** models were assessed based on calibration and discrimination,and following this assessment,they were externally validated in new study participants from 2017 to ***:The AUC values of the short-term EPLR risk prediction model were 0.800 for the internal validation and 0.751 for the external validation *** the long-term EPLT risk prediction model,the area under the receiver operating characteristic curve was 0.692 and 0.760 in internal and external validations,*** net reclassification improvement index of the EPLT relative to the Gail and the Han Chinese Breast Cancer Prediction Model(HCBCP)models for external validation was 0.193 and 0.233,respectively,indicating that the EPLT model has higher classification ***:We developed the EPLR and EPLT models to screen populations with a high risk of developing *** can serve as useful tools to aid in risk-stratified screening and BC prevention.

关键词： Breast cancer Cancer prevention Models Women Risk assessment

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