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Studies on Pharmacokinetics of Porcine Somatotropin Liposomes

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Chemical Research in Chinese Universities 2005年第2期21卷 187-190页

作者： XUChuan-lai JICheng HAOKai lixiang-qian YAOHui-yuan SchoolofFoodScienceandTechnology SouthernYangtzeUniversityWuxi214036P.R.China CollegeofAnimalScienceandTechnology ChinaAgriculturalUniversityBeijing100094P.R.China

This paper focuses on the pharmacokinetics in fattening pigs as well as the change of serum resulting from the use of porcine somatotropin(PST) and its liposomes. A slow-release model was determined to be relevant to following an examination of all dynamic parameters. The results indicate that the slow-release effect of PST liposomes was significant, with an extended release time of over 7 d.

关键词： Porcine somatotropin(PST) liposomes Pharamacokinetics Slow-release

A nearly optimal distributed algorithm for computing the weighted girth

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Science China(Information Sciences) 2021年第11期64卷 80-94页

作者： qiang-Sheng HUA lixiang qian Dongxiao YU Xuanhua SHI Hai JIN National Engineering Research Center for Big Data Technology and System/Services Computing Technology and System Lab/Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and Technology School of Computer Science and Technology Shandong University

Computing the weighted girth, which is the sum of weights of edges in the minimum weight cycle,is an important problem in network analysis. The problem for distributively computing girth in unweighted graphs has garnered lots of attention, but there are few studies in weighted graphs. In this paper, we propose a distributed randomized algorithm for computing the weighted girth in weighted graphs with integral edge weights in the range [1, nc], where n is the number of vertices and c is a constant. The algorithm is devised under the standard synchronous CON GE S T model, which limits each vertex can only transfer O（log n） bits information along each incident edge in a round. The upper bound of the algorithm is O（n log;n） rounds. We also prove the lower bound for computing the weighted girth is ?（D + n/log n） where D is the hop diameter of the weighted graph. This means our distributed algorithm is optimal within a factor of O（log;n）.

关键词： distributed algorithms weighted girth $\mathcal{CONGEST}$ model communication complexity round complexity

Revealing the dynamics of the alloying and segregation of Pt-Co nanoparticles via in-situ environmental transmission electron microscopy

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Nano Research 2023年第2期16卷 3055-3062页

作者： Xing Li Shaobo Cheng Yanghua He lixiang qian Dmitri Zakharov Gang Wu Chongxin Shan Liang Zhang Dong Su Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY 14260USA Center for Combustion Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Thermal treatment is a general and efficient way to synthesize intermetallic catalysts and may involve complicated physical *** far,the mechanisms leading to the size and composition heterogeneity,as well as the phase segregation behavior in Pt-Co nanoparticles(NPs)are still not well *** in-situ environmental transmission electron microscopy,the formation dynamics and segregation behaviors of Pt-Co alloyed NPs during the thermal treatment were *** is found that Pt-Co NPs on zeolitic imidazolate frameworks-67-derived nanocarbon(NC)are formed consecutively through both particle migration coalescence and the Ostwald ripening *** existence of Pt NPs is found to affect the movement of Co NPs during their *** the help of theoretical calculations,the correlations between the composition and migration of the Pt and Co during the ripening process were *** complex alloying processes are revealed as key factors leading to the heterogeneity of the synthesized Pt-Co alloyed *** oxidation environment,the Pt-Co NPs become surface faceted gradually,which can be attributed to the oxygen facilitated relatively higher segregation rate of Co from the(111)*** work advances the fundamental understanding of design,synthesis,and durability of the Pt-based nanocatalysts.

关键词： intermetallic catalyst alloying ripening segregation dynamics environmental transmission electron microscopy(ETEM)

Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B

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Animal Models and Experimental Medicine 2024年第3期7卷 324-336页

作者： Bowen Niu Lingling Liu qian Gao Meng-Min Zhu lixiang Chen Xiu-Hua Peng Boying Qin Xiaohui Zhou Feng Li Department of Laboratory Animal Science Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Biology College of Life SciencesShanghai Normal UniversityShanghaiPeople's Republic of China

Background:Bitter taste receptors(Tas2rs)are generally considered to sense various bitter compounds to escape the intake of toxic *** taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in ***:To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues,multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique.A mixture containing Cas9 and sgRNA mRNAs for Tas2rs and Gnat3 gene was microinjected into the cytoplasm of the ***,T7EN1 assays and sequencing were used to screen genetic mutation at the target sites in founder *** real-time polymerase chain reaction(qRT-PCR)and immunostaining were used to study the expression level of taste signaling cascade and bitter taste receptor in taste *** to taste substance was also studied using twobottle preference ***:We successfully produced several Tas2rs and Gnat3 mutant mice using the CRISPR/Cas9 *** results showed that the expression of GNAT3 and PLCB2 was not altered in Tas2rs mutant *** qRT-PCR results revealed the changed expression profile of m Tas2rs gene in taste buds of these mutant *** two-bottle preference tests,these mutant mice eliminate responses to cycloheximide due to genetic mutation of *** addition,these mutant mice showed a loss of taste perception to quinine dihydrochloride,denatonium benzoate,and cucurbitacin B(CuB).Gnat3-mediated taste receptor and its signal pathway contribute to CuB ***:These findings implied that these mutant mice would be a valuable means to understand the biological functions of TAS2Rs in extraoral tissues and investigate bitter compound-induced responses mediated by these TAS2Rs in many extraoral tissues.

关键词： bitter taste receptor CRISPR/Cas9 genetic mutation two-bottle preference test type 2 taste receptors(Tas2rs)

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孤本总集《今文类体》价值考论

浙江大学学报（人文社会科学版） 2021年第2期51卷 229-239页

作者：徐永明钱礼翔浙江大学人文学院浙江杭州310058

《今文类体》是目前所见的孤本文献保存量最大的明文总集,具有极高的文学和史料价值。《今文类体》以按文体类别对搜集到的明刻别集进行直接拆分重编的方式,再现了编纂活动的原生面貌。该总集的孤本价值主要有三:一是文学价值,保存了明... 详细信息

《今文类体》是目前所见的孤本文献保存量最大的明文总集,具有极高的文学和史料价值。《今文类体》以按文体类别对搜集到的明刻别集进行直接拆分重编的方式,再现了编纂活动的原生面貌。该总集的孤本价值主要有三:一是文学价值,保存了明代17家31种孤本著述,可推进袁宏道、赵琦美等著名文人个案和《江南春》等文学现象研究;二是史学价值,可增补上海会馆社会史料、明朝与琉球外交史料和明代北虏边防史料;三是校勘与辑佚价值,可补充众多作家的文集版本,为明别集的整理提供校勘版本,同时为明代诗、词、文等断代总集的编纂提供可资辑佚的材料。

关键词：《今文类体》孤本总集袁宏道赵琦美上海会馆琉球

薪火相传,发扬踔厉——哈佛燕京图书馆馆长杨继东访谈

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图书馆杂志 2023年第9期42卷 44-50页

作者：钱礼翔孔凡晶北京大学信息管理系东北师范大学图书馆

2022年8月,哈佛燕京图书馆迎来第四任馆长杨继东先生,笔者在哈佛大学量化社会科学研究所(IQSS)做访问学者期间对他进行了访谈。首先,杨馆长回顾自己学科交融的研究经历,分享管理多所美国顶尖高校图书馆东亚分馆的经验,阐明接任哈佛燕京... 详细信息

2022年8月,哈佛燕京图书馆迎来第四任馆长杨继东先生,笔者在哈佛大学量化社会科学研究所(IQSS)做访问学者期间对他进行了访谈。首先,杨馆长回顾自己学科交融的研究经历,分享管理多所美国顶尖高校图书馆东亚分馆的经验,阐明接任哈佛燕京图书馆的3个机缘,揭示当前面临的空间与人手的挑战以及应对措施。其次,杨馆长介绍哈佛燕京图书馆珍善本等特藏资源的建设现状与数字化进程,阐明学科服务的内容和方式,展望后疫情时代图书馆服务模式的变化。最后,杨馆长提出元宇宙技术应用于图书馆的见解,指出现今图书馆业的两大热门趋势即特藏与数字人文,巡礼哈佛与斯坦福的数字人文项目,并给出针对国内数字人文发展的建议。

关键词：哈佛燕京图书馆杨继东学科服务元宇宙特藏数字人文

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明清书船贸易的水运环境与地域网络

印刷文化（中英文） 2023年第3期 53-60页

作者：钱礼翔北京大学信息管理系

明清书船贸易活动主要由购书、换书、藏书三维构成,贸易活动催生出特定的“书客”制度,并成为政府课税的对象。明清水运环境的极大改善是书船贸易繁荣的重要原因,其归结于运河体系、程图路引和船舶的成熟。在地理学视域下,明清书船至少... 详细信息

明清书船贸易活动主要由购书、换书、藏书三维构成,贸易活动催生出特定的“书客”制度,并成为政府课税的对象。明清水运环境的极大改善是书船贸易繁荣的重要原因,其归结于运河体系、程图路引和船舶的成熟。在地理学视域下,明清书船至少出现在5个省份的16个城市,借助CHGIS地理信息系统和QGIS制图软件,发现书船活动的地域分布表现出“大中心”“范围广”的特质,且书船贸易与明清书籍商业出版的关系网络呈现出正相关性的特点。

关键词：书船活动运河程图路引地域分布贸易网络

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杜德桥及其《醒世姻缘传》研究

国际汉学 2023年第2期 44-49,156页

作者：钱礼翔北京大学信息管理系

英国汉学家杜德桥对中国古典小说《醒世姻缘传》的研究别开蹊径,可以作为我国学者研究中国古典小说的他山之石。他的成就在于:第一,运用历史眼光研究中国古典小说,将文学作品《醒世姻缘传》看作历史文献,深入解读文本背后社会史、宗教... 详细信息

英国汉学家杜德桥对中国古典小说《醒世姻缘传》的研究别开蹊径,可以作为我国学者研究中国古典小说的他山之石。他的成就在于:第一,运用历史眼光研究中国古典小说,将文学作品《醒世姻缘传》看作历史文献,深入解读文本背后社会史、宗教史的内涵;第二,从文本的内部声音和外在观察两个向度,重点阅读《醒世姻缘传》中“泰山进香”回目,探讨了泰山进香史、宗教组织、财务与后勤、游山、个人动机与家庭紧张等方面的内容;第三,为国内外学者提供新的思路,启发人们将《醒世姻缘传》从文学文本转变到社会文本研读。

关键词：杜德桥《醒世姻缘传》历史眼光泰山进香社会文本

《明诗综》诗人地理分布可视化与朱彝尊的明诗版图

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江苏第二师范学院学报 2020年第1期36卷 24-30,124页

作者：钱礼翔浙江大学人文学院浙江杭州310028

借助CHGIS地理信息系统和QGIS制图软件,对《明诗综》中可考籍贯诗人进行数据分析和可视化呈现,并与《列朝诗集小传》进行对比,探讨朱彝尊构建的明诗版图及其背后的政治、经济、文化原因。首先,朱彝尊推崇南方诗人,建立了以浙江为核心,... 详细信息

借助CHGIS地理信息系统和QGIS制图软件,对《明诗综》中可考籍贯诗人进行数据分析和可视化呈现,并与《列朝诗集小传》进行对比,探讨朱彝尊构建的明诗版图及其背后的政治、经济、文化原因。首先,朱彝尊推崇南方诗人,建立了以浙江为核心,以江苏、安徽、福建、江西、上海为辅的诗人省份版图;其次又确立了以嘉兴为核心,以苏州、鄞县、上海、吴县为辅的诗人城市版图;另外,朱彝尊与钱谦益明诗观区别较大,表现为朱彝尊客观对待“复古诸子”以及十分重视“遗民诗人”。

关键词：《明诗综》地理分布可视化明诗版图