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Journal of Management Science and Engineering 2020年第3期5卷 195-211页

作者： lixia zheng School of Management Tianjin University of CommerceTianjin300134China Graduate School Aichi UniversityNagoya Aichi453-8777Japan

With the acceleration of China's urbanization,the functions and benefits of mega-projects are required *** the deepening of"the Silk Road Economic Belt and the 21st-Century Maritime Silk Road",the quantitative evaluation of multinational investment projects will help strengthen cross-border communication among gov-ernment,society and enterprises,which provide a basis for mutual *** study empirically analyzes and evaluates the impact of mega-projects on carrying capacity of cities,by using the DID method based on the panel data of 15 cities in China from 2000 to *** results show that the construction and operation of the first-line project of the West-East gas pipeline has a significant positive impact on the improvement of carrying capacity of cities along the ***,the degree of impact on three di-mensions is slightly *** impact on the social carrying capacity is the greatest,then the ecological and economic carrying ***,the decisions of do-mestic mega-projects should be unified with urban planning to promote the sustain-able development of China's economy and *** investment of mega-projects abroad should also be coordinated with the carrying capacity of host cities,in order to enhance the competitiveness and creativity of Chinese multinational mega-projects investment.

关键词： Mega-projects Carrying capacity of cities Urban planning Multinational mega-project investment

64 × 64 GM-APD array-based readout integrated circuit for 3D imaging applications

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Science China(Information Sciences) 2019年第6期62卷 130-140页

作者： Jin WU Zhiming QIAN Yang ZHAO Xiangrong YU lixia zheng Weifeng SUN Branch School of Southeast University National ASIC System Engineering Research Center Southeast University

Using the high sensitivity of the avalanche photodiode(APD) detector operated in the Geigermode(GM), an array readout integrated circuit(ROIC) comprising a two-segment time-to-digital converter(TDC) is employed for wide-dynamic time interval measurement, where a 1-bit low-segment TDC is implemented by discriminating a single-phase clock period. The proposed 64 × 64 GM-APD array ROIC fabricated using Taiwan semiconductor manufacturing company(TSMC) 0.18-μm complementary metal oxide semiconductor(CMOS) technology can operate at a maximum frequency of 500 MHz provided by an external phase-locked loop clock. The time resolution is reduced to < 1 ns along with a maximum range of4 μs; the differential non-linearity(DNL) and integral non-linearity(INL) are restricted to approximately-0.15 to 0.15 least significant bit(LSB) and-0.3 to 0.32 LSB, respectively; and the power consumption is490 mW under a frame rate of 20 kH z. The developed ROIC is successfully used in imaging applications in two different ways.

关键词： single photon detection avalanche photodiode readout integrated circuit time-to-digital converter ranging imaging application

Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia–reperfusion injury

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Journal of Molecular Cell Biology 2023年第6期15卷 65-67页

作者： lixia zheng Yuanyuan Chen zhengyuan Wu Xiaojun Zhu Jing-Wei Xiong Beĳing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular MedicineCollege of Future Technologyand State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeĳing 100871China PKU-Nanjing Institute of Translational Medicine Nanjing 211800China

Dear Editor,Myocardial infarction(MI)is one of the leading causes of cardiovascular-related mortality *** restoration of the blood supply to ischemic my-ocardium by thrombolysis or percuta-neous coronary intervention ... 详细信息

关键词： mortality cardiovascular ischemia

Cohort study of use of the hands-and knees-position as the first approach to resolving shoulder dystocia and preventing neonatal birth trauma

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Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 160-163页

作者： lixia zheng Hong Li Hongyu Zhang The Second Maternal and Neonatal Hospital of Jinan in Shandong 271100China Department of Delivery Unit of Affiliated Lujun Zong Hospital of Chongqing City Sichuan Province400037China Department of Midwifery Education of Hainan Medical University 571109China

Background:McRoberts'maneuver,turning the woman's thighs up in the supine position,has become the dominant method for resolving shoulder dystocia(defined as failure to deliver the fetal shoulder(s)with gentle downward traction on the fetal head,requiring additional obstetric maneuvers to effect delivery).Another method that is less commonly used is the Gaskin maneuver,which was first described by the midwife Ina May Gaskin,who learned of it from traditional midwives in Central America,and involves turning women to the hands-and-knees *** retrospective observational study reported an 84%higher resolution of shoulder dystocia and less injury to the baby with the use of the hands-and-knees position as the first approach to resolving shoulder *** hands-and-knees position was reported to result in a wider pelvic diameter than the supine position and hence facilitate rotation of the baby and delivery,so it is possibly to resolving shoulder *** purpose of this study is to explore whether applying the Gaskin maneuver as the first approach for resolving cases of shoulder dystocia is a safer and better method than applying the McRoberts'maneuver ***:A time series cohort study was conducted in Laiwu Maternal and Child Health Hospital in Shandong,China over a seven-year *** January 2011 and July 2013 all women receiving traditional support at delivery were enrolled as a control *** this time period,when shoulder dystocia was suspected,McRoberts’maneuver(MR)was the most commonly employed first maneuver as described in the HELPERR *** October 2013 and December 2017,a change of practice was implemented for all vaginal births at the site,whereby midwives were instructed to use the Gaskin maneuver(i.e.,moving the mother onto hands-and-knees position)as the first protocol if shoulder dystocia was *** in this group were assigned to the experimental *** neonatal outcomes including birth asphyxia

关键词： Gaskin maneuver Hands and knees delivery Shoulder dystocia

Critical role of zebrafish dnajb5 in myocardial proliferation and regeneration

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Journal of Genetics and Genomics 2020年第8期47卷 493-496页

作者： Meijun Pang Connie Xiong Chenglu Xiao Jianyong Du lixia zheng Linlu Bai Xiaojun Zhu Jing-Wei Xiong Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China

Myocardial infarction is a devastating disease *** present,nearly 40 million patients suffer from heart *** to a lack of adequate blood supply,25%of cardiomyocytes are subjected to apoptosis and necrosis within a few hours after *** remains challenging to find effective therapeutic methods for heart *** the other hand,zebrafish and neonatal mouse hearts have a strong ability to regenerate(Poss et al.,2002;Raya et al.,2003;Porrello et al.,2011),and their regeneration derives from existing cardiomyocytes(Jopling et al.,2010;Kikuchi et al..

关键词： al. infarction neonatal

Molecular regulation of myocardial proliferation and regeneration

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Cell Regeneration 2021年第1期10卷 139-155页

作者： lixia zheng Jianyong Du Zihao Wang Qinchao Zhou Xiaojun Zhu Jing-Wei Xiong Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100871China

Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed asophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here,we review both the classical and recent literature on the molecular and cellular mechanisms underlying heartregeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes toreplenish their massive loss after myocardial infarction or ventricular resection. We highlight several importantsignaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-inducedsignals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses onheart regeneration for investigators in the field of regeneration biology.

关键词： Cardiac regeneration Cardiomyocyte proliferation Signaling pathways Zebrafish Mouse

Chemical screening links disulfiram with cardiac protection after ischemic injury

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Cell Regeneration 2023年第1期12卷 163-173页

作者： Yuanyuan Chen Jianyong Du lixia zheng Zihao Wang Zongwang Zhang zhengyuan Wu Xiaojun Zhu Jing-Wei Xiong Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular MedicineCollege of Future Technologyand State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100871China School of Health and Life Sciences University of Health and Rehabilitation SciencesQingdao 266071China PKU-Nanjing Institute of Translational Medicine Nanjing 211800China

Ischemia-reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction,however the underlying mechanisms are incompletely understood and effective pharmacological interventions are ***,we report the identification and characterization of the FDA-approved drug disulfiram(DSF)as a cardioprotective *** applying high-throughput chemical screening,we found that DSF decreased H_(2)O_(2)-induced cardiomyocyte death by inhibiting Gasdermin D,but not ALDH1,in *** gavage of DSF decreased myocardial infarct size and improved heart function after myocardial ischemia-reperfusion injury in ***,this work reveals DSF as a potential therapeutic compound for the treatment of ischemic heart disease.

关键词： Small molecule High-throughput chemical screening Disulfiram Gasdermin D Ischemia/reperfusion injury Rat cardiomyocytes

Deformation Resistance Effect of PAN-based Carbon Fibers

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Journal of Wuhan University of Technology(Materials Science) 2009年第3期24卷 415-417页

作者：郑立霞 School of Science Wuhan University of Technology

The deformation resistance effect of polyacrylonitrile （PAN）-based carbon fibers was investigated, and the variatipn law of electrical resistivity under tensile stress was analyzed. The results show that the gauge factor （fractional change in resistance per unit strain） of PAN-based carbon fibers is 1.38, which is lower than that of the commonly-used resistance strain gauge. These may due to that the electrical resistivity of carbon fibers decreases under tensile stress. In addition when the carbon fibers are stretched, the change of its resistance is caused by fiber physical dimension and the change of electric resistivity, and mainly caused by the change of physical dimension. The mechanical properties of carbon fiber monofilament were also measured.

关键词： PAN-based carbon fibers resistance strain gauge factor

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我国高等教育亚中心及其发展逻辑

高等工程教育研究 2008年第5期56卷 57-63页

作者：别敦荣郑利霞华中科技大学教育科学研究院

地市州域高等教育已经支撑起了全国高等教育的半壁江山。一些高校设置比较集中的非省会城市,成为高等教育亚中心,表现出高校数量多、高等教育体系化和办学形式多样化等特征。高等教育亚中心是我国高等教育大众化和地方化新的主要生长点... 详细信息

地市州域高等教育已经支撑起了全国高等教育的半壁江山。一些高校设置比较集中的非省会城市,成为高等教育亚中心,表现出高校数量多、高等教育体系化和办学形式多样化等特征。高等教育亚中心是我国高等教育大众化和地方化新的主要生长点,地方经济社会发展需要、地方政府重视、高校主动为地方服务和制度创新是高等教育亚中心快速成长的主要影响因素。

关键词：高等教育亚中心高等教育地方化地市州高等教育高等教育大众化

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基于自适应反演的超细金刚线张力控制系统

中国机械工程 2021年第24期32卷 2995-3000,3007页

作者：周锋郑丽霞沈烨超金波浙江大学流体动力与机电系统国家重点实验室杭州310027 浙江晶盛机电股份有限公司绍兴312300

针对多线切割机张力控制系统存在库仑摩擦和摆角耦合等较强非线性特征,以及收放卷轮直径变化引起的参数不确定问题,提出了一种基于自适应反演的非线性补偿控制方法。该方法结合实验辨识和自适应参数控制器设计方法分别对多线切割机的多... 详细信息

针对多线切割机张力控制系统存在库仑摩擦和摆角耦合等较强非线性特征,以及收放卷轮直径变化引起的参数不确定问题,提出了一种基于自适应反演的非线性补偿控制方法。该方法结合实验辨识和自适应参数控制器设计方法分别对多线切割机的多轴电机同步运动控制系统和不确定系统参数进行简化分析和在线估计,使用李雅普诺夫稳定性理论保证了系统全局渐近稳定性以及系统状态的有界性。仿真和实验结果表明,所设计的自适应控制器可以实现多轴同步运动,并将张力摆角控制在较小的范围内,获得更高的张力控制精度。

关键词：多线切割机非线性自适应控制多轴同步张力控制