检索结果-南通市图书馆

艾灸调节circ Pan3/mi R-667-5p/Ghrelin信号通路减轻膝骨关节炎大鼠的软骨病变

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第12期29卷 2475-2483页

作者：廖晴曾静陈峻袁立霞刘刚南方医科大学中医药学院广东省广州市510000 南方科技大学医院广东省深圳市518000 南方医科大学南方医院康复科广东省广州市510000

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghre... 详细信息

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghrelin信号通路探究艾灸对大鼠膝骨关节炎软骨的影响。方法:SD大鼠随机分为假手术组、模型组和艾灸组(n=10),对后2组大鼠行右后肢膝关节前交叉韧带横断和内侧半月板部分切除术建立膝骨关节炎大鼠模型;假手术组大鼠仅接受关节囊切开术。6周后,艾灸组大鼠每日艾灸“足三里”“肾俞”穴区20 min,持续4周,其余2组不予以特殊处理。4周后通过组织病理学染色观察膝关节滑膜病变和软骨损伤程度,通过酶联免疫吸附实验检测血清中炎症因子白细胞介素6和肿瘤坏死因子α的变化。此外,取上述3组大鼠右侧膝关节软骨细胞分为:正常对照组、模型组和艾灸组,通过Western blot和qRT-PCR检测各组细胞中软骨基质合成代谢分子(Ⅱ型胶原蛋白和Sox9)、基质降解分子(基质金属蛋白酶13和ADAMTS5)、自噬标志物(ATG5、Beclin-1、微管相关蛋白1轻链3)、Ghrelin、CircPan3以及miR-667-5P的表达水平。结果与结论:①治疗4周后,相对于假手术组,模型组大鼠滑膜显著增厚,炎症细胞浸润显著,关节间隙狭窄,软骨表面粗糙不平,变薄,软骨细胞数量减少,滑膜炎和OARSI评分显著升高,白细胞介素6和肿瘤坏死因子α水平明显上调(P<0.0001);与模型组相比,艾灸组滑膜增厚减轻,炎症细胞浸润减少,关节间隙增宽,软骨更光滑完整、变厚,软骨细胞数量增多,滑膜炎和OARSI评分降低,白细胞介素6和肿瘤坏死因子α水平显著降低(P<0.0001)。②体外实验结果表明,与正常对照组相比,模型组软骨细胞基质金属蛋白酶13、ADAMTS5和miR-667-5P表达增多,Ⅱ型胶原蛋白、Sox9、自噬标志物、Ghrelin和Circpan3表达减少(P<0.01);与模型组相比,艾灸可逆转上述指标改变(P<0.01)。③结果说明艾灸可能通过调节circPan3/miR-667-5p/Ghrelin信号通路增强软骨细胞自噬,抑制膝骨关节炎炎症和软骨破坏,对软骨发挥保护作用。

关键词：膝骨关节炎艾灸 ghrelin 软骨自噬大鼠信号通路

Prescribing Curvature Problems on the Bakry-Emery Ricci Tensor of a Compact Manifold with Boundary

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2014年第1期35卷 139-160页

作者： Weimin SHENG lixia yuan Department of Mathematics Zhejiang University Department of Mathematics Xinjiang Normal University

t The authors consider the problem of conformally deforming a metric such that the k-curvature defined by an elementary symmetric function of the eigenvalues of the Bakry-Emery Ricci tensor on a compact manifold with boundary to a prescribed function. A consequence of our main result is that there exists a complete metric such that the Monge-Amp^re type equation with respect to its Bakry-Emery Ricci tensor is solvable, provided that the initial Bakry-Emery Ricci tensor belongs to a negative convex cone.

关键词： k-Curvature Bakry-Emery Ricci tensor Complete metric Dirichletproblem

Tuning the solubility of polysulfides for constructing practical lithium-sulfur battery

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第8期95卷 611-617,I0013页

作者： Jiapeng Li Jianlong Cong Haijin Ji Ting Shi lixia yuan Yunhui Huang State Key Laboratory of Material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Li-S batteries are regarded as one of the most promising candidates for next-generation battery systems with high energy density and low ***,the dissolution-precipitation reaction mechanism of the sulfur(S)cathode enhances the kinetics of the redox processes of the insulating sulfu r,which also arouses the notorious shuttle effect,leading to serious loss of S species and corrosion of Li *** get a balance between the shuttle restraining and the kinetic property,a combined strategy of electrolyte regulation and cathode modification is proposed via introducing 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoroprpyl ether(HFE)instead of 1,2-dimethoxyethane(DME),and SeS_(7)instead of S_*** introduction of HFE tunes the solvation structure of the LiTFSI and the dissolution of intermediate polysulfides with Se doping(LiPSSes),and optimize the interface stability of the Li anode *** minor Se substitution compensates the decrease in kinetic due to the decreased solubility of *** this way,the Li-SeS_(7)batteries deliver a reversible capacity of 1062 and 1037 mAh g^(-1)with 2.0 and 5.5 mg SeS_(7)cm^(-2)loading condition,***,an electrolyte-electrode loading model is established to explain the relationship between the optimal electrolyte and cathode *** makes more sense to guide the electrolyte design for practical Li-S batteries.

关键词： Li-S batteries Lithium polysulfides Solubility Shuttle effect Interface Se doping

Facile synthesis of Li2S@C composites as cathode for Li–S batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第10期28卷 111-116页

作者： Xin Chen Linfeng Peng lixia yuan Rui Zeng Jingwei Xiang Weilun Chen Kai yuan Jie Chen Yunhui Huang Jia Xie State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Lithium sulfide (Li2S) provides a promising route for lithium storage due to high theoretical specific capacity (1166 mAh g-1). The electrochemical performance of Li2S can be significantly enhanced by forming Li2S-carbon composites with the introduction of carbon. However, the complex synthesis method of Li2S-carbon composites restrains the large-scale productivity. Herein, we propose a facile route to prepare carbon coated Li2S-carbon nanotube composites (Li2S@C-CNT) via spray drying and heat treatment, which is a low-cost and large-scale method for facile synthesis of Li2S-carbon composites. For the Li2S@C-CNT composites, Li2S nanoparticles are contacted with surrounding particles due to the 3D CNTs framework. The novel construction not only suppresses the diffusion of polysulfides during cycling, but also remarkably accelerates the transport of electron and ion, resulting in a high specific capacity (1100 mAh g^-1) and good cycling performance. The rational designed architecture and good electrochemical performance of Li2S@C-CNT will pave the avenue for realizing high energy density of Li2S-based batteries.

关键词： Spray drying Li2S@C-CNT Lithium-sulfur batteries

Uncovering the solid-phase conversion mechanism via a new range of organosulfur polymer composite cathodes for lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第9期84卷 459-466页

作者： Xiang Li Dezhong Liu Ziyi Cao Yaqi Liao Zexiao Cheng Jie Chen Kai yuan Xing Lin Zhen Li Yunhui Huang lixia yuan State Key Laboratory of Material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

The sulfur cathodes operating via solid phase conversion of sulfur have natural advantages in suppressing polysulfide dissolution and lowering the electrolyte dosage,and thus realizing significant improvements in both cycle life and energy *** realize an ideal solid-phase conversion of sulfur,a deep understanding of the regulation path of reaction mechanism and a corresponding intentional material and/or cathode design are highly ***,via covalently fixing of sulfur onto the triallyl isocyanurate,a series of S-triallyl isocyanurate organosulfur polymer composites(STIs) are *** between the structure and the electrochemical conversion behavior of STIs is systematically *** is found that the structure of STIs varies with the synthetic temperature,and correspondingly the electrochemical redox of sulfur can be controlled from conventional "solid-liquid-solid" conversion to the "solid-solid" *** the STI series,the STI-5 composite realizes an ideal solid-phase conversion and demonstrates great potential for building a Li-S battery with high-energy density and long-cyclelife:it realizes stable cycling over 1000 cycles in carbonate electrolyte,with a degradation rate of0.053% per cycle;the corresponding pouch cell shows almost no capacity decay for 125 cycles under the conditions of high sulfur loading(4.5 mg cm^(-2)) and lean electrolyte(8 μL mg_s^(-1)).In addition,the tailoring strategy of STI can also apply to other precursors with allyl functional groups to develop new organosulfur polymers for "solid-solid" sulfur *** vulcanized triallyl phosphate(STP) and triallylamine(STA) both show great lithium storage *** strategy successfully develops a new family of organosulfur polymers as cathodes for Li-S batteries via solid-phase conversion of sulfur,and brings insights to the mechanism study in Li-S batteries.

关键词： Organosulfur polymer Lithium–sulfur batteries Allyl functional groups Reaction mechanism Solid–solid conversion

Facile synthesis of sulfurized polyacrylonitrile composite as cathode for high-rate lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2020年第10期29卷 161-165页

作者： Jingwei Xiang Zezhou Guo Ziqi Yi Yi Zhang lixia yuan Zexiao Cheng Yue Shen Yunhui Huang State Key Laboratory of Material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Sulfurized polyacrylonitrile(SPAN)as a promising cathode material for lithium sulfur(Li-S)batteries has drawn increasing attention for its improved electrochemical performance in carbonate-based ***,the relatively poor electronic and ionic conductivities of SPAN limit its high-rate and lowtemperature *** this work,a novel one-dimensional nanofiber SPAN(SFPAN)composite is developed as the cathode material for Li-S *** from its one-dimensional nanostructure,the SFPAN composite cathode provides fast channels for the migration of ions and electronics,thus effectively improving its electrochemical performance at high rates and low *** a result,the SFPAN maintains a high reversible specific capacity^1200 mAh g−1 after 400 cycles at 0.3 A g−1 and can deliver a high capacity of^850 mAh g−1 even at a high current density of 12.5 A g−*** is more,the SFPAN can achieve a capacity of^800 mAh g−1 at 0℃and^1550 mAh g−1 at 60℃,thus providing a wider temperature range of *** work provides new perspectives on the cathode design for high-rate lithium-sulfur batteries.

关键词： Sulfurized polyacrylonitrile One-dimensional nanofiber High-rate peformance Lithium sulfur batteries

Morphology-controllable solvothermal synthesis of nanoscale LiFePO_4 in a binary solvent

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2012年第32期57卷 4170-4175页

作者： WU Miao WANG ZhaoHui yuan lixia ZHANG WuXing HU XianLuo HUANG YunHui State Key Laboratory of Material Processing and Die and Mould Technology School of Materials Scienee and EngineeringHuazhong University of Science and TechnologyWuhan 430000China

LiFePO4(LFP) nanobars,microplates and nanorods have been selectively synthesized via a solvothermal method in a water-ethylene glycol(EG) binary solvent with H3PO4,LiOH·H2O,and FeSO4·7H2O as starting *** morphology and size of the as-obtained LFP products can be deliberately controlled by varying the volume ratio of EG to *** formation mechanism and electrochemical properties of different LFP morphologies have been *** carbon coating,the Li-ion diffusion coefficients of LFP nanorods,nanobars and micro-plates are 2.58×10-9,2.91×10-10,and 7.22×10-10 cm2 s-1,*** the carbon-coated nanorods,excellent rate capability and cyclability were *** 5 C,the capacity was 141 mAh g-1 for the first cycle and maintained 120 mAh g-1 after 100 cycles;at 10 C,the capacity was still as high as 132 mAh g-1.

关键词：溶剂热合成磷酸铁锂二元溶剂纳米级电化学性能可控形貌循环性能

Synthesis and modification of well-ordered layered cathode oxide LiNi_(2/3)Mn_(1/3)O_2

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2010年第30期55卷 3419-3423页

作者： XIONG XiaoQin JIANG Yan XIA ShengAn ZHANG WuXing yuan lixia LIU ShanTang HUANG YunHui School of Materials Science and Engineering State Key Laboratory of Materials Processing and Die & Mould Technology Huazhong Univer- sity of Science and Technology Wuhan 430074 China School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan 430073 China

Oxalic-acid-based co-precipitation method was employed to prepare LiNi2/3Mn1/3O2 sample with a high-ordered structure. Li+,Ni2+ and Mn2+ acetates were used as starting materials. The influence of the amount of lithium source in the starting materials on Li+ content,disorder of Li+-Ni2+ ions,and electrochemical performance has been investigated. Rietveld refinement shows that the sample prepared with 20% excess Li-source in the starting materials exhibits a perfect ordered structure. A specific discharge capacity is as high as 172 mAh/g at C/20 in the voltage range of 4.35?2.7 V. However,the cyclability is not satisfactory:about 25.3% fade in capacity was observed over 50 cycles. Chemically stable SiO2 was coated on the surface of LiNi2/3Mn1/3O2 particles. A significant improvement in cyclability was attained with 3 wt% SiO2 coating,which is ascribable to the protection of LiNi2/3Mn1/3O2 particles from being dissolved into the electrolyte.

关键词：二氧化硅涂层有序结构 Rietveld拟合正极层状修改合成起始原料

Solid electrolyte interphase in water-in-salt electrolytes

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2021年第7期64卷 1571-1579页

作者： Dezhong Liu lixia yuan Yunhui Huang State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The water-in-salt strategy successfully expands the electrochemical window of the aqueous electrolyte from1.23 to~3.0 V,which can lead to a breakthrough in the energy output of the aqueous battery system while maintaining the advantage of high *** expanded electrochemical window of the water-in-salt electrolytes can be ascribed to the decreased water activity and the solid electrolyte interphase formed on the *** solid electrolyte interphase in the aqueous system is not fully understood,and the basic composition,the structure,and the formation mechanism are still cloaked in *** perspective summarizes the published research with emphasis on the most possible formation mechanism and composition of the interphase layer in the aqueous *** understanding of the interphase as well as rounded assessment of the water-in-salt electrolyte in practical operating conditions is *** full understanding of the interface will guide the design of aqueous electrolytes and help to build novel aqueous batteries with high safety and high energy density.

关键词： solid electrolyte interphase water-in-salt electrolytes aqueous rechargeable Li-ion batteries