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China Welding 1995年第1期4卷 57-64页

作者： Zhou lixia Wang shiyuan and shi Yaowu (Xi’an Jiaotong University)L. Dorn(Technical University of Berlin)

A micro shear testing method which can suit to measure the mechanical properties of heterogeneous materials is introduced, and the properties in each zone of welded joint for CO2 arc welding can be evaluated by using this method in this paper. Moreover, these results are compared with those results of Charpy V-notch impact test and their correlation is discussed.

关键词： mechanical properties micro shear test CO_2 arc welding welded

THE ROLE OF SEROTONINERGIC DESCENDING INHIBITION IN ACUPUNCTURE ANALGESIA (AA) AND ITS RELATION TO OLS AND SP

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针刺研究 1989年第Z1期 152-153页

作者： Zhu lixia Li Chunguan Fang Zongren shi Qingyao Ji Changfu Dept. of physiology, Inst. of Acupuncture and moxibustion, China ocademy of traditional Chinese Medicine, Beijing

In this paper a series of experiments on the role of serotoninergic desce-nding inhibition in AA and its potential relation to opiate-like substance (OLS)and substance P (SP) were performed. 1. We have found that the analgesic effect of acupuncture could be signi-ficantly attenuated by lesion of nucleus raphe magnus (NRM), intraperitonealinjection of para-chlorophenylalanine (PCPA), infracisternal injection of5, 7-dihydroxytryptamine (5, 7-DHT) and intrathecal or iontophoretic administra-tion of Methysergide (MSG). AII these results suggest that serotoninergic desce-

关键词： OLS THE ROLE OF SEROTONINERGIC DESCENDING INHIBITION IN ACUPUNCTURE ANALGESIA AND ITS RELATION TO OLS AND SP AA ITS

Evaluation of Morphology-Stable Critical Size of KNbO3 Crystals

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Journal of Materials Science & Technology 2002年第1期18卷 95-96页

作者： lixia CAI, Weiqing JIN, Zhilei PAN and Xin’an LIANGShanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, Chinashinichi YodaNational Space Development Agency of Japan, 2-1-1 Sengen, Tsukuba-shi, Ibaraki 305 Japan [ Manuscript receiv Chinese Acad Sci Shanghai Inst Ceram Shanghai 200050 Peoples R China Natl Space Dev Agcy Japan Tsukuba Ibaraki 305 Japan

Skeletal form of KNbO3 crystals growing in Li2B4O7 solvent was in-situ observed at 900℃ and it was found that shallow depression started to develop on the surface of KNbO3 crystals when the crystal size exceeded several micron, typically 7 micron. Based on the quantitative criterion derived by Chernov, the estimated critical size of KNbO3 crystals was 1 micron, which was consistent with the experimental measurement. The kinetic coefficients, kcorner and kcr, in the criterion were experimentally obtained in the diffusive-convective and diffusive-advective flow states respectively.

关键词： Morphology instability KNbO3 In-situ observation Electron microprobe analyses

In vitro expression and analysis of the 826 human G protein-coupled receptors

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Protein & Cell 2016年第5期7卷 325-337页

作者： Xuechen Lv Junlin Liu Qiaoyun shi Qiwen Tan Dong Wu John J. Skinner Angela L. Walker lixia Zhao Xiangxiang Gu Na Chen Lu Xue Pei Si Lu Zhang Zeshi Wang Vsevolod Katritch Zhijie Liu Raymond C. Stevens iHuman Institute ShanghaiTech University Shanghai 201210 China Department of Biological Sciences Bridge Institute University of Southern California Los Angeles CA 90089 USA

G protein-coupled receptors （GPCRs） are involved in all human physiological systems where they are responsible for transducing extracellular signals into cells. GPCRs signal in response to a diverse array of stimuli including light, hormones, and lipids, where these signals affect downstream cascades to impact both health and disease states. Yet, despite their importance as therapeutic tar- gets, detailed molecular structures of only 30 GPCRs have been determined to date. A key challenge to their structure determination is adequate protein expression. Here we report the quantification of protein expression in an insect cell expression system for all 826 human GPCRs using two different fusion constructs. Expression char- acteristics are analyzed in aggregate and among each of the five distinct subfamilies. These data can be used to identify trends related to GPCR expression between dif- ferent fusion constructs and between different GPCR families, and to prioritize lead candidates for future structure determination feasibility.

关键词： G protein-coupled receptors insect,protein expression surface expression analysis fusionconstruct

The coxsackievirus A16 infection suppresses MAVS-induced apoptosis and type Ⅰ interferon activation

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The coxsackievirus A16 infection suppresses MAVS-induced apo...

多重效应:胰高血糖素样肽-1受体激动剂治疗肥胖相关阻塞性睡眠呼吸暂停的潜在新策略

第十一届全国免疫学学术大会

作者： shi Yingying Tu Huilin Qiu Wenhong Huang lixia Gong Yeli He Xiaohua Liu Wanhong Department of Immunology School of MedicineJianghan University Pathogenic Organism and Infectious Diseases Research Institute School of Basic Medical SciencesWuhan University

Background: Coxsackievirus A16(CA16) is one of the major causative agents of hand, foot and mouth disease(HFMD), which is characterized by herpetic lesions on the hands, feet and oral mucosa in children less than 5 years old. The mitochondrial antiviral signaling protein(MAVS) plays important roles in host defense against viral infection by inducing type I interferon. However, the relationship between CA16 infection and MAVS still remain ***: The aim of this study was to investigate the relationship between CA16 infection and ***: Quantitative real time PCR(qRT-PCR) and western blot were adopted to study the effect of CA16 infection on MAVS expression. Both overexpression and silencing of MAVS expression were employed to detect the effect of MAVS on CA16 replication. In addition, the plasmids over-expressing each viral nonstructural proteins were constructed and transfected into RD cells to investigate the influence of CA16 proteins on the functions of ***: CA16 infection inhibited MAVS expression. MAVS in turn suppressed CA16 replication by both apoptosis induction depending on JNK and ERK signals and type I interferon activation. We further demonstrated that viral protein 2C, 3D downregulated MAVS-induced apoptosis. Meanwhile, 2A and 3C greatly blocked the MAVS mediated activation of IFN-β. Furthermore, MAVS can be cleaved by 3C which is a vital ***: These data provide direct and compelling evidence that CA16 has evolved new strategies by which CA16 evades the host immune system and regulates apoptosis by targeting MAVS, which suggest new targets for anti-HFMD strategies.

关键词： Coxsackievirus A16(CA16) viral protein apoptosis type I interferon

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中华内科杂志 2024年第11期63卷 1041-1045页

作者：王利霞石穿肖毅中国医学科学院、北京协和医学院、北京协和医院呼吸与危重症医学科北京100730

阻塞性睡眠呼吸暂停(OSA)是一种异质性疾病, 其治疗策略正向个体化和精准化方向发展。长期以来, 尽管药物治疗在OSA领域未能取得令人满意的疗效, 但近年来一系列的研究显示, 最初用于治疗2型糖尿病的胰高血糖素样肽-1受体激动剂(GLP-1RA... 详细信息

阻塞性睡眠呼吸暂停(OSA)是一种异质性疾病, 其治疗策略正向个体化和精准化方向发展。长期以来, 尽管药物治疗在OSA领域未能取得令人满意的疗效, 但近年来一系列的研究显示, 最初用于治疗2型糖尿病的胰高血糖素样肽-1受体激动剂(GLP-1RA)不仅具有良好的减重效果, 亦可能减少睡眠呼吸暂停事件, 抑制炎症反应, 降低心血管并发症风险, 在伴有肥胖的OSA患者中显示出良好的应用前景。本文着重探讨此类药物在OSA个体化治疗中的价值及未来可能的应用。

关键词：睡眠呼吸暂停阻塞性肥胖症心血管疾病胰高血糖素样肽-1受体激动剂

The inhibitory mechanism of pentacyclic triterpenoid acids on pancreatic lipase and cholesterol esterase

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Food Bioscience 2023年第1期51卷 1076-1088页

作者： Heyu Shen Jun Wang Jingfang Ao lixia Ye Yubing shi Yujie Liu Mengyang Li Anwei Luo College of Food Science and Engineering Northwest A&F UniversityYanglingChina

Inhibiting pancreatic Lipase(PL)and cholesterol esterase(CEase)can effectively control blood triglycerides and cholesterol *** interaction characteristics of pentacyclic triterpenoid acids(oleanolic acid[OA],ursolic acid[UA],and corosolic acid[CA])with PL and CEase were studied by inhibition kinetics,multispectroscopy,and molecular docking *** inhibition and inhibition kinetics showed that pentacyclic triterpenoid acids effectively inhibited PL and CEase in a competitive manner with IC50 values ranging from 0.077 mg/mL to 0.446 mg/***-Vis,fourier transform infrared,fluorescence quenching,and circular dichroism analysis demonstrated that OA,UA,and CA disrupted the conformation of PL and CEase through hydrogen bonding and hydrophobic forces,resulting in loose protein *** docking analysis revealed that pentacyclic triterpenoid acids could stably bind at key residues in the active site of PL and *** dynamics(MD)simulation further confirmed the stable binding of pentacyclic triterpene acids to PL and *** study suggested that OA,UA,and CA could have an essential value as digestive enzyme inhibitors.

关键词： Digestive enzymes Oleanolic acid Ursolic acid Corosolic acid Inhibition mechanism Molecular docking

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新型冠状病毒与干扰素相互作用研究进展

中华微生物学和免疫学杂志 2021年第1期41卷 6-11页

作者：施璐刘永娟黄丽霞史颖颖江汉大学医学院免疫学教研室武汉430056 江苏省连云港市第一人民医院中心实验室 222002

新型冠状病毒(2019-nCoV)是新型冠状病毒肺炎(COVID-19)的病原体,部分严重患者可能会出现呼吸衰竭甚至死亡,给全球公共卫生带来了巨大挑战。2019-nCoV编码的蛋白质不仅参与病毒增殖,而且在拮抗宿主固有免疫尤其是干扰素(interferon,IFN... 详细信息

新型冠状病毒(2019-nCoV)是新型冠状病毒肺炎(COVID-19)的病原体,部分严重患者可能会出现呼吸衰竭甚至死亡,给全球公共卫生带来了巨大挑战。2019-nCoV编码的蛋白质不仅参与病毒增殖,而且在拮抗宿主固有免疫尤其是干扰素(interferon,IFN)应答中发挥重要作用。本文对调控宿主干扰素应答反应的2019-nCoV蛋白进行总结,对2019-nCoV和干扰素之间复杂的相互作用进行概述,以期为疾病防控提供理论依据。

关键词：新型冠状病毒干扰素病毒蛋白免疫抑制

Plants from‘Book of Songs’thrive in Wuhan

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Changjiang Weekly 2022年第18期 8-9页

作者： Wang Yongfang Guo lixia 不详

The"Book of Songs"(诗经)(shi jing)is the oldest collection of poetry in world literature and the finest treasure of traditional songs from *** verses in the book are so beautiful that they have been read by Chinese people from generation to *** more than 2,500 years ago,it mentions more than 130 kinds of *** Congkang,deputy director of Publishing Center for Science&Technology and Children under the Wuhan Publishing House.

关键词： beautiful Wuhan poetry

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基于可调谐静电啁啾镜的电子脉冲压缩技术

强激光与粒子束 2016年第4期28卷 64-67页

作者：康轶凡史瑞玲张利霞空军工程大学理学院西安710051 西安应用光学研究所西安710065

分析了基于双级反射静电系统的电子脉冲压缩技术方法。类比于光子脉冲压缩用多层介质啁啾镜,将该静电系统称为可调谐静电啁啾镜:根据静电啁啾镜电气结构参数的设置,入射电子脉冲在系统中U形反射运动飞行时间与其初始轴向能量具有相应不... 详细信息

分析了基于双级反射静电系统的电子脉冲压缩技术方法。类比于光子脉冲压缩用多层介质啁啾镜,将该静电系统称为可调谐静电啁啾镜:根据静电啁啾镜电气结构参数的设置,入射电子脉冲在系统中U形反射运动飞行时间与其初始轴向能量具有相应不同的色散关系,也即正负啁啾特性。讨论了该啁啾镜正负啁啾属性的可调谐性及脉冲压缩技术细节,并给出了计算实例。

关键词：双级反射静电系统静电啁啾镜电子脉冲压缩正负啁啾飞行时间