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Genetic analysis of transcription factors in dopaminergic neuronal development in Parkinson’s disease

Chinese Medical Journal 2024年第4期137卷 450-456页

作者： Yuwen Zhao lixia qin Hongxu Pan Tingwei Song Yige Wang Xiaoxia Zhou Yaqin Xiang Jinchen Li Zhenhua Liu Qiying Sun Jifeng Guo Xinxiang Yan Beisha Tang Qian Xu Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Bioinformatics Center National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangshaHunan 410008China

Background:Genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson’s disease(PD)risk factors;however,no comprehensive analyses of these genes in patients with PD have been undertaken.Therefore,we aimed to genetically analyze 16 dopaminergic transcription factor genes in Chinese patients with PD.Methods:Whole-exome sequencing(WES)was performed using a Chinese cohort comprising 1917 unrelated patients with familial or sporadic early-onset PD and 1652 controls.Additionally,whole-genome sequencing(WGS)was performed using another Chinese cohort comprising 1962 unrelated patients with sporadic late-onset PD and 1279 controls.Results:We detected 308 rare and 208 rare protein-altering variants in the WES and WGS cohorts,respectively.Gene-based association analyses of rare variants suggested that MSX1 is enriched in sporadic late-onset PD.However,the significance did not pass the Bonferroni correction.Meanwhile,72 and 1730 common variants were found in the WES and WGS cohorts,respectively.Unfortunately,single-variant logistic association analyses did not identify significant associations between common variants and PD.Conclusions:Variants of 16 typical dopaminergic transcription factors might not be major genetic risk factors for PD in Chinese patients.However,we highlight the complexity of PD and the need for extensive research elucidating its etiology.

关键词： Parkinson’s disease Transcription factors Dopaminergic neurons Genetic Variants

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Down-regulation of GhADF1 in cotton(Gossypium hirsutum)improves plant drought tolerance and increases fiber yield

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The Crop Journal 2022年第4期10卷 1037-1048页

作者： lixia qin Huanyang Zhang Jing Li Yonghong Zhu Gaili Jiao Chuangyun Wang Shenjie Wu Shanxi Agricultural University Taiyuan 030031ShanxiChina

Fiber productivity and quality of cotton are severely affected by abiotic stresses.In this study,we identified the role of GhADF1,an actin depolymerizing factor,in cotton response to drought stress.GhADF1 expression in cotton could be induced by PEG6000.GhADF1-RNAi transgenic cotton showed increased tolerance to drought stress during seed germination and seedling development as well as at the reproductive stage.In contrast,overexpression of GhADF1 led to a drought-sensitive phenotype in transgenic plants.GhADF1-RNAi plants produced an enlarged root system with longer primary roots,more lateral roots,increased root dry biomass,and increased cell size.In leaves of GhADF1-RNAi cotton,proline content and activities of reactive oxygen species-scavenging enzymes were increased following drought stress compared with those in wild type.GhADF1-RNAi lines showed higher water-use efficiency than the wild type,accompanied by reduced leaf stomatal density and conductance.GhADF1-RNAi cotton produced higher fiber yield in the field under both normal and drought conditions.Transcriptomic analyses identified 124 differentially expressed genes in leaves of GhADF1-RNAi lines compared with the wild type following drought treatment.Upregulated genes included those encoding transcription factors,protein kinases,heat shock proteins,and other proteins known to be involved in stress responses.We conclude that GhADF1 reduces the expression of abiotic stress-associated genes in cotton response to drought stress and may be a promising candidate gene for crop improvement by genetic manipulation.

关键词： Cotton(Gossypium hirsutum) Actin depolymerizing factors Drought stress Fiber yield Transcriptomic analysis

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Facile Preparation of Ag2ZnGeO4 Flower-like Hierarchical Nanostructure and Its Photocatalytic Activity

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Journal of Materials Science & Technology 2017年第1期33卷 47-51页

作者： Wei Zhou Xiangqing Li lixia qin Shi-Zhao Kang Center of Graphene Research School of Chemical and Environmental Engineering Shanghai Institute of Technology Shanghai 201418 China

In this study, Ag2ZnGeO4 flower-like hierarchical nanostructure was prepared using a simple and mild method. The as-prepared samples were characterized with X-ray diffraction, scanning electron micros- copy, transmission electron microscopy, energy dispersive X-ray spectroscopy, UV-vis diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy, and N2 adsorption and desorption isotherms. Mean- while, the photocatalytic activity of the as-prepared samples was explored using Rhodamine B as a model pollutant, The results indicated that the Ag2ZnGeO4 hierarchical nanostructures obtained consisted of nanoplates and nanurods, and adopted spherical flower-like morphology. Moreover, the as-prepared Ag2ZnGeO4 hierarchical nanostructure was an efficient and stable visible-light photocatalyst for the deg- radation of organic dyes in water. After visible light irradiation for 105 rain, the degradation of Rhodamine B was up to 92%. Moreover, the photocatalytic activity of Ag2ZnGeO4 remained unchanged after three successive cycles,

关键词： Ag2ZnGeO4 Nanostructured and nanocrystalline material Synthesis Photocatalysis

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Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of β cells

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Journal of Environmental Sciences 2022年第5期34卷 162-172页

作者： Weiping qin Xiaomin Ren lixia Zhao Lianghong Guo State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China

Per-and polyfluoroalkyl substances(PFAS)are found to have multiple adverse outcomes on human health.Recently,epidemiological and toxicological studies showed that exposure to PFAS had adverse impacts on pancreas and showed association with insulin abnormalities.To explore how PFAS may contribute to diabetes,we studied impacts of perfluorooctane sul-fonate(PFOS)on cell viability and insulin release capacity of pancreatic β cells by using in vivo and in vitro methods.We found that 28-day administration with PFOS(10 mg/(kg body weight·day))caused reductions of pancreas weight and islet size in male mice.PFOS admin-istration also led to lower serum insulin level both in fasting state and after glucose infusion among male mice.For cell-based in vitro bioassay,we used mouse β-TC-6 cancer cells and found 48-hr exposure to PFOS decreased the cell viability at 50 μmol/L.By measuring insulin content in supernatant,48-hr pretreatment of PFOS(100 μmol/L)decreased the insulin re-lease capacity of β-TC-6 cells after glucose stimulation.Although these concentrations were higher than the environmental concentration of PFOS,it might be reasonable for high con-centration of PFOS to exert observable toxic effects in mice considering mice had a faster removal efficiency of PFOS than human.PFOS exposure(50 μmol/L)to β-TC-6 cells induced intracellular accumulation of reactive oxidative specie(ROS).Excessive ROS induced the re-active toxicity of cells,which eventually invoke apoptosis and necrosis.Results in this study provide evidence for the possible causal link of exposure to PFOS and diabetes risk.

关键词： Perfluorooctane sulfonate Insulin secretion Pancreaticβcells Apoptosis Reactive oxidative species

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壶关方言中的反预期话语标记“说咧”

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忻州师范学院学报 2024年第1期40卷 44-51页

作者：秦煜松郭利霞南开大学汉语言文化学院

“说咧”是壶关方言中的一种规约性间接否定的表达形式，其既可以表示对听话者观点的否定，又可以表示对听话者言语行为的否定。与此同时，“说咧”在本质上属于反预期话语标记，它在语篇中的功能主要包括对听话者观点或言语行为的否定... 详细信息

“说咧”是壶关方言中的一种规约性间接否定的表达形式，其既可以表示对听话者观点的否定，又可以表示对听话者言语行为的否定。与此同时，“说咧”在本质上属于反预期话语标记，它在语篇中的功能主要包括对听话者观点或言语行为的否定、话轮转接、标示信息的不对称。通过对“说咧”共时分布进行调查，发现其主要分布在晋语和冀鲁官话的部分地区，并在此基础上认为其与普通话中“看你说的”有着不同的形成路径。

关键词：壶关方言反预期话语标记说咧

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课程思政融入大学公共体育课程的路径探析

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当代体育科技 2024年第6期14卷 128-131页

作者：王克海秦立霞山东中医药大学山东济南250355

对于高等学校而言,要想有效地实现立德树人目标、“三全育人”目标、培养学生正确的价值观,就需要加强课程思政改革,推动各门课程相互融合,尤其是将课程思政育人理念融入大学公共体育课程中,从多个方面对大学生进行知识传授、技能培养,... 详细信息

对于高等学校而言,要想有效地实现立德树人目标、“三全育人”目标、培养学生正确的价值观,就需要加强课程思政改革,推动各门课程相互融合,尤其是将课程思政育人理念融入大学公共体育课程中,从多个方面对大学生进行知识传授、技能培养,发挥多学科育人的协同效应,实现教学全过程育人。该文从提升教师体育课程思政能力、丰富教学内容、将思政内容融入体育教学实践、将课程思政元素有机融入考核体系和课程思政建设、创新课程设计等方面,分析大学公共体育课程思政建设的方法路径,助力大学公共体育课程思政建设目标的实现。

关键词：课程思政大学公共体育课育人路径

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基于格子玻尔兹曼方法的梯度化扩散层降解研究

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新能源进展 2024年第2期12卷 175-181页

作者：齐丽霞许浩锴董晓燕秦世位王誉霖天津商业大学天津市制冷技术重点实验室天津300134

采用随机算法重建了不同老化程度的梯度化气体扩散层二维微观结构。随后,采用多相伪势格子玻尔兹曼方法,研究不同降解程度的梯度设计扩散层内液态水的传输行为。结果表明,随着扩散层降解的加剧,扩散层排水性能显著降低,大量液态水残留... 详细信息

采用随机算法重建了不同老化程度的梯度化气体扩散层二维微观结构。随后,采用多相伪势格子玻尔兹曼方法,研究不同降解程度的梯度设计扩散层内液态水的传输行为。结果表明,随着扩散层降解的加剧,扩散层排水性能显著降低,大量液态水残留在扩散层内。此外,梯度化设计的扩散层在进口区域初始分布较多聚四氟乙烯有利于扩散层的水管理,同时在老化后还具有较高的毛细压力进而控制水驱面积,展现出较高的排水性能及抗老化性能。研究结果可为制作高抗老化性能和高排水性能的扩散层提供研究基础和设计思路。

关键词：气体扩散层格子玻尔兹曼方法老化排水性能

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发酵食品的滋味特性及其形成机制研究进展

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食品与发酵工业 2024年第10期50卷 388-396页

作者：覃芳丽邹宇晓王思远黎尔纳穆利霞李庆荣刘军仲恺农业工程学院轻工食品学院广东广州510225 广东省农业科学院蚕业与农产品加工研究所/广东省农产品加工重点实验室/农业农村部功能食品重点实验室广东广州510610 广东翔顺调味食品有限公司广东云浮527499

肉类、豆类、水产类和蔬菜类等原料经过自然的或人工接种的微生物发酵后,转变为滋味诱人但迥异于新鲜食材的发酵食品,从古至今一直广受世界各地消费者的喜爱。食品原料在发酵过程中形成的有机酸、氨基酸、多肽和糖类等是重要的呈味物质... 详细信息

肉类、豆类、水产类和蔬菜类等原料经过自然的或人工接种的微生物发酵后,转变为滋味诱人但迥异于新鲜食材的发酵食品,从古至今一直广受世界各地消费者的喜爱。食品原料在发酵过程中形成的有机酸、氨基酸、多肽和糖类等是重要的呈味物质,决定了发酵食品的滋味与风味。该文在广泛查阅文献的基础上,综述了发酵食品中酸、甜、苦、咸、鲜、厚等6种滋味特性及其形成机制的相关研究进展,并对传统发酵食品的未来研究方向进行展望,以期为优质发酵食品的风味品质调控提供参考。

关键词：发酵食品滋味特性形成机制研究进展

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Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer

Phenomics

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Phenomics 2024年第1期4卷 34-45页

作者： Youyang Shi Yuanyuan Wu Feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng Chunyu Wu Yuenong qin Xiaofei Liu Sheng Liu Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineWanping South Road725Shanghai 200033China First Clinical College Shandong University of Traditional Chinese MedicineNo.16369Jingshi RoadLixia DistrictJinan 250011ShandongChina

Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still persist.Immunogenic cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead cells.Nevertheless,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well understood.In this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)analysis.To investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were identifed.Analysis of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,respectively.In addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and generalizability.The ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies.

关键词： Immunogenic cell death Triple-negative breast cancer Tumor immune microenvironment Prognostic signature

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唐宋时期“西南”地域空间探究

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玉溪师范学院学报 2024年第2期40卷 106-111页

作者：和丽霞云南民族大学云南昆明650504

唐宋以前,关于西南认知以秦汉时期为代表,具体来说相当于今甘肃、四川、云南、贵州等省的相关地区。而当时的“西南”,只规定一条明晰的以巴蜀为界的“华夷”分界线,并没有规定“西南夷”的外部边界,因此,其外部范围有多大,则是模糊的... 详细信息

唐宋以前,关于西南认知以秦汉时期为代表,具体来说相当于今甘肃、四川、云南、贵州等省的相关地区。而当时的“西南”,只规定一条明晰的以巴蜀为界的“华夷”分界线,并没有规定“西南夷”的外部边界,因此,其外部范围有多大,则是模糊的。唐代的“西南”指今陕西南部、甘肃南部、四川、云南、贵州、重庆等广大区域,比较秦汉的西南范围更广,甚至延展到陕西和甘肃地区。宋代因疆域收缩,其关于“西南”的界定极为矛盾和模糊,而贯之以“西南”之名的“西南蕃”,只是秦汉时广大西南地区中的一小部分。

关键词：唐宋西南地域空间

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