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中医药治疗糖尿病肾脏病的现状及研究进展

中医药导报 2024年第6期30卷 152-155页

作者：刘晓芹王雯程丽霞潍坊医学院山东潍坊261053 昌邑市中医院山东潍坊261300 潍坊市人民医院山东潍坊261000

糖尿病肾脏病(DKD)是糖尿病常见的微血管并发症之一,威胁着人类的生命健康。对中医、西医在DKD的发病机理及治疗方面的研究进展进行总结,发现中医和西医在DKD治疗中各有利弊,但中西药联合治疗能明显提高DKD的治疗效果,并能有效干预肾实... 详细信息

糖尿病肾脏病(DKD)是糖尿病常见的微血管并发症之一,威胁着人类的生命健康。对中医、西医在DKD的发病机理及治疗方面的研究进展进行总结,发现中医和西医在DKD治疗中各有利弊,但中西药联合治疗能明显提高DKD的治疗效果,并能有效干预肾实质病变,延缓病情发展。

关键词：糖尿病肾脏病中医治疗中西医结合辨证论治综述

Identification of key gene networks controlling monoterpene biosynthesis during grape ripening by integrating transcriptome and metabolite profiling

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Horticultural Plant Journal 2023年第5期9卷 931-946页

作者： Xiangpeng Leng Jiameng Cong lixia cheng Haoliang Wan Yuanxia Liu Yongbing Yuan Jinggui Fang Institute of Grape Science and Engineering College of HorticultureQingdao Agricultural UniversityQingdaoShandong 266109China Engineering Laboratory of Genetic Improvement of Horticultural Crops of Shandong Province College of HorticultureQingdao Agricultural UniversityQingdaoShandong 266109China Laboratory of Quality&Safety Risk Assessment for Fruit(Qingdao) Ministry of Agriculture and Rural AffairsNational Technology Centre for Whole Process Quality Control of FSEN Horticultural Products(Qingdao)Qingdao Agricultural UniversityQingdaoShandong 266109China

Monoterpenes are typical aroma components of muscat grape cultivars,providing pleasant floral and fruity aromas to grapes and ***,the molecular mechanism of monoterpene biosynthesis between muscat and non-muscat grape remains ***,the muscat grape cultivar‘Jumeigui’and the non-muscat grape cultivar‘Kyoho’were chosen as plant materials for a comprehensive transcriptome and metabolite *** gas chromatography-mass spectrometry(GC-MS)analysis demonstrated that a total of 27 and 23 monoterpene compounds were identified and quantified in the‘Jumeigui’and‘Kyoho’grape,respectively.‘Jumeigui’grape accumulated significantly higher concentrations of monoterpenes than‘Kyoho’***,geraniol,linalool,geranic acid,and β-citronellol might be important odorants contributing to the floral character of the‘Jumeigui’grape due to the high levels odor activity values(OAVs).Transcriptome analysis demonstrated that the expression profiles of VvDXS,***1,Vv TPS-b/g showed a positive correlation with monoterpene accumulation in *** addition,the expression patterns of the genes involved in jasmonic acid(JA)synthesis and signal were also positively correlated with monoterpene *** these results will help guide the functional verification of candidate genes related to monoterpene biosynthesis,as well as identify the master transcriptional and hormonal regulators of this pathway in grapes.

关键词： Grape Muscat Monoterpene Transcriptome Monoterpene biosynthesis

新生儿出生体格与父母体质指数及母亲孕期营养的关系

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中国初级卫生保健 2024年第1期38卷 63-66页

作者：张永花成丽霞鲁春兰禹蕾裴树伟兰州市妇幼保健院甘肃兰州730000 兰州大学公共卫生学院甘肃兰州730000

目的:探讨新生儿出生体格与父母体质指数及母亲孕期增重、贫血的关系,为提高妇幼保健质量提供理论依据。方法:对2020年1—12月在兰州市妇幼保健院进行孕产期系统保健管理的100名孕产妇及其新生儿进行调查。采用自行的设计问卷对孕产妇... 详细信息

目的:探讨新生儿出生体格与父母体质指数及母亲孕期增重、贫血的关系,为提高妇幼保健质量提供理论依据。方法:对2020年1—12月在兰州市妇幼保健院进行孕产期系统保健管理的100名孕产妇及其新生儿进行调查。采用自行的设计问卷对孕产妇进行调查,通过面对面访谈、就诊时检测的方式收集父母亲一般情况、围孕产期生活习惯、父母亲身高、体重、新生儿分娩情况、体质指数(BMI)、血红蛋白(Hb)检测值、出生体格等资料,并对资料进行统计学分析。结果:不同父亲BMI类型与新生儿出生体格相关,低体重组、正常体重组、超重/肥胖组父亲的新生儿出生体重分别为(3.01±0.28)kg、(3.25±0.44)kg、(3.40±0.34)kg,3组比较,差异有统计学意义(F=9.793,P<0.05)。母亲孕期增重与新生儿出生体重相关,增重不足、增重正常、增重超重组母亲的新生儿出生体重分别为(3.22±0.42)kg、(3.19±0.34)kg、(3.40±0.45)kg,3组比较,差异有统计学意义(F=9.878,P<0.01)。多元线性回归分析显示,父亲BMI,母亲孕期增重、孕前BMI与新生儿出生体重呈正相关,父亲饮酒与新生儿出生体重呈负相关。父亲BMI、母亲身高与新生儿出生身长呈正相关。结论:新生儿出生体格与父母体质指数及母亲孕期增重有关,应多关注父亲因素对儿童早期发育的影响。

关键词：新生儿出生体格父母BMI 孕期营养

Oxidative coupling of cinnamic acid derivatives and their radical-scavenging activities

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Chinese Science Bulletin 2010年第25期55卷 2885-2890页

作者： JIN XiaoLing YANG RuTing SHANG YaJing DAI Fang QIAN YiPing cheng lixia ZHOU Bo LIU ZhongLi State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

4-Hydroxycinnamic acid derivatives,including ferulic acid (FA) (1),sinapic acid (SA) (2) and caffeic acid (CA) (3),are widely distributed in the plant kingdom,and undergo oxidative cross-coupling leading to the corresponding dehydrodimers,trimers and even higher oligomers in plants. In order to evaluate the antioxidative ability of these 4-hydroxycinnamic acid derivatives and their oligomers,we synthesized 8-8'-bis-lactone-dimers (8-8'-DiFA (4),8-8'-DiSA (5) and 8-8'-DiCA (6)),as well as a new trimer (7),by the reaction of the corresponding monomers (1-3) with Ag2O in methanol,and assayed their free radical-scavenging activity by the reaction with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·). It was found that CA (3) and 8-8'-DiCA (6) bearing o-dihydroxyl groups exhibited significantly higher radical-scavenging activity than those bearing no such groups,and oxidative coupling of CA (3) resulted in remarkable enhancement in the activity.

关键词：氧化偶联衍生物肉桂酸自由基清除 DPPH自由基抗氧化能力羟基酸低聚物

ATP-bioluminescence assay indicates the treatment of recurrent non-small cell lung cancer combined with malignant pleural effusion

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The Chinese-German Journal of Clinical Oncology 2010年第8期9卷 441-443页

作者： Jing Zhu lixia Ma Ying cheng Department of Physical Oncology Jilin Provincial Tumor Hospital Changchun 130012 China

Objective:This study was aimed to research the feasibility of ATP-bioluminescence assay(ATP-TCA) guiding the treatment on recurrent non-small cell lung cancer(NSCLC) combined with malignant pleural ***:We collected 30 pleural fluid samples which were approved to be positive by cytology from recurrent NSCLC *** cells were cocultured with chemotherapy medicines,single agent or drugs *** drug concentrations,two parallel holes were examined in vitro for 4 days,the results were measured by adding luciferase-fluorescein working system and luminescence *** applied chemotherapy medicines according to the results in vitro of ***:There were differences among drug sensitivities of *** the samples could be *** single drugs included cisplatinum,mitomycin C,doxorubicin,and pemetrexed disodium;sensitive drugs in the combination therapy were gemcitabine plus cisplatin,vinorelbine plus cisplatin,paclitaxel plus cisplatin,docetaxel plus cisplatin,and mitomycin C,vindesine plus cisplatin,in which gemcitabine + cisplatin(GEM + DDP) in vitro was the most efficient ***:ATP-TCA in vitro sensitivity assay is rapid,reliable,and simple to guide the treatment of recurrent NSCLC with malignant pleural effusion,and can help clinicians to make the individual chemotherapy program.

关键词： ATP-bioluminescence assay (ATP-TCA) recurrent advanced non-small cell lung cancer (NSCLC) pleural fluid

Model Building and Anisotropy of PrFeB Permanent Magnetic Materials

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Materials Sciences and Applications 2020年第11期11卷 757-766页

作者： Min Liu Xuehui Cai Weiping Gong Yajie Li lixia cheng Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices Huizhou College Huizhou China

This paper considers that the crystal grains of HDDR Pr2Fe14B permanent magnetic material are cubic, the size is 0.3 μm, and the crystal grains are in simple cubic accumulation. It is considered that there are boundary phases between grains. It is assumed that the boundary phases are non-magnetic phases with the thickness of d, and evenly distributed between grains. The anisotropy expression of single grain boundary is given considering structure defect and intergranular exchange coupling interaction. Based on micro-magnetic simulation calculation, the variation of the average anisotropy of a single grain with the structural defects and boundary phases was calculated. The results show that when the thickness of structural defects is constant, the average anisotropy of a single grain decreases with increasing of grain boundary phase thickness, and while the thickness of grain boundary phase is constant, it also decreases with increasing of structural defect thickness.

关键词： Structural Defects Boundary Phases Exchange Coupling Interactions Anisotropy

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左偏置结构频率统计与话题结构的显现

外语教学与研究 2006年第2期38卷 101-107页

作者：程丽霞大连理工大学大连理工大学外国语学院116023

话题结构的显现与话语功能、使用频率、语用推理等因素密切相关。本文以英汉历代具代表性作品中的会话语篇为语料,利用语法化理论,对话题结构进行历时研究。语料和统计数据表明,左偏置结构在古汉语中就高频出现,它是汉语话题语法化的原... 详细信息

话题结构的显现与话语功能、使用频率、语用推理等因素密切相关。本文以英汉历代具代表性作品中的会话语篇为语料,利用语法化理论,对话题结构进行历时研究。语料和统计数据表明,左偏置结构在古汉语中就高频出现,它是汉语话题语法化的原型结构。受事提前为话题后,句子的施事主语与受事话题开始竞争语法优先权。英语话题因主语概念的完善阻碍了它的发展,因而始终处于话语功能层面。汉语话题在近代进入句法领域,其语义关系的多样性和句法地位的独立性促使其语法化为汉语特有的语法范畴。汉语新话题结构(TC3-TC6)的出现为话题类型学提供了新的例证。

关键词：话题结构左偏置结构频率语法化

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基于“哲学共有”的人力资源管理路径模型

中国人力资源开发 2013年第1期30卷 38-43页

作者：程丽霞北京大学光华管理学院首都经济贸易大学工商管理学院

本文认为传统人力资源管理模式的存在根基已经遭到了破坏,并呈现出诸多的弊端。以此为基础,文章对时下受到学者关注的基于"哲学共有"的人力资源管理模式及其运作形态进行了深入探讨。

关键词：哲学共有人力资源管理文化管理

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交际模式研究的整合趋势与整合语言学

外语教学 2004年第5期25卷 1-5页

作者：程丽霞厦门大学外文学院福建厦门361005

以 Roy Harris为代表的整合语言学认为语言以交际为先决条件 ,交际是发生在具体语境中的言语行为 ,语言研究应包括宏观社会性、生物机械性和外界环境特征三方面。以往对交际的片面理解导致了语言研究的孤立主义模式。这一模式以结构主... 详细信息

以 Roy Harris为代表的整合语言学认为语言以交际为先决条件 ,交际是发生在具体语境中的言语行为 ,语言研究应包括宏观社会性、生物机械性和外界环境特征三方面。以往对交际的片面理解导致了语言研究的孤立主义模式。这一模式以结构主义、行为主义及生成语法为代表 ,其研究对象局限于单纯的语言结构。2 0世纪 80年代以来的交际模式研究强调语用、功能、社会文化对交际的重要影响 ,体现了语言研究的整合主义倾向。文章以语言学研究不同时期的典型图式为依据 ,着重分析孤立法和整合法各自的特点 ,拟讨论说明交际模式研究呈现出整合的趋势与整合语言学的观点不谋而合 ,结构与语用。

关键词：交际模式整合趋势整合语言学孤立主义