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Acta Pharmaceutica Sinica B 2024年第5期14卷 2358-2358页

作者： Yi Qian Meimei Zhao Qinghua Han Jingkang Wang lixi liao Heng Yang Dan Liu Pengfei Tu Hong Liang Kewu Zeng State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Proteomics Laboratory Medical and Healthy Analytical CenterPeking University Health Science CenterBeijing 100191China

The authors regret that the representative images of tumor tissue staining for the intraperitoneal injection of J13 in the left panel of Fig.5E and G(Page 1862)were incorrect due to an inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Photoshop *** our studies,at least three biological replicates were included in each treatment group and at least three images were taken for different fields of each *** corrected version of Fig.5E and G have been provided below,and the change did not affect the results and conclusions of this *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： correction figures assembling

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1853-1866页

Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer *** dynamics balance is exactly regulated by molecular motor consisted of myosin and actin cytoskeleton ***,targeting myosin eactin molecular motor is considered as a promising strategy for *** this study,we performed a proof-of-concept study with a natural-derived small-molecule J13 to test the feasibility of anti-cancer therapeutics via pharmacologically targeting molecular ***,we found J13 could directly target myosin-9(MYH9)eactin molecular motor to promote mitochondrial fission progression,and markedly inhibited cancer cells survival,proliferation and *** study revealed that J13 impaired MYH9 eactin interaction to inactivate molecular motor,and caused a cytoskeleton-dependent mitochondrial dynamics ***,stable isotope labeling with amino acids in cell culture(SILAC)technology-coupled with pulldown analysis identified HSPA9 as a crucial adaptor protein connecting MYH9 eactin molecular motor to mitochondrial *** together,we reported the first natural small-molecule directly targeting MYH9 eactin molecular motor for anti-cancer translational ***,our study also proved the conceptual practicability of pharmacologically disrupting mitochondrial fission/fusion dynamics in human cancer therapy.

关键词： Anti-cancer Liver hepatocellular carcinoma Mitochondrial fission Small molecule Target identification Molecular motor MYH9 HSPA9

Baoyuan decoction alleviates myocardial infarction through the regulation of metabolic dysfunction and the mitochondria-dependent caspase-9/3 pathway

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Acupuncture and Herbal Medicine 2021年第1期1卷 49-58页

作者： Zhiyong Du Zeliu Shu Chun Li Xiaomin Song Xiaoli Ma lixi liao Jun Li Pengfei Tu Kewu Zeng Yong Jiang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective:Baoyuan decoction(BYD)is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological *** present study aimed to investigate the effect and mechanism of BYD on alleviating myocardial infarction(MI).Methods:Nuclear magnetic resonance-based serum and urinary metabolomics were employed to explore the metabolic regulation effects of BYD in rats with MI induced by left anterior descending ***-glucose deprivation/recovery(OGD/R)model in H9c2 cells and multiple molecular biology approaches were used to clarify the underlying action mechanisms of ***:BYD treatment recovered the serum and urinary metabolite profiles of the MI rats toward normal metabolic status and significantly improved mitochondrial energy metabolism and apoptosis pathways perturbed by *** of the molecular mechanism of BYD indicated that it suppressed OGD/R-induced H9c2 cell apoptosis in a concentration-dependent manner by inhibiting the mitochondria-dependent caspase-9/3-poly ADP-ribose polymerase ***:Our results demonstrate that BYD protects against myocardial apoptosis via the mitochondrial metabolic and apoptosis *** also provide novel insights into the clinical application of BYD for the treatment of ischemic heart diseases.

关键词： Baoyuan decoction Caspase-9/3 pathway Mechanisms Metabolomics Mitochondrial energy metabolism Myocardial infarction

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计算机网络的安全问题及其关键技术

湖南广播电视大学学报 2002年第2期 16-17页

作者：廖翊希湖南广播电视大学教学指导中心

本文指出了信息时代的网络安全问题,阐述了网络系统的安全威胁和系统安全与系统安全结构,提出了需要解决的网络安全问题和几个关键技术即防火墙技术、数据加密技术、智能卡技术。

关键词：防火墙数据加密智能卡计算机网络安全

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CGI安全问题及安全实施方法

湖南广播电视大学学报 2001年第4期 41-42页

作者：廖翊希湖南广播电视大学湖南长沙410004

本文指出CGI存在的CGI语言与WEB服务器两方面的安全问题。阐述了CGI语言安全问题主要表现在程序设计的Buffer溢出、Shell跟后字符和Shell滥用;WEB服务器的安全问题是错误配置和使用JAVA技术时由JAVA的漏洞所致。提出了CGI安全实现方法。

关键词： CGI CGI语言 JAVA技术漏洞

成都市龙泉驿区老年人血小板相关参数参考区间的建立

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华西医学 2024年第4期39卷 599-603页

作者：李淑华廖红艳马莉赵国江何冬梅康昕阳丽熙代琴四川大学华西医院实验医学科成都610041 成都市龙泉驿区第一人民医院检验科成都610100 四川大学华西护理学院/医院管理研究所/门诊部成都610041 成都市龙泉驿区第一人民医院急诊科成都610100 成都市龙泉驿区第一人民医院产科成都610100 成都市龙泉驿区第一人民医院眼科成都610100

目的建立成都市龙泉驿区老年人群血小板相关参数参考区间。方法选取2021年11月1日—12月31日四川大学华西医院自然人群队列研究项目龙泉驿分中心60~80周岁的研究个体,对纳入人群进行全血细胞分析,得到血小板相关参数;利用IBM SPSS Stati... 详细信息

目的建立成都市龙泉驿区老年人群血小板相关参数参考区间。方法选取2021年11月1日—12月31日四川大学华西医院自然人群队列研究项目龙泉驿分中心60~80周岁的研究个体,对纳入人群进行全血细胞分析,得到血小板相关参数;利用IBM SPSS Statistics 25软件对参考数据进行处理,获得老年人血小板相关参数参考区间。结果通过纳入排除标准筛选出参考个体1938人,检测数据排除离群值后得到参考个体1669人,其中男665人,女1004人。血小板计数参考区间:老年男性为(95.03~301.32)×10^(9)/L,老年女性为(112.13~320.75)×10^(9)/L;平均血小板体积参考区间:老年男性为8.97~13.80 fL,老年女性为9.10~13.90 fL;血小板压积参考区间:老年男性为0.13%~0.30%,老年女性为0.14%~0.32%;血小板体积分布宽度参考区间:老年男性为15.80~16.90,老年女性为15.70~16.90。结论建立本区域老年人血小板相关参数具有一定的实际意义。

关键词：老年人血小板相关参数参考区间

系统级封装中一种新型埋入式电源滤波结构的测量

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电子测量与仪器学报 2009年第S1期23卷 108-111页

作者：李君万里兮廖成西南交通大学电磁场与微波技术研究所成都610031 中国科学院微电子研究所北京100029

高密度小尺寸封装中通常需要多芯片共用一个电源网络,瞬态电流产生的电源噪声会降低系统的噪声容限,导致芯片误动作或通过供电网络干扰到临近敏感电路,产生信号完整性和电磁干扰问题。新型埋入式电源滤波结构代替传统的电源/地平面能够... 详细信息

高密度小尺寸封装中通常需要多芯片共用一个电源网络,瞬态电流产生的电源噪声会降低系统的噪声容限,导致芯片误动作或通过供电网络干扰到临近敏感电路,产生信号完整性和电磁干扰问题。新型埋入式电源滤波结构代替传统的电源/地平面能够提供很低的电源阻抗(几十毫欧姆),在较宽的频带内隔离噪声。对这种极低阻抗结构的精确测量很容易受到信噪比以及夹具的重复性的影响,因此测量方法非常重要。本文针对新型电源滤波结构改进了测量方法,讨论了测量系统以及测量流程,并得到了比较好的测量结果。

关键词：新型埋入式电源滤波结构 2端口测量矢量网络分析仪