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Chinese Journal of Clinical Oncology 2006年第1期3卷 66-69页

作者： Xiangtao Ma Xu Wang liwei Yu Jing fu Shan Wang Ruyu Du Zhirong Cui Department of Surgery Beijing Haidian Hospital Beijing 100080 China Department of Neurology Beijing Haidian Hospital Beijing 10080 China Department of Pathology Beijing Haidian Hospital Beijing 100080 China Department of Surgery and Division of Surgical Oncology Peking University People＇s Hospital Beijing 100044 China

Lung cancer is the most common cancer-related death in both men and women in the world. Approximately 25% of all cancer deaths are attributable to lung carcinoma. Moreover, about one-half of patients with lung cancer have metastases at the time of initial diagnosis, most frequently of lymph nodes, adrenals, liver, bone and brain. However metastasis to the colon is very rare. Over the past 25 years about 13 cases of symptomatic colonic metastases from lung malignancies of all types have been reported in the literature. Hypercalcemia and leukocytosis are two of the most common paraneoplastic syndromes associated with various malignancies. However, concomitant manifestation of hypercalcemia and leukocytosis are occasionally observed in the same cancer patients. Here, we present a rare case of colonic metastasis from a squamous cell carcinoma of the lung associated with paraneoplastic syndromes of hypercalcemia and leukocytosis.

关键词： paraneoplastic syndrome lung cancer hypercalcemia leukocytosis prognosis.

Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells

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Cellular & Molecular Immunology 2021年第2期18卷 440-451页

作者： Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang liwei Lu Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Immunology Jiangsu Key Laboratory of Laboratory MedicineSchool of MedicineJiangsu UniversityZhenjiangChina Department of Rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong Kong Center for Clinical Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Rheumatology The Second Affiliated Hospital of Dalian Medical UniversityLiaoningChina

Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal *** previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of *** this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO ***,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS ***,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in *** addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by *** together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases.

关键词： mesenchymal stem cells exosomes MDSCs Sjögren’s syndrome autoimmune diseases

Operando surface science methodology reveals surface effect in charge storage electrodes

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National Science Review 2021年第3期8卷 70-77页

作者： Chao Wang Yanxiao Ning Haibo Huang Shiwen Li Chuanhai Xiao Qi Chen Li Peng Shuainan Guo Yifan Li Conghui Liu Zhong-Shuai Wu Xianfeng Li liwei Chen Chao Gao Chuan Wu Qiang fu State Key Laboratory of Catalysis iChEMDalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences MOE Key Laboratory of Macromolecular Synthesis and functionalization Department of Polymer Science and Engineering Zhejiang University Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science &Engineering Beijing Institute of Technology

Surface and interface play critical roles in energy storage devices,calling for operando characterization techniques to probe the electrified surfaces/*** this work,surface science methodology,including electron spectroscopy and scanning probe microscopy,has been successfully applied to visualize electrochemical processes at operating electrode surfaces in an Al/graphite model *** of anions together with cations is directly observed in the surface region of a graphite electrode with tens of nanometers thickness,the concentration of which is one order higher than that in *** intercalation pseudocapacitance mechanism and a double specific capacity in the electrode surface region are expected based on the super-dense intercalants and anion/cation co-intercalation,which are in sharp contrast to the battery-like mechanism in the electrode *** distinct electrochemical mechanism at the electrode surface is verified by performance tests of real battery devices,showing that a surface-dominant,nanometer-thick graphite cathode outperforms a bulk-dominant,micrometer-thick graphite *** findings highlight the important surface effect of working electrodes in charge storage systems.

关键词： surface science methodology aluminum ion battery operando characterization surface effect

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基于烟丝填充值提升的滚筒干燥工艺参数优化

轻工学报 2021年第1期36卷 45-50页

作者：徐德龙米强付立伟周显生刘杰孙连江岳珩孔德望刘伟山东中烟工业有限责任公司济南卷烟厂山东济南250104 山东中烟工业有限责任公司技术中心山东青岛266101

采用正交试验极差分析的方法研究了滚筒干燥工艺参数(筒壁温度、切丝后含水率和HT(隧道式烟丝增温增湿装置)蒸汽压力)对烟丝填充值、烟丝结构和感官品质的影响,并对3个滚筒干燥工艺参数进行了优化.结果表明:对干燥后烟丝填充值影响的主... 详细信息

采用正交试验极差分析的方法研究了滚筒干燥工艺参数(筒壁温度、切丝后含水率和HT(隧道式烟丝增温增湿装置)蒸汽压力)对烟丝填充值、烟丝结构和感官品质的影响,并对3个滚筒干燥工艺参数进行了优化.结果表明:对干燥后烟丝填充值影响的主次顺序为HT蒸汽压力>切丝后含水率>筒壁温度;对干燥后烟丝结构影响的主次顺序为HT蒸汽压力>筒壁温度>切丝后含水率;对干燥后烟丝感官品质影响的主次顺序为切丝后含水率>筒壁温度>HT蒸汽压力;HT蒸汽压力对烟丝填充值和整丝率的影响最大,对感官品质的影响最小;增大烟丝填充值的最优组合为切丝后含水率21.0%,HT蒸汽压力0.40 MPa,筒壁温度140℃,在该最优组合下,烟丝填充值增大了0.21 cm3/g.

关键词：滚筒干燥工艺参数填充值含水率感官品质

CO_(2)地质利用与封存环境下钢材腐蚀行为与腐蚀控制措施研究进展

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热力发电 2024年第2期53卷 37-47页

作者：王翰文张力为梅开元程小伟薛泉王燕付晓娟中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 中国科学院大学北京100049 西南石油大学新能源与材料学院四川成都610500

CO_(2)地质利用与封存(CO_(2) geological utilization and storage,CGUS)是实现“碳中和”目标的重要技术手段,解决CGUS过程中的钢材腐蚀问题对于降低CGUS技术风险、实现CGUS技术规模化推广应用至关重要。综述了目前已经提出的CO_(2)... 详细信息

CO_(2)地质利用与封存(CO_(2) geological utilization and storage,CGUS)是实现“碳中和”目标的重要技术手段,解决CGUS过程中的钢材腐蚀问题对于降低CGUS技术风险、实现CGUS技术规模化推广应用至关重要。综述了目前已经提出的CO_(2)腐蚀钢材反应机制,总结了CO_(2)腐蚀钢材的主要影响因素,阐明了CO_(2)分压、温度、矿化度及pH值、CO_(2)封存环境中含有杂质、流体流动等因素对钢材腐蚀行为的影响,归纳了适用于CO_(2)腐蚀钢材防护的主要措施。基于此,提出了CGUS环境下钢材遭受CO_(2)腐蚀问题的重点研究方向。主要包括:CO_(2)腐蚀钢材反应机制的进一步探究;各项环境因素耦合作用影响CO_(2)腐蚀规律和腐蚀程度的量化研究;高浓度CO_(2)条件下腐蚀防护技术的开发与应用。

关键词：地质封存 CO_(2)腐蚀腐蚀影响因素缓蚀剂涂层耐蚀合金

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生态系统服务制图研究进展

生态学报 2014年第2期34卷 316-325页

作者：张立伟傅伯杰中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085

生态系统服务是生态学研究的前沿方向之一,生态系统服务制图是将生态系统服务的评估结果纳入到生态环境保护规划与管理决策制定与实施过程中的重要组成部分。生态系统服务制图是根据决策需求,选择合适的制图评价方法,对特定时空尺度上... 详细信息

生态系统服务是生态学研究的前沿方向之一,生态系统服务制图是将生态系统服务的评估结果纳入到生态环境保护规划与管理决策制定与实施过程中的重要组成部分。生态系统服务制图是根据决策需求,选择合适的制图评价方法,对特定时空尺度上生态系统服务的空间分布以及在各种自然-社会因素共同影响下生态系统服务的情景变化进行量化描述的过程。它最终为决策参与者提供研究区域生态系统服务时空变化特征具体的、可视的量化描述,辅助决策者权衡利弊,最终制定出符合区域生态环境与人类社会共同可持续发展的最优决策。综述了生态系统服务制图的内涵及其在辅助决策过程中的重要作用;介绍了生态系统服务的重点研究内容(生态系统服务的提供、需求及权衡协同关系制图)及研究方法;并对目前研究中所存在的问题进行了深入的探讨,归纳了生态系统服务的制图评价流程及未来重点的研究方向。

关键词：生态系统服务生态系统服务制图环境保护决策制定

Technique for Ecological Pond Breeding of Charybdis japonica

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Asian Agricultural Research 2023年第1期15卷 26-29,35页

作者： Lijun SHI liwei SHI Hua YANG Wenping JIA Zhiru fu Tianjin Binhai New Area Huawei Marine Technology Co. Ltd.Tianjin 301800China Tianjin Fisheries Research Institute Tianjin 300221China Tianjin Agricultural Development Service Center Tianjin 300061China

In 2016 and 2017,the ecological pond breeding experiment of Charybdis japonica was carried out,with a total of experimental area up to 4 *** two years of experimental research,it obtained a total of 48950 kg of ***,with an average output of 12237.5 kg/*** production output value was 2.3675 million yuan,the total production cost was 831700 yuan,the net profit was 1.5358 million yuan,the average profit was 384000 yuan/ha,and the input-output ratio was 1∶*** average proportion of *** population with a production weight of 150 g or more was 7.9%.The proportion of the group of 120-150 g was relatively large,with an average of 80%in two years,and the proportion of the group below 120 g was relatively small,with an average of 12%in two *** cumulative harvest of shellfish in two years was 65700 kg,with an average output of 16425 kg/ha,the production output value of 738100 yuan,the production cost of 295500 yuan,the net profit of 442600 yuan,and the average profit of 110700 yuan/ha.

关键词： Charybdis japonica Shellfish Ecological breeding

内蒙古通辽市肉犊牛3种主要咳喘病病原感染调查

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中国动物检疫 2024年第7期41卷 10-13页

作者：郑海英王梓高丽娟吴佳琦付明山吕宗林赵江还王立伟通辽市农牧科学研究所内蒙古通辽028000 通辽市科尔沁区动物疫病预防控制中心内蒙古通辽028000

为了解通辽市犊牛咳喘病主要病原牛传染性鼻气管炎病毒(IBRV)、牛病毒性腹泻病毒(BVDV)、多杀性巴氏杆菌(Pasteurella multocida,Pm)的感染情况,对7个旗县区213家养殖场户的产犊及咳喘发病情况进行了调查,采集400份咳喘犊牛血清样品进行... 详细信息

为了解通辽市犊牛咳喘病主要病原牛传染性鼻气管炎病毒(IBRV)、牛病毒性腹泻病毒(BVDV)、多杀性巴氏杆菌(Pasteurella multocida,Pm)的感染情况,对7个旗县区213家养殖场户的产犊及咳喘发病情况进行了调查,采集400份咳喘犊牛血清样品进行了ELISA抗体检测。结果显示:犊牛咳喘病病原感染率为10.21%,IBRV、BVDV和Pm的抗体阳性率分别为26.50%、19.25%、33.50%;不同旗县区的IBRV、BVDV和Pm抗体阳性率分别为8.33%~41.79%、10.26%~32.26%和17.95%~46.77%;IBRV在秋、冬两季抗体阳性率较高,分别为32.22%和30.08%,BVDV在春、冬两季抗体阳性率较高,分别为19.72%和22.56%,Pm在秋、冬两季抗体阳性率较高,分别为36.67%和39.85%;单一感染率为41.00%,混合感染率为18.00%,其中二重感染率为15.75%,以IBRV+Pm混合感染为主,三重感染率为2.25%。结果表明:IBRV、BVDV、Pm是导致犊牛咳喘病的重要病原,其流行呈现地区和季节性差异。建议养殖场户根据本地区病原的流行情况和季节特征,对犊牛咳喘病进行科学合理防控。

关键词：犊牛咳喘血清流行病学 ELISA检测

Preparation of Mo_(2)C by MPCVD and Its Photocatalytic Properties

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真空与低温 2021年第5期27卷 439-443页

作者： HAO Jianxin CAI Kang fu Qiuming WENG Jun XIONG liwei ZHAO Hongyang Hubei Provincial Key Laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of TechnologyNo.206 Guanggu 1st RoadWuhan 430205China

Mo2C was prepared by microwave plasma chemical vapor deposition(MPCVD)technique with the power of 800 W and pressure of 18 *** with traditional preparation methods,MPCVD has faster growth rate and higher purity of the *** influence of growth time on the morphology and structure of Mo_(2)C was characterized by X-ray diffraction and Scanning Electron *** photocatalytic performance of Mo_(2)C was *** was found that Mo_(2)C had good photocatalytic performance and the 6 h sample had the highest photodegradation rate,indicating the great potential of Mo_(2)C as photocatalyst.

关键词： microwave plasma chemical vapor deposition(MPCVD) molybdenum carbide(Mo_(2)C) photocatalysis

计及动态电压稳定约束的分区柔性互联电网最大供电能力计算

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电网技术 2023年第2期47卷 553-561页

作者：伏祥运朱立位赵喆葛乐国网江苏省电力有限公司连云港供电分公司江苏省连云港市222004 南京工程学院电力工程学院江苏省南京市211167

最大供电能力计算是分区柔性互联电网规划的重要问题,随着可再生能源大量接入电网,动态电压失稳问题愈发突出。计及动态电压稳定约束的最大供电能力计算模型非线性特征明显,给模型求解带来较大挑战。首先,运用改进的小干扰分析法对动态... 详细信息

最大供电能力计算是分区柔性互联电网规划的重要问题,随着可再生能源大量接入电网,动态电压失稳问题愈发突出。计及动态电压稳定约束的最大供电能力计算模型非线性特征明显,给模型求解带来较大挑战。首先,运用改进的小干扰分析法对动态电压稳定进行分析,建立计及动态电压稳定性指标的最大供电能力的数学模型。其次,给出基于深度确定性策略梯度算法的最大供电能力计算方法框架,设计其动作与状态空间、奖励函数、神经网络与学习流程。最后,以某电网为例进行验证,该方法在有效避免电网动态电压失稳的同时优化分区互联电网的最大供电能力计算。

关键词：动态电压最大供电能力深度强化学习分区柔性互联