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Study and Application of Nb-V-Ti Microalloyed Cast Steel

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Journal of Iron and Steel Research International 2005年第3期12卷 56-59页

作者： HANJian-min LIUYuan-fu liwei-jing LIRong-hua XUXiang-yang WANGJin-hua BeijingJiaotongUniversity Beijing100044China

A new type of Nb-V-Ti microalloyed cast steel was produced. Computer simulation was adopted to optimize the content of alloying elements. The microstructure of the microalloyed steel was analyzed. The fatigue property, wear and friction properties and rupture toughness of the steel were investigated. The service and operating properties of Nb-V-Ti microalloyed cast steel coupler were also examined. The results show that the steel has excellent comprehensive mechanical properties. The granular bainite structure and precipitation strengthening are the primary strengthening mechanism. The fine grain brings the steel good plasticity and excellent toughness. Various service and operating properties of Nb-V-Ti microalloyed cast steel automatic coupler are excellent.

关键词： microalloying cast steel microstructure mechanical property

甲基丙烯酰化透明质酸/脱细胞华通胶水凝胶支架的制备与表征

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中国组织工程研究 2024年第22期28卷 3517-3523页

作者：袁勋丁振罡付力伟吴江郑亚哲张智超田广招眭翔刘舒云郭全义贵州医科大学附属医院骨科贵州省贵阳市550004 解放军总医院第一医学中心骨科研究所骨科再生医学北京市重点实验室全军骨科战创伤重点实验室北京市100853

背景:随着组织工程为关节软骨损伤修复这一世界难题带来了新的希望,构建成分仿生的光固化3D打印水凝胶支架对软骨组织工程具有重要意义。目的:通过数字光处理3D打印技术构建成分仿生的甲基丙烯酰化透明质酸/脱细胞华通胶水凝胶支架,评... 详细信息

背景:随着组织工程为关节软骨损伤修复这一世界难题带来了新的希望,构建成分仿生的光固化3D打印水凝胶支架对软骨组织工程具有重要意义。目的:通过数字光处理3D打印技术构建成分仿生的甲基丙烯酰化透明质酸/脱细胞华通胶水凝胶支架,评价其生物相容性。方法:从人脐带中分离提取华通胶组织后进行脱细胞处理,冷冻干燥后磨成粉末,溶于PBS中制备50 g/L的脱细胞华通胶溶液。制备甲基丙烯酰化透明质酸,冻干后溶于PBS中制备50 g/L的甲基丙烯酰化透明质酸溶液。将脱细胞华通胶溶液与甲基丙烯酰化透明质酸溶液以体积比1∶1混合,加入光引发剂后作为生物墨水。通过数字光处理3D打印技术分别制备甲基丙烯酰化透明质酸水凝胶支架(记为HAMA水凝胶支架)与甲基丙烯酰化透明质酸/脱细胞华通胶水凝胶支架(记为HAMA/WJ水凝胶支架),表征支架的微观结构、溶胀性能、生物相容性与促软骨分化性能。结果与结论:①扫描电镜下见两组支架均呈三维立体的网状结构,其中HAMA/WJ水凝胶支架纤维连接更加均匀;两组支架均在10 h内达到溶胀平衡,HAMA/WJ水凝胶支架的平衡溶胀比低于HAMA水凝胶支架(P<0.05)。②CCK-8实验显示相较于HAMA水凝胶支架,HAMA/WJ水凝胶支架可促进骨髓间充质干细胞的增殖;死活染色显示骨髓间充质干细胞在两组支架上生长良好,并且HAMA/WJ水凝胶支架上的细胞立体分布均匀、细胞数量更多;鬼笔环肽染色显示相较于HAMA水凝胶支架,HAMA/WJ水凝胶支架上的骨髓间充质干细胞黏附与铺展更佳。③将骨髓间充质干细胞接种于两组支架后进行成软骨诱导培养,qRT-PCR检测结果显示,HAMA/WJ水凝胶支架组聚集蛋白聚糖、SOX9、Ⅱ型胶原mRNA表达量均高于HAMA水凝胶支架组(P<0.05,P<0.01)。④结果表明,数字光处理3D生物打印HAMA/WJ水凝胶支架可促进骨髓间充质干细胞的增殖、黏附及成软骨分化。

关键词：华通胶甲基丙烯酰化透明质酸水凝胶支架数字光处理3D打印软骨损伤骨髓间充质干细胞组织工程

Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration

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Regenerative Biomaterials 2020年第6期7卷 527-542页

作者： liwei fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo School of Medicine Nankai UniversityNo.94 Weijin RoadNankai DistrictTianjin 300071China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLAInstitute of OrthopedicsThe First Medical CenterChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853China Department of Bone and Joint Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityNo.160 Pujian RoadPudong New DistrictShanghai 200127China

Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative *** defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to *** engineering techniques bring new hope for AC *** meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been *** multilayered scaffolds should generate zone-specific functional tissue similar to native AC *** review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and *** challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed.

关键词： biomimetic multilayered scaffold articular cartilage regeneration tissue engineering osteochondral

RGB-guided hyperspectral image super-resolution with deep progressive learning

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 679-694页

作者： Tao Zhang Ying fu liwei Huang Siyuan Li Shaodi You Chenggang Yan School of Computer Science and Technology Beijing Institute of TechnologyBeijingChina Satellite Information Intelligent Processing and Application Research Laboratory Beijing Institute of Remote SensingBeijingChina Key Laboratory of Spectral Imaging Technology Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of SciencesXi'anChina Institute of Informatics University of AmsterdamAmsterdamNetherlands School of Communication Engineering Hangzhou Dianzi UniversityHangzhouChina

Due to hardware limitations,existing hyperspectral(HS)camera often suffer from low spatial/temporal ***,it has been prevalent to super-resolve a low reso-lution(LR)HS image into a high resolution(HR)HS image with a HR RGB(or mul-tispectral)image *** approaches for this guided super-resolution task often model the intrinsic characteristic of the desired HR HS image using hand-crafted ***,researchers pay more attention to deep learning methods with direct supervised or unsupervised learning,which exploit deep prior only from training dataset or testing *** this article,an efficient convolutional neural network-based method is presented to progressively super-resolve HS image with RGB image ***-ically,a progressive HS image super-resolution network is proposed,which progressively super-resolve the LR HS image with pixel shuffled HR RGB image ***,the super-resolution network is progressively trained with supervised pre-training and un-supervised adaption,where supervised pre-training learns the general prior on training data and unsupervised adaptation generalises the general prior to specific prior for variant testing *** proposed method can effectively exploit prior from training dataset and testing HS and RGB images with spectral-spatial *** has a good general-isation capability,especially for blind HS image *** experimental results show that the proposed deep progressive learning method out-performs the existing state-of-the-art methods for HS image super-resolution in non-blind and blind cases.

关键词： computer vision deep neural networks image processing image resolution unsupervised learning

Tetrahedral framework nucleic acids enhance the chondrogenic potential of human umbilical cord mesenchymal stem cells via the PI3K/AKT axis

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Regenerative Biomaterials 2023年第1期10卷 1552-1565页

作者： liwei fu Pinxue Li Jiang Wu Yazhe Zheng Chao Ning Zhiyao Liao Xun Yuan Zhengang Ding Zhichao Zhang Xiang Sui Sirong Shi Shuyun Liu Quanyi Guo School of Medicine Nankai UniversityTianjin 300071People’s Republic of China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Laboratory of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing 100853People’s Republic of China Guizhou Medical University GuiyangGuizhou 550004People’s Republic of China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041People’s Republic of China

The field of regenerative medicine faces a notable challenge in terms of the regeneration of articular *** proper treatment,it can lead to *** on the research findings,human umbilical cord mesenchymal stem cells(hUMSCs)are considered an excellent choice for regenerating ***,there is still a lack of suitable biomaterials to control their ability to self-renew and *** address this issue,in this study using tetrahedral framework nucleic acids(tFNAs)as a new method in an in vitro culture setting to manage the behaviour of hUMSCs was ***,the influence of tFNAs on hUMSC proliferation,migration and chondrogenic differentiation was explored by combining bioinformatics *** addition,a variety of molecular biology techniques have been used to investigate deep molecular *** results demonstrated that tFNAs can affect the transcriptome and multiple signalling pathways of hUMSCs,among which the PI3K/Akt pathway is significantly ***,tFNAs can regulate the expression levels of multiple proteins(GSK3β,RhoA and mTOR)downstream of the PI3K-Akt axis to further enhance cell proliferation,migration and hUMSC chondrogenic *** provide new insight into enhancing the chondrogenic potential of hUMSCs,which exhibits promising potential for future utilization within the domains of AC regeneration and clinical treatment.

关键词： tFNAs articular cartilage hUMSCs chondrogenic differentiation

Multiwalled Carbon Nanotubes Reinforced Alumina Composites

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Journal of Wuhan University of Technology(Materials Science) 2011年第6期26卷 1171-1173页

作者：张金咏 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

1wt% multiwalled carbon nanotube （MWNTs） reinforced alumina composites was sintered to full density by spark plasma sintering. And pure alumina and graphite/alumina composites were also prepared by the same way for comparison. Indentation and single edge V-notched beam （SEVNB） toughness were measured respectively. The experimental results show that MWNTs could not improve toughness of alumina too much as that once expected. And SEVNB toughness was more valid than indentation toughness.

关键词： MWNT alumina toughness

Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ

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Bioactive Materials 2022年第3期7卷 411-427页

作者： liwei fu Pinxue Li Junyao Zhu Zhiyao Liao Cangjian Gao Hao Li Zhen Yang Tianyuan Zhao Wei Chen Yu Peng fuyang Cao Chao Ning Xiang Sui Quanyi Guo Yunfeng Lin Shuyun Liu School of Medicine Nankai UniversityTianjin300071People’s Republic of China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Laboratory of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLANo.28 Fuxing RoadHaidian DistrictBeijing100853People’s Republic of China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041People’s Republic of China Stomatology Department The Fifth Hospital of Sichuan ProvinceChengdu610031People’s Republic of China

Many recent studies have shown that joint-resident mesenchymal stem cells(MSCs)play a vital role in articular cartilage(AC)in situ ***,synovium-derived MSCs(SMSCs),which have strong chondrogenic differentiation potential,may be the main driver of cartilage ***,both the insufficient number of MSCs and the lack of an ideal regenerative microenvironment in the defect area will seriously affect the regeneration of *** framework nucleic acids(tFNAs),notable novel nanomaterials,are considered prospective biological regulators in biomedical ***,we aimed to explore whether tFNAs have positive effects on AC in situ regeneration and to investigate the related *** results of in vitro experiments showed that the proliferation and migration of SMSCs were significantly enhanced by *** addition,tFNAs,which were added to chondrogenic induction medium,were shown to promote the chondrogenic capacity of SMSCs by increasing the phosphorylation of Smad2/*** animal models,the injection of tFNAs improved the therapeutic outcome of cartilage defects compared with that of the control treatments without *** conclusion,this is the first report to demonstrate that tFNAs can promote the chondrogenic differentiation of SMSCs in vitro and enhance AC regeneration in vivo,indicating that tFNAs may become a promising therapeutic for AC regeneration.

关键词： Tetrahedral framework nucleic acids Articular cartilage regeneration Mesenchymal stem cells Chondrogenic differentiation

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging

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Science China(Life Sciences) 2024年第4期67卷 745-764页

作者： Shujie Chen Liujing Huang Bingdong Liu Huimin Duan Ze Li Yifan Liu Hu Li Xiang fu Jingchao Lin Yinlan Xu Li Liu Dan Wan Yulong Yin liwei Xie Department of Endocrinology and Metabolism Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Public Health Xinxiang Medical UniversityXinxiang 453003China Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Metabo-Profile Biotechnology(Shanghai)Co.Ltd. Shanghai 201315China Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsSchool of Medical TechnologyGuangdong Medical UniversityDongguan 524023China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China

The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle ***,the interplay between gut microbiota/metabolites and the regulation of satellite cell(SC)homeostasis,particularly during aging,remains *** propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development,regeneration,and aging *** investigation reveals that microbial dysbiosis manipulated by either antibiotic treatment or fecal microbiota transplantation from aged to adult mice,leads to the activation of SCs or a significant reduction in the total ***,employing multi-omics(e.g.,RNA-seq,16S r RNA gene sequencing,and metabolomics)and bioinformatic analysis,we demonstrate that the reduced butyrate levels,alongside the gut microbial dysbiosis,could be the primary factor contributing to the reduction in the number of SCs and subsequent impairments during skeletal muscle ***,butyrate supplementation can mitigate the antibiotics-induced SC activation irrespective of gut microbiota,potentially by inhibiting the proliferation and differentiation of SCs/*** butyrate effect is likely facilitated through the monocarboxylate transporter 1(Mct1),a lactate transporter enriched on membranes of SCs and *** a result,butyrate could serve as an alternative strategy to enhance SC homeostasis and function during skeletal muscle *** findings shed light on the potential application of microbial metabolites in maintaining SC homeostasis and preventing skeletal muscle aging.

关键词： gut microbiota aging satellite cells butyrate Slc16a1(Mct1)

射频激励二维6通道CO_2波导激光器列阵的研究

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中国激光 1999年第2期26卷 113-115页

作者：朱钧陈钰清王静环傅丽伟浙江大学近代光学仪器国家重点实验室

报道了一种新型的射频激励二维６通道ＣＯ２波导激光器列阵。实验研究了该器件的特性，在增益长度为３８０ｍｍ时，获得激光输出功率为２０Ｗ。

关键词：波导激光器列阵射频激励二氧化碳激光器