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microRNA Expression in Rat Apical Periodontitis Bone Lesion

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Bone Research 2013年第2期1卷 170-185页

作者： Bo Gao liwei zheng Department of Pathology University of Alabama at Birmingham Department of Orofacial Sciences University of California

Apical periodontitis, dominated by dense inflammatory infiltrates and increased osteoclast activities, can lead to alveolar bone destruction and tooth loss. It is believed that miRNA participates in regulating various biological processes, osteoclastogenesis included. This study aims to investigate the differential expression of miRNAs in rat apical periodontitis and explore their functional target genes. Microarray analysis was used to identify differentially expressed miRNAs in apical periodontitis. Bioinformatics technique was applied for predicting the target genes of differentially expressed miRNAs and their biological functions. The result provided us with an insight into the potential biological effects of the differentially expressed miRNAs and showed particular enrichment of target genes involved in the MAPK signaling pathways. These findings may highlight the intricate and specific roles of miRNA in inflammation and osteoclastogenesis, both of which are key aspects of apical periodontitis, thus contributing to the future investigation into the etiology, under- lying mechanism and treatment of apical periodontitis.

关键词： microRNA osteoclast apical periodontitis bone resorption alveolar bone

Fuzzy control decision-making framework adapted to the uncertainty environment of complex software system

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第2期13卷 168-186页

作者： Jingjing He liwei zheng Zhanqi Cui Computer School Beijing Information Science and Technology UniversityBeijing 100101China

As the system becomes more intelligent and embedded,the operating environment is gradually changed from closed,static,and controllable to more open,dynamic,and difficult to *** a result,the design of complex software systems is faced with many challenges arising from the uncertainty of the environment(UoE).On the one hand,ignoring the UoE to manually describe requirements is not only a tough job,but it can also hinder the discovery of potential requirements;on the other hand,it is a challenge to integrate the representation of and reasoning of UoE into the process of modeling complex *** on the analysis of the characteristics of complex systems engineering,this paper takes solving the UoE caused by stakeholders prefer-ences and complex environment context as the entry point and designs a fuzzy con-trol decision-making ***,the framework contributes to the spiral of complex systems while solving the UoE by constructing a closed-loop intelligent sys-tem based on automatic data flow between information space and physical space for environment sensing,uncertainty analysis,requirements mining,fuzzy reasoning,deci-sion execution as well as feedback ***,the framework is validated with a concrete example of an adaptive treadmill system based on the support tools developed.

关键词： UoE decision making fuzzy control

Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress

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维普期刊数据库

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International Journal of Oral Science 2020年第2期12卷 123-131页

作者： Wenjing Liu Yujia Cui Jieya Wei Jianxun Sun liwei zheng Jing Xie State Key Laboratory of Oral Diseases&National Clinical Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengdu China

Homoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks. Intercellular communication is largely mediated by gap junctions(GJs), a type of specialized membrane contact composed of variable number of channels that enable direct communication between cells by allowing small molecules to pass directly into the cytoplasm of neighbouring cells. Although considerable evidence indicates that gap junctions contribute to the functions of many organs, such as the bone, intestine, kidney, heart, brain and nerve, less is known about their role in oral development and disease. In this review, the current progress in understanding the background of connexins and the functions of gap junctions in oral development and diseases is discussed. The homoeostasis of tooth and periodontal tissues, normal tooth and maxillofacial development, saliva secretion and the integrity of the oral mucosa depend on the proper function of gap *** of this pattern of cell–cell communication is required for a better understanding of oral diseases. With the everincreasing understanding of connexins in oral diseases, therapeutic strategies could be developed to target these membrane channels in various oral diseases and maxillofacial dysplasia.

关键词： diseases organs intestine

Cell Cycle Arrest Protein CDKN2C Is Not an HBV Host Factor

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Virologica Sinica 2021年第4期36卷 810-813页

作者： Guiwen Guan liwei zheng Jingyuan Xi Xingwen Yang Xiangmei Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing 100044China Department of Microbiology&Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Dear Editor,Hepatitis B virus(HBV)infection remains a major cause of liver diseases worldwide,which affects approximately 250 million people globally(Yuen et al.2018).Individuals with chronic HBV infection are at high risk of developing liver cirrhosis,and ultimately hepatocellular carcinoma(HCC).HBV is a Hepadnavirus DNA virus,which specifically infects and efficiently replicates in *** has been proposed for decades that HBV replicates preferentially in non-dividing quiescent hepatocytes(Ozer et al.1996).

关键词： al. infection diseases

Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis

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Bone Research 2017年第3期5卷 177-194页

作者： Xin Xu Xiaoyue Jia Longyi Mo Chengcheng Liu liwei zheng Quan Yuan Xuedong Zhou State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Department of Periodontics West China Hospital of Stomatology Sichuan University Department of Pediatric Dentistry West China Hospital of Stomatology Sichuan University Department of Dental Implantology West China Hospital of Stomatology Sichuan University

Postmenopausal osteoporosis （PMO） is a prevalent metabolic bone disease characterized by bone loss and structural destruction, which increases the risk of fracture in postmenopausal women. Owing to the high morbidity and serious complications of PMO, many efforts have been devoted to its prophylaxis and treatment. The intestinal microbiota is the complex community of microorganisms colonizing the gastrointestinal tract. Probiotics, which are dietary or medical supplements consisting of beneficial intestinal bacteria, work in concert with endogenous intestinal microorganisms to maintain host health. Recent studies have revealed that bone loss in PMO is closely related to host immunity, which is influenced by the intestinal microbiota. The curative effects of probiotics on metabolic bone diseases have also been demonstrated. The effects of the intestinal microbiota on bone metabolism suggest a promising target for PMO management. This review seeks to summarize the critical effects of the intestinal microbiota and probiotics on PMO, with a focus on the molecular mechanisms underlying the pathogenic relationship between bacteria and host, and to define the possible treatment options.

关键词： PMO

Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation

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Bone Research 2017年第4期5卷 375-383页

作者： Wei Kuang liwei zheng Xin Xu Yao Lin Jiong Lin Jiahua Wu Jiali Tan Department of Stomatology Guangzhou General Hospital of Guangzhou Military Command State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Department of Orthodontics Guanghua School of Stomatology Hospital of Stomatology Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology

Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population. Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor （TNF）-a, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem ceils （BMSCs）, induces miR-146a and decreases Smad4. Moreover, overexpression of miR-146a inhibited the osteogenic ability of BMSCs, whereas blocking miR-146a partially rescued the osteogenesis deficiency under TNF-a treatment. Molecularly, miR-146a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 3＇-untranslated region, and restoration of Smad4 reversed the inhibitory effects of miR-146a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-ol inhibits osteogenesis via upregulation of miR-146a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of miR-146a maybe a potential strategy to improve osteogenesis in the context of osteoporosis.

关键词： BMSCs TNF

Effects of Brassinosteroid Associated with Auxin and Gibberellin on Apple Tree Growth and Gene Expression Patterns

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Horticultural Plant Journal 2019年第3期5卷 93-108页

作者： liwei zheng Cai Gao Caide Zhao Lizhi Zhang Mingyu Han Na An Xiaolin Ren College of Horticulture Northwest A&F University College of Life Science Northwest A & F University

Brassinosteroid is an important hormone that interacts with auxin and gibberellin to regulate plant growth and development. However,there is currently a relative lack of information regarding brassinosteroid in apple. Previous study confirmed that exogenous brassinosteroid treatments increased growth and endogenous brassinosteroid, auxin, as well as gibberellin levels of apple nursery trees. Here we succeeded to find that exogenous brassinosteroid treatments upregulated the transcript expression of auxin biosynthesis, transport, and positive signal transduction genes as well as gibberellin biosynthesis genes. In contrast, the application of exogenous brassinosteroid downregulated the expression of genes encoding negative regulators of auxin and gibberellin signal transductions. Rapid responses of several brassinosteroid-,auxin-, and gibberellin-related genes to the brassinosteroid and brassinazole treatments inferred the crosstalk of BR and IAA or GA. Furthermore,the expression levels of cell growth-related genes were also enhanced by exogenous brassinosteroid. Auxin and gibberellin treatments also influenced growth of apple tree and enhanced the expression of brassinosteroid-and cell growth-related genes. These results indicate that the growth of apple tree is regulated by the interaction between brassinosteroid, auxin, and gibberellin. Our work opened new avenues for deep portfolio of apple tree growth and laid the foundation for future studies aimed at elucidating the mechanisms regulating hormone interactionsmediated growth in apple trees.

关键词： Malus domestica Brassinosteroid Auxin Gibberellin Growth and development Gene expression

Transforming growth factor-β in stem cells and tissue homeostasis

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Bone Research 2018年第1期6卷 1-31页

作者： Xin Xu liwei zheng Quan Yuan Gehua Zhen Janet L.Crane Xuedong Zhou Xu Cao State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics West China Hospital of StomatologySichuan University State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry West China Hospital of Stomatology Sichuan University State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Implantology West China Hospital of Stomatology Sichuan University Department of Orthopedic Surgery Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University

TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β.

关键词： cells metastasis TGF-β1 ligand human lead can not

Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

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Nano-Micro Letters 2020年第8期12卷 184-212页

作者： Yujia Sun liwei zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082People’s Republic of China Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional GenomicsUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFL 32611USA Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicine and College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Institute of Cancer and Basic Medicine(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022People’s Republic of China Foundation for Applied Molecular Evolution 13709 Progress BoulevardAlachuaFL 32615USA

Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent *** are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical *** this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first ***,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building *** the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were ***,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.

关键词： Metal-organic frameworks Drugs Biomolecules Drug delivery Biomedical applications