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Association between vitamin D and hepatitis C virus infection: A meta-analysis

World Journal of Gastroenterology 2013年第35期19卷 5917-5924页

作者： livia melo villar José Antonio Del Campo Isidora Ranchal Elisabeth Lampe Manuel Romero-Gomez Laboratory of Viral Hepatitis Oswaldo Cruz Institute Fiocruz Rio de Janeiro RJ 210360-040 Brazil Unit for the Clinical Management of Digestive Diseases and CIBERehd Hospital Universitario de Valme41014 SevillaSpain

AIM:To evaluate the association between 25-hydroxyvitamin D[25(OH)D]and sustained virological response(SVR)in hepatitis C virus(HCV)infected individuals.METHODS:Relevant studies were identified by systematically searching MEDLINE databases up to March2012 and abstracts of the European and American Congress of Hepatology conducted in 2011.Studies must provide information on SVR and the levels of 25(OH)D3and/or 25(OH)D2[henceforth referred to as 25(OH)D]in sera samples from HCV infected individuals.The inclusion criteria were:clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group;provided information on SVR rates;and were reported in the English languageas full papers.Due to the heterogeneity of studies in categorizing serum vitamin D levels,a cut-off value of30 ng/mL of serum 25(OH)D was used.Heterogeneity was assessed using I2statistics.The summary odds ratios with their corresponding 95%CI were calculated based on a random-effects model.RESULTS:Overall,11 studies(8 observational and 3interventional)involving 1575 individuals were included and 1117 HCV infected individuals(71%)showed low vitamin D levels.Most of the studies included monoinfected HCV individuals with the mean age ranging from 38 to 56 years.Four studies were conducted in human immunodeficiency virus/HCV infected individuals.Regarding vitamin D measurement,most of the studies employed radioimmunoassays(n=5)followed by chemiluminescence(n=4)and just one study employed high performance/pressure liquid chromatography(HPLC).Basal vitamin D levels varied from 17 to43 ng/mL in the studies selected,and most of the HCV infected individuals had genotype 1(1068/1575)with mean viral load varying from log 4.5-5.9 UI/mL.With regard to HCV treatment,most of the studies(n=8)included HCV individuals without previous treatment,where the pooled SVR rate was 46.4%.High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL(OR=1.57;95%CI:1.12-2.2)and those supplemented with v

关键词： Vitamin D Hepatitis C Therapy Metaanalysis Sustained virological response

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Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil

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World Journal of Hepatology 2018年第11期10卷 867-876页

作者： Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez livia melo villar Laboratory of Viral HepatitisOswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazi Postgraduate Program in Pathology Federal University of Ceará Fortaleza Ceará 60020181 Brazil Postgraduate Program in Medical Sciences University of Fortaleza Ceará 60430160 Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazil Institute of Communication and Scientifc Information and Technology for Health Oswaldo Cruz Foundation Rio de Janeiro 21040900 Brazil Laboratory of Epidemiology and Molecular Systematics Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040900 Brazil Orientation and Counselling Centre Curitiba Paraná 80810070 Brazil

AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as "low"(0-28 correct answers) or "desirable"(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas.

关键词：病毒性肝炎治疗方法临床分析肝病

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Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations

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World Journal of Hepatology 2021年第4期13卷 504-514页

作者： Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Custódio Miguel Denise Vigo Potsch JoséHenrique Pilotto Danielle Malta Lima JeováKeny Baima Colares Carlos Eduardo Brandão-Mello Marcia Maria Amendola Pires Jurema Corrêa da Mota Francisco I Bastos Lia Laura Lewis-Ximenez livia melo villar Viral Hepatitis Laboratory FIOCRUZRio de Janeiro 21040360Brazil Postgraduate Program in Pathology Federal University of CearáFortaleza 60020181CearaBrazil Clementino Fraga Filho Hospital Federal University of Rio de JaneiroRio de Janeiro 21040360Brazil Nova Iguaçu General Hospital Nova Iguaçu 26041061Brazil Molecular Immunology Laboratory Oswaldo Cruz InstituteRio de Janeiro 21040360Brazil Postgraduate Program in Medical Sciences University of FortalezaFortaleza 60811905CearáBrazil Escola de Medicina e Cirurgia Gaffrée&Guinle University HospitalFederal University of Rio de Janeiro StateRio de Janeiro 20270901Brazil Institute of Communication and Information on Science and Technology in Health FIOCRUZRio de Janeiro 21040360Brazil

BACKGROUND To achieve the elimination of hepatitis B and C,there is an urgent need to develop alternative strategies to increase the access of diagnosis,particularly among key populations such as people living with human immunodeficiency virus(HIV),individuals with coagulopathies and chronic kidney disease(CKD)patients.AIM To evaluate the use of dried blood spot(DBS)in the detection of hepatitis B virus(HBV)and hepatitis C virus(HCV)markers.METHODS A total of 430 individuals comprised of people living with HIV,coagulopathies and CKD provided paired serum and DBS samples.HBsAg,anti-HBc and anti-HCV were tested in those samples using a commercial electrochemiluminescence.Demographic and selected behavioral variables were evaluated to assess possible association with HBV and HCV positivity.RESULTS Using DBS,HBsAg prevalence varied from 3.9%to 22.1%,anti-HBc rates varied from 25.5%to 45.6%and anti-HCV positivity ranged from 15.9%to 41.2%in key populations.Specificities of HBV and HCV tests using DBS varied from 88.9%to 100%.The HBsAg assay demonstrated the best performance in CKD and coagulopathy individuals and the anti-HCV test had a sensitivity and specificity of 100%in people living with HIV.Accuracy of HBV and HCV detection in DBS varied from 90.2%to 100%.In the CKD group,HBsAg positivity was associated with infrequent use of condoms,and anti-HBc positivity was associated with sharing nail cutters/razors/toothbrushes.Anti-HCV reactivity was positively associated with a history of transplantation and length of time using hemodialysis in both specimens.In people living with HIV,only the male gender was associated with anti-HBc positivity in serum and DBS.CONCLUSION DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.

关键词： Dried blood spot Electrochemiluminescence Hepatitis B Hepatitis C Key populations Diagnosis

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Update on hepatitis B and C virus diagnosis

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World Journal of Virology 2015年第4期4卷 323-342页

作者： livia melo villar Helena Medina Cruz Jakeline Ribeiro Barbosa Cristianne Sousa Bezerra Moyra Machado Portilho Letícia de Paula Scalioni Viral Hepatitis Laboratory Oswaldo Cruz Institute Oswaldo Cruz Foundation

Viral hepatitis B and C virus(HBV and HCV) are responsible for the most of chronic liver disease worldwide and are transmitted by parenteral route, sexual and vertical transmission. One important measure to reduce the burden of these infections is the diagnosis of acute and chronic cases of HBV and HCV. In order to provide an effective diagnosis and monitoring of antiviral treatment, it is important to choose sensitive, rapid, inexpensive, and robust analytical methods. Primary diagnosis of HBV and HCV infection is made by using serological tests for detecting antigens and antibodies against these viruses. In order to confirm primary diagnosis, to quantify viral load, to determine genotypes and resistance mutants for antiviral treatment, qualitative and quantitative molecular tests are used. In this manuscript, we review the current serological and molecular methods for the diagnosis of hepatitis B and C.

关键词： Diagnostic methods Genotypes Hepatitis B virus Molecular diagnostic techniques Serological tests Hepatitis C virus

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