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Relationship between maternal pathology and infant social withdrawal: Analysis of a 268-outpatient population

Open Journal of Psychiatry 2013年第3期3卷 311-315页

作者： Maria Lucia Maulucci Vincenzo Currò Silvia Maulucci Emilia de Rosa livia de giovanni department of Neuroscience Catholic University Hospital Rome Italy Statistic department Lumsa University Rome Italy

Objective: Sustained withdrawal is a sign of infant distress and may be determined by extreme conditions like organic pathology or relationship problems. The Alarm Distress Baby Scale is the best instrument to identify withdrawal in infants between 2 and 24 months of age. The aim of this study was to assess the association between infant social withdrawal behavior and maternal pathology in the perinatal period. Method: The target sample of the study was 134 mother-child couples examined at the Policlinico Agostino Gemelli General Pediatric Outpatient Clinic and Psychiatric Outpatient Clinic, in Rome. We analyzed the relationship between withdrawal behavior and psychological and organic prenatal/postnatal pathology, using the Chi Square exact test. Results: When the mother suffers from both organic and psychological pathologies in the perinatal period, the risk of withdrawal is increased: the probability of infant withdrawal behavior is increased by maternal organic postnatal pathology by 14 times, by maternal psychological postnatal pathology by 9 times, and by maternal psychological postnatal depression, measured by Edinburgh Postnatal depression Scale, by almost 4 times. Conclusion: Increased or sustained withdrawal reactions can be observed in unsatisfactory mother-child interaction. Maternal risk factors should be strictly considered in the pediatric clinical evaluation.

关键词： Maternal Pathology Infant Social Withdrawal Early Prevention Alarm Distress Baby Scale

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Keratinous and corneous-based products towards circular bioeconomy: A research review

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Environmental Science and Ecotechnology 2024年第6期22卷 25-37页

作者： giovanni Davide Barone Irene Tagliaro Rodrigo Oliver-Simancas Matteo Radice livia M.Kalossaka Michele Mattei Antonino Biundo Isabella Pisano Amparo Jiménez-Quero Institute of Biology University of Graz8010GrazAustria department of Materials Science University of Milano-Bicocca20126MilanoItaly Division of Industrial Biotechnology Department of Life SciencesChalmers University of TechnologyGothenburg41296Sweden department of Biosciences Biotechnology and BiopharmaceuticsUniversity of Bari Aldo MoroVia E.Orabona470125BariItaly department of Chemistry Molecular Sciences Research HubImperial College LondonW120BZ LondonUnited Kingdom Libera UniversitàInternazionale degli Studi Sociali“Guido Carli” I-00198RomeItaly CIRCC-Interuniversity Consortium Chemical Reactivity and Catalysis Via C.Ulpiani 2770126BariItaly

Keratins and corneous proteins are key components of biomaterials used in a wide range of applications and are potential substitutes for petrochemical-based products. Horns, hooves, feathers, claws, and similar animal tissues are abundant sources of α-keratin and corneous β-proteins, which are by-products of the food industry. Their close association with the meat industry raises environmental and ethical concerns regarding their disposal. To promote an eco-friendly and circular use of these materials in novel applications, efforts have focused on recovering these residues to develop sustainable, non-animal-related, affordable, and scalable procedures. Here, we review and examine biotechnological methods for extracting and expressing α-keratins and corneous β-proteins in microorganisms. This review highlights consolidated research trends in biomaterials, medical devices, food supplements, and packaging, demonstrating the keratin industry's potential to create innovative value-added products. Additionally, it analyzes the state of the art of related intellectual property and market size to underscore the potential within a circular bioeconomic model.

关键词： Alpha-keratin Corneous beta-protein Environmentally sustainable technology Biotechnology Resource recovery

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Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study

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World Journal of Clinical Cases 2019年第17期7卷 2463-2476页

作者： Francesco Giudici Letizia Lombardelli Edda Russo Tiziana Cavalli Daniela Zambonin Federica Logiodice Ornela Kullolli Lamberto Giusti Tatiana Bargellini Marilena Fazi livia Biancone Stefano Scaringi Ann Maria Clemente Eloisa Perissi giovanni delfino Maria G Torcia Ferdinando Ficari Francesco Tonelli Marie-Pierre Piccinni Cecilia Malentacchi department of Experimental and Clinical Medicine University of FirenzeFirenze 50134Italy Dipartimento Chirurgico Ortopedico Ospedale Carlo Poma di MantovaFirenze 50134Italy department of Experimental and Clinical Biomedical Sciences “Mario Serio” University of FirenzeFirenze 50134Italy Surgical Unit Department of Surgery and Translational MedicineUniversity of FirenzeFirenze 50134Italy department of Internal Medicine University of Roma Tor VergataRoma 00133Italy

BACKGROUND Crohn’s disease (CD) is a complex disorder resulting from the interaction of genetic,environmental,and microbial *** pathogenic process may potentially affect any segment of the gastrointestinal tract,but a selective location in the terminal ileum was reported in 50% of *** To characterize clinical sub-phenotypes (colonic and/or ileal) within the same disease,in order to identify new therapeutic *** 14 consecutive patients undergoing surgery for ileal CD were recruited for this *** blood samples from each patient were collected and the main polymorphisms of the gene Card15/Nod2 (R702W,G908R,and 1007fs) were analyzed in each *** addition,tissue samples were taken from both the tract affected by CD and from the apparently healthy and disease-free margins (internal controls).We used a multiplex gene assay in specimens obtained from patients with ileal localization of CD to evaluate the simultaneous expression of 24 genes involved in the pathogenesis of the *** also processed surgery gut samples with routine light microscopy (LM) and transmission electron microscopy (TEM) techniques to evaluate their structural and ultrastructural *** We found a significant increase of Th17 (IL17A and IL17F,IL 23R and CCR6) and Th1 (IFN-γ) gene expression in inflamed mucosa compared to non-inflamed sites of 14 CD ***4 and HAMP,two genes coding for antimicrobial peptides,were also strongly activated in inflamed ileal mucosa,suggesting the overwhelming stimulation of epithelial cells by commensal ***-γ and CCR6 were more expressed in inflamed mucosa of CD patients with ileal localization compared with patients with colonic localization suggesting a more aggressive inflammation process in this *** analysis of the epithelial lining of Lieberkün crypts disclosed enhanced release activity from goblet mucocytes,whereas the lamina propria contained numerous cells pertaining to vari

关键词： Crohn's disease Ileum Colon Messenger ribonucleic acid Th1/Th17 Microbiota Inflammation

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Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease

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World Journal of Gastroenterology 2012年第42期18卷 6088-6095页

作者： Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri giovanni Simonetti Francesco Pallone livia Biancone department of Systems Medicine University "Tor Vergata"00133 RomeItaly department of Surgery University "Tor Vergata"00133 RomeItaly Radiology Unit Department of ImagingUniversity "Tor Vergata"00133 RomeItaly Pathology Unit University "Tor Vergata"00133 RomeItaly

AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold ***:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively *** patients were under *** study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed *** and CTE were performed ≤ 3 mo before surgery,followed by surgical *** following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel *** between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold ***:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal *** analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients *** from CTE,SICUS was feasible in all the 15 patients *** complications were observed when using SICUS or *** pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 *** order to compare fi

关键词： Crohn's disease Ileal lesions Computed tomography enteroclysis Small intestine contrast ultrasonography Surgical findings

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