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Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

Gastroenterology Report 2022年第1期10卷 90-107页

作者： carolina Gubert Juciano Gasparotto livia H.Morais Florey Institute of Neuroscience and Mental Health Melbourne Brain CentreUniversity of MelbourneParkvilleVictoriaAustralia Instituto de Ciencias Biomedicas Universidade Federal de AlfenasRua Gabriel Monteiro da SilvaAlfenasMinas GeraisBrasil Division of Biology&Biological Engineering California Institute of TechnologyPasadenaCAUSA

Recent research has been uncovering the role of the gut microbiota for brain health and *** studies highlight the role of gut microbiota on regulating brain function and behavior through immune,metabolic,and neuronal *** this review we provide an overview of the gut microbiota axis pathways to lay the groundwork for upcoming sessions on the links between the gut microbiota and neurogenerative *** also discuss how the gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and *** on the current literature,we further examine the potential for different microbiota-based therapeutic strategies to prevent,to modify,or to halt the progress of neurodegeneration.

关键词： gut microbiota-brain axis neurodegeneration inflammation microbial metabolism gut microbiota

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Effects of Probiotic Lactobacillus gasseri Strains of Breast-Fed Infant in a Murine Model

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Journal of Food Science and Engineering 2014年第6期4卷 271-281页

作者： Maria da Penha Piccolo Ramos Joao Alexandre Tres Pancoto Iracilda Zeppone Carlos rogeria Comastri deCastro Almeida Danielle Cardoso Geraldo Maia livia carolina de.abre. ribe.ro Femanda Paulin Benzatti Luciana rodrigues Cunha Aline Costa e Silva Celia Lucia de Luces Fortes Ferreira departamento de Ciencias da Saude Universidade Federal do Espirito Santo S6o Mateus Espirito Santo CEP. 29.932-540 Brazil Laboratorio de Imunonologia Clinica Universidade Estadual Paulista Faculdade de Ciencias Farmaceuticas Araraquara Sao Paulo CEP: 14.801-902 Brazil departamento de Ciencia dos Alimentos Universidade Federal da Bahia Eseola de Nutricao Salvador Bahia CEP. 40.110-160 Brazil departamento de Tecnologia de Alimentos Universidade Federal de Ouro Preto Ouro Preto Minas Gerais CEP: 35.400-970 Brazil departamento de Tecnologia de Alimentos Universidade Federal de Vigosa Vigosa Minas Gerais CEP: 36.570-000 Brazil

The ingestion of probiotic lactic acid bacteria has been evaluated and noted that it has an effect on the balance of desirable microbiota in the gastrointestinal tract. Lactobacillus gasseri demonstrates good survival in the gastrointestinal tract, and it has been associated with a variety of probiotic activities and roles, including the reduction of fecal mutagenic enzymes, the production of bacteriocins and the stimulation of macrophages immunomodulation. The aim of the study was to evaluate the effects of a pool of L. gasseri strains isolated from the feces of breastfed infants added in the human milk of healthy women. The milk was both pasteurized and unpasteurized, to verify the cell cytotoxicity of macrophages and to quantify the production of immunologic mediators such as IL-4, IL-6, IFN-γ, TNF-α, NO and oxygen intermediary compounds （H2O2）. The administration of raw human milk and pasteurized human milk to infants is a regular, encouraged practice in units of intensive therapy （UITs） and our present investigation verified the beneficial effect of addition of a pool of L. gasseri to pasteurized human milk （PHML）. Our results show that probiotic supplementation helped to maintain cell viability, reduced IL-6 and IFN-γ production and stimulated TNF-α, NO, H2O2, IL-4 production. Nevertheless, the results indicate that the addition of lactobacillus to human milk was not a determinant in the production of TNF-α. L. gasseri added to breast milk did not present a cytotoxic risk, and the addition ofL. gasseri to pasteurized milk of human milk bank would benefit newborns that depend on milk banks for the colonization of more desirable microbiota.

关键词： Probiotic human milk bank immunology Lactobacillus gasseri.

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