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Genes & Diseases 2022年第6期9卷 1478-1492页

作者： Jianjian Li Zhe Ming liuyi yang Tingxuan Wang Gaowen Liu Qing Ma Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsCAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055PR China

Sexual dimorphism has been reported in various human diseases including autoimmune diseases,neurological diseases,pulmonary arterial hypertension,and some types of cancers,although the underlying mechanisms remain poorly *** long noncoding RNA(lncRNA)X-inactive specific transcript(XIST)is involved in X chromosome inactivation(XCI)in female placental mammals,a process that ensures the balanced expression dosage of X-linked genes between *** is abnormally expressed in many sex-biased *** addition,escape from XIST-mediated XCI and skewed XCI also contribute to sex-biased ***,its expression or modification can be regarded as a biomarker for the diagnosis and prognosis of many sex-biased *** manipulation of XIST expression can inhibit the progression of some of these diseases in animal models,and therefore XIST has been proposed as a potential therapeutic *** this manuscript,we summarize the current knowledge about the mechanisms for XIST-mediated XCI and the roles of XIST in sex-biased diseases,and discuss potential therapeutic strategies targeting XIST.

关键词： Epigenetic regulation Long noncoding RNA Sex-biased diseases X chromosome inactivation XIST

Induction ofγ-aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae^°°

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Journal of Integrative Plant Biology 2020年第11期62卷 1797-1812页

作者： Xiangxiong Deng Xuwen Xu Yu Liu Yan Zhang liuyi yang Shuqun Zhang Juan Xu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Division of Biochemistry University of MissouriColumbiaMissouri 65211USA

Gamma-aminobutyric acid(GABA)is an important metabolite which functions in plant growth,development,and stress ***,its role in plant defense and how it is regulated are largely ***,we report a detailed analysis of GABA induction during the resistance response to Pseudomonas syringae in Arabidopsis *** searching for the mechanism underlying the pathogen-responsive mitogenactivated protein kinase(MPK)3/MPK6 signaling cascade in plant immunity,we found that activation of MPK3/MPK6 greatly induced GABA biosynthesis,which is dependent on the glutamate decarboxylase genes GAD1 and *** with Pseudomonas syringae pv tomato DC3000(Pst)and Pst-avrRpt2 expressing the civrRpt2 effector gene induced GACH and GAD4 gene expression and increased the levels of *** evidence revealed that GAD1,GAD2,and GAD4 play important roles in bothGABA biosynthesis and plant resistance in response to Pst-avrRpt2 *** gad1/2/4 triple and gad1/2/4/5 quad-ruple mutants,in which the GABA levels were extremelylow,were more susceptible to both Pst and *** loss of MPK3/MPK6,or their upstream MKK4/MKK5,or their downstream substrate WRKY33 sup-pressed the induction of GAD1 and GAD4 expression afterPst-avrRpt2 *** findings shed light on both theregulation and role of GABA in the plant immunity to abacterial pathogen.

关键词： resistance Arabidopsis immunity

Co-regulation of indole glucosinolates and camalexin biosynthesis by CPK5/CPK6 and MPK3/MPK6 signaling pathways^°°

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Journal of Integrative Plant Biology 2020年第11期62卷 1780-1796页

作者： liuyi Vang Yan Zhang Rongxia Guan Sen Li Xuwen Xu Shuqun Zhang Juan Xu State Key Lab oratory of Plant Physiology and Biochem istry College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Division of Biochemistry University of MissouriColumbiaMO 65211USA

Secondary plant metabolites,represented by indole glucosinolates(IGS)and camalexin,play important roles in Arabidopsis ***,we demonstrated the importance of MPK3 and MPK6,two closely related MAPKs,in regulating Botrytis cinerea(Bc)-induced IGS and camalexin *** we report that CPK5 and CPK6,two redundant calcium-dependent protein kinases(CPKs),are also involved in regulating the biosynthesis of these secondary *** loss-of-function of both CPK5 and CPK6 compromises plant resistance to *** profiling of CPK5-VK transgenic plants,in which a truncated constitutively active CPK5 is driven by a steroidinducible promoter,revealed that biosynthetic genes of both IGS and camalexin pathways are coordinately upregulated after the induction of CPK5-VK,leading to high-level accumulation of camalexin and 4-methoxyindole-3-ylmethylglucosinolate(4MI3G).Induction of camalexin and 4MI3G,as well as the genes in their biosynthesis pathways,is greatly compromised in cpks cpk6 mutant in response to *** a conditional cpk5 cpk6 mpk3 mpk6 quadruple mutant,Be resistance and induction of IGS and camalexin are further reduced in comparison to either cpks cpk6 or conditional mpk3 mpk6 double mutant,suggesting that both CPK5/CPK6 and MPK3/MPK6 signaling pathways contribute to promote the biosynthesis of 4MI3G and camalexin in defense against Be.

关键词： indole coordinate constitutive

Sporophytic control of anther development and male fertility by glucose-6-phosphate/phosphate translocator 1(OsGPT1) in rice

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Journal of Genetics and Genomics 2021年第8期48卷 695-705页

作者： Aili Qu Yan Xu Xinxing Yu Qi Si Xuwen Xu Changhao Liu liuyi yang Yueping Zheng Mengmeng Zhang Shuqun Zhang Juan Xu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China Department of Plant Pathology College of Plant ProtectionNanjing Agricultural UniversityNanjingJiangsu 210095China Division of Biochemistry University of MissouriColumbiaMO 65211USA

Coordination between the sporophytic tissue and the gametic pollen within anthers is tightly controlled to achieve the optimal pollen fitness. Glucose-6-phosphate/phosphate translocator(GPT) transports glucose-6-phosphate, a key precursor of starch and/or fatty acid biosynthesis, into plastids. Here, we report the functional characterization of Os GPT1 in the rice anther development and pollen fertility. Pollen grains from homozygous osgpt1 mutant plants fail to accumulate starch granules, resulting in pollen sterility. Genetic analyses reveal a sporophytic effect for this mutation. Os GPT1 is highly expressed in the tapetal layer of rice anther. Degeneration of the tapetum, an important process to provide cellular contents to support pollen development, is impeded in osgpt1 plants. In addition, defective intine and exine are observed in the pollen from osgpt1 plants. Expression levels of multiple genes that are important to tapetum degeneration or pollen wall formation are significantly decreased in osgpt1 anthers. Previously, we reported that At GPT1 plays a gametic function in the accumulation of lipid bodies in Arabidopsis pollen. This report highlights a sporophytic role of Os GPT1 in the tapetum degeneration and pollen development. The divergent functions of Os GPT1 and At GPT1 in pollen development might be a result of their independent evolution after monocots and dicots diverged.

关键词： Glucose-6-phosphate/phosphate translocator Male fertility Starch accumulation Sporophytic control Pollen development Tapetum degeneration Intine and exine formation Rice

Is Compulsory School a Heaven or a Hell?

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Journal of Educational Theory and Management 2019年第2期3卷 43-45页

作者： liuyi yang Yujie Liu Northeast Normal University ChangchunJilin130024China Harbin University HarbinHeilongjiang150086China

With the development of education and the society revolution,in the last few years,the word“freedom”has been discussed intensely,and the debates on some items like human rights,racial discrimination and political liberty have never *** the same time,the discussion of freedom in the field of education is also *** article quotes Lynda Barry and John Taylor Gatto’s paper,clearly analyzing the effect of compulsory education through 3 aspects:national identity,creative approach and personal psychology.

关键词： Compulsory education Human rights Education wisdom Educational equity

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查阜西古琴美学思想及其时代价值探赜

河南师范大学学报（哲学社会科学版） 2021年第5期48卷 149-156页

作者：杨浏祎杨光钦中央音乐学院音乐学系北京100031 郑州大学教育学院河南郑州450001

查阜西是20世纪中国历史上最卓越的古琴艺术家之一。他的卓越源于他在推进古琴艺术发展过程中形成的特定美学思想及其时代价值,也源于他早年有缘加入中国共产党及其服务于人民大众的共产主义信仰。查阜西的古琴美学思想,祛魅古琴艺术的... 详细信息

查阜西是20世纪中国历史上最卓越的古琴艺术家之一。他的卓越源于他在推进古琴艺术发展过程中形成的特定美学思想及其时代价值,也源于他早年有缘加入中国共产党及其服务于人民大众的共产主义信仰。查阜西的古琴美学思想,祛魅古琴艺术的神秘色彩,进而为古琴艺术黜雅还俗的功能定位、移情正心的人格省思、雅俗共赏的人民情怀,以及政教风化的时代传承等做了深度的价值功能阐释。由此出发,也为直接推动古琴艺术置入人民之中,并促使其彰显新时代的美学价值意蕴,提供了难能可贵的思想财富。

关键词：查阜西古琴艺术美学思想时代价值

基于单胞有限元模型的织物复合材料弯曲刚度预报

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复合材料学报 2018年第5期35卷 1192-1202页

作者：杨留义谭惠丰曹宗胜哈尔滨工业大学航天学院哈尔滨150080

织物复合材料沿厚度方向纤维束分布不均匀,当层数较少时,采用工程常数得到的弯曲刚度与试验值偏差较大。为提高弯曲刚度预报精度,采用凸透镜状截面假设和周期性三次贝塞尔函数描述纤维束几何模型,建立了一种可直接计算织物复合材料弯曲... 详细信息

织物复合材料沿厚度方向纤维束分布不均匀,当层数较少时,采用工程常数得到的弯曲刚度与试验值偏差较大。为提高弯曲刚度预报精度,采用凸透镜状截面假设和周期性三次贝塞尔函数描述纤维束几何模型,建立了一种可直接计算织物复合材料弯曲刚度的单胞有限元模型。根据弯曲与扭曲情况下的周期性位移边界条件,结合六面体体素网格划分方法,给出了非均匀分布周期性位移边界条件的约束方程,并基于ABAQUS平台实现了约束方程的逐点施加。开展了拉伸、四点弯曲及悬臂薄板弯曲试验。结果表明:所建立的单胞有限元模型可准确预报织物复合材料的弯曲刚度;对于悬臂薄板弯曲构型预测,相比采用工程常数得到的结果,采用本文预报的弯曲刚度作为输入条件时,分析结果与试验吻合更好。

关键词：织物复合材料弯曲刚度单胞有限元法周期性边界条件

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高校思想政治教育审美化叙事的生成与优化

江苏高教 2024年第2期 89-96页

作者：裴晓敏杨浏祎郑州大学马克思主义学院郑州450001 郑州大学政治与公共管理学院郑州450001

作为思想政治教育的一种新形式,高校思想政治教育审美化叙事是指高校思想政治教育者借助审美化的叙事形式,契合受教育者的审美心理需求,并将思想政治教育系统化、概念化、抽象化的知识性内容转化为可观、可感、可欣赏的感性体验的教育... 详细信息

作为思想政治教育的一种新形式,高校思想政治教育审美化叙事是指高校思想政治教育者借助审美化的叙事形式,契合受教育者的审美心理需求,并将思想政治教育系统化、概念化、抽象化的知识性内容转化为可观、可感、可欣赏的感性体验的教育形式。高校思想政治教育审美化叙事可以让受教育者在沉浸式的学习体验中感受教育事件的温度,增强对思想政治教育的认同感。解读高校思想政治教育审美化叙事的理论内涵和价值意蕴,探寻高校思想政治教育审美化叙事的生成逻辑与优化思路,对彰显思想政治教育效能具有现实意义。

关键词：思想政治教育审美化叙事生成逻辑优化策略

制度变迁与规则流变:普及后阶段我国高校的生存境遇及可能演化

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江苏高教 2022年第4期 36-43页

作者：罗志敏杨浏祎郑州大学教育学院郑州450001 中央音乐学院音乐学系北京100031

进入高等教育普及化深入发展阶段即“普及后阶段”后,中国高校在迎来发展机遇的同时也会面临不同的生存挑战。基于制度变迁理论,当外生条件发生变化时,高校的生存博弈规则将会发生流变:一是政府以重构财政安排转移财政压力,将会重塑高... 详细信息

进入高等教育普及化深入发展阶段即“普及后阶段”后,中国高校在迎来发展机遇的同时也会面临不同的生存挑战。基于制度变迁理论,当外生条件发生变化时,高校的生存博弈规则将会发生流变:一是政府以重构财政安排转移财政压力,将会重塑高校财政经费配置格局;二是生源规模状况的转变,将倒逼高校实现市场博弈中的供需角色互换;三是以人工智能为代表的现代技术革新大潮,将打破传统高校的发展格局。而以上流变又会使高校在此非均衡的外生条件下持续地进行组织演化,具体呈现为高校的不同生存境遇以及由此而来的不同发展态势(发展壮大或衰落、消亡)。为此,无论是主管机构还是高校都应未雨绸缪,针对今后可能出现的问题,积极采取防范与应对措施。

关键词：普及后阶段高校制度变迁博弈规则组织演化生存境遇

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浅析西方古典建筑竖向构图的一般规律

中外建筑 2019年第1期 33-35页

作者：杨刘毅华侨大学建筑学院

西方古典建筑作为西方建筑发展史的重要组成部分,其蕴含的形式美学基础一直被后世所推崇和模仿。本文从历史的维度,分析西方古典建筑在竖向构图的一般规律,以期对现代建筑创作提供借鉴和反思。

关键词：西方古典建筑构图规律建筑创作