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A mosquito mouthpart-like bionic neural probe

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Microsystems & Nanoengineering 2023年第4期9卷 77-90页

作者： Yu Zhou Huiran Yang Xueying Wang Heng Yang Ke sun Zhitao Zhou liuyang sun Jianlong Zhao Tiger H.Tao Xiaoling Wei State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina School of Graduate Study University of Chinese Academy of Sciences100049 BeijingChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031 ShanghaiChina Neuroxess Co. Ltd.(Jiangxi)330029 NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology Hengqin519031 ZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

Advancements in microscale electrode technology have revolutionized the field of neuroscience and clinicalapplications by offering high temporal and spatial resolution of recording and stimulation. Flexible neural probes, withtheir mechanical compliance to brain tissue, have been shown to be superior to rigid devices in terms of stability andlongevity in chronic recordings. Shuttle devices are commonly used to assist flexible probe implantation;however, theprotective membrane of the brain still makes penetration difficult. Hidden damage to brain vessels duringimplantation is a significant risk. Inspired by the anatomy of the mosquito mouthparts, we present a biomimeticneuroprobe system that integrates high-sensitivity sensors with a high-fidelity multichannel flexible electrode *** customizable system achieves distributed and minimally invasive implantation across brain regions. Mostimportantly, the system’s nonvisual monitoring capability provides an early warning detection for intracranial softtissues, such as vessels, reducing the potential for injury during implantation. The neural probe system demonstratesexceptional sensitivity and adaptability to environmental stimuli, as well as outstanding performance in postoperativeand chronic recordings. These findings suggest that our biomimetic neural-probe device offers promising potential forfuture applications in neuroscience and brain-machine interfaces.

关键词： neural implantation recording

A silk-based self-adaptive flexible opto-electro neural probe

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Microsystems & Nanoengineering 2022年第6期8卷 85-96页

作者： Yu Zhou Chi Gu Jizhi Liang Bohan Zhang Huiran Yang Zhitao Zhou Meng Li liuyang sun Tiger H.Tao Xiaoling Wei State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina School of Graduate Study University of Chinese Academy of Sciences100049 BeijingChina School of Physical Science and Technology ShanghaiTech University200031 ShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031 ShanghaiChina Neuroxess Co. Ltd.(Jiangxi)330029 NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology Hengqin519031 ZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits,which provides a promising approach for the study of progressive neurophysiological ***-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable ***,lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less ***,we report a hybrid probe(Silk-Optrode)consisting of a silk protein optical fiber and multiple flexible microelectrode *** Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving *** plays an important role due to its high transparency,excellent biocompatibility,and mechanical *** the hydration of the silk optical fiber,the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding *** probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses,surpassing previous work of a similar *** months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions.

关键词： neural recording implantation

Through-polymer,via technology-enabled,flexible,lightweight,and integrated devices for implantable neural probes

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Microsystems & Nanoengineering 2024年第2期10卷 279-291页

作者： Cunkai Zhou Ye Tian Gen Li Yifei Ye Lusha Gao Jiazhi Li Ziwei Liu Haoyang Su Yunxiao Lu Meng Li Zhitao Zhou Xiaoling Wei Lunming Qin Tiger H.Tao liuyang sun College of Electronics and Information Engineering Shanghai University of Electric PowerShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina School of Graduate Study University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Neuroxess Co. Ltd.(Jiangxi)NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology HengqinZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal *** advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated *** conventional approach adds considerable weight and volume to the package,especially for high channel count *** address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional *** innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without ***,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action *** findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.

关键词： alloy neural recording

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既有简支薄壁C形钢檩条连续化加固研究

建筑结构学报 2021年第12期42卷 101-112页

作者：黄炳生冯方涛孙留洋王鹏南京工业大学土木工程学院江苏南京211816 同圆设计集团有限公司山东济南250101 南京工大建设工程技术有限公司江苏南京210009

为提高既有简支薄壁C形钢檩条的承载能力,对相邻简支C形钢檩条在支座附近采用内嵌薄壁L形钢连接成为连续檩条。对仅腹板有螺钉连接和腹板及上、下翼缘均有螺钉连接的2组加固C形钢檩条进行静力加载试验,分析了加固后檩条的破坏模态、刚... 详细信息

为提高既有简支薄壁C形钢檩条的承载能力,对相邻简支C形钢檩条在支座附近采用内嵌薄壁L形钢连接成为连续檩条。对仅腹板有螺钉连接和腹板及上、下翼缘均有螺钉连接的2组加固C形钢檩条进行静力加载试验,分析了加固后檩条的破坏模态、刚度、延性、承载能力及应变发展,并与简支C形钢檩条的受力性能进行了对比。试验结果表明:加固试件的两跨檩条以整体弯曲变形为主,C形钢檩条跨中和加载处上翼缘与受压区腹板发生局部屈曲而破坏,薄壁L形钢翼缘达到屈服。简支檩条连续化加固后的承载能力、刚度均有显著提高,延性提高较小。腹板及上下翼缘均有螺钉连接加固檩条的刚度和屈服荷载提高幅度明显高于仅腹板螺钉连接加固,但两者极限荷载和延性差别较小。采用三线性钢材本构模型和壳单元,建立了同时考虑几何非线性和材料非线性的三维有限元模型进行数值模拟,计算结果与试验结果的对比验证了有限元模型的准确性。分析了不同薄壁L形钢长度对加固檩条受力性能的影响,结果表明,薄壁L形钢长度的增加对承载能力、刚度的提高幅度由大变小,刚度的提高幅度大于承载能力的提高幅度,薄壁L形钢长度宜取檩条单跨跨度的10%~15%。

关键词：简支薄壁C形钢檩条连续化加固自攻螺钉连接静力试验有限元分析受力性能

Linear Infinite Horizon Quadratic Differential Games for Stochastic Systems:Discrete-Time Case

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Linear Infinite Horizon Quadratic Differential Games for Sto...

2011 Chinese Control and Decision Conference（CCDC）

作者： Huiying sun,liuyang Jiang are with the College of Information and Electrical Engineering,Shandong University of Science and Technology,Qingdao 266510,China

This paper deals with the infinite horizon linear quadratic （LQ） differential games for discrete-time stochastic systems with both state and control dependent *** Popov-Belevitch-Hautus （PBH） criteria for exact observability and exact detectability of discrete-time stochastic systems are *** using them,we give the optimal strategies （Nash equilibrium strategies） and the optimal cost values for infinite horizon stochastic differential *** is indicated that the infinite horizon LQ stochastic differential games are associated with four coupled matrix-valued equations.

关键词： Discrete-time stochastic systems Exact observability Exact detectability Differential games Nash equilibrium

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高精度可编程信号发生器的设计与实现

核技术 2014年第7期37卷 43-46页

作者：潘金云武杰刘列峰孙刘洋中国科学技术大学核探测技术与核电子学国家重点实验室合肥230026 中国科学技术大学近代物理系合肥230026

随着集成电路的发展,现代物理电子设备的仿真、测试、检测和维护过程中,经常需要使用到高精度的信号发生器。传统意义上的信号发生器主要利用振荡器产生信号,但振荡器的精度不高成为了限制其应用范围的瓶颈。所以为了解决高精度的需求,... 详细信息

随着集成电路的发展,现代物理电子设备的仿真、测试、检测和维护过程中,经常需要使用到高精度的信号发生器。传统意义上的信号发生器主要利用振荡器产生信号,但振荡器的精度不高成为了限制其应用范围的瓶颈。所以为了解决高精度的需求,本文利用频率合成的技术,提出了一种基于Sigma-Delta数模转换器(Digital to Analog Converter,DAC)的可编程高精度信号发生器的设计与实现方法。经过实际测量,设计的信号发生器信噪比(Signal-to-Noise Ratio,SNR)好于110dB,总谐波失真(Total Harmonic Distortion,THD)小于-110dB,支持单端和差分输出,同时便携稳定。精度方面远高于市面上可以买到的信号发生器。

关键词：信号发生器可编程 Sigma—Delta调制高精度

冠心病患者实施CT冠状动脉血管成像的价值分析

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中国社区医师 2014年第24期 121-122页

作者：孙留洋李超河南兰考县中心医院CT室

目的:对冠心病患者实施CT冠状动脉血管成像的临床价值进行探讨。方法:收治冠心病患者50例,作为研究对象,对所有患者分别实施CT冠状动脉血管成像以及冠状动脉造影,观察和比较两种检查方法的诊断效果。结果:CT冠状动脉血管成像以及冠状动... 详细信息

目的:对冠心病患者实施CT冠状动脉血管成像的临床价值进行探讨。方法:收治冠心病患者50例,作为研究对象,对所有患者分别实施CT冠状动脉血管成像以及冠状动脉造影,观察和比较两种检查方法的诊断效果。结果:CT冠状动脉血管成像以及冠状动脉造影在斑块检出数量、血管狭窄情况上相仿,差异无统计学意义(P>0.05)。结论:冠心病患者实施CT冠状动脉血管成像检查,具有较高的可靠性,且不具有创伤性,鉴别能力较高,值得普及和应用。

关键词：冠心病 CT冠状动脉血管成像价值分析

长河坝水电站地下厂房顶拱镀锌压型承板施工技术

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水力发电 2016年第10期42卷 87-91页

作者：孙留阳陈明梁波李功子中国水利水电第十四工程局有限公司曲靖分公司云南曲靖655000

长河坝水电站地下厂房顶棚为现浇钢筋混凝土叠合结构,由拱板、肋梁、拱梁三部分组成,厂房顶拱具有高差大、跨度大、安全风险大、干扰协调难度大等特点。顶棚施工中,通过计算,确定了在拱梁4 mm厚镀锌压型钢模板底部增加定型槽型钢模板作... 详细信息

长河坝水电站地下厂房顶棚为现浇钢筋混凝土叠合结构,由拱板、肋梁、拱梁三部分组成,厂房顶拱具有高差大、跨度大、安全风险大、干扰协调难度大等特点。顶棚施工中,通过计算,确定了在拱梁4 mm厚镀锌压型钢模板底部增加定型槽型钢模板作为主要荷载支撑体系,较好地解决了顶棚施工时施工干扰、承载要求。上部肋梁及板混凝土厚度较薄,入仓强度低、浇筑速度慢,质量控制难度大,通过精心施工,完成了顶棚混凝土浇筑。

关键词：地下厂房顶拱压型承板立体交叉施工长河坝水电站

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泸定水电站厂房清水混凝土施工技术

水力发电 2011年第5期37卷 59-62页

作者：张述毕谢龙江孙留阳陈湘斌中国水利水电第十四工程局有限公司曲靖分公司云南曲靖655000 四川华电泸定水电有限公司四川泸定626100 中国水利水电建设工程咨询中南公司湖南长沙410014

结合泸定水电站厂房清水混凝土施工,分析了饰面清水混凝土的质量控制标准、原材料及半成品的质量控制和模板施工工艺,从外观色差、平整度、分缝、棱角等方面总结了施工工艺及控制措施。最终泸定水电站清水混凝土色泽一致、表面洁净光泽... 详细信息

结合泸定水电站厂房清水混凝土施工,分析了饰面清水混凝土的质量控制标准、原材料及半成品的质量控制和模板施工工艺,从外观色差、平整度、分缝、棱角等方面总结了施工工艺及控制措施。最终泸定水电站清水混凝土色泽一致、表面洁净光泽、棱角方正,获得各方好评。

关键词：饰面清水混凝土:原材料控制施工工艺缺陷控制措施泸定水电站