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考虑刀盘影响的饱和土盾构对地层干扰分析

应用力学学报 2023年第2期40卷 386-396页

作者：武崇福胥刘奇王立伟燕山大学河北省土木工程绿色建造与智能运维重点实验室秦皇岛066004 燕山大学建筑工程与力学学院秦皇岛066004 长葛市城乡规划中心长葛461500

为深入研究盾构施工过程中饱和土所受扰动问题,在已有研究的基础上,使用Biot固结方程变换求解得出的土体初始位移解和超孔隙水压力解,经坐标变换,推导了包括面板式刀盘与辐条式刀盘在内的,刀盘正面摩擦力和刀盘侧面摩擦力引起饱和土体... 详细信息

为深入研究盾构施工过程中饱和土所受扰动问题,在已有研究的基础上,使用Biot固结方程变换求解得出的土体初始位移解和超孔隙水压力解,经坐标变换,推导了包括面板式刀盘与辐条式刀盘在内的,刀盘正面摩擦力和刀盘侧面摩擦力引起饱和土体竖向变形与孔隙水压力值解析式,对引起土体变形各因素进行模拟,并给出了盾构施工引起饱和土竖向总变形与总超静孔隙水压力的表达式。结合工程算例进行计算模拟,切口附加推力、盾壳摩擦力、土体损失的沉降曲线在垂直于盾构推进方向上对称分布,最大值集中在盾构轴线正上方。盾构刀盘正面与侧面摩擦力对地表盾构轴线两侧产生非对称变形,在盾构轴线正上方的地表处刀盘因素对地表变形基本无影响。两类刀盘对地表变形影响区别不大,辐条式刀盘在刀盘所处断面处引起隧道周围孔隙水压力的响应较为明显,沿盾构方向衰减也较快。

关键词：盾构施工竖向变形孔隙水压力 Biot固结理论饱和土隧道工程

论元杂剧《东篱赏菊》中的陶渊明形象与思想主题

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九江学院学报（社会科学版） 2023年第2期42卷 13-18页

作者：徐柳琪山东大学文学院山东济南250100

在现存有关陶渊明的元杂剧中,无名氏的《陶渊明东篱赏菊》是唯一一篇完整之作。《东篱赏菊》中的陶渊明兼具儒士风度与隐士风雅,而在生产劳动方面则与陶诗文及史传有较大差异。与元杂剧中的其他隐逸剧相比较,《东篱赏菊》同样表现出了... 详细信息

在现存有关陶渊明的元杂剧中,无名氏的《陶渊明东篱赏菊》是唯一一篇完整之作。《东篱赏菊》中的陶渊明兼具儒士风度与隐士风雅,而在生产劳动方面则与陶诗文及史传有较大差异。与元杂剧中的其他隐逸剧相比较,《东篱赏菊》同样表现出了兴亡之叹、仕途之畏与隐居之乐的思想内容,但多了一重对仕途功名的留恋幻想,这透露出了元人在科举被废、求仕无门的处境下,既渴望功名又厌倦世事的矛盾心态,但加官赐赏依旧是其最高理想。

关键词：《东篱赏菊》陶渊明形象思想主题

当前中学政治课教学的“活路”——对当前中学政治课教学的几点思考

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新课程学习(下) 2014年第9期 62-63页

作者：徐流奇江苏省苏州市相城区陆慕高级中学

长久以来,传统的教学观念束缚着教师的思维,进而影响到教学行为并表现在平时的课堂教学中。视学生为接受知识的"容器",让学生最大限度、最大可能地识记课堂传授的知识,以"练"代"讲"。而好的课堂教学应该体现主体性、创新性、民主性和活... 详细信息

长久以来,传统的教学观念束缚着教师的思维,进而影响到教学行为并表现在平时的课堂教学中。视学生为接受知识的"容器",让学生最大限度、最大可能地识记课堂传授的知识,以"练"代"讲"。而好的课堂教学应该体现主体性、创新性、民主性和活动性的特征。生动活泼,让教师活动起来、让学生活跃起来、让教法活泛起来,让课堂活泼起来是突破当前中学思想政治课瓶颈的一条"活路"。

关键词：中学政治课活跃

Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： Jing Niu Shutao xu Yingxu Wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism

Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期68卷 303-305页

作者： Ziqian xu Lianpan Dai Jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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