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Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization

CCS Chemistry 2024年第1期6卷 196-207页

作者： liujun xu Yawei Feng Tong Wang Shenhuan Li Kangli xu Yue Sun Yi Luo Yishan Ye Yan Miao Yun Dong Zhenzhen Guo Qing Zhang Benshang Li He Huang xue-Qiang Wang Liping Qiu Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of MedicineChinese Academy of SciencesHangzhouZhejiang 310022 Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 Institute of Hematology Zhejiang UniversityHangzhou 310003 Department of Hematology and Oncology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200127

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer *** mass cytometry(MC)enables synchronous detection of over 40 cellular parameters,its full potential in disease classification is challenged by the limited types of recognition probes currently *** this work,we synthesize a panel of heavy isotopeconjugated aptamers to profile cancer-associated signatures on the surface of hematological malignancy(HM)*** on 15 molecular signatures,we performed cell-surface profiling that allowed the precise classification of 8 HM cell *** with machine-learning technology,this aptamer-based MC platform also achieved multiclass identification of HM subtypes in clinical sampleswith 100%accuracy in the training cohort and 80%accuracy in the test ***,we report an effective and practical strategy for precise cancer classification at the singlecell level,paving the way for its clinical use in the near future.

关键词： molecular profiling cancer diagnosis mass cytometry aptamers machine learning

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Chameleonlike metashells in microfluidics: A passive approach to adaptive responses

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 135-141页

作者： liujun xu JiPing Huang State Key Laboratory of Surface Physics and Key Laboratory of Micro and Nano Photonic Structures (MOE) Department of PhysicsFudan University

Heat energy can transfer via convection, conduction, and radiation. Based on convection and conduction in microfluidics, people have designed and fabricated many novel devices. However, almost none of them has adaptivity, thus restricting practical applications under different conditions. To solve this problem, here we propose a passive approach to adaptive responses. That is,we consider the thermal convection-conduction process in microfluidic structures where Darcy’s law and Fourier’s law are both valid. By carefully designing two key parameters(i.e., tensorial thermal conductivity and tensorial permeability) of a metashell,we theoretically reveal that its effective properties(i.e., effective thermal conductivity and effective permeability) can adaptively change according to the inside object, thus yielding the "chameleonlike metashell". Further, this metashell is passive since it requires no prior knowledge of the inside object. We also report that the chameleonlike behavior can occur for anisotropic inside objects, nonuniform external fields, or even complex shapes. All theoretical analyses agree well with finite-element *** chameleonlike metashell can act as an intelligent metamaterial in microfluidics for its adaptive responses, and it can also benefit other physical fields where convection plays a role, such as mass diffusion.

关键词： chameleonlike metashells intelligent metamaterials microfluidics

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Negative Thermal Transport in Conduction and Advection

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Chinese Physics Letters 2020年第8期37卷 19-24页

作者： liujun xu Jiping Huang Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China

Negative refractive index has drawn a great deal of attention due to its unique properties and practical applications in wave *** promote the related physics in thermotics,here we manage to coin a complex thermal conductivity whose imaginary part corresponds to the real part of complex refractive ***,the thermal counterpart of negative refractive index is just negative imaginary thermal conductivity,which is featured by the opposite directions of energy flow and wave vector in thermal conduction and advection,thus called negative thermal transport *** avoid violating causality,we design an open system with energy exchange and explore three different cases to reveal negative thermal *** further provide experimental suggestions with a solid ring *** finite-element simulations agree with theoretical analyses,indicating that negative thermal transport is physically *** results have potential applications such as designing the inverse Doppler effect in thermal conduction and advection.

关键词： structure. imaginary refractive

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Breaking efficiency limit of thermal concentrators by conductivity couplings

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Science China(Physics,Mechanics & Astronomy) 2022年第11期65卷 68-77页

作者： Pengfei Zhuang liujun xu Peng Tan Xiaoping Ouyang Jiping Huang Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)FudanUniversityShanghai200438China Department of Physics and State Key Laboratory of Surface Physics Fudan UniversityShanghai 200438China School of Materials Scienceand Engineering Xiangtan UniversityXiangtan 411105China

The concentrating efficiency of a thermal concentrator can be reflected in the ratio of its interior to exterior temperature gradients,which, however, has an upper limit in existing schemes. Here, we manage to break this upper limit by considering the couplings of thermal conductivities and improve the concentrating efficiency of thermal concentrators. For this purpose, we first discuss a monolayer scheme with an isotropic thermal conductivity, which can break the upper limit but is still restricted by its geometric configuration. To go further, we explore another degree of freedom by considering the monolayer scheme with an anisotropic thermal conductivity or by adding the second shell with an isotropic thermal conductivity, thereby making the concentrating efficiency completely free from the geometric configuration. Nevertheless, apparent negative thermal conductivities are required, and we resort to external heat sources realizing the same effect without violating the second law of thermodynamics. Finite-element simulations are performed to confirm the theoretical predictions, and experimental suggestions are also provided to improve feasibility. These results may have potential applications for thermal camouflage and provide guidance to other diffusive systems such as static magnetic fields and dc current fields for achieving similar behaviors.

关键词： thermal concentrator concentrating efficiency conductivity coupling apparent negative conductivity

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Black-hole-inspired thermal trapping with graded heat-conduction metadevices

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National Science Review 2023年第2期10卷 131-138页

作者： liujun xu Jinrong Liu Peng Jin Guoqiang xu Jiaxin Li Xiaoping Ouyang Ying Li Cheng-Wei Qiu Jiping Huang Department of Physics State Key Laboratory of Surface Physics and Key Laboratory of Micro and Nano Photonic Structures (MOE) Fudan University Department of Electrical and Computer Engineering National University of Singapore Graduate School of China Academy of Engineering Physics School of Materials Science and Engineering Xiangtan University Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang University International Joint Innovation Center Key Laboratory of Advanced Micro/Nano Electronic Devices and Smart Systems of Zhejiang The Electromagnetics Academy of Zhejiang University Zhejiang University

The curved space-time produced by black holes leads to the intriguing trapping *** far,metadevices have enabled analogous black holes to trap light or sound in laboratory ***,trapping heat in a conductive environment is still challenging because diffusive behaviors are *** by black holes,we construct graded heat-conduction metadevices to achieve thermal trapping,resorting to the imitated advection produced by graded thermal conductivities rather than the trivial solution of using insulation materials to confine thermal *** experimentally demonstrate thermal trapping for guiding hot spots to diffuse towards the *** heat-conduction metadevices have advantages in energy-efficient thermal regulation because the imitated advection has a similar temperature field effect to the realistic advection that is usually driven by external energy *** results also provide an insight into correlating transformation thermotics with other disciplines,such as cosmology,for emerging heat control schemes.

关键词： thermal trapping graded metadevices imitated advection

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Development of a novel critical nitrogen concentration-cumulative transpiration curve for optimizing nitrogen management under varying irrigation conditions in winter wheat

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The Crop Journal 2024年第4期12卷 1242-1251页

作者： Tianyang Ye Yu Zhang Jingyan xuan Xintian Wang Yang Li Junhao xu liujun Xiao Leilei Liu Liang Tang Weixing Cao Bing Liu Yan Zhu National Engineering and Technology Center for Information Agriculture Engineering Research Center of Smart AgricultureMinistry of EducationKey Laboratory for Crop System Analysis and Decision MakingMinistry of AgricultureJiangsu Key Laboratory for Information AgricultureJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Remote Sensing and Digital Agriculture Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina

Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop *** widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water *** three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water *** Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different *** equation Nc=6.43T0.24 established a consistent relationship across varying irrigation *** test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root ***,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller *** novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation *** findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.

关键词： Crop dry matter Crop cumulative transpiration Bayesian statistical model Critical nitrogen dilution curve Nitrogen nutrition index

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粉末冶金制备TNZS基生物材料的体外组织相容性

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稀有金属材料与工程 2017年第9期46卷 2601-2606页

作者：朱利华吴刘军许晓静陈婷卓江苏大学先进制造与现代装备技术工程研究院江苏镇江212013

采用高能球磨与冷压烧结相结合的粉末冶金法制备了TNZS、5%TiO_2/TNZS及5%HA/TNZS(质量分数,下同)生物材料,并研究了TiO_2和HA的添加对TNZS体外组织相容性的影响。结束表明:3种TNZS基生物材料均无细胞毒性;5%TiO_2/TNZS和5%HA/TNZS表面... 详细信息

采用高能球磨与冷压烧结相结合的粉末冶金法制备了TNZS、5%TiO_2/TNZS及5%HA/TNZS(质量分数,下同)生物材料,并研究了TiO_2和HA的添加对TNZS体外组织相容性的影响。结束表明:3种TNZS基生物材料均无细胞毒性;5%TiO_2/TNZS和5%HA/TNZS表面在1,3,5和7 d的细胞相对增殖抑制率CPIR值大幅低于TNZS组,TiO_2和HA的添加显著提高了TNZS材料表面的细胞增殖速度,增强了其细胞增殖能力,更有助于诱导成骨细胞的体外增殖;3种TNZS基材料表面贴附的成骨细胞伪足伸展状态良好,而5%TiO_2/TNZS表面贴附的成骨细胞分布更加均匀。

关键词：粉末冶金 TNZS基生物材料体外组织相容性

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大采高沿空留设小煤柱宽度优选

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山西煤炭 2018年第3期38卷 31-33,40页

作者：徐留军山西新村煤业有限公司山西长治046000

为减少井下因留设区段煤柱造成煤炭资源的丢失,以内蒙某矿大采高沿空掘巷留设小煤柱为研究背景,通过对地质资料勘察、有限元数值模拟方法对留设不同小煤柱宽度尺寸进行研究,研究结果表明:当煤柱宽度为3 m、4 m时,巷道处于煤柱支承应力... 详细信息

为减少井下因留设区段煤柱造成煤炭资源的丢失,以内蒙某矿大采高沿空掘巷留设小煤柱为研究背景,通过对地质资料勘察、有限元数值模拟方法对留设不同小煤柱宽度尺寸进行研究,研究结果表明:当煤柱宽度为3 m、4 m时,巷道处于煤柱支承应力升高区域内;煤柱宽度为5m、6m、7m时,巷道处于煤柱应力降低区域,留5 m时的煤柱应力峰值依然较高,峰值为23 MPa,留7m小煤柱时煤柱的应力降低幅度不大,留设7m煤柱浪费煤柱资源,不符合现场生产效益的要求。所以,从煤柱承载稳定性和煤炭的采出率角度,留设6m小煤柱最为经济合理,现场工业性试验表明该条件下沿空掘巷巷道控制效果良好。

关键词：大采高沿空掘巷小煤柱煤柱宽度

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云南壮剧乐器——云南壮剧音乐初探之十六

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文山学院学报 2018年第5期31卷 62-66,121-124页

作者：许六军文山学院云南文山663099

云南壮剧三个分支由于流布的区别,音乐形态必然存在差异,乐器也存在共性的特征和个性的色彩,由此而使云南壮剧更加具有浓郁的、绚丽多姿的风格和特点,盛开在祖国戏曲百花园中。在云南壮剧的吹奏乐器、拉奏乐器、弹奏乐器、击奏乐器中,... 详细信息

云南壮剧三个分支由于流布的区别,音乐形态必然存在差异,乐器也存在共性的特征和个性的色彩,由此而使云南壮剧更加具有浓郁的、绚丽多姿的风格和特点,盛开在祖国戏曲百花园中。在云南壮剧的吹奏乐器、拉奏乐器、弹奏乐器、击奏乐器中,有很多种乐器是民间艺人因地制宜、就地取材自制的,形成了壮剧的音乐特点,但保护那些濒临失传的乐器已经是摆在我们面前的刻不容缓的任务。

关键词：云南壮剧乐器自制色彩

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新中式家具和北欧现代家具的设计事理比较研究

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淮南师范学院学报 2017年第2期19卷 88-90页

作者：许留军淮南师范学院美术与设计学院安徽淮南232038

新中式家具和北欧风格现代家具在功能上大同小异,可以确定二者在目的性上是一致的。分析影响新中式风格和北欧家具现代风格内外部因素,二者在各自的地域环境下,以不同的材质及工艺而达到了相似的目的,新中式家具受中国传统家具,特别是... 详细信息

新中式家具和北欧风格现代家具在功能上大同小异,可以确定二者在目的性上是一致的。分析影响新中式风格和北欧家具现代风格内外部因素,二者在各自的地域环境下,以不同的材质及工艺而达到了相似的目的,新中式家具受中国传统家具,特别是明式家具影响很深,而北欧风格现代家具则受到了现代主义、民主思想等因素的影响。

关键词：新中式北欧现代家具功能

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