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Ordered coalescence of nano-crystals in alkaline niobate ceramics with high remanent polarization

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Journal of materiomics 2017年第4期3卷 267-272页

作者： Zhijian Shen Daniel Gruner mirva Eriksson Lyubov m.belova Ce-Wen Nan Haixue Yan Department of materials and Environmental Chemistry Arrhenius LaboratoryStockholm University10691StockholmSweden Department of materials Science and Engineering Royal Institute of Technology10044StockholmSweden School of materials Science and Engineering Tsinghua UniversityBeijing100084China School of Engineering and materials Science Queen Mary University of LondonMile End RoadLondonE14NSUK

Lead-free alkali niobates Na_(0.5)K_(0.5)NbO_(3)(NKN)ceramics,with significantly enhanced ferroelectric remanent polarization(Pr),were prepared using Spark Plasma Sintering(SPS).Three types of boundaries were observed in the ceramics,being grain boundaries between faceted grains,domain boundaries that separate ferroelectric domains inside individual grains,and nanoscale sub-grain boundaries that reveal the nano-scale mosaicity of individual *** of the sub-grain boundaries were from initial powder *** other sub-grain boundaries were built by ordered coalescence of nano-crystals during rapid SPS *** was worthwhile to emphasize that the ordered coalescence of nano-crystals in bulk ceramics during sintering takes place and completes within *** sub-grain features would disappear at higher temperature by long time *** Spark Plasma Sintering allowed us to capture this transient *** significantly enhanced ferroelectric Pr of NKN was attributed to nanoscale sub-boundaries,which stimulated the dynamics of ferroelectric domain formation and switching.

关键词： Lead-free NKN SPS Remanent polarization Ordered coalescence

Luminescent Composite Films Based on mechanically Strong Ladder-like Polyphenylsilsesquioxane and Oligophenyleuropiumsiloxane

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Chinese Journal of Polymer Science 2024年第11期 1793-1801页

作者： E.E.Kim T.O.Ershova A.S.belova D.A.Khanin E.V.Bashkova G.G.Nikiforova Yu.N.Kononevich A.A.Anisimov O.I.Shchegolikhina A.m.muzafarov A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences Tula State Lev Tolstoy Pedagogical University V.Topchiev Institute of Petrochemical Synthesis Russian Academy of Sciences moscow Institute of Physics and Technology (National Research University) N.S.Enikolopov Institute of Synthetic Polymeric materials Russian Academy of Sciences

Nowadays organosilicon luminescent materials are of increasing interest due to the variety of their synthetic or modification techniques and application fields. Ladder polyphenylsilsesquioxanes(L-PPSQ) are a unique class of organosilicon polymers, which can be ideal matrices for the luminescent composites due to their high thermal stability, optical transparency and mechanical strength. In this work, new mechanically strong, heat-resistant, transparent and sensitive to ammonia vapor luminescent composite films based on L-PPSQ have been obtained. As the source of Europium ions oligophenyleuropiumsiloxane was used, demonstrating perfect compatibility to the matrix due to the similar *** improve luminescent properties of the films, new organosilicon ligands were introduced into the composites and their influence on the properties of the materials was studied. Valuable properties of described composites may allow their further application as multifunctional coatings.

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Dissection of a rapidly evolving wheat resistance gene cluster by long-read genome sequencing accelerated the cloning of Pm69

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Plant Communications 2024年第1期5卷 69-83页

作者： Yinghui Li Zhen-Zhen Wei Hanan Sela liubov Govta Valentyna Klymiuk Rajib Roychowdhury Harmeet Singh Chawla Jennifer Ens Krystalee Wiebe Valeria Bocharova Roi Ben-David Prerna B.Pawar Yuqi Zhang Samidha Jaiwar Istvan molnar Jaroslav Dolezel Gitta Coaker Curtis J.Pozniak Tzion Fahima Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel The Department of Evolutionary and Environmental Biology University of HaifaMt.CarmelHaifa 3498838Israel The Institute of Plant Protection Sichuan Academy of Agricultural SciencesChengdu 610066China Crop Development Centre and Department of Plant Sciences University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Department of Vegetables and Field Crops Institute of Plant SciencesAgricultural Research Organization(ARO)–Volcani CenterRishon Lezion 7505101Israel Department of Crop Genomics and Bioinformatics China Agricultural UniversityBeijing 100094China Institute of Experimental Botany of the Czech Academy of Sciences Centre of the Region Hana´for Biotechnological and Agricultural ResearchSlechtitelu 3177900 OlomoucCzech Republic Plant Pathology Department University of CaliforniaDavisDavisCA 95616USA Present address:Department of Plant Science University of ManitobaWinnipegMB R3T 2N2Canada Present address:Agricultural Institute Centre for Agricultural ResearchELKHMartonvasar 2462Hungary

Gene cloning in repeat-rich polyploid genomes remains ***,we describe a strategy for overcoming major bottlenecks in cloning of the powdery mildew resistance gene(R-gene)Pm69 derived from tetraploid wild emmer wheat.A conventional positional cloning approach was not effective owing to suppressed *** sorting was compromised by insufficient purity.A Pm69 physical map,constructed by assembling Oxford Nanopore Technology(ONT)long-read genome sequences,revealed a rapidly evolving nucleotide-binding leucine-rich repeat(NLR)R-gene cluster with structural variations.A single candidate NLR was identified by anchoring RNA sequencing reads from susceptible mutants to ONT contigs and was validated by virus-induced gene ***69 is likely a newly evolved NLR and was discovered in only one location across the wild emmer wheat distribution range in ***69 was successfully introgressed into cultivated wheat,and a diagnostic molecular marker was used to accelerate its deployment and pyramiding with other R-genes.

关键词： cluster resistance Israel

High yield production of ultrathin fibroid semiconducting nanowire of Ta2Pd3Se8

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Nano Research 2020年第9期13卷 1627-1635页

作者： Xue Liu Sheng Liu liubov Yu.Antipina Yibo Zhu Jinliang Ning Jinyu Liu Chunlei Yue Abin Joshy Yu Zhu Jianwei Sun Ana m.Sanchez Pavel B.Sorokin Zhiqiang mao Qihua Xiong Jiang Wei Department of Physics and Engineering Physics Tulane UniversityNew OrleansLouisiana70118USA Division of Physics and Applied Physics Nanyang Technological UniversitySingapore637371Singapore National University of Science and Technology“mISiS” Moscow119049Russia Department of Polymer Science The University of AkronAkronOhio44325USA Technological Institute for Superhard and Novel Carbon materials Moscow108840Russia moscow Institute of Physics and Technology Dolgoprudny141700Russia Department of mechanical Engineering Columbia UniversityNew YorkNew York10027USA Department of Physics University of WarwickCoventryCV47ALUK

Immediately after the demonstration of the high-quality electronic properties in various two dimensional(2D)van der Waals(vdW)crystals fabricated with mechanical exfoliation,many methods have been reported to explore and control large scale *** with recent advancements in fabricating 2D atomic layered crystals,large scale production of one dimensional(1D)nanowires with thickness approaching molecular or atomic level still remains ***,we demonstrate the high yield production of a 1D vdW material,semiconducting Ta2Pd3Se8 nanowires,by means of liquid-phase *** thinnest nanowire we have readily achieved is around 1 nm,corresponding to a bundle of one or two molecular *** electron microscopy(TEm)and transport measurements reveal the as-fabricated Ta2Pd3Se8 nanowires exhibit unexpected high crystallinity and chemical *** low-frequency Raman spectroscopy reveals clear evidence of the existing of weak inter-ribbon *** fabricated nanowire transistors exhibit high switching performance and promising applications for photodetectors.

关键词： van der Waals nanowire 1D semiconductor liquid exfoliation micro Raman spectroscopy electronic and optoelectronic device

Conodonts from Lower Silurian Strata of the Subpolar Urals

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地学前缘 2009年第S1期16卷 251-251页

作者： Sokolova liubov Institute of Geology Pervomajskaya Str 54167982 Syktyvkar

The distribution of Lower Silurian conodonts from the sections on the Kozhym River was studied first by S.V. *** additional studies of the Upper Ordovician-Lower Silurian strata,Oulodus? ***, Walliserodus ***,Panderod... 详细信息

关键词： conodonts Lower Silurian Subpolar Urals

癫痫大鼠模型中miR-134-5p和神经元迁移蛋白双皮质素(DCX)的异常表达

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癫痫大鼠模型中miR-134-5p和神经元迁移蛋白双皮质素(DCX)的异常...

作者： KRIVOSHAPKINA liubov 大连医科大学

学位级别：硕士

2.1.背景及目的:目前,癫痫的诊断主要依据临床表现、脑电图及影像学检查。据世界卫生组织统计,癫痫是最目前常见的疾病之一。截至到2016年,全球范围内约有5千万癫痫患者,发病率约为0.85%。因此目前研究尝试从形态学,神经化学,神经生理学... 详细信息

2.1.背景及目的:目前,癫痫的诊断主要依据临床表现、脑电图及影像学检查。据世界卫生组织统计,癫痫是最目前常见的疾病之一。截至到2016年,全球范围内约有5千万癫痫患者,发病率约为0.85%。因此目前研究尝试从形态学,神经化学,神经生理学,神经药理学等多方面去探索癫痫疾病的机制及治疗(Scharfman.,2002,Harvey.B.D et al.,2003,Kalinichenko S.G et al.,2004)。目前研究发现脑组织可以分泌数种miRNA,进而影响树突的形态,神经元的迁移和胶质细胞的功能(***-mateos,***,2013),并可以通过影响基因及蛋白的表达水平参与癫痫疾病的病理生理过程。miRNA是一类由20-24个核苷酸组成的,非编码小分子RNA,其主要的生物学功能是抑制靶基因的表达。有研究发现miR-134的功能与神经触突的可塑性有关,并且参与神经细胞的迁移与分化(E.m.J-mateos,2012)。目前研究发现,miRNA-134-5p(miRNA-134)的靶基因有PUm2(Fiore et al.2009),CREB(Gao et al.2010)and DCX(Gaughwin et al.2011)等。而双皮质素(DCX)参与皮质发育过程中的神经细胞的迁移。DCX基因的突变可以引起神经元迁移的异常导致癫痫。DCX可以用测量作齿状回成熟神经元的标志物,与无脑回畸形和灰质异位症的致病机制有关(Rayner et al.2006)。故本文采用PCR、Western blot等方法研究miR-134及DCX在癫痫动物模型中的异常表达,探讨其在癫痫中的作用。2.2.材料与方法:采用匹罗卡品-氯化锂点燃模型作为大鼠的癫痫发作模型,将实验大鼠分为对照组、急性期(发作后24小时)组、亚急性期(发作3周)组,慢性期(发作后2个月)组。采集模型大鼠脑组织中的海马标本,采用q PT-PCR检测miRNA-134的表达,Western blot等检测DCX的表达,探寻其异常表达及关系。2.3.结果:qPT-PCR检测发现大鼠癫痫模型的海马组织中的miRNA-134在发作24小时后升高明显,而三周及两个月组则无明显升高。Western blot发现大鼠癫痫模型的海马组织中的DCX在各个时期的表达均下降明显。2.4.结论:癫痫大鼠模型海马组织中miR-134在急性发作时升高明显,此后在亚急性期及慢性期又逐渐下降至正常,而DCX在癫痫大鼠模型海马组织中发作后各个时期均程下降。二者可能参与癫痫的致病机制及发作后的神经元损伤与修复过程。

关键词：癫痫 miRNA-134 双皮质素神经发育

Reversible hydrogenation restores defected graphene to graphene

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Science China Chemistry 2021年第6期64卷 1047-1056页

作者： Lin Jiang Pauline mGvan Deursen Hadi Arjmandi-Tash liubov ABelyaeva Haoyuan Qi Jiao He Vincent Kofman Longfei Wu Valery muravev Ute Kaiser Harold Linnartz Emiel JmHensen Jan PHofmann Grégory FSchneider Leiden Institute of Chemistry Leiden UniversityEinsteinweg 552333CC LeidenThe Netherlands Central Facility for Electron microscopy Electron Microscopy Group of Materials ScienceUlm UniversityAlbert-Einstein-Allee 11Ulm 89081Germany Laboratory for Astrophysics Leiden ObservatoryLeiden UniversityNiels Bohrweg 22333 CA LeidenThe Netherlands Laboratory for Inorganic materials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technical University of Dresden010069 DresdenGermany

Graphene as a two-dimensional material is prone to hydrocarbon contaminations,which can significantly alter its intrinsic electrical ***,we implement a facile hydrogenation-dehydrogenation strategy to remove hydrocarbon contaminations and preserve the excellent transport properties of monolayer *** electron microscopy we quantitatively characterized the improved cleanness of hydrogenated graphene compared to untreated *** situ spectroscopic investigations revealed that the hydrogenation treatment promoted the adsorption of water at the graphene surface,resulting in a protective layer against the re-deposition of hydrocarbon ***,the further dehydrogenation of hydrogenated graphene rendered a more pristine-like basal plane with improved carrier mobility compared to untreated pristine *** findings provide a practical post-growth cleaning protocol for graphene with maintained surface cleanness and lattice integrity to systematically carry a range of surface chemistry in the form of a well-performing and reproducible transistor.

关键词： graphene reversible hydrogenation surface cleanness in situ spectroscopy transistors

一个疑似青少年起病成人型糖尿病家系的mODY3（HNF-1alpha）家系报告及基因筛查

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一个疑似青少年起病成人型糖尿病家系的MODY3（HNF-1alpha）家系...

作者： liubov DESIATKINA 大连医科大学

学位级别：硕士

糖尿病(Dm)是一组以慢性高血糖为特征的代谢性疾病,其特点是胰岛素分泌和(或)作用缺陷.目前糖尿病的发病率呈逐年上升趋势,业已成为全球性的健康问题,尤其是在发展中国家。据统计,中国目前大约有9200万糖尿病患者,已成为糖尿病大国。青... 详细信息

糖尿病(Dm)是一组以慢性高血糖为特征的代谢性疾病,其特点是胰岛素分泌和(或)作用缺陷.目前糖尿病的发病率呈逐年上升趋势,业已成为全球性的健康问题,尤其是在发展中国家。据统计,中国目前大约有9200万糖尿病患者,已成为糖尿病大国。青少年起病的成人型糖尿病(mODY)是一种单基因突变型糖尿病,是由不同的基因突变引起的,通常在幼年,青春期或成年早期发病。mODY3是由于编码肝细胞核因子1α(HNF-1alpha)基因杂合突变(HNF 1α)所引起,呈常染色体显性遗传,发病年龄早,β细胞功能进行性衰竭,磺脲类药物治疗有效。mODY患者经常被误诊为1型或2型糖尿病,究其原因主要是其早期临床表现有相似之处。这种误诊可能导致不必要的胰岛素治疗。正确识别及进行分子诊断有助于患者及其家族成员的更加合理的治疗选择。目的:对一个高度怀疑mODY3的家系中三个成员进行编码HNF-1alpha基因启动子及外显子序列突变分析。材料与方法:19岁男性糖尿病患者,有显著糖尿病家族史(三代),起病前无明显肥胖,糖尿病相关自身抗体阴性,入院后短时间胰岛素治疗后,改用口服磺脲类治疗反应良好。因此,高度怀疑患有mODY3(HNF-1α)基因突变。收集其母亲(无糖尿病),祖母(2型糖尿病)的血样。常规抽提外周血白细胞全基因组DNA,按网上报道的引物序列扩增启动子及外显子序列,进行测序。现病史:患者,19岁,因“多饮、多尿伴消瘦3个月”入院。查体:BP140/80mm Hg,心率90次/分,体重87Kg,身高180cm,BmI 26.85 kg/m2,发育正常。祖母在52岁时被诊断为2型糖尿病,父亲在三年前被诊断为2型糖尿病(当年是43岁)。实验室检查:空腹血糖(FBG):17.6 mmol/l,尿酮体+++。空腹血糖(FBG):19.77mmol/L,空腹血清胰岛素(FINS):18.64 u U/ml,空腹血清C肽(FCP):1.42ug/ml。自身抗体(GADA,IAA)均为阴性。胰岛功能刺激试验:1h血糖:23.57 mmol/l,1h胰岛素:28.42 u U/ml,1小时C肽:2.21 ug/ml、2h血糖:27 mmol/L,2h胰岛素:18.29 u U/ml,及2小时C肽:1.91ug/ml;糖化血红蛋白12.30%。祖母平时血糖控制在FBG 7-8 mmol/L、餐后11-12mmol/L,糖化血红蛋白8.30%。父亲平时血糖8-9 mmol/L、餐后10-11mmol/L,糖化血红蛋白7.6%。治疗:患者目前降糖方案:口服降糖药物(二甲双胍0.5 g 1次/天,阿卡波糖50 mg 3次/天,格列美脲2 mg 1次/天)和饮食/运动。其祖母目前降糖方案:胰岛素30u/天(16u/早,14 u/晚)。其父亲目前降糖方案:胰岛素治疗,且目前无任何糖尿病并发症。结果:根据DNA提取试剂盒说明,提取患者外周血淋巴细胞DNA。对10个外显子和启动子进行扩增和测序。我们发现在其祖母这一家系G突变>c.1460 p.s487n。这种突变不存在于患者和其母亲。结论:该患者无mODY3-HNF-1alpha突变,虽然其祖母有一变异,该变异系一种SNP,与mODY3无关,因此,此患仍需要进行其他类型的mODY基因检测。

关键词：糖尿病/mODY3 HNF-1alpha

Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses

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Bioactive materials 2022年第1期7卷 39-46页

作者： liubov A.Osminkina Svetlana N.Agafilushkina Ekaterina A.Kropotkina Nikolay Yu Saushkin Ivan V.Bozhev Sergei S.Abramchuk Jeanne V.Samsonova Alexandra S.Gambaryan Lomonosov moscow State University Physics DepartmentLeninskie Gory 1119991MoscowRussian Federation Institute for Biological Instrumentation of Russian Academy of Sciences 142290PushchinoMoscow RegionRussian Federation Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products Russian Academy of Sciences108819MoscowRussian Federation Lomonosov moscow State University Faculty of ChemistryLeninskie Gory 1119991MoscowRussian Federation Quantum Technology Center Lomonosov Moscow State UniversityPhysics DepartmentLeninskie Gory 1119991MoscowRussian Federation A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences Vavilova 28119991MoscowRussian Federation

New viral infections,due to their rapid spread,lack of effective antiviral drugs and vaccines,kill millions of people every *** global pandemic SARS-CoV-2 in 2019-2021 has shown that new strains of viruses can widespread very quickly,causing disease and death,with significant socio-economic ***,the search for new methods of combating different pathogenic viruses is an urgent task,and strategies based on nanoparticles are of significant *** work demonstrates the antiviral adsorption(virucidal)efficacy of nanoparticles of porous silicon(PSi NPs)against various enveloped and non-enveloped pathogenic human viruses,such as Influenza A virus,Poliovirus,Human immunodeficiency virus,West Nile virus,and Hepatitis *** NPs sized 60 nm with the average pore diameter of 2 nm and specific surface area of 200 m^(2)/g were obtained by ball-milling of electrochemically-etched microporous silicon *** interaction with PSi NPs,a strong suppression of the infectious activity of the virus-contaminated fluid was observed,which was manifested in a decrease in the infectious titer of all studied types of viruses by approximately 104 times,and corresponded to an inactivation of 99.99%viruses in *** sorption capacity of PSi NPs is possible due to their microporous structure and huge specific surface area,which ensures efficient capture of virions,as confirmed by ELISA analysis,dynamic light scattering measurements and transmission electron microscopy *** results obtained indicate the great potential of using PSi NPs as universal viral sorbents and disinfectants for the detection and treatment of viral diseases.

关键词： Pathogenic human viruses Porous silicon nanoparticles Virus Antiviral activity Virucide