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Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro

World Journal of Gastroenterology 2015年第23期21卷 7165-7171页

作者： Zhi-Zhi Xing liu-ye huang Cheng-Rong Wu Hong You Hong Ma Ji-Dong Jia Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Liver Research Center Beijing Friendship Hospital Capital Medical University

AIM: To investigate the effects of activated rat hepatic stellate cells(HSCs) on rat Th1/Th2 profile in ***: Growth and survival of activated HSCs and CD4+ T lymphocytes cultured alone or together was assessed after 24 or 48 h. CD4+ T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon(IFN)-γ+] and Th2 [interleukin(IL)-4+] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from CD4+ T lymphocytes that were positive for CD25 but did not express IFN-γ or IL-4 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated ***: Co-culture of CD4+ T lymphocytes with activated rat HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions(-1.73% ± 0.71%; P < 0.05), whereas the proportion of Th2 cells was not altered; the Th1/Th2 ratio was significantly decreased(-0.44 ± 0.13; P < 0.05). In addition, the level of IFN-γ in Th1 cells wasdecreased(-65.71 ± 9.67; P < 0.01), whereas the level of IL-4 in Th2 cells was increased(82.79 ± 25.12; P < 0.05) by co-culturing, as measured by mean fluorescence intensity by flow cytometry. Apoptosis rates in Th1(12.27% ± 0.99%; P < 0.01) and Th2(1.71% ± 0.185%; P < 0.01) cells were increased 24 h after co-culturing with activated HSCs; the Th1 cell apoptosis rate was significantly higher than in Th2 cells(P < 0.01). Galectin-9 protein expression was significantly decreased in HSCs only 24 h after coculturing(P < 0.05) but not after 48 h. Co-culture for 48 h significantly increased the differentiation of Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells(1.85% ± 0.4

关键词： Hepatic stellate cells Th1 cells Th2 cells Galectin-9

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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi huang Xiangliang Chen Shen liu Junshan Zhou Hongdong Zhao ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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炎症性肠病与血栓栓塞性疾病

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世界华人消化杂志 2017年第7期25卷 589-595页

作者：田玲玲黄留业青岛大学附属烟台毓璜顶医院消化内科山东省烟台市264000

血栓栓塞是炎症性肠病(inflammatory bowel disease,IBD)的一种肠外表现,既往病理研究指出IBD合并血栓栓塞的发生率高达41%,但在日常工作中,这一肠外表现并未受到足够的重视.本文总结了目前IBD并发血栓栓塞的临床研究结果,并对IBD药物... 详细信息

血栓栓塞是炎症性肠病(inflammatory bowel disease,IBD)的一种肠外表现,既往病理研究指出IBD合并血栓栓塞的发生率高达41%,但在日常工作中,这一肠外表现并未受到足够的重视.本文总结了目前IBD并发血栓栓塞的临床研究结果,并对IBD药物治疗的潜在致血栓风险进行了分析,同时详细阐述了其防治现状,以期为临床工作提供参考.

关键词：炎症性肠病血栓栓塞性疾病治疗

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Clinical Control Study of Endoscopic Full-thickness Resection and Laparoscopic Surgery in the Treatment of Gastric Tumors Arising from the Muscularis Propria

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Chinese Medical Journal 2015年第11期128卷 1455-1459页

作者： Cheng-Rong Wu liu-ye huang Juan Guo Bo Zhang Jun Cgi Cheng-Ming Sun Li-Xin Jiang Zhi-Hua Wang Ai-Hong Ju Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Clinical Laboratory Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Abdominal Surgery Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China

Background： Gastric stromal tumors arising from the muscularis propria are located in deeper layers. Endoscopic resection may be contraindicated due to the possibility of perforation. These tumors are therefore usually removed by surgical or laparoscopic procedures. This study evaluated the curative effects, safety and feasibility of endoscopic full-thickness resection （EFR） of gastric stromal tumors originating from the muscularis propria. Methods： This study enrolled 92 patients with gastric stromal tumors 〉2.5 cm originating from the muscularis propria. Fifty patients underwent EFR, and 42 underwent laparoscopic intragastric surgery. Operation time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rates were compared in these two groups. Results： EFR resulted in complete resection of all 50 gastric stromal tumors, with a mean procedure time of 85± 20 min, a mean hospitalization time of 7.0± 1.5 days and no complications. Laparoscopic intragastric surgery also resulted in a 100% complete resection rate, with a mean operation time of 88 ± 12 min and a mean hospitalization period of 7.5 ± 1.6 days. The two groups did not differ significantly in operation time, complete resection rates, hospital stay or incidence of complications （P 〉 0.05）. No patient in either group experienced tumor recurrence. Conclusions： EFR technique is effective and safe for the resection of gastric stromal tumors arising from the muscularis propria.

关键词： Endoscopy Full-thickness Excision Gastric Stromal Tumor Muscularis Propria Treatment

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen Pei liu Tao huang Zhencheng huang Yuying liu Jiaojiao Deng Shenghua ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao Ding huang Yunyi Yiyu liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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基于车辆运动模型辅助的智能手机平台车载组合导航算法

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中国惯性技术学报 2017年第2期25卷 203-208页

作者：许建新熊智刘建业黄欣张苗南京航空航天大学导航研究中心南京211106

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台... 详细信息

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台中所采用的消费级MEMS惯性传感器模块其精度很低,通常难以满足车载DR导航算法的性能需求;同时在车辆行驶过程中,不可避免会经过高架、隧道等路径,也会导致GPS信号受到遮挡和屏蔽从而无法定位。针对以上问题,设计了适用于智能手机平台的基于车辆运动模型辅助的车载DR/GPS组合导航方案,推导建立了基于车辆侧向速度约束的组合导航算法模型,并以智能手机作为验证平台,测试验证了所设计的算法在无GPS环境下,采用智能手机平台中的消费级MEMS惯性测量组件,仍然可以在短时间内维持较高的导航定位性能。

关键词：车载导航车辆运动模型组合导航卡尔曼滤波

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Primary Cell Culture and Characteristic Morphologies of Neurons in the Eyestalks from the Kuruma Shrimp,Marsupenaeus japonicus

Primary Cell Culture and Characteristic Morphologies of Neur...

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中国甲壳动物学会第十一届年会暨学术研讨会

作者： Jinshen liu Haihui ye Huiyang huang Yan Xu Guizhong Wang Department of Oceanography,Xiamen University,Xiamen 361005,China

＜正＞The neurons obtained from the kuruma shrimp,Marsupenaeus japonicus eyestalk were cultured in vitro in this *** neurons showed outgrowth in the culture medium supplemented with *** neurons are adapted to not only...

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自身免疫性肝病的临床及影像学分析43例

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世界华人消化杂志 2009年第22期17卷 2320-2325页

作者：崔俊吴承荣刘运祥黄留业青岛大学医学院附属烟台毓璜顶医院消化内科山东省烟台市264000

目的:分析自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)及原发性硬化性胆管炎(PSC)患者的临床特点及影像学特征.方法:2003-10/2008-02在烟台毓璜顶医院消化内科住院的自身免疫性肝病患者43例,排除其他原因引起肝脏损害.其中AIH12例,PB... 详细信息

目的:分析自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)及原发性硬化性胆管炎(PSC)患者的临床特点及影像学特征.方法:2003-10/2008-02在烟台毓璜顶医院消化内科住院的自身免疫性肝病患者43例,排除其他原因引起肝脏损害.其中AIH12例,PBC19例,PSC12例.对患者的临床及影像学资料进行回顾性分析,观察药物治疗的效果.结果:除PSC外,AIH多发于中年女性,患者具有较高的转氨酶,PBC、PSC患者具有较明显的GGT、ALP升高.临床表现上AIH、PBC、PSC黄疸的发生率分别为42%、80%、91%,皮肤瘙痒的发生率分别为38%、68%、79%.合理应用熊去氧胆酸和免疫抑制剂可使68%的PBC和AIH患者症状在6mo内得到缓解、肝功能明显改善.结论:AIH的肝功能异常以转氨酶升高为主,PBC、PSC以胆汁淤积为主.熊去氧胆酸和免疫抑制剂可改善绝大多数患者的症状和肝功能.

关键词：自身免疫性肝病临床影像学分析原发性胆汁性肝硬化

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