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Endoscopic mucosal resection for rectal carcinoids under micro-probe ultrasound guidance

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World Journal of Gastroenterology 2013年第16期19卷 2555-2559页

作者： Fu-Run Zhou liu-ye huang Cheng-Rong Wu Department of Gastroenterology Yu Huang Ding Hospital affiliated to Qingdao University School of Medicine

AIM: To assess the therapeutic value of endoscopic mucosal resection (EMR) under micro-probe ultrasound guidance for rectal carcinoids less than 1 cm in diameter. METHODS: Twenty-one patients pathologically diagnosed with rectal carcinoids following colonoscopy in our hospital from January 2007 to November 2012 were included in this study. The patients consisted of 14 men and 7 women, with a mean age of 52.3 ± 12.2 years (range: 36-72 years). The patients with submucosal tumors less than 1 cm in diameter arising from the rectal and muscularis mucosa detected by micro-probe ultrasound were treated with EMR and followed up with conventional endoscopy and micro-probe ultrasound. RESULTS: All of the 21 tumors were confirmed by micro-probe ultrasound as uniform hypoechoic masses originating from the rectal and muscularis mucosa, without invasion of muscularis propria and vessels, and less than 1 cm in diameter. EMR was successfully completed without bleeding, perforation or other complications. The resected specimens were immunohistochemically confirmed to be carcinoids. Patients were followed up for one to two years, and no tumor recurrence was reported. CONCLUSION: EMR is a safe and effective treatment for rectal carcinoids less than 1 cm in diameter.

关键词： Micro-probe ultrasound Endoscopic mucosal resection Rectal carcinoid Endoscopic submucosal dissection Submucosal tumors

TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor

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World Journal of Gastroenterology 2023年第19期29卷 2932-2949页

作者： Cheng-Ming Guo Li Tang Xu Li liu-ye huang Department of Gastroenterology The Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000Shandong ProvinceChina

BACKGROUND Gastrointestinal stromal tumor(GIST)is a common neoplasm with high rates of recurrence and metastasis,and its therapeutic efficacy is still not *** is an unmet need to find new molecular therapeutic targets for ***-boxbinding protein-associated factor 15(TAF15)contributes to the progress of various tumors,while the role and molecular mechanism of TAF15 in GIST progression are still *** To explore new molecular therapeutic targets for GIST and understand the biological role and underlying mechanisms of TAF15 in GIST *** Proteomic analysis was performed to explore the differentially expressed proteins in *** blotting and immunohistochemical analysis were used to verify the expression level of TAF15 in GIST tissues and cell *** counting kit-8,colony formation,wound-healing and transwell assay were executed to detect the ability of TAF15 on cell proliferation,migration and invasion.A xenograft mouse model was applied to explore the role of TAF15 in the progression of *** blotting was used to detect the phosphorylation level and total level of RAF1,MEK and ERK1/*** A total of 1669 proteins were identified as differentially expressed proteins with 762 upregulated and 907 downregulated in ***15 was selected for the further study because of its important role in cell proliferation and ***15 was significantly over expressed in GIST tissues and cell *** of TAF15 was associated with larger tumor size and higher risk stage of ***15 knockdown significantly inhibited the cell proliferation and migration of GIST in vitro and suppressed tumor growth in ***,the inhibition of TAF15 expression significantly decreased the phosphorylation level of RAF1,MEK and ERK1/2 in GIST cells and xenograft tissues,while the total RAF1,MEK and ERK1/2 had no significant *** TAF15 is over expressed in GIST tissues and cell *** of TAF15 was associ

关键词： Gastrointestinal stromal tumor Proteomics TATA-box-binding protein-associated factor 15 Biomarker Cell proliferation Cell migration

Endoscopic full-thickness resection for gastric submucosal tumors arising from the muscularis propria layer

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World Journal of Gastroenterology 2014年第38期20卷 13981-13986页

作者： liu-ye huang Jun Cui Shu-Juan Lin Bo Zhang Cheng-Rong Wu Department of Gastroenterology Yantai Yu Huang Ding Hospital

AIM: To evaluate the efficacy, safety and feasibility of endoscopic full-thickness resection (EFR) for the treatment of gastric submucosal tumors (SMTs) arising from the muscularis propria.

关键词： Submucosal tumor Stomach Endoscopic full-thickness resection Muscularis propria layer Excision

Screening for Differentially Expressed Genes of Gastric Stromal Tumor Originating from Muscularis Propria

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Chinese Medical Journal 2017年第6期130卷 737-740页

作者： Ju huang Bo Zhang liu-ye huang Department of Clinical Medicine Queen Mary School of Nanchang University Nanchang Jiangxi 330031 China Department of Gastroenterology Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai Shandong 264000 China

INTRODUCTION Gastric stromal tumor （GST） is a set of gastrointestinal mesenchymal tumors those originate from interstitial cells of Cajal. Its early diagnosis and treatment are critical to prognosis. The occurrence of GST remains obscure; this study used Affymetrix expression spectrum chip to detect the gene expression spectrum of GST and explore new molecular target that is used in the treatment and prognosis of GST.

关键词： Gene Expression Gastric Stromal Tumor Microarray Analysis Muscularis Propria

Small intestinal vascular malformation bleeding:A case report with imaging findings

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World Journal of Gastroenterology 2014年第38期20卷 14076-14078页

作者： Jun Cui liu-ye huang Shu-Juan Lin Long-Zhi Yi Cheng-Rong Wu Bo Zhang Department of Gastroenterology Yan tai Yu Huang Ding Hospital

The small intestine is approximately 5-6 m long and occupies a large area in the abdominal cavity. These factors preclude the use of ordinary endoscopy and X-ray to thoroughly examine the small intestine for bleeding of vascular malformations. Thus,the diagnosis of intestinal bleeding is very difficult. A 47-year-old man presented at the hospital 5 mo ago with dark stool. Several angiomas were detected by oral approach enteroscopy,but no active bleeding was observed. Additionally,no lesions were detected by anal approach enteroscopy;however,gastrointestinal tract bleeding still occurred for an unknown reason. We performed an abdominal vascular enhanced computed tomography examination and detected ileal vascular malformations. Ileum angioma and vascular malformation were detected by a laparoscopic approach,and segmental resection was performed for both lesions,which were confirmed by pathological diagnosis. This report systemically emphasizes the imaging findings of small intestinal vascular malformation bleeding.

关键词： Small intestine Vascular malformation Bleeding Imaging Diagnosis

Effect of Double-Balloon Enteroscopy on Diagnosis and Treatment of Small-Bowel Diseases

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Chinese Medical Journal 2018年第11期131卷 1321-1326页

作者： Li Tang liu-ye huang Jun Cui Cheng-Rong Wu Department of Clinical Medicine Qingdao University Medical College Qingdao Shandong 266021 China Department of Gastroenterology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai Shandong 264000 China

Background： The diagnosis and treatment of small-bowel diseases is clinically difficult. The purpose of this study was to evaluate the diagnostic and therapeutic value of double-balloon enteroscopy in small-bowel diseases. Methods： The history and outcomes of 2806 patients who underwent double-balloon enteroscopy from July 2004 to April 2017 were reviewed, which included 562 patients with obscure digestive tract bleeding, 457 patients with obscure diarrhea, 930 patients with obscure abdominal pain, 795 patients with obscure weight loss, and 62 patients with obscure intestinal obstruction. Examinations were performed through the mouth and/or anus according to the clinical symptoms and abdominal images, lfa lesion was not detected through one direction, examination through the other direction was performed as necessary. Eighty-four patients with small-bowel polyps, 26 with intestinal obstruction caused by enterolith, and 18 with bleeding from Dieulafoy＇s lesions in the small intestine were treated endoscopically. Results： A total of 2806 patients underwent double-balloon enteroscopy, and no serious complications occurred. An endoscopic approach through both the mouth and anus was used in 212 patients. Lesions were detected in 1696 patients, with a detection rate of 60.4%： the rates for obscure digestive tract bleeding, diarrhea, abdominal pain, weight loss, and intestinal obstrtlction were 85.9% （483/562）, 73.5% （336/457）, 48.2% （448/930）, 49.1% （390/795）, and 62.9% （39/62）, respectively. For patients with small-bowel polyps who underwent endoscopic therapy, no complications such as digestive tract bleeding and perforation occurred. Intestinal obstruction with enteroliths was relieved with endoscopic lithotripsy. Among the 18 patients with bleeding from small-bowel Dieulafoy＇s lesions, 14 patients were controlled with endoscopic hemostasis. Conclusion： Double-balloon enteroscopy is useful for diagnosing and treating some small-bowel disease.

关键词： Diagnosis Double-Balloon Enteroscopy Small Bowel Therapy

Endoscopic therapy for gastric stromal tumors originating from the muscularis propria

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World Journal of Gastroenterology 2012年第26期18卷 3465-3471页

作者： liu-ye huang Jun Cui Yun-Xiang liu Cheng-Rong Wu De-Liang Yi Department of Gastroenterology Yantai Yu Huang Ding HospitalYantai 264000Shandong ProvinceChina

AIM:To explore endoscopic therapy methods for gastric stromal tumors originating from the muscularis ***:For 69 cases diagnosed as gastric stromal tumors originating from the muscularis propria,three types of endoscopic therapy were selected,based on the size of the *** methods included endoscopic ligation and resection(ELR),endoscopic submucosal excavation(ESE) and endoscopic full-thickness resection(EFR).The wound surface and the perforation of the gastric wall were closed with metal *** for CD34,CD117,Dog-1,S-100 and smooth muscle actin(SMA) was performed on the resected ***:A total of 38 cases in which the tumor size was less than 1.2 cm were treated with ELR;three cases were complicated by perforation,and the perforations were closed with metal ***,18 cases in which the tumor size was more than 1.5 cm were treated with ESE,and no perforation ***,13 cases in which the tumor size was more than 2.0 cm were treated with EFR;all of the cases were complicated by artificial perforation,and all of the perforations were closed with metal *** of the 69 cases recovered with medical treatment,and none required surgical *** demonstrated that among all of the 69 gastric stromal tumors diagnosed by gastroscopy,12 cases were gastric leiomyomas(SMA-positive),and the other 57 cases were gastric stromal ***:Gastric stromal tumors originating from the muscularis propria can be treated successfully with endoscopic techniques,which could replace certain surgical operations and should be considered for further application.

关键词： Gastrointestinal stromal tumors Therapy Endoscopy Muscularis propria Resection

Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors

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World Journal of Gastroenterology 2014年第25期20卷 8253-8259页

作者： liu-ye huang Jun Cui Cheng-Rong Wu Bo Zhang Li-Xin Jiang Xiang-Shu Xian Shu-Juan Lin Ning Xu Xiao-Ling Cao Zhi-Hua Wang Department of Gastroenterology Yantai Yu Huang Ding Hospital Department of Abdominal Surgery Yantai Yu Huang Ding Hospital

AIM: To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria.

关键词： Gastric stromal tumors Treatment Endoscopy Muscularis propria Full-thickness resection

Efficacy of endoscopic therapy for gastrointestinal bleeding from Dieulafoy’s lesion

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World Journal of Gastroenterology 2011年第10期17卷 1368-1372页

作者： Jun Cui liu-ye huang Yun-Xiang liu Bo Song Long-Zhi Yi Ning Xu Bo Zhang Cheng-Rong Wu Department of Gastroenterology Yantai Yu Huang Ding Hospital Yantai 264000 Shandong Province China

AIM： To investigate the endoscopic hemostasis for gastrointestinal bleeding due to Dieulafoy＇s lesion. METHODS： One hundred and seven patients with gastrointestinal bleeding due to Dieulafoy＇s lesion were treated with three endoscopic hemostasis methods： aethoxysklerol injection （46 cases）, endoscopic hemoclip hemostasis （31 cases）, and a combination of hemoclip hemostasis with aethoxysklerol injection （30 cases）. RESULTS： The rates of successful hemostasis using the three methods were 71.7% （33/46）, 77.4% （24/31） and 96.7% （29/30）, respectively, with significant differences between the methods （P 〈 0.05）. Among those who had unsuccessful treatment with aethoxysklerol injection, 13 were treated with hemoclip hemostasis and 4 underwent surgical operation; 9 cases were successful in the injection therapy. Among the cases with unsuccessful treatment with hemoclip hemostasis,7 were treated with injection of aethoxysklerol and 3 cases underwent surgical operation; 4 cases were successful in the treatment with hemoclip hemostasis. Only 1 case had unsuccessful treatment with a combined therapy of hemoclip hemostasis and aeth- oxysklerol injection, and surgery was then performed. No serious complications of perforation occurred in the patients whose bleeding was treated with the endoscopic hemostasis, and no releeding was found during a 1-year follow-up. CONCLUSION： The combined therapy of hemoclip hemostasis with aethoxysklerol injection is the most effective method for gastrointestinal bleeding due to Dieulafoy＇s lesion.

关键词： Dieulafoy's lesion Gastrointestinal bleeding Endoscopic therapy Aethoxysklerol Therapeutic efficacy