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空间偏移拉曼光谱分析技术及其在食品次表层检测中的应用

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光谱学与光谱分析 2024年第5期44卷 1201-1208页

作者：刘振方黄敏朱启兵赵鑫闫胜琪江南大学轻工过程先进控制教育部重点实验室江苏无锡214122

空间偏移拉曼光谱(SORS)是一种应用于浑浊/分层介质深层无损检测的新型拉曼光谱分析技术。分层物质不同深度的拉曼信号随传输距离增加对探测器的贡献产生规律性变化,SORS技术通过采集偏移激光入射点不同距离的拉曼光谱,结合最佳偏移距... 详细信息

空间偏移拉曼光谱(SORS)是一种应用于浑浊/分层介质深层无损检测的新型拉曼光谱分析技术。分层物质不同深度的拉曼信号随传输距离增加对探测器的贡献产生规律性变化,SORS技术通过采集偏移激光入射点不同距离的拉曼光谱,结合最佳偏移距离信号增强、次表层谱峰识别、次表层信号分离等方法降低表层的干扰,获取纯净的次表层物质拉曼信号,然后借助拉曼的分子特异性实现无损的次表层物质定性和定量检测。介绍了空间偏移拉曼光谱技术的基本概念及测量技术,详细阐述了空间偏移拉曼光谱数据的分析方法及该技术在食品次表层检测中的应用,讨论了空间偏移拉曼光谱技术的限制条件并展望了该领域的未来发展。

关键词：空间偏移拉曼光谱次表层无损检测食品品质检测信号识别信号分离

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： huang Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang liu Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun huang Yuan ZHU sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang huang Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

2D编织C/SiC孔边致密化结构多尺度混合模型与拉伸性能

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航空学报 2024年第13期45卷 242-257页

作者：姜卓群黄盛王占学西北工业大学动力与能源学院西安710129

针对一种开孔2D编织C/SiC复合材料在化学气相浸渗过程中出现的孔边致密化结构,提出了一种表征孔边致密化结构的建模方法。考虑孔隙的随机分布,建立了纤维束尺度代表体积元模型,实现了2D编织C/SiC复合材料等效弹性模量的计算。在此基础上... 详细信息

针对一种开孔2D编织C/SiC复合材料在化学气相浸渗过程中出现的孔边致密化结构,提出了一种表征孔边致密化结构的建模方法。考虑孔隙的随机分布,建立了纤维束尺度代表体积元模型,实现了2D编织C/SiC复合材料等效弹性模量的计算。在此基础上,建立了具有孔边致密化结构的2D编织C/SiC复合材料宏-细观组合模型。基于3D hashin失效准则与修正的Von Mises失效准则,建立了2D编织C/SiC复合材料的渐进损伤模型,模拟了其单轴拉伸应力-应变行为。通过与实验数据的对比分析,验证了模型的有效性。计算不同孔隙率、致密带半径以及孔径的开孔2D编织C/SiC复合材料拉伸强度并分析其影响规律。计算结果表明:随着孔隙率的增大,材料刚度与拉伸强度不断减小,当孔隙率从5%上升到20%时,抗拉强度降低26.05%;随着致密带半径的增加,材料刚度下降越缓慢,失效强度越大,当致密带半径从0 mm增大到0.75 mm时,抗拉强度提高14.17%;随着孔径增大,孔边应力集中效应增强,孔边损伤程度加剧,材料损伤越快,当孔径从0.5 mm增大到2 mm时,抗拉强度降低35.01%。

关键词： 2D编织C/SiC复合材料化学气相浸渗孔边致密化结构宏-细观混合模型渐进损伤拉伸性能

基于随机森林的个体锻炼意愿-行为鸿沟预测变量与组合路径

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上海体育大学学报 2024年第10期48卷 19-28页

作者：黄敬意张盛上海体育大学经济管理学院上海200438 上海体育大学新闻与传播学院上海200438

身体活动水平低下是全球共同关注的公共健康问题,实现身体活动促进的挑战之一在于消除锻炼意愿-行为鸿沟。基于对2024年上海市杨浦区的调研数据,建立随机森林模型并进行特征重要度分析,发现:当个体对锻炼行为的感知障碍较小、对缺乏身... 详细信息

身体活动水平低下是全球共同关注的公共健康问题,实现身体活动促进的挑战之一在于消除锻炼意愿-行为鸿沟。基于对2024年上海市杨浦区的调研数据,建立随机森林模型并进行特征重要度分析,发现:当个体对锻炼行为的感知障碍较小、对缺乏身体活动的感知严重性较大时,出现锻炼意愿-行为鸿沟的概率较低。认为:感知障碍是预测个体锻炼意愿-行为鸿沟存在与否的首要变量,感知严重性以及移动媒介的使用同样有助于消除意愿-行为鸿沟。在此基础上,提出通过降低感知障碍、增强感知严重性,推广移动媒介的使用,进一步开展因果机制研究等策略缓解并消除个体锻炼意愿-行为鸿沟,实现促进身体活动的目标。

关键词：身体活动促进意愿-行为鸿沟机器学习随机森林

XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao Liang liu Dong-sheng Zhang Li-Ping Wang Wen-Wei Hu De-sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-Jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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运动界面的电磁波相位匹配

物理学报 2024年第13期73卷 121-125页

作者：袁金健顾民黄润生南京大学物理学院南京210093

电磁波在运动物体表面的折射反射和内部的传播研究中,运动界面的电磁场相位匹配作为一个重要问题,只有用Galileo变换的讨论,但运动边界对电磁波传播的相对论效应是不应被忽略的.本文从空间曲面方程的定义和相对性原理出发导出了运动曲... 详细信息

电磁波在运动物体表面的折射反射和内部的传播研究中,运动界面的电磁场相位匹配作为一个重要问题,只有用Galileo变换的讨论,但运动边界对电磁波传播的相对论效应是不应被忽略的.本文从空间曲面方程的定义和相对性原理出发导出了运动曲面单位法向量的变换式,基于该变换式导出了运动边界的电磁场边界条件.同时基于单位法向量的变换式导出考虑相对论效应时电磁波在运动边界的相位匹配.虽然该工作不涉及量子效应的影响,但可以为电磁波通讯和电磁遥感遥测的理论分析提供一些参考.

关键词：电磁波运动界面相位匹配相对性原理

First-principles study on stability and superconductivity of ternary hydride LaYH_(x)(x=2,3,6 and 8)

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Chinese Physics B 2024年第8期33卷 415-420页

作者：颜小珍周幸姿刘超飞徐寅力黄毅斌盛晓伟陈杨梅 School of Science Jiangxi University of Science and TechnologyGanzhou 341000China Department of Physics Anhui Normal UniversityWuhu 241000China Anhui Province Key Laboratory of Optoelectric Materials Science and Technology Wuhu 241000China

Recent studies have shown that the La-and Y-hydrides can exhibit significant superconducting properties under high *** this paper,we investigate the stability,electronic and superconducting properties of LaYH_(x)(x=2,3,6 and 8)under 0-200 *** is found that LaYH_(2) stabilizes in the C2/m phase at ambient pressure,and transforms to the Pmmn phase at 67 ***_(3) stabilizes in the C2/m phase at ambient pressure,and undergoes phase transitions of C2/m→P2_(1)/m→R3m at 12 GPa and 87 GPa,***_(6) stabilizes in the P4_32_12 phase at ambient pressure,and undergoes phase transitions of P4_(3)2_(1)2→P4/mmm→Cmcm at 28 GPa and 79 GPa,***_(8) stabilizes in the Imma phase at 60 GPa and transforms to the P4/mmm phase at 117 *** of the electronic band structures show that the P4/mmm-LaYH_(8) and all phases of LaYH_(2) and LaYH_(3) exhibit metallic *** the metallic phases,we then study their superconducting *** calculated superconducting transition temperatures(T_c)are 0.47 K for C2/m-LaYH_(2) at 0 GPa,0 K for C2/m-LaYH_(3) at 0 GPa,and 55.51 K for P4/mmm-LaYH_(8) at 50 GPa.

关键词： superconductivity high pressure first-principles study phase transitions

Gastric cancer liver metastasis will reduce the efficacy of immunotherapy

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2760-2764页

作者： Liang Wang Shan-Shan liu sheng-Mei Zhang Xiao-Qian Chen Tao huang Rong Tian Ya-Qi Zhao Zhou Chen Cai-Rang Xianba Department of Gastrointestinal Oncology Surgery The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Intensive Care Unit The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Ultrasound The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of General Surgery Hainan State People's Hospital of Qinghai ProvinceHainan Tibetan Autonomous Prefecture 813000Qinghai ProvinceChina

Immune checkpoint inhibitors augment the antitumor activity of T cells by inhibiting the negative regulatory pathway of T cells,leading to notable efficacy in patients with non-small cell lung cancer,melanoma,and other malignancies through immunotherapy ***,secondary malignant liver tumors not only lower the liver's sensitivity to immunotherapy but also trigger systemic immune suppression,resulting in reduced overall effectiveness of immune *** receiving immunotherapy for non-small cell lung cancer and melanoma experience reduced response rates,progression-free survival,and overall survival when secondary malignant tumors develop in the *** liu's retrospective analysis,valuable insights are provided for the future clinical management of these ***,in patients with gastric cancer(GC),the occurrence of liver metastasis might be indicative of reduced efficacy of *** liver immune tolerance mechanisms and their negative impacts allows for the potential benefits of immunotherapy in patients with GC and liver *** Gastric cancer(GC)ranks among the prevalent malignancies affecting the digestive system *** on the latest epidemiological data[1,2],it holds the fifth position for incidence and the fourth position for mortality among all malignant *** cases and fatalities in China make up roughly half of the worldwide *** investigations[3]have demonstrated that the median overall survival(mOS)among advanced GC patients left untreated typically ranges from 3 to 4 *** chemotherapy recipients often experience a mOS of around one year,accompanied by a marked improvement in the quality of life among patients with advanced *** mainstay of treatment for advanced GC patients involves chemotherapeutic medications such as fluoropyrimidines,platinum compounds,and ***,their efficacy in tumor control is constrained by acquired resistance and pr

关键词： Immune checkpoint inhibitors Gastric cancer Gastric cancer with liver metastasis Immunotherapy Liver immune tolerance

强吸收纳米粒子团簇的光泳力悬浮及热泳力下的迁移行为

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物理学报 2024年第13期73卷 164-174页

作者：黄雪峰刘敏卢山张敏琦李盛姬罗丹杭州电子科技大学物理系杭州310018 杭州电子科技大学材料与环境工程学院杭州310018

为了探索空气中强吸收纳米粒子团簇在激光作用下的悬浮以及迁移行为,提出采用反向传输的双贝塞尔光束对纳米粒子团簇进行捕获及悬浮,而后释放团簇,观察和计算分析团簇的迁移行为.两束贝塞尔光束由锥透镜和偏振分光方式产生,进行反向水... 详细信息

为了探索空气中强吸收纳米粒子团簇在激光作用下的悬浮以及迁移行为,提出采用反向传输的双贝塞尔光束对纳米粒子团簇进行捕获及悬浮,而后释放团簇,观察和计算分析团簇的迁移行为.两束贝塞尔光束由锥透镜和偏振分光方式产生,进行反向水平布置,形成三维光阱,光阱刚度可通过调节两束贝塞尔光束的功率比进行控制.悬浮室内的粒子通过微弱气流进行流化,而后被光阱捕获和悬浮.采用高速摄像仪对团簇的悬浮及迁移过程进行记录,然后通过图像分析来获取粒子运动参数.以强吸收性超细煤粉粒子团簇为对象,首先对其进行悬浮和释放迁移的实验研究,而后对团簇所受的光泳力、重力、浮力、曳力以及热泳力进行计算和分析.实验和计算的结果表明:强吸收性纳米粒子团簇在激光作用下产生的光泳力占主导作用;团簇能够被稳定地悬浮在反向传输的双贝塞尔光束形成的三维势阱中,通过调整悬浮的位置而达到与重力、浮力、曳力等的动态平衡;利用悬浮的相对不稳定度分析评价强吸收性粒子团簇的稳定性,超细煤粉粒子团簇的最小相对不稳定度可达0.075;通过对团簇释放后的高速图像进行分析,可获得团簇的迁移运动参数,从而测量出团簇所受的热泳力;对于等效粒径为13—21μm的超细煤粉粒子团簇,其热泳力量级为10-11—10-10N,随着团簇粒径的增大,热泳力线性增大,与理论计算结果趋势一致.通过利用激光对粒子进行悬浮和释放的方式为热泳力的测量和研究提供了一种新的研究思路,也为气体介质中粒子的控制和输运展现了一种新的操控手段.

关键词：激光悬浮光泳力热泳力强吸收性纳米团簇