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Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer:A review

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World Journal of Diabetes 2023年第11期14卷 1585-1602页

作者： Hong-Min Zhang meng-liu yang Jia-Zhuang Xi Gang-Yi yang Qi-Nan Wu Department of Endocrinology People’s Hospital of Chongqing Liangjiang New AreaChongqing 400030China Department of Endocrinology The Second Affiliated Hospital of The Chongqing Medical UniversityChongqing 400030China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 406230China

The complication of diabetes,which is known as diabetic foot ulcer(DFU),is a significant concern due to its association with high rates of disability and *** not only severely affects patients’quality of life,but also imposes a substantial burden on the healthcare *** spite of efforts made in clinical practice,treating DFU remains a challenging *** mesenchymal stem cell(MSC)therapy has been extensively studied in treating DFU,the current efficacy of DFU healing using this method is still ***,in recent years,several MSCs-based drug delivery systems have emerged,which have shown to increase the efficacy of MSC therapy,especially in treating *** review summarized the application of diverse MSCs-based drug delivery systems in treating DFU and suggested potential prospects for the future research.

关键词： Diabetic foot ulcer Mesenchymal stem cells Drug delivery systems Diabetes Wound healing

High-resolution full waveform seismic imaging: Progresses, challenges, and prospects

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Science China Earth Sciences 2025年第2期68卷 315-342页

作者： Dinghui yang Xingpeng DONG Jiandong HUANG Zhilong FANG Xueyuan HUANG Shaolin liu mengxue liu Weijuan meng Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Institute of Geology China Earthquake AdministrationBeijing 100029China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China

Full waveform inversion(FWI) is a seismic imaging method with a unified mathematical framework based on wave equation constraints. The FWI method can be used to generate a variety of high-resolution seismic parameter models(e.g.,velocity, anisotropy, viscoelasticity, and attenuation), which can facilitate an in-depth understanding of important scientific problems such as the Earth's interior structure and material composition, earthquake preparation and occurrence, and plate motion and dynamic processes. With the development and cross-integration of disciplines such as geophysics, applied mathematics, and computer science, FWI imaging theories and methods not only play a crucial role in revealing the Earth's interior structure, dynamic evolution, and earthquake mechanisms but also show a wide range of application potential in fields such as resource exploration, medical imaging, engineering inspection, carbon dioxide geological sequestration, and earthquake disaster prediction. In this paper, we provide a comprehensive review and analysis of the development of the FWI method,addressing its current challenges, identifying key issues, future directions, and potential research areas in the theory, methodology, and application of high-resolution FWI imaging. We also offer new insights and perspectives to promote advancements of high-resolution FWI research and applications in Earth sciences and other related fields.

关键词： Full waveform inversion High-resolution imaging Interior structure of the Earth Earthquake preparation me-chanism Multidisciplinary integration

Jump and Variational Inequalities for Singular Integral with Rough Kernel

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Acta Mathematica Sinica,English Series 2025年第1期41卷 149-168页

作者： Yanping Chen liu yang meng Qu Department of Applied Mathematics University of Science and Technology BeijingBeijing 100083P.R.China Department of Mathematics Northeastern UniversityShenyang 110004P.R.China Department of Mathematics Chaohu universityHefei 238000P.R.China

In this paper,we consider the jump and variational inequalities of truncated singular integral operator with rough kernel TΩ,β,εf(x)=∫_(|y|>ε)Ω(y)/|y|^(n−β)f(x−y)dy,where the kernelΩ∈(L(log+L)^(2))n/(n−β)(S^(n−1))satisfies the vanishing condition and the homogeneous condition of degree *** kind of singular integral appears in the approximation of the surface quasigeostrophic(SQG)equation from the generalized SQG *** establish the(L^(p),L^(q))estimate of the jump and variational inequalities of the families{T_(Ω,β,ε)}ε>0 for 1/q=1/ p−β/n and 0<β<***,one can get the L^(p) boundedness of the Calder´on–Zygmund operator with the same kernel by lettingβ→0^(+).

关键词： Jump and variational inequalities rough kernel singular integral

Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy

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Chinese Journal of Integrative Medicine 2025年第1期31卷 19-27页

作者： liu Tian-yi HAO Yu MAO Qin ZHOU Na liu meng-hua WU Jun WANG Yi yang Ming-rui School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Experimental Research Center China Academy of Chinese Medical SciencesBeijing100700China

Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages infected with influenza A virus and the underlying mechanism based on mitophagy pathway. Methods:The inflammatory model of murine macrophage J774A.1 induced by influenza A virus [strain A/Puerto Rico/8/1934(H1N1), PR8] was constructed and treated by TRQ, while the mitochondria-targeted antioxidant Mito-TEMPO and autophagy specific inhibitor 3-methyladenine(3-MA) were used as controls to intensively study the anti-inflammatory mechanism of TRQ based on mitophagy-mitochondrial reactive oxygen species(mt ROS)-NLRP3 inflammasome pathway. The levels of NLRP3, Caspase-1 p20, microtubule-associated protein 1 light chain 3 Ⅱ(LC3Ⅱ) and P62 proteins were measured by Western blot. The release of interleukin-1β(IL-1β) was tested by enzyme linked immunosorbent assay, the mt ROS level was detected by flow cytometry, and the immunofluorescence and co-localization of LC3 and mitochondria were observed under confocal laser scanning microscopy. Results: Similar to the effect of Mito-TEMPO and contrary to the results of 3-MA treatment, TRQ could significantly reduce the expressions of NLRP3, Caspase-1 p20, and autophagy adaptor P62, promote the expression of autophagy marker LC3Ⅱ, enhance the mitochondrial fluorescence intensity, and inhibit the release of mt ROS and IL-1β(all P<0.01).Moreover, LC3 was co-localized with mitochondria, confirming the type of mitophagy. Conclusion: TRQ could reduce the level of mt ROS by promoting mitophagy in macrophages infected with influenza A virus, thus inhibiting the activation of NLRP3 inflammasome and the release of IL-1β, and attenuating the inflammatory response.

关键词： Tanreqing Injection influenza virus anti-inflammation mitophagy nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome Chinese medicine

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

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Chinese Chemical Letters 2015年第2期26卷 243-247页

作者： Yong Sun Cui-Lin Lu Chang-Yuan Wang Rui-Rui Wang Ke-Xin liu liu-meng yang Yu-Hong Zhen Hou-Li Zhang Chao Wang Yong-Tang Zheng Xiao-Dong Ma College of Pharmacy Dalian Medical University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province.Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences

Searching for more safe and effective agents for HIV treatments is still an urgent topic *** on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase（RT）inhibitors,a new template bearing N-phenylbenzenesulfonamide（PBSA） structure was designed to enhance the interactions with HIV-1 *** this manuscript,a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 *** preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC_（50） values ranging of 0.105-14.531 μmol/*** particular,compound 13 f not only has high anti-HIV-1 activity（0.108 μmol/L）,but also possesses low toxicity with a Tl value of ***,the major interactions of the inhibitor 13 f with HIV-1 RT were also investigated using the molecular *** discovered structure-activity relationships（SARs） of these analogues may serve as an important clue for further optimizations.

关键词： Benzophenone N-Phenylbenzenesulfonamide Structure modification Anti-HIV activity

High-frequency enhanced ultrafast compressed active photography

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Opto-Electronic Advances 2025年第1期8卷 32-43页

作者： Yizhao meng Yu Lu Pengfei Zhang Yi liu Fei Yin Lin Kai Qing yang Feng Chen State Key Laboratory for Manufacturing System Engineering and Shaanxi Key Laboratory of Photonics Technology for Information School of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame ***,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame ***,a high-frequency enhanced compressed active photography(H-CAP)is *** uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling *** sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image *** superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,*** applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.

关键词： ultrafast compressed imaging high-frequency enhanced sampling spectral-temporal transform transient processes high-fidelity reconstruction

A PHYB-PIF4-auxin module promotes tomato graft formation in response to elevated ambient temperature

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Horticultural Plant Journal 2025年第1期11卷 227-238页

作者： Xianmin meng Feng Zhang Wencai yang Qingmao Shang State Key Laboratory of Vegetable Biobreeding Key Laboratory of Horticultural Crop Biology and Germplasm Innovation(Ministry of Agriculture)Institute of Vegetables and FlowersChinese Academy of Agriculture SciencesBeijing 100081China Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops Department of Vegetable ScienceCollege of HorticultureChina Agricultural UniversityBeijing 100193China

Grafting is an effective technique for increasing the resistance of vegetables to biotic and abiotic *** has been widely applied to produce solanaceous and melon *** is an important external factor affecting graft ***,the molecular mechanism by which external ambient temperature affects tomato graft formation remains *** this study,we demonstrated that elevating ambient temperature during grafting to 35℃ for more than 24 h after grafting accelerated vascular *** generated self-or heterografted combinations between phyB1B2 and pif4 loss-of-function mutant and wild-type plants,and were mutants unresponsive to graft formation at elevated ambient *** addition,elevated ambient temperature induced SlPIF4 expression during ***4 directly binds the promoters of auxin biosynthesis genes SlYUCCAs and activates their *** investigation revealed auxin accumulation in the graft junction under elevated ambient *** results illuminate the mechanism by which the PHYB-PIF4-auxin module promotes tomato graft formation in response to elevated ambient temperature.

关键词： Graft formation Tomato Temperature Vascular Auxin

Study on the Fluid-Solid Coupling Seepage of the Deep Tight Reservoir Based on 3D Digital Core Modeling

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Energy Engineering 2025年第2期122卷 537-560页

作者： Haijun yang Zhenzhong Cai Hui Zhang Chong Sun Jing Li Xiaoyu meng Chen liu Chengqiang yang PetroChina Tarim Oilfield Company Korla841000China CNPC R&D Center for Ultra-Deep Complex Reservoir Exploration and Development Korla841000China National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580China Structure and Shipping Department Offshore Oil Engineering(Qingdao)Co.Ltd.Qingdao266520China

Deep tight reservoirs exhibit complex stress and seepage fields due to varying pore structures,thus the seepage characteristics are significant for enhancing oil *** study conducted triaxial compression and permeability tests to investigate the mechanical and seepage properties of tight sandstone.A digital core of tight sandstone was built using Computed Tomography(CT)scanning,which was divided into matrix and pore phases by a pore equivalent diameter threshold.A fluid-solid coupling model was established to investigate the seepage characteristics at *** results showed that increasing the confining pressure decreased porosity,permeability,and flow velocity,with the pore phase becoming the dominant seepage *** and large pores closed first under increasing pressure,resulted in a steep drop in ***,permeability slightly decreased under high confining pressure,which followed a first-order exponential *** velocity increased with seepage *** the damage mainly occurred in stress-concentration regions under low seepage *** behavior followed linear Darcy flow,the damage emerged at seepage entrances under high pressure,which decreased rock elastic modulus and significantly increased permeability.

关键词： Digital core fluid-solid coupling pore structure microscopic seepage

Regulation effects of rosemary(Rosmarinus officinalis Linn) on hepatic lipid metabolism in OA induced NAFLD rats

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中国药理学与毒理学杂志 2019年第9期33卷 699-700页

作者： WANG Si-jian CHEN Qian liu meng-yang YU Hai-yang XU Jing-qi WU Jia-qi ZHANG Yi WANG Tao Institute of Traditional Chinese Medicine 2.Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE To highlight the pharmacological effects of rosemary and its active compounds and eluci⁃date its related mechanisms in nonalcoholic fatty liver disease(NAFLD)management both in vitro and in *** In orotic acid induced NAFLD rats model,rats were administrated with 100,200 and 400 mg·kg^-1 rosemary ethanol extract(RO),10,25 and 50 mg·kg^-1 rosemary acid(RA),and 5,10 and 25 mg·kg^-1 carnosic acid(CA)for three weeks respec⁃*** oleate induced HepG2 cell model was used to study the regulation effect of rosemary ethanol extract and its main metabolites on fat *** metabolism related gene expression was analyzed by Western blotting and real-time PCR to clarify the specific molecular mechanism of RO,RA and CA in lipid *** RO,RA and CA significantly reduced the contents of liver triglyceride(TG),total cholesterol(TC),free fatty acids(FFA)and improved cell hypertrophy,vacuolation,and cell necrosis in liver of orotic acid induced NAFLD model *** mecha⁃nism and related pathways of RO and its main metabolites against lipid disorder was related to the up-regulation of the phosphorylation of adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)and inhibition of the sterol regu⁃latory element binding protein-1c(SREBP-1c)cracking into the nuclear,following down-regulation of fatty acid *** The rosemary has effectively function to regulate lipid metabolism through AMPK/SREBP1c signaling pathway.

关键词： rosermary NAFLD rosermary acid carnosic acid AMPK SREBP-1c