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Development of Ti_(0.85)Zr_(0.17)(Cr-Mn-V)_(1.3)Fe_(0.7)-based Laves phase alloys for thermal hydrogen compression at mild operating temperatures

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Rare Metals 2022年第8期41卷 2588-2594页

作者： Zi-Ming Cao Pan-Pan Zhou Xue-zhang Xiao Liu-Jun Zhan Zhi-Fei Jiang Shu-Mao Wang Li-jun Jiang Li-Xin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Department of Materials Science and Engineering The University of ManchesterManchesterM139PLUK Institute of Energy Materials and Technology General Research Institute for Non-ferrous MetalsBeijing100088China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou310013China

Metal hydride with proper hydrogen storage properties is the key component of hydride thermal hydrogen compressor.In this work,Ti_(0.85)Zr_(0.17)(Cr-Mn-V)_(1.3)Fe_(0.7)-based alloys were developed to achieve thermal hydrogen compression at mild operating temperatures of water bath.The results indicate the single C 14-type Laves phase as well as homogeneously distributed elements of all alloys.With increased Mn content in Ti_(0.85)Zr_(0.17)Cr_(1.2-x)Mn_xFe_(0.7)V_(0.1)(x=0,0.1,0.2,0.3)alloys.

关键词： alloys hydrogen Laves

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

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当代医学科学（英文） 2024年第2期44卷 333-345页

作者： jun-li ZHAO Lin ZHAO Qiu-nan zhan Miao liu Ting zhanG Wen-wen CHU Department of Nephrology Shanghai University of Medicine & Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to PD.Methods:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25％glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5％PDF group,2.5％PDF group,4.25％PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of PDF.HE and Masson staining were performed to evaluate the extent of PF.The therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function analyses.Epithelial-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25％PDF.Cells were divided into control group,4.25％PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Cell Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 cells.Results:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to BMSCs.The RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD mice.We found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD mice.Compared with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious fibroproliferative response,with markedly increas

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelial-mesenchymal transition

Lipoxin A4 Ameliorates Lipopolysaccharide-lnduced A549 Cell Injury through Upregulation of N-myc Downstream-Regulated Gene-1

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Chinese Medical Journal 2018年第11期131卷 1342-1348页

作者： jun-Zhi zhang zhan-Li liu Yao-Xian zhang Hai-Jiu Lin Zhong-jun zhang Department of Anesthesiology 2nd Clinical Medical College of Jinan University Shenzhen Guangdong 518020 China Department of Anesthesiology Shenzhen People's Hospital Shenzhen Guangdong 518020 China Research and Development Department Shenzhen Acen Regenerative Medicine Shenzhen Guangdong 518122 China

Background： Lipoxin A4 （LXA4） can alleviate lipopolysaccharide （LPS）-induced acute lung injury （ALl） and acute respiratory distress syndrome through promoting epithelial sodium channel （ENaC） expression in lung epithelial cells. However, how LXA4 promote ENaC expression is still largely elusive. The present study aimed to explore genes and signaling pathway involved in regulating ENaC expression induced by LXA4. Methods： A549 cells were incubated with LPS and LXA4, or in combination, and analyzed by quantitative real-time polymerase chain reaction （qRT-PCR） of ENaC-α/γ. Candidate genes affected by LXA4 were explored by transcriptome sequencing ofA549 cells. The critical candidate gene was validated by qRT-PCR and Western blot analysis ofA549 cells treated with LPS and LXA4 at different concentrations and time intervals. LXA4 receptor （ALX） inhibitor BOC-2 was used to test induction of candidate gene by LXA4. Candidate gene siRNA was adopted to analyze its influence on A549 viability and ENaC-α expression. Phosphoinositide 3-kinase （PI3K） inhibitor LY294002 was utilized to probe whether the PI3K signaling pathway was involved in LXA4 induction of candidate gene expression. Results： The A549 cell models of ALl were constrticted and subjected to transcriptome sequencing. Among candidate genes, N-myc downstream- regulated gent- 1 （NDRG 1 ） was validated by real-time-PCR and Western blot. NDRG 1 mRNA was elevated in a dose-dependent manner of LXA4, whereas BOC-2 antagonized NDRG 1 expression induced by LXA4. NDRG I siRNA suppressed viability of LPS-treated A549 cells （treatment vs. control, 0.605± 0.063 vs. 0.878 ± 0.083, P = 0.040） and ENaC-α expression （treatment vs. control, 0.458 ± 0.038 vs. 0.711 ± 0.035, P = 0.008）. LY294002 inhibited NDRG 1 （treatment vs. control, 0.459 ± 0.023 vs. 0.726 ± 0.020, P 0.001 ） and ENaC-α （treatment vs. control, 0.236 ± 0.021 vs. 0.814 ±0.025, P 〈 0.001 ） expressions and serum- and glucocorticoid-inducible kinase I phosphorylation （treatment vs. control, 0.442± 0.024 vs. 1.046 ± 0.0

关键词： Acute Lung Injury Epithelial Sodium Channel Lipopolysaccharide Lipoxin A4 N-myc Downstream-Regulated Gene-1

Evolution of inclusion and microstructure in Ti-Zr deoxidized steel during hot compression

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Journal of Iron and Steel Research(International) 2023年第10期30卷 1987-1999页

作者： Yong-kun Yang Jia-yu Zhu Xiao-ming Li Yang Wang Cheng-jun liu Dong-ping zhan School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The effects of different hot deformation amounts on the evolution of inclusion and microstructure in Ti-Zr deoxidized steel were studied by utilizing the Thermecmaster-Z hot simulation test machine,automatic scanning electron microscope equipped with energy-dispersive spectrometer,and electron backscattered diffraction.The results indicated that hot deformation amount has no significant effect on the number density of oxide,but the MnS that precipitated on the Ti-Zr oxide surface undergoes extension and breakage,resulting in the changes in oxide aspect ratio.Moreover,the fracture of nitride mainly occurs in the sample with the second pass deformation amount of 42.9%and 71.4%,and the degree of fragmentation of nitride is more serious with the deformation amount increasing.During the hot compression,sulfide undergoes breakage and extension,and with the second pass deformation amount increasing,the breakage and extension of sulfide present a periodic change.Finally,with the increase in hot compression amount,the ferrite types in microstructure change from acicular ferrite and bainitic ferrite to polygonal ferrite,and the ferrite grain size is refined.When the total deformation amount increases from 30%to 80%,the ferrite grain sizes of grain boundary with the misorientation of 4°and 15°decrease from 4.14 and 5.67μm to 3.47 and 4.40μm,respectively.However,when the total deformation amount increases to 80%,the harmful ferrite/pearlite banded structure appears in the micro structure.Refining ferrite grain size and avoiding harmful microstructure are the key for the optimization of hot compression process.

关键词： Hot compression Oxide Nitride Sulfide Microstructure Grain size Ti-Zr deoxidized steel

Association between Serum Uric Acid and the Early Marker of Kidney Function Decline among Chinese Middle-Aged and Older Population:Evidence from the China Health and Retirement Longitudinal Study

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Biomedical and Environmental Sciences 2023年第3期36卷 231-240页

作者： TANG Xu XU Lu MENG Ruo Gu DU Yi Qing liu Shi jun zhan Si Yan XU Tao Department of Urology Peking University People’s HospitalBeijing 100044China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China National Institute of Health Data Science Center for Data Science in Health and MedicinePeking UniversityBeijing 100191China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Center for Intelligent Public Health Institute for Artificial IntelligencePeking UniversityBeijing 100191China

Objective To evaluate the association between serum uric acid(SUA)and kidney function decline.Methods Data was obtained from the China Health and Retirement Longitudinal Study on the Chinese middle-aged and older population for analysis.The kidney function decline was defined as an annual estimated glomerular filtration rate(e GFR)decrease by>3 mL/min per 1.73 m^(2).Multivariable logistic regression was applied to determine the association between SUA and kidney function decline.The shape of the association was investigated by restricted cubic splines.Results A total of 7,346 participants were included,of which 1,004 individuals(13.67%)developed kidney function decline during the follow-up of 4 years.A significant dose-response relation was recorded between SUA and the kidney function decline(OR 1.14,95%CI 1.03-1.27),as the risk of kidney function decline increased by 14%per 1 mg/d L increase in SUA.In the subgroup analyses,such a relation was only recorded among women(OR 1.22,95%CI 1.03-1.45),those aged5 mg/dL was associated with a significantly higher risk of kidney function decline.Conclusion The SUA level was associated with kidney function decline.An elevation of SUA should therefore be addressed to prevent possible kidney impairment and dysfunction.

关键词： Uric acid Glomerular filtration rate Kidney function decline

Isolated elevated aspartate aminotransferase in an asymptomatic woman due to macro-aspartate aminotransferase: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4414-4419页

作者： Meng-Ru zhan Xu liu Ming-Yuan zhang jun-Qi Niu Department of Hepatology The First Hospital of Jilin University

BACKGROUND Macro-aspartate aminotransferase(AST), a macroenzyme, is a high-molecular mass complex formed by self-polymerization or association with other serum components that are difficult for the kidney to clear, leading to the isolated elevation of serum AST activity. Cases of macro-AST formation are rare, with only 3 published in the English language literature up to September 2019 in China. In this paper, we present a case in which an asymptomatic woman with persistent isolated elevated AST was confirmed as having macro-AST by the polyethylene glycol precipitation method.CASE SUMMARY A 34-year-old woman was referred to our clinic for elevated AST levels with normal levels of other liver-associated enzymes on November 12, 2018. Her AST level of liver function test had been abnormal for 7 mo before she came to the clinic. The patient was asymptomatic with a normal physical examination. There was no relevant family history and no alcohol consumption or smoking. She had a several-month history of traditional Chinese medical taking and had stopped it 1 year prior. The laboratory tests in our clinic showed only the elevation of AST(89.5 U/L) with no other significant abnormalities. We performed the precipitation technique with polyethylene glycol to confirm the presence of macro-AST. Then for almost a year, her AST level still fluctuated in the abnormal range.CONCLUSION This case highlights that clinical physicians should be familiar with this rare condition of persistent isolated AST elevation due to the presence of macro-AST to avoid unnecessary investigation and patient anxiety.

关键词： Aspartate aminotransferase Macroenzymes Macro-aspartate aminotransferase Polyethylene glycol precipitation method China Case report

Effect of soft reduction process on segregation of a 400 mm thick high-alloy steel slab

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Journal of Iron and Steel Research(International) 2021年第3期28卷 272-278页

作者： Ren-sheng Chu zhan-jun Li Jin-gang liu Yong Fan Yang liu Chang-wen Ma Research Institute of Technology Shougang Group Co.Ltd.Beijing100043China Beijing Engineering Research Center of Energy Steel Beijing100043China Beijing Key Laboratory of Green Recyclable Process for Iron and Steel Production Technology Beijing100043China Institute of Iron and Steel Technology TU Bergakademie FreibergFreiberg09599SachsenGermany

During the solidification of high-alloy steel(0.4C–1.5Mn–2Cr–0.35Mo–1.5Ni),the high temperature gradient of solidified shell as well as the columnar crystal development would contribute to the centre segregation and cracking due to the high carbon and alloy contents.The effect of soft reduction process on the segregation of a 400 mm thick high-alloy steel slab was analysed.Industrial trials in a steel mill were performed combining with segregation analysis.The inner quality of the high-alloy steel slab produced through the optimised soft reduction procedures and had a significant improvement in centre segregation.The reduction amount is increased from 20%of solid phase fraction,to avoid the segregation due to the long liquid core,and the reduction rate is deceased from 1.35 to 0.88 mm/m as well.This operation would contribute to the symmetrical distribution of solute element and decrease the segregation to avoid the cracking.An obvious improvement in centre segregation to mainly 1.0 class of high-alloy slab after procedure optimization was achieved.The quality improvement of slab would ensure the quality of downstream forging.

关键词： Continuous casting Soft reduction High-alloy steel Segregation Cracking

Preparation of tanshinone Ⅱ_(A) self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts

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Chinese Herbal Medicines 2023年第2期15卷 251-262页

作者： Yanshan zhan Xiaoqi Xu Xi Luo Ruiping liu Yujian Lin Ping Zhao jun Shi School of Chinese Material Medica Guangdong Pharmaceutical University of ChinaGuangzhou 510006China Department of Chemistry and Chemical Engineering Guangdong Pharmaceutical University of ChinaZhongshan 528458China Engineering&Technology Research of Topical Precise Drug Delivery System Guangzhou Higher Education Mega CenterGuangzhou 510006China

Objective:Hypertrophic scars(HS)are a variety of skin tissue fibrosis disease that occurs in human skin,the effective therapeutic method of which is still inaccessible up to now.As a bioactive constituent of a well-known medical plant,Salvia miltiorrhiza(Danshen in Chinese),tanshinone Ⅱ_(A)(TSA)is reported to inhibit cell proliferation in HS.Therefore,the aim of this study was to prepare TSA self-soluble microneedles to strengthen its dermal retention and break through the difficulty of significantly thickening epidermal connective tissue and stratum corneum at the HS site.The possible mechanism of action in suppressing HS was studied using human skin fibroblasts(HSF).Methods:Tanshinone Ⅱ_(A) self-dissolving microneedles(TSA-MN)was prepared using a negative mold casting method.The prescription process of microneedle was optimized by Box-Behnken effect surface method.Different media were selected to investigate the ability of transdermal absorption and in vitro release.Furthermore,according to Cell Counting Kit-8(CCK8)method as well as the Western blot method,the effect of TSA-MN on the biological characteristics of HSF was investigated.Results:With remarkable slow release effect and dermal retention,the release and transdermal properties of TSA-MN in vitro were better than both TSA and ordinary dosage forms.Its effect of HSF confirmed the essential decrease in cell motility during cell proliferation and cell migration in vitro,which plays a significant role in down-regulating the secretion of transforming growth factor-β1(TGF-β1)in HSF and increasing the expression level of Smad7.Conclusion:The prepared TSA self-soluble microneedles is helpful in solving the problem of hypertrophic scars,with a stable dermal retention effect after process optimization.

关键词： human skin fibroblasts hypertrophic scar tanshinoneⅡ_(A) tanshinoneⅡ_(A)self-dissolving microneedles TGF-β1

Anion Defects Engineering of Ternary Nb-Based Chalcogenide Anodes Toward High-Performance Sodium-Based Dual-Ion Batteries

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Nano-Micro Letters 2023年第7期15卷 218-232页

作者： Yangjie liu Min Qiu Xiang Hu jun Yuan Weilu Liao Liangmei Sheng Yuhua Chen Yongmin Wu Hongbing zhan Zhenhai Wen College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108People’s Republic of China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of Materials and Techniques Toward Hydrogen EnergyFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002People’s Republic of China Fujian Normal University Fuzhou 350108People’s Republic of China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power Sources2965 Dongchuan RoadShanghai 200245People’s Republic of China

Sodium-based dual-ion batteries(SDIBs) have gained tremendous attention due to their virtues of high operating voltage and low cost, yet it remains a tough challenge for the development of ideal anode material of SDIBs featuring with high kinetics and long durability. Herein, we report the design and fabrication of N-doped carbon film-modified niobium sulfur–selenium(NbSSe/NC) nanosheets architecture, which holds favorable merits for Na^(+) storage of enlarged interlayer space, improved electrical conductivity, as well as enhanced reaction reversibility, endowing it with high capacity, high-rate capability and high cycling stability. The combined electrochemical studies with density functional theory calculation reveal that the enriched defects in such nanosheets architecture can benefit for facilitating charge transfer and Na+ adsorption to speed the electrochemical kinetics. The NbSSe/NC composites are studied as the anode of a full SDIBs by pairing the expanded graphite as cathode, which shows an impressively cyclic durability with negligible capacity attenuation over 1000 cycles at 0.5 A g^(-1), as well as an outstanding energy density of 230.6 Wh kg^(-1) based on the total mass of anode and cathode.

关键词： NbSSe Sodium-based dual-ion battery Anode Nanosheets architecture Anion defects engineering