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罗哌卡因用于亚高原地区脊麻剖宫产的剂量研究

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复旦学报（医学版） 2024年第5期51卷 778-783页

作者：张乐马孟召董王军路耀军高也悦黄绍强杨晨复旦大学附属妇产科医院麻醉科上海200090 云南省永平县人民医院麻醉科大理672600

目的探讨罗哌卡因用于亚高原地区脊麻剖宫产的半数有效剂量(median effective dose,ED50)。方法选择一直生活在亚高原地区,拟在腰硬联合麻醉下行择期剖宫产的单胎产妇30例,采用上下序贯法,脊麻罗哌卡因初始剂量14 mg(1.4 mL),有效定义... 详细信息

目的探讨罗哌卡因用于亚高原地区脊麻剖宫产的半数有效剂量(median effective dose,ED50)。方法选择一直生活在亚高原地区,拟在腰硬联合麻醉下行择期剖宫产的单胎产妇30例,采用上下序贯法,脊麻罗哌卡因初始剂量14 mg(1.4 mL),有效定义为脊麻注药后15 min内针刺双侧感觉阻滞平面T6或以上,胎儿娩出前不需额外硬膜外麻醉。根据前一例是否有效决定下一例产妇的剂量递增或递减1 mg。分别用Dixon上下序贯法和保序回归,计算罗哌卡因的ED50和95%CI,记录研究期间产妇低血压、恶心呕吐等不良反应的发生率。结果共30名产妇参与研究,平均年龄(30.88±5.56)岁,孕周(40±1.41)周,身高(156.69±5.80)cm,体重(67.44±10.48)kg。Dixon上下序贯法计算等比重罗哌卡因的ED50为10.68 mg(95%CI:9.65~12.58 mg)。保序回归计算ED50为10.33 mg(95%CI:9.41~12.07 mg),验证结论的准确性和敏感性。术中产妇出现低血压8例,心动过缓1例,恶心呕吐7例,未出现高血压、寒颤。结论罗哌卡因用于亚高原地区脊麻剖宫产的ED50为10.68 mg,高于目前已知的平原地区患者所需的ED50。

关键词：亚高原罗哌卡因剖宫产半数有效剂量(ED50) 脊麻

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Sludge concentration dynamic distribution and its impact on the performance of UNITANK

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Journal of Environmental Sciences 2007年第2期19卷 141-147页

作者： ZHANG Fa-gen liu jun-xin SUI jun Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Guangzhou Municipal Engineering Design and Research Institute Guangzhou 510060 China

UNITANK is a biological wastewater treatment process that combines the advantages of traditional activated sludge process and sequencing batch reactor, which is divided into Tank A, B and C. In this study, the sludge distribution and its impact on performance of UNITANK were carried out in Liede Wastewater Plant （WWTP） of Guangzhou, China. Results showed that there was a strong affiliation between Tank A and B of the system in sludge concentration distribution. The initial sludge concentration in Tank A could present the sludge distribution of the whole system. The sludge distribution was mainly influenced by hydraulic condition. Unsteady sludge distribution had an impact on variations of substrates in reactors, especially in decisive reactor, and this could lead to failure of system. Settler could partially remove substrates such as COD and NO3-N, but there was adventure of sludge deterioration. The rational initial sludge concentration in Tank A should be 4000-6000 mg/L MLSS.

关键词： UNITANK sludge concentration dynamic distribution in-process study

碱性过氧化氢改性预处理对玉米芯不溶性膳食纤维的理化性质及功能特性的影响

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中国粮油学报 2024年第3期39卷 48-55页

作者：李金隆魏书音孟珺邢杨丁长河游艳芝河南工业大学粮油食品学院郑州450001 浙江科技学院环境与资源学院杭州310023 北京市疾病预防控制中心食品中毒诊断与溯源技术北京市重点实验室北京100013

采用不同质量分数的碱性过氧化氢(AHP)对玉米芯不溶性膳食纤维(IDF)进行改性预处理,评估比较了AHP改性前后玉米芯IDF的理化性质和功能特性。结果表明,改性后玉米芯中IDF的持水力(WHC)、持油力(OHC)、吸水膨胀力(WSC)和葡萄糖吸附能力(G... 详细信息

采用不同质量分数的碱性过氧化氢(AHP)对玉米芯不溶性膳食纤维(IDF)进行改性预处理,评估比较了AHP改性前后玉米芯IDF的理化性质和功能特性。结果表明,改性后玉米芯中IDF的持水力(WHC)、持油力(OHC)、吸水膨胀力(WSC)和葡萄糖吸附能力(GAC)明显提高。与未经处理的IDF相比,改性后WHC、OHC、WSC和GAC分别由(2.24±0.03)g/g、(1.88±0.01)g/g、(1.97±0.16)mL/g、(102.16±4.98)mg/g提高至(4.36±0.18)g/g、(3.18±0.04)g/g、(2.94±0.08)mL/g、(217.77±18.95)mg/g。在pH为2.0时,改性后玉米芯IDF的亚硝酸根离子吸附能力(NAC)明显增加,2.0%AHP改性后达到最大值68.45μg/g。此外,扫描电子显微镜(SEM)观察到AHP改性后表面出现褶皱,并具有多孔网状结构。傅里叶变换红外光谱(FT-IR)和X射线衍射(XRD)图谱表明,AHP改性能够降解玉米芯IDF中的半纤维素和木质素。总体来说,AHP改性可以有效地改善玉米芯IDF的性能。

关键词：玉米芯不溶性膳食纤维碱性过氧化氢理化性质功能特性

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Wave-particle duality relation with a quantum N-path beamsplitter

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Chinese Physics B 2021年第5期30卷 220-228页

作者： Dong-yang Wang jun-Jie Wu Yi-Zhi Wang Yong liu An-Qi Huang Chun-Lin Yu Xue-jun yang Institute for Quantum Information&State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China College of Information and Communication National University of Defense TechnologyXi'an 710006China China Greatwall Quantum Laboratory China Greatwall Technology Group CO.LTD.Changsha 410073China

The wave-particle duality relation derived by Englert sets an upper bound of the extractable information from wave and particle properties in a two-path ***,previous studies demonstrated that the introduction of a quantum beamsplitter in the interferometer could break the limitation of this upper bound,due to interference between wave and particle *** the other line,a lot of efforts have been made to generalize this relation from the two-path setup to the N-path ***,it is an interesting question that whether a quantum N-path beamsplitter can break the limitation as *** paper systemically studies the model of a quantum N-path beamsplitter,and finds that the generalized wave-particle duality relation between interference visibility and path distinguishability is also broken in certain *** further study the maximal extractable information's reliance on the interference between wave and particle properties,and derive a quantitative *** then propose an experimental methodology to verify the break of the *** work reflects the effect of quantum superposition on wave-particle duality,and exhibits a new aspect of the relation between visibility and path distinguishability in N-path ***,it implies the observer's influence on wave-particle duality.

关键词： wave-particle duality interference visibility path distinguishability quantum N-path beamsplitter

不同初加工方式对太白贝母性状及化学成分的影响

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中国中药杂志 2024年第11期49卷 2930-2939页

作者：王计瑞谭均王继朋张小梅彭锐阳勇孙年喜重庆市中药研究院中药新药创制川渝重点实验室国家中医药管理局中药化学三级实验室重庆400065 中国中医科学院中药资源中心重庆分中心重庆400065 重庆市潼南区中药研究院有限公司重庆402660

为探究不同初加工方式对太白贝母品质的影响,该研究分别考察了防褐变处理、干燥方式和干燥温度对太白贝母性状、色度和生物碱及核苷类成分的影响,并通过相关性分析(CA)、主成分分析(PCA)和层次聚类分析(HCA)对结果进行综合评价。与直接... 详细信息

为探究不同初加工方式对太白贝母品质的影响,该研究分别考察了防褐变处理、干燥方式和干燥温度对太白贝母性状、色度和生物碱及核苷类成分的影响,并通过相关性分析(CA)、主成分分析(PCA)和层次聚类分析(HCA)对结果进行综合评价。与直接干燥(WD60)组相比,刮去外皮(FHB1)组和拌石灰粉(FHB2)组的色度值ΔE^(*)显著降低,可降低褐变程度;拌原生土(FHB3)组和FHB2组的总生物碱含量无明显变化,5%NaClO溶液漂洗(FHB4)组的总生物碱含量最低。与恒温鼓风干燥(WD50)组相比,冷冻干燥(FS6)组和减压干燥(FS5)组ΔE^(*)显著降低,总生物碱含量升高;阴干(FS1)组和晒干(FS2)组的ΔE^(*)显著增加,褐变严重,总生物碱含量降低;热泵干燥(FS4)组的总生物碱含量变化不大,ΔE^(*)显著降低,褐变程度轻,商品性状佳。在40~80℃,鼓风干燥的样品总生物碱含量呈先升后降趋势,70℃时最高;高温下(70~80℃)ΔE^(*)更小,褐变程度轻,但质地紧实,粉性不足。CA表明,尿嘧啶含量与太白贝母色度值关系显著(P<0.05);PCA和HCA结果可视化地展现了不同处理组样品间的聚类关系。综合分析表明拌石灰鼓风干燥及50~60℃鼓风干燥更适合于大生产,热泵干燥可作为未来推广发展的方向。该研究为优选太白贝母产地加工方法提供了科学依据。

关键词：太白贝母防褐变初加工方式色度值总生物碱核苷类

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柑橘黄龙病菌原噬菌体的遗传多样性分析

园艺学报 2024年第4期51卷 727-736页

作者：游平杨进周俊黄爱军鲍敏丽易龙赣南师范大学生命科学学院江西赣州341000 国家脐橙工程技术研究中心江西赣州341000

以采自广东、广西、海南、云南、四川、贵州等6个地区共300份感染柑橘黄龙病菌的DNA样本作为试验材料,通过PCR技术对黄龙病菌携带的3种类型原噬菌体基因进行特异扩增、测序,利用相关生物信息学软件进行遗传多样性分析。结果共鉴定出8种... 详细信息

以采自广东、广西、海南、云南、四川、贵州等6个地区共300份感染柑橘黄龙病菌的DNA样本作为试验材料,通过PCR技术对黄龙病菌携带的3种类型原噬菌体基因进行特异扩增、测序,利用相关生物信息学软件进行遗传多样性分析。结果共鉴定出8种原噬菌体组合;携带单一原噬菌体类型的黄龙病菌株为6个地理种群的优势菌株,占比53.3%,其中以Type 2型为主;3类原噬菌体基因位点中A+T含量均高于G+C,表现出AT偏好特点;重组分析结果显示黄龙病菌间无重组信号,表明未发生重组事件;基因流N_(m)值均大于1,说明黄龙病菌在各种群中基因交流频繁;中性检验结果显示Tajima’s D、Fu and Li’s D、Fu and Li’s F值均小于0,表明黄龙病菌种群存在过历史扩张。

关键词：柑橘黄龙病原噬菌体遗传多样性

Host-mediated biofilm forming promotes post-graphene pathogen expansion via graphene micron-sheet

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Frontiers of Materials Science 2020年第2期14卷 221-231页

作者： Kun yang Jinghuan TIAN Wei QU Bo LUAN Ke liu jun liu Likui WANG junhui JI Wei ZHANG Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Graphene is a potential candidate for applications in biomedical *** is inevitable that graphene is in contact with the ubiquitous bacterial *** attention has been paid to the antimicrobial activity of graphene derivatives(graphene oxide,reduced graphene oxide)than the interaction between graphene and ***,we explore interaction between graphene micron-sheet and bacteria from micro(gene expression)and macro(colonies)*** demonstrate that graphene micron-sheet accelerates the biofilm forming thus promoting pathogen expansion toward both Gram-negative bacteria *** and Gram-positive bacteria *** graphene micron-sheet acts as a“habitat”for increasing bacterial attachment and biofilm *** ***,graphene micron-sheet,firstly changes the integrity of periplasmic and outer membrane components,then makes membraneassociated and cell division genes increased,and finally promotes bacterial proliferation;For ***,graphene micron-sheet can accelerate biofilm forming and develop bacterial expansion owing to the regulation of the quorum-sensing system and global regulatory *** work can shed new light on the range of possible mode of actions,developing a better understanding of the capabilities of graphene micronstructures.

关键词： graphene micron-sheet bacteria gene expression biofilm forming

PTHrP promotes subchondral bone formation in TMJ-OA

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International Journal of Oral Science 2022年第4期14卷 489-496页

作者： jun Zhang Caixia Pi Chen Cui yang Zhou Bo liu Juan liu Xin Xu Xuedong Zhou Liwei Zheng State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Yunnan Key Laboratory of Stomatology KunmingChina Department of Affiliated Stomatological HospitalKunming Medical UniversityKunmingChina

PTH-related peptide(PTHr P) improves the bone marrow micro-environment to activate the bone-remodelling, but the coordinated regulation of PTHr P and transforming growth factor-β(TGFβ) signalling in TMJ-OA remains incompletely understood. We used disordered occlusion to establish model animals that recapitulate the ordinary clinical aetiology of TMJ-OA. Immunohistochemical and histological analyses revealed condylar fibrocartilage degeneration in model animals following disordered occlusion. TMJ-OA model animals administered intermittent PTHr P(i PTH) exhibited significantly decreased condylar cartilage degeneration. Micro-CT,histomorphometry, and Western Blot analyses disclosed that i PTH promoted subchondral bone formation in the TMJ-OA model animals. In addition, i PTH increased the number of osterix(OSX)-positive cells and osteocalcin(OCN)-positive cells in the subchondral bone marrow cavity. However, the number of osteoclasts was also increased by i PTH, indicating that subchondral bone volume increase was mainly due to the i PTH-mediated increase in the bone-formation ability of condylar subchondral *** vitro, PTHr P treatment increased condylar subchondral bone marrow-derived mesenchymal stem cell(SMSC) osteoblastic differentiation potential and upregulated the gene and protein expression of key regulators of osteogenesis. Furthermore, we found that PTHr P-PTH1R signalling inhibits TGFβ signalling during osteoblastic differentiation. Collectively, these data suggested that i PTH improves OA lesions by enhancing osteoblastic differentiation in subchondral bone and suppressing aberrant active TGFβsignalling. These findings indicated that PTHr P, which targets the TGFβ signalling pathway, may be an effective biological reagent to prevent and treat TMJ-OA in the clinic.

关键词： TMJ degeneration occlusion

利用光谱学分析探究高温木叶黑釉瓷的实验模拟

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光谱学与光谱分析 2024年第8期44卷 2381-2387页

作者：熊露袁寅洁李丹杨轩季然李其江吴军明景德镇陶瓷大学古陶瓷研究中心江西景德镇333001 江西陶瓷文物遗存保护暨御窑研究协同创新中心江西景德镇333001

高温木叶黑釉瓷作为一种兼具雅致和审美特点的文化符号,因其独特的装饰效果逐渐成为中国茶道文化中备受青睐的陶瓷器具。然而,其配烧技术至今仍然神秘莫测,虽得到学者们的持续关注仍未完全披露其形成和机理。为此,采用实验模拟方法并结... 详细信息

高温木叶黑釉瓷作为一种兼具雅致和审美特点的文化符号,因其独特的装饰效果逐渐成为中国茶道文化中备受青睐的陶瓷器具。然而,其配烧技术至今仍然神秘莫测,虽得到学者们的持续关注仍未完全披露其形成和机理。为此,采用实验模拟方法并结合光谱学分析,通过利用样品色调角h°、饱和度C*以及反射光谱曲线和超景深显微镜观察分析釉面显微结构及其与黑釉呈色之间的关系,揭示了黑釉呈色和木叶纹清晰展现的机理,并基于传统黑釉筛选出了一组最佳的釉料配烧参数,其中Si/Al摩尔比在10.14~10.47,MgO摩尔量为0.19~0.22,CaO摩尔量为0.42~0.47,施釉厚度在0.7~0.9 mm之间可使黑釉呈现出最稳定的色泽和清晰度,并且木叶纹装饰较为理想。研究结果表明,合理的釉料配方组成及施釉厚度等对于黑釉的色调呈现和木叶纹清晰装饰具有至关重要的作用,同时,所采用的光谱学分析方法和实验模拟方法可以有效地辅助陶瓷行业中的釉料配方优选研发,有望提高制瓷工艺的精细化和智能化水平。同时,实现了对木叶黑釉显微结构与反射光谱曲线特征的解析,凸显了光谱学分析方法在陶瓷泥釉料研发方面的应用前景,有助于促进陶瓷文化的发展,为珍贵文化遗产的保护、传承和发扬提供理论支持,具有重要的实际应用价值。

关键词：木叶黑釉光谱学分析实验模拟配方筛选反射光谱曲线