检索结果-南通市图书馆

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan liu Jia-lin CHEN Geng-xin SHEN Dan-ting ZHU Wang CHEN Xin-lin liu feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

裙带菜多糖抑制肝癌细胞增殖和迁移的机制

引用

中国药理学通报 2024年第4期40卷 670-678页

作者：刘伟萍陈建芬安金琪罗艺刘凤斌广州中医药大学第一附属医院脾胃病科广东广州510405 广州中医药大学博士后科研流动站广东广州510405 广州中医药大学第一临床医学院广东广州510405 广东燕岭医院中医骨伤科广东广州510507 粤北人民医院中医科广东韶关512000 广州中医药大学第一附属医院白云分院内一科广东广州510000

目的探讨裙带菜多糖(sulfated polysaccharide from Undaria pinnatifida,SPUP)对肝癌细胞增殖、迁移的影响及潜在机制。方法MTT和克隆形成实验检测SPUP对肝癌细胞HepG2、SMMC-7721增殖的影响;Hoechst 33258染色和Western blot法检测SPUP干预后对HepG2、SMMC-7721细胞凋亡的影响;Transwell和划痕法检测HepG2、SMMC-7721细胞的迁移和侵袭;免疫荧光和Western blot法检测SPUP对肝癌细胞自噬、上皮-间质转化(epithelial-mesenchymal transition,EMT)和基质金属蛋白酶2(matrix metalloproteinase 2,MMP-2)、MMP-9蛋白的影响。结果SPUP对HepG2、SMMC-7721细胞有短期和长期的抑制增殖作用,对正常肝细胞L-02无明显抑制作用,SPUP可促进两种肝癌细胞凋亡和自噬水平。同时,SPUP可以抑制肝癌细胞的迁移侵袭能力,降低EMT和MMPs水平。结论SPUP通过促进凋亡和自噬、抑制EMT和MMPs,进而抑制肝癌细胞的增殖和迁移。

关键词：裙带菜多糖肝细胞癌增殖自噬凋亡侵袭迁移上皮间质转化基质金属蛋白酶

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Three-dimensional conjugated macrocycle with large polyaromatic blocks constructed by post-π-extension

引用

Science China Chemistry 2020年第11期63卷 1626-1631页

作者： Shun-He liu Hao Hou Ze-Ying Deng Xin-Rong Wang Chun Tang Yang-Yang Ju liu-bin feng Yuan-Zhi Tan State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Generally,the conjugated homo-macrocycles(CHMs)are synthesized by covalently linking the repeating ***,large subunits are often difficult to conjugate together due to severe ***,large polyaromatic blocks can not only incorporate its appealing electronic and optical properties into CHMs but also distort the CHMs from planar to three-dimensional(3D)molecular *** we synthesized the 3D CHM composed of large polyaromatic units by post-π-***,cyclo-m-phenylenes,as the cyclic precursor,wereπ-extended by C-C coupling and then subjected to dehydrocyclization,affording cyclo-1,3-dibenzo[e,l]pyrenylenes(CMDP).The structures of CMDPs were unambiguously characterized by single crystal X-ray diffraction,showing a congested and strained 3D conformation,which was also confirmed by theoretical *** with the monomer,CMDPs showed redshifted absorption and emission,as well as a ten-fold enhancement in photoluminescence quantum yield,which could be attributed to their 3D conformation.

关键词： macrocycle 7r-extension polyaromatic photoluminescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controversies on the Values for Health Instruments of Chinese Medicine

引用

Chinese Journal of Integrative Medicine 2017年第2期23卷 146-152页

作者： HOU Zheng-kun CHANG Xiang liu feng-bin Nelson XIE Nicole GUO CHEN Xin-lin Gastroenterology Department First Affiliated HospitalGuangzhou University of Chinese Medicine，Medicine，Guangzhou，510405，China Encephalopathy Department Xi'an Hospital of Traditional Chinese Medicine，Xi’an，710001，China Department of Neurosciences School of Medicine University of California，San Diego，CA，92093，USA Department of Preventive Medicine and Health Statistics School of Medical and Molecular Biosciences University of Technology Sydney，Ultimo，2007Australia Nursing Department Repatriation General HospitalSA ，5041，Australia College of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou，510006，China

Currently, there are increasing debates on the necessity of health instruments in Chinese medicine（CM） emerging in China. This study aims to reevaluate its status and values. Analyzing the causes, limits, advantages, and properties characters of health instruments in CM, it is found that weak fundamental research, incomplete self-awareness, and complicated social factors are the primary causes of debates. A comprehensive analysis showed health instruments in CM have health evaluation benefits to people from a dominant Chinese culture, meet the requirements of cultural background, and bring long-term value to Chinese instrument researches. However, its values and status should be treated differently depending on various subtypes. Although little theoretical and practical evidences proved that patients-reported health instruments in CM should be proposed independently, the doctors- and nurses-reported questionnaires are necessary. With this in mind, the study group proposes the ＇Chinese cultural instruments（CCIs）＇ and ＇health-related CCIs＇. The latter one aims to evaluate the health status of people in a dominant Chinese culture. The CCIs theory represents Chinese instrument researches on a larger regional and higher level, and resolves the debates on instruments between CM and Western medicine in China. Health instruments in CM bring more scientific and social benefits for Chinese instrument researches. However, it does not include cultural demands, and lacks scientific significance. CCIs have all its virtues, and add solutions to the latter＇s theory bottleneck and scientific debates, thus bringing increased benefits to clinical assessment in complementary and alternative medicine researches.

关键词： Chinese culture Chinese medicine instrument clinical outcome assessment patient-reported outcome value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

自动监测及信息化施工技术在基坑工程施工中的应用

引用

建筑技术 2024年第2期55卷 140-142页

作者：王建党袁长发刘彬锋王非洲贵州桥梁建设集团有限公司贵阳550001

通过基坑开挖过程中预埋的位移传感器及锚杆轴力计,自动监测岩土水平变形及锚杆轴力变化等信息,通过数值模拟技术与基坑支护设计方案进行比较分析,结合基坑实际变形情况进行动态反演获取反映场地特征的岩土参数,利用反演的岩土参数再次... 详细信息

通过基坑开挖过程中预埋的位移传感器及锚杆轴力计,自动监测岩土水平变形及锚杆轴力变化等信息,通过数值模拟技术与基坑支护设计方案进行比较分析,结合基坑实际变形情况进行动态反演获取反映场地特征的岩土参数,利用反演的岩土参数再次计算基坑理论变形量,通过理论计算值与实际检测值进行分析动态对比,指导后续开挖与支护施工,达到了较好的施工效果。

关键词：深基坑自动监测信息化施工数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancement and Removal of PM_(2.5)by Cold and Warm Air Masses Accompanying Certain Synoptic Weather Systems across Hangzhou,China during 2014-2020

引用

Journal of Meteorological Research 2024年第3期38卷 620-634页

作者： Bu YU feng CHEN Hanqing KANG bin ZHU Hongnian liu Hangzhou Meteorological Bureau Hangzhou310051China Hangzhou International Urbanology Research Center for Urban Governance Studies Hangzhou311121China Zhejiang Institute of Meteorological Sciences Hangzhou310008China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science&TechnologyNanjing210044China School of Atmospheric Sciences Nanjing UniversityNanjing210023China

Local air pollution is strongly affected by synoptic weather systems,such as fronts,troughs,low-altitude vortices,or high-altitude ***,few studies have analyzed the meteorological properties of cold or warm air masses associated to these systems and their impact on local air *** this study,hourly observations of fine particulate matter(diameter of up to 2.5µm,i.e.,PM_(2.5)),wind(V),temperature(T),pressure(P),and precipitation(R),acquired in Hangzhou in 2014-2020,were *** this analysis,weather patterns were categorized into 27 types;89 and 94 cases illustrating the passage of warm and cold air masses over Hangzhou were identified,respectively;the influence of air mass temperature,wind speed,and wind direction on PM_(2.5) concentrations and local accumulation or removal was *** main results are as follows.(1)Pollution events occurred more frequently for cold than for warm air masses,but average pollutant concentration was lower for cold air masses;(2)48%of the cold air mass cases corresponded to PM_(2.5) decreases and 52%to PM_(2.5) increases,with strong cold air masses(ΔT_(24h)>4°C;∣V∣_(average)>4 m s^(−1))markedly reducing local pollution,but weak cold air masses(ΔT24h4°C)reduced the PM_(2.5) concentration whereas weaker winds(∣V∣_(average)<2 m s^(−1))increased it;and(4)PM_(2.5) concentration decreased sharply within 4 h after the passage of strong cold air masses,but more gradually within 14 h after the passage of strong warm air *** results considerably improve the current understanding of the influence of cold and warm air masses on local pollution patterns.

关键词： weather type air mass enhancement removal meteorological condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Urea-induced interfacial engineering enabling highly reversible aqueous zinc-ion battery

引用

Rare Metals 2024年第4期43卷 1599-1609页

作者： bin-Rui Xu Quan-An Li Yong liu Guang-bin Wang Zi-He Zhang feng-Zhang Ren School of Material Science and Engineering Henan University of Science and TechnologyLuoyang471023China School of Information Engineering Henan University of Science and TechnologyLuoyang471023China Longmen Laboratory Luoyang471023China Provincial and Ministerial Co-Construction of Collaborative Innovation Center for Non-Ferrous Metal New Materials and Advanced Processing Technology Luoyang471023China

Aqueous zinc-ion batteries(AZIBs)have been regarded as prospective rechargeable energy storage devices because of the high theoretical capacity and low redox potential of Zn ***,the uncontrollable formation of dendrites and the water-induced side reactions at the Zn/electrolyte interface,and the poor reversibility under a high current density(>2 mA·cm^(-2))and large area capacity(>2 mAh·cm^(-2))still limit the practical applications of ***,a strategy that can overcome these difficulties is urgently ***,we introduce an environmentally friendly and low-cost additive,namely urea,to the electrolyte of AZIBs to induce uniform Zn deposition and suppress the side *** of the adsorption behavior,electrochemical characterization,and observations of the morphology revealed the interfacial modification induced by urea on the Zn/electrolyte interface,demonstrating its huge potential in ***,the long-term cycling stability(over2100 h)of a Zn/Zn symmetric cell under a high current density of 5 mA·cm^(-2)and a capacity of 5 mAh·cm^(-2)was achieved with a 1 mol·L^(-1)ZnSO_(4)electrolyte with the urea ***,the assembled Zn/NH_4V_4O_(10)full cell with urea exhibited excellent cycling performance and an outstanding average Coulombic efficiency of 99.98%.These results indicate that this is a low-cost and effective additive strategy for realizing highly reversible AZIBs.

关键词： Zn anode Urea additive Interface engineering Dendrite growth Side reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

引用

Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong bin Kerui feng Shang Ma Ke liu Yong Cheng Jing Chen Qifa liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high Q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

刘凤斌教授从脾虚论治腹泻型肠易激综合征的临证经验

引用

世界中西医结合杂志 2024年第5期19卷 903-906,940页

作者：杨希玲张佳河祝旺侯秋科刘凤斌广州中医药大学第一临床医学院广东广州510405 广州中医药大学第一附属医院广东广州510405

腹泻型肠易激综合征(Irritable bowel syndrome with predominant diarrhea,IBS-D)是临床常见的胃肠道疾病之一,刘凤斌教授治疗IBS-D经验丰富,认为其归属于中医学“泄泻”病范畴,病因病机以脾虚为本,常见证型有肝郁脾虚证、脾虚湿滞证... 详细信息

腹泻型肠易激综合征(Irritable bowel syndrome with predominant diarrhea,IBS-D)是临床常见的胃肠道疾病之一,刘凤斌教授治疗IBS-D经验丰富,认为其归属于中医学“泄泻”病范畴,病因病机以脾虚为本,常见证型有肝郁脾虚证、脾虚湿滞证、脾虚湿热证、脾肾不足证,治疗上以健脾补气、顾护中土为主,兼疏肝、祛湿、清热、补肾,调畅全身气机,常用的药对有甘草-白芍、陈皮-青皮、防风-白芍、柴胡-枳实,木香-黄连等,刘凤斌教授每以此法在临床辨证论治时,均能取得较好疗效,因此值得推广使用。

关键词：刘凤斌脾虚腹泻型肠易激综合征临证经验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新橙皮苷对非酒精性脂肪性肝炎小鼠NLRP3/NF-κB信号通路的影响

引用

时珍国医国药 2024年第3期35卷 602-607页

作者：陆一慧黄超原王恺疌雍秋红郑逸远彭冲赵利娜刘凤斌广州中医药大学第一临床医学院广东广州510405 广州中医药大学第二附属医院广东广州510120 广州中医药大学第一附属医院广东广州510405 岭南医学实验研究中心广东广州510405 广州中医药大学第一附属医院白云医院广东广州510470

目的探讨新橙皮苷(Neohesperidin,NHP)对非酒精性脂肪性肝炎(NASH)小鼠的治疗作用及其机制。方法24只SPF级C57BL6雄性小鼠随机分为正常组、模型组和NHP组(40mg/kg)。通过喂饲高脂高胆固醇饲料(HFHC)制备NASH小鼠模型,造模同时给予相应... 详细信息

目的探讨新橙皮苷(Neohesperidin,NHP)对非酒精性脂肪性肝炎(NASH)小鼠的治疗作用及其机制。方法24只SPF级C57BL6雄性小鼠随机分为正常组、模型组和NHP组(40mg/kg)。通过喂饲高脂高胆固醇饲料(HFHC)制备NASH小鼠模型,造模同时给予相应药物治疗,12周后进行葡萄糖耐量试验、胰岛素耐量试验,计算小鼠的体重、肝重、肝指数,采集血清和肝组织标本,检测血清中胆固醇(TC),甘油三酯(TG),丙氨酸氨基转移酶(ALT),天门冬氨酸氨基转移酶(AST);蛋白免疫印迹法(Western blot)检测肝脏中炎症小体3(NLRP3)的蛋白表达及磷酸化核转录因子-κB(NF-κB)的蛋白表达情况;苏木素-伊红(HE)染色和油红O染色观察肝脏病理形态学变化。结果与正常组比较,模型组小鼠血清中TC、TG、ALT、AST含量、肝脏中NLRP3和NF-κB的mRNA和蛋白表达及p-NF-κB的蛋白表达水平显著升高(P<0.05);与模型组比较,NHP组小鼠血清中TC、TG、ALT、AST含量、肝脏中NLRP3和NF-κB的mRNA和蛋白表达及p-NF-κB的蛋白表达水平均明显降低(P<0.05)。HE染色和油红O染色结果提示其能明显减轻肝脏脂肪变性程度。结论NHP可能通过抑制NLRP3/NF-κB信号通路,减轻炎症反应来治疗NASH。

关键词： NHP 非酒精性脂肪肝性炎炎症小体3/核转录因子-κB(NLRP3/NF-κB)信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：