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A Systematic Investigation of Complement and Coagulation-Related Protein in Autism Spectrum Disorder Using Multiple Reaction Monitoring Technology

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Neuroscience Bulletin 2023年第11期39卷 1623-1637页

作者： Xueshan Cao Xiaoxiao Tang Chengyun Feng Jing Lin Huajie Zhang qiong liu Qihong Zheng Hongbin Zhuang Xukun liu Haiying Li Naseer Ullah Khan Liming She College of Life Science and Oceanography Shenzhen UniversityShenzhen518060China College of Physics and Optoelectronics Engineering Shenzhen UniversityShenzhen518060China Maternal and Child Health Hospital of Baoan Shenzhen518100China Department of Endocrinology Guiyang First People’s HospitalGuiyang550002China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen518055China Shenzhen Key Laboratory of Marine Biotechnology and Ecology Shenzhen518060China

Autism spectrum disorder(ASD)is one of the common neurodevelopmental disorders in *** etiology and pathogenesis are poorly *** studies have suggested potential changes in the complement and coagulation pathways in individuals with *** this study,using multiple reactions monitoring proteomic technology,16 of the 33 proteins involved in this pathway were identified as differentially-expressed proteins in plasma between children with ASD and *** them,CFHR3,C4BPB,C4BPA,CFH,C9,SERPIND1,C8A,F9,and F11 were found to be altered in the plasma of children with ASD for the first ***1 expression was positively correlated with the CARS *** the machine learning method,we obtained a panel composed of 12 differentially-expressed proteins with diagnostic potential for *** also reviewed the proteins changed in this pathway in the brain and blood of patients with *** complement and coagulation pathways may be activated in the peripheral blood of children with ASD and play a key role in the pathogenesis of ASD.

关键词： pathogenesis children complement

An Evaluation of the Infection Status and Source of Subgroup J Avian Leukosis Virus in Cloned Free-Range Layers

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Journal of Integrative Agriculture 2013年第4期12卷 687-693页

作者： ZHANG Pei-pei liu Shao-qiong WANG Jian WANG Bo ZHAO Cheng-di ZHANG Yong-guang SUN Shu-hong College of Veterinary Medicine Shandong Agricultural University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences

In recent years, subgroup J avian leukosis virus （ALV-J） has been found to frequently infect layers in China. This virus is responsible for economic losses due to both mortality and decreased performance in chickens. In this study, 45-d-old cloned flee-range layers were suspected to be infected with ALV and other immunosuppressive diseases because their feathers were unkempt and their growth rate was impaired. To estimate the infection status and determine the source of ALV-J in the flock, 30 cloacal swabs were randomly collected to measure the p27 antigen level by enzyme-linked immunosorbent assay （ELISA）. Among the birds that were tested, 87% （26/30） were positive. In addition, 6 anticoagulant blood samples were aseptically collected at random from the flock when the layers were 60 d old. These samples were centrifuged to obtain the leukocytes, which were then used to inoculate chicken embryo fibroblast （CEF） cells for the identification of ALV-J by indirect immunofluorescence （IFA）. Of the samples tested, 100% （6/6） were positive. The flock＇s production performance was also investigated, and 10 layers were necropsied to evaluate pathological changes at 115 d of age. The flock never laid eggs even though they reached the age of the first laying （110 d）. Furthermore, there were pathological changes present, including atrophy of the thymus and bursa of Fabricius, undeveloped ovaries, glandular stomach haemorrhage, and hepatosplenomegaly. Paraffin-embedded sections of intumescent liver and spleen were prepared for antigen localisation using IFA. Positive signals were prevalent in paraffin-embedded sections of the intumescent liver and spleen. Furthermore, provirus DNA was extracted from 4 cloned flee-range layers, and 2 patemal parents （HR native cocks）, and the gp85 gene of ALV-J was amplified by PCR to analyse the genetic variation. The results of the autogenous variation analysis showed that the 6 strains were 98.5-99.7% homologous. This study indicated that there

关键词： cloned free-range layers ALV-J infection status hereditary variation source exploration

Straw mulch-based no-tillage improves tillering capability of dryland wheat by reducing asymmetric competition between main stem and tillers

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The Crop Journal 2022年第3期10卷 864-878页

作者： Hongkun Yang Yun Xiao Peng He Dailong Ai Qiaosheng Zou Jian Hu qiong liu Xiulan Huang Ting Zheng Gaoqiong Fan Crop Ecophysiology and Cultivation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Crop Eco-Physiology&Farming System in Southwest China Ministry of Agriculture and Rural AffairsChengdu 611130SichuanChina State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Ministry of Science and TechnologyChengdu 611130SichuanChina

The moisture-conserving effect of straw mulch-based no-tillage(SMNT)is expected to increase fertile spikes and grain yield in environments with rainfall less than 200 ***,the mechanisms under-lying the positive effect of SMNT on wheat tillering are not fully elucidated.A split-plot experiment was designed to investigate the combined effects of SMNT and cultivars on tillering of dryland wheat grown under both dry and favorable *** of SMNT to a cultivar with 1-2 tillers exploited both tillering and kernel-number plasticity,increasing the mean grain yield by 20.5%.This increase was attrib-uted primarily to an increased first-tiller emergence rate resulting from increased N uptake,leaf N con-tent,and N remobilization from tillers to their *** second and third tillers,as transient sinks,contributed to the tiller survival rate,which depends on tiller leaf *** increased total N uptake by SMNT also increased the dry mass yield of tillers and the C:N ratio,reducing the asymmetric compe-tition between main stem and *** to these beneficial effects,reduced mitogen-activated pro-tein kinase(MAPK)and abscisic acid signals were observed under SMNT,whereas indole-3-acetic acid(IAA)signals and genes involved in DNA replication and mismatch repair were *** signals activated three critical transcription factors(the calmodulin-binding transcription activator,GRAS domain,and cysteine-2/histidine-2 family)and further increased rapid drought response and tiller main-tenance after stem *** biosynthesis,sphingolipid biosynthesis,and galactose metabolism were most relevant to increased tillering under SMNT because of their critical role in drought response and lignin *** results suggest that straw mulch-based no-tillage activates rapid drought response and improved wheat tillering by coordinating root N uptake,N remobilization,and asymmetric competition between main stem and tillers.

关键词： Straw mulch-basedno-tillage Wheat tillering Stable isotopetracing Transcriptome Metabolomics

How Can We Save the Great Wall?——Interview with Dong Yaohui,vice president of the China Great Wall Society

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China Today 2008年第1期57卷 20-25页

作者： staff reporter liu qiong

I visited Dong Yaohui, vice-president of the China Great Wall society, at his home in songzhuang, a new residential extension of urban Beijing’s Tongzhou District.

关键词：中国经济状态长城油漆颜色

Just Call Me“Three F Li”

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China Today 2009年第10期58卷 18-23页

作者： LI YINING liu qiong

THEY used to call me Private Enterprise Li （Li Minying）, but I would rather be known as ＂Three F Li＂（Li Sannong）. It was by accident that I became an economist. At the very beginning of China＇s economic reform, I presented the concept of transforming China＇s economy through shareholding, and suggested that the private sector and the state-owned sector enjoy equal status in the economy. As a participant in economic policymaking in China I have witnessed a lot of changes to the People＇s Republic.

关键词：中国经济经济学家股份制改造民营企业经济改革经济决策参与者共和国

Mannanase improves the growth performance of broilers by alleviating inflammation of the intestinal epithelium and improving intestinal microbiota

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Animal Nutrition 2024年第1期16卷 376-394页

作者： Xiaodan Zhang Huiping Xu Lu Gong Jiao Wang Jianyang Fu Zengpeng Lv Liangjuan Zhou Xuejun Li qiong liu Pingyu Xia Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Beijing Strowin Biotechnology Co. Ltd.Beijing100094China

This experiment aimed to discuss and reveal the effect and mechanism of mannanase on intestinal inflammation in broilers triggered by a soybean meal *** this experiment,384 Arbor Acres broilers at1 d old were randomly divided into 3 treatment *** broilers were fed a corn-soybean meal basal diet,a low-energy diet(metabolizable energy reduced by 50 kcal/kg),and a low-energy diet supplemented with 100 mg/kg mannanase for 42 *** low-energy diet increased feed conversion ratio from0 to 42 d,reduced ileal villus height and villus height-to-crypt depth ratio and upregulated the expression of nuclear factor kappa B(NF-κB)in the ileum(Plium of broilers(P<0.05).In addition,mannanase upregulated the expression of claudin-1(CLDN1)and zonula occludens-1(ZO-1)in the jejunum at 21 d,downregulated the expression of ileal NF-κB,and increased the content of isobutyric acid in the cecum of broilers(P<0.05).The results for the ileal microbiota showed that a low-energy diet led to a decrease in the relative abundance of Lactobacillus reuteri in the ileum of *** addition of mannanase increased the relative abundance of Lactobacillus-KC45b and Lactobacillus johnsonii in ***,a low-energy diet reduced the relative abundance of Butyricicoccus in the intestine of broilers and inhibited oxidative phosphorylation and phosphoinositol *** increased the relative abundance of Odoribacter,promoted energy metabolism and N-glycan biosynthesis,and increased the activities of GH3 and *** is concluded that mannanase could improve the growth performance of broilers by reducing the expression of NF-κB in the ileum,increasing the production of SCFA in the cecum,suppressin

关键词： Broiler Low-energy diet Mannanase Intestinal inflammatory response Intestinal microbiota Metagenome

A Novel Protein Found in Selenium-rich Silkworm Pupas

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Chinese Chemical Letters 2005年第10期16卷 1347-1350页

作者： De Cong HU qiong liu Hui Bi XU Hai Rong CUI Si Wang YU Xiao Da YANG Kui WANG Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 Technology Center of Hubei Entry-Exit Inspection and Quarantine Bureau Wuhan 430022 Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing 100085

A novel protein was isolated and characterized in selenium-rich silkworm pupas. The peptide mass fingerprint of the protein was found to be new. Partial amino acid sequencing also confn-med to be a new protein. The no... 详细信息

关键词： Silkworm pupa selenium peptide mass fingerprint (PMF) amino acid sequence.

Ferroelectric catalytic BaTiO_(3)-based composite insoles to promote healing of infected wounds:Analysis of antibacterial efficacy and angiogenesis

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Interdisciplinary Materials 2024年第5期3卷 757-774页

作者： qiong liu Xudan liu Linfeng Fan Xinna Bai Hao Pan Hang Luo Dou Zhang Haitao Huang Chris R.Bowen State Key Laboratory of Powder Metallurgy Central South UniversityChangshaHunanChina Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Department of Periodontics Hunan Key Laboratory of Oral Health Research&Hunan 3D Printing Engineering Research Center of Oral Care&Hunan Clinical Research Center of Oral Major Diseases and Oral Health&Xiangya Stomatological Hospital&Xiangya School of StomatologyCentral South UniversityChangshaHunanChina Department of Mechanical Engineering University of BathBathUK

Our feet are often subjected to moist and warm environments,which can promote the growth of harmful bacteria and the development of severe infection in wounds located in the *** a result,there is a need for new and innovative strategies to safely sterilize feet,when shoes are worn,to prevent any potential foot-related *** this paper,we have produced a non-destructive,biocompatible and convenient-to-use insole by embedding a BaTiO_(3)(BT)ferroel ectric material into a conventional polydimethylsilane(PDMS)insole material to exploit a ferroelectric catalytic effect to promote the antibacterial and healing of infected wounds via the ferroelectric charges generated during *** formation of reactive oxygen species generated through a ferroelectric catalytic effect in the PDMS-BT composite is shown to increase the oxidative stress on bacteria and decrease both the activity of bacteria and the rate of formation of bacterial *** addition,the ferroelectric field generated by the PDMS-BT insole can enhance the level of transforming growth factor-beta and CD31 by influencing the endogenous electric field of a wound,thereby promoting the proliferation,differentiation of fibroblasts and *** work therefore provides a new route for antimicrobial and tissue reconstruction by integrating a ferroelectric biomaterial into a shoe insole,with significant potential for health-related applications.

关键词： ferroelectric filed effect PDMS-BaTiO3 insole piezo-catalysis wound healing

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艺术与科技的变奏:从机器美学到生物艺术

文艺理论研究 2020年第4期40卷 171-181页

作者：刘琼重庆大学人文社会科学高等研究院 400044

机器之美发端于巴洛克时期艺术对智巧和新奇的重视,经过18—19世纪新古典主义时期将机器功用(理性效率)接受为美,到20世纪"形式跟随功能"这一美学理念确立所标志的机器美学全盛期,及至当下,从机器之美延伸至生物艺术以及其他各类侧重科... 详细信息

机器之美发端于巴洛克时期艺术对智巧和新奇的重视,经过18—19世纪新古典主义时期将机器功用(理性效率)接受为美,到20世纪"形式跟随功能"这一美学理念确立所标志的机器美学全盛期,及至当下,从机器之美延伸至生物艺术以及其他各类侧重科技要素的先锋艺术。机器之美的发展和繁盛基于机器对真、善、美的不同侧重,以及对真、善、美不同方式、不同程度的结合,尤其是对"真"所意指的科技的重视。但机器理性的极致发展引发了对机器的膜拜与人的迷失,又逆向导致对机器功用的消解,机器之美重又接近传统的纯粹美。不过此一迂回并未中断机器美学历史进程,当今人工智能和生命科学等前沿科技使机器美学朝向科技与文艺深度融合的方向,以极具革命性的方式不断拓展美的内涵和外延。

关键词：机器美学机器功用机器膜拜守贞机器生物艺术