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Multimodality management for chronic subdural hematoma in China: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study

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中华神经外科杂志(英文) 2024年第02期10卷 124-133页

作者： liu Tao Zhao Zhihao Huang Jinhao Zhu Xide Chen Weiliang Lin Kun Yu Yunhu Li Zhanying Fan Yibing liu mingqi Nie Meng liu Xuanhui Gao Chuang Quan Wei Qian Yu Wu Chenrui Yuan Jiangyuan Wu Di Lv Chuanxiang Dong Shiying Mi Liang Tian Yu Tian Ye Zhang Jianning Jiang Rongcai Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Ministry of Education Tianjin Neurological Institute Key Laboratory of Post Neuro-injury Neuro-repair and Regeneration in Central Nervous System Tianjin Medical University General Hospital Tianjin China Department of Neurosurgery Linyi People’s Hospital Shandong China Department of Neurosurgery Haining People’s Hospital Zhejiang China Department of Neurosurgery Fujian Provincial Hospital Fujian China Department of Clinical Research Center for Neurological Disease the People’s Hospital of HongHuaGang District of ZunYi Guizhou China Department of Neurosurgery Kailuan General Hospital Hebei China Department of Neurosurgery Tianjin First Central Hospital Tianjin China Department of Neurosurgery The First Hospital of Jilin University Changchun China

Background Despite its prevalence, there is ongoing debate regarding the optimal management strategy for chronic subdural hematoma (CSDH), reflecting the variability in clinical presentation and treatment outcomes. This ambidirectional, nationwide, multicenter registry study aims to assess the efficacy and safety of multimodality treatment approaches for CSDH in the Chinese ***/design A multicenter cohort of CSDH patients from 59 participating hospitals in mainland China was enrolled in this study. The treatment modalities encompassed a range of options and baseline demographics, clinical characteristics, radiographic findings, and surgical techniques were documented. Clinical outcomes, including hematoma resolution, recurrence rates, neurological status, and complications, were assessed at regular intervals during treatment, 3 months, 6 months, 1 year, and 2 years *** Between March 2022 and August 2023, a comprehensive cohort comprising 2173 individuals who met the criterion was assembled across 59 participating clinical sites. Of those patients, 81.1% were male, exhibiting an average age of 70.12 ± 14.53 years. A historical record of trauma was documented in 48.0% of cases, while headache constituted the predominant clinical presentation in 58.1% of patients. The foremost surgical modality employed was the burr hole (61.3%), with conservative management accounting for 25.6% of cases. Notably, a favorable clinical prognosis was observed in 88.9% of CSDH patients at 3 months, and the recurrence rate was found to be 2.4%.Conclusion This registry study provides critical insights into the multimodality treatment of CSDH in China, offering a foundation for advancing clinical practices, optimizing patient management, and ultimately, improving the quality of life for individuals suffering from this challenging neurosurgical *** registration ChiCTR2200057179

关键词： Chronic subdural hematoma Multimodality therapy Outcome Recurrence

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“别指望”:从跨层结构到反预期推论情态

世界华文教学 2024年第1期 320-335页

作者：刘明奇上海师范大学人文学院

“别指望”在现代汉语中有两种用法:一是跨层结构“别指望1”,用于阻止他人抱有期待;二是反预期推论情态成分“别指望2”,用于否定他人意愿预期。“别指望1”和“别指望2”在句法表现、语用功能及焦点成分上具有差异,“别指望2”的情态... 详细信息

“别指望”在现代汉语中有两种用法:一是跨层结构“别指望1”,用于阻止他人抱有期待;二是反预期推论情态成分“别指望2”,用于否定他人意愿预期。“别指望1”和“别指望2”在句法表现、语用功能及焦点成分上具有差异,“别指望2”的情态义由预期语篇解读赋予。“别指望2”主要用于评价语体,表达说话者对命题的否定断言,凸显亲涉事件的高信度。“别指望”在言语行为迁移的作用下,经历了语法化四阶段,在自知事件的意外与感叹基础上,亲涉事件由他反预期进一步推理获得“不可能”含义。“别指望2”处于预期语篇的推理层,与命题层的“不可能”存在本质区别。

关键词：别指望言语行为迁移自知亲涉他反预期语用推理

Dynamics of thinning and destruction of the continental cratonic lithosphere: Numerical modeling

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Science China Earth Sciences 2018年第7期61卷 823-852页

作者： mingqi liu Zhonghai LI Key Laboratory of Computational Geodynamics College of Earth and Planetary Sciences University of Chinese Academy of Sciences Institute of Geology Chinese Academy of Geological Sciences

Thinning of the cratonic lithosphere is common in nature, but its destruction is not. In either case, the mechanisms for both thinning and destruction are still widely under debate. In this study, we have made a review on the processes and mechanisms of thinning and destruction of cratonic lithosphere according to previous studies of geological/geophysical observations and numerical simulations, with specific application to the North China Craton(NCC). Two main models are suggested for the thinning and destruction of the NCC, both of which are related to subduction of the oceanic lithosphere. One is the "bottom-up" model, in which the deeply subducting slab perturbs and induces upwelling from the hydrous mantle transition zone(MTZ). The upwelling produces mantle convection and erodes the bottom of the overriding lithosphere by the fluid-meltperidotite reaction. Mineral compositions and rheological properties of the overriding lithospheric mantle are changed, allowing downward dripping of lithospheric components into the asthenosphere. Consequently, lithospheric thinning or even destruction occurs. The other is the "top-down" model, characterized by the flat subduction of oceanic slab beneath the overriding cratonic lithosphere. Dehydration reactions from the subducting slab would significantly hydrate the lithospheric mantle and decrease its rheological strength. Then the subduction angle may be changed from shallow to steep, inducing lateral upwelling of the asthenosphere. This upwelling would heat and weaken the overriding lithospheric mantle, which led to the weakened lithospheric mantle dripping into the asthenosphere. These two models have some similarities, in that both take the subducting oceanic slab and relevant fluid migration as the major driving mechanism for thinning or destruction of the overriding cratonic lithosphere. The key difference between the two models is the effective depth of the subducting oceanic slab. One is stagnation and flattening in t

关键词： Lithospheric thinning Cratonic destruction Big mantle wedge Plate subduction Fluid migration Numericalmodeling

Material transportation and fluid-melt activity in the subduction channel: Numerical modeling

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Science China Earth Sciences 2015年第8期58卷 1251-1268页

作者： LI ZhongHai liu mingqi Taras GERYA State Key Laboratory of Continental Tectonics and Dynamics Institute of Geology Chinese Academy of Geological Sciences Institute of Geophysics Department of Earth SciencesETH-Zurich

The subduction channel is defined as a planar to wedge-like area of variable size,internal structure and composition,which forms between the upper and lower plates during slab subduction into the *** materials in the channel may experience complex pressure,temperature,stress and strain evolution,as well as strong fluid and melt activity.A certain amount of these materials may subduct to and later exhume from>100 km depth,forming high to ultra-high pressure rocks on the surface as widely discovered in *** deformation in the channel is strongly assisted by metamorphic fluids activities,which change composition and mechanical properties of rocks and thus affect their subduction and exhumation *** this study,we investigate the detailed structure and dynamics of both oceanic and continental subduction channels,by conducting highresolution petrological-thermomechanical numerical simulations taking into account fluid and melt *** numerical results demonstrate that subduction channels are composed of a tectonic rock melange formed by crustal rocks detached from the subducting slab and the hydrated mantle rocks scratched from the overriding *** rocks may either extrude sub-vertically upward through the mantle wedge to the crust of the upper plate,or exhume along the subduction channel to the surface near the suture *** on our numerical results,we first analyze similarities and differences between oceanic and continental subduction *** further compare numerical models with and without fluid and melt activity and demonstrate that this activity results in strong weakening and deformation of overriding ***,we show that fast convergence of orogens subjected to fluid and melt activity leads to strong deformation of the overriding lithosphere and the topography builds up mainly on the overriding *** contrast,slow convergence of such orogens leads to very limited deformation of the overriding lithosphere

关键词： subduction channel fluid activity partial melting topography numerical modeling

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基于虚拟电力系统稳定器的低频振荡抑制策略

电机与控制学报 2024年第5期28卷 82-90,100页

作者：王海鑫何海文刘铭崎杨子豪郝炎杨俊友陈哲沈阳工业大学电气工程学院辽宁沈阳110870 丹麦奥尔堡大学能源技术系奥尔堡丹麦DK-9220

基于虚拟同步发电机(VSG)控制的新能源机组虽可增强电网惯量及频率稳定性,但可能继承与同步机类似的低频振荡问题。针对该问题,首先基于单台VSG并网的线性化模型,构建了适用于VSG的Phillips-Heffron模型,借助阻尼转矩法挖掘了VSG低频振... 详细信息

基于虚拟同步发电机(VSG)控制的新能源机组虽可增强电网惯量及频率稳定性,但可能继承与同步机类似的低频振荡问题。针对该问题,首先基于单台VSG并网的线性化模型,构建了适用于VSG的Phillips-Heffron模型,借助阻尼转矩法挖掘了VSG低频振荡的诱发机理。进一步提出一种附加于VSG无功环节的虚拟电力系统稳定器(VPSS),并给出了控制结构及基于相位补偿法的参数设计过程。研究结果表明:VSG发生低频振荡是由于系统受扰后,虚拟功角的振荡信号经过虚拟励磁调节器对VSG机电振荡回路产生了负阻尼转矩。将所提VPSS接入系统可在几乎不影响振荡频率的前提下,实现0.1~3 Hz下VSG低频振荡的有效抑制。

关键词：虚拟同步发电机虚拟电力系统稳定器低频振荡阻尼转矩分析相位补偿法

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基于多分支多尺度卷积网络的心房颤动检测模型

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生物医学工程学杂志 2024年第4期41卷 700-707页

作者：赵思宇刘明刘名起杨晓茹熊鹏张杰烁河北大学电子信息工程学院河北保定071002 保定市生产力促进中心河北保定071023

心房颤动(房颤)是危及生命的心脏病之一,其早期检测和治疗近年来备受医生关注。传统的房颤检测方式主要依靠医生对心电图的诊断,但长时间的心电信号分析非常耗时。本文设计出一种基于Inception模块的房颤检测模型,构建多分支检测通道来... 详细信息

心房颤动(房颤)是危及生命的心脏病之一,其早期检测和治疗近年来备受医生关注。传统的房颤检测方式主要依靠医生对心电图的诊断,但长时间的心电信号分析非常耗时。本文设计出一种基于Inception模块的房颤检测模型,构建多分支检测通道来处理房颤时的心电图原始信号、梯度信号和频率信号。该模型利用梯度信号高效地提取QRS波段和RR间期特征,利用频率信号提取P波与f波特征,并使用原始信号补充丢失信息。Inception模块中多尺度卷积核提供多种感受视野,并对多分支结果进行综合分析,从而实现房颤的早期检测。相较于目前的机器学习算法仅利用RR间期和心率变异性等特征,本文提出的算法额外使用频率特征,充分利用信号中的信息;对于使用原始信号和频率信息的深度学习方法,本文提出强化QRS波段的方法,使网络更有效地提取特征,并通过多分支输入模式综合考虑房颤RR间期不规律和P波与f波特征信息。在麻省理工房颤数据集上的检测结果显示,患者间检测的准确率为96.89%,灵敏度为97.72%,特异性为95.88%。该模型表现出色,能够实现房颤的自动检测。

关键词：房颤检测多分支网络多尺度卷积混合损失函数

Feature-Based Fusion of Dual Band Infrared Image Using Multiple Pulse Coupled Neural Network

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Journal of Beijing Institute of Technology 2019年第1期28卷 129-136页

作者： Yuqing He Shuaiying Wei Tao Yang Weiqi Jin mingqi liu Xiangyang Zhai Key Laboratory of Photoelectronic Imaging Technology and System Ministry of Education of ChinaBeijing Institute of Technology

To improve the quality of the infrared image and enhance the information of the object,a dual band infrared image fusion method based on feature extraction and a novel multiple pulse coupled neural network(multi-PCNN)is *** this multi-PCNN fusion scheme,the auxiliary PCNN which captures the characteristics of feature image extracting from the infrared image is used to modulate the main PCNN,whose input could be original infrared ***,to make the PCNN fusion effect consistent with the human vision system,Laplacian energy is adopted to obtain the value of adaptive linking strength in *** that,the original dual band infrared images are reconstructed by using a weight fusion rule with the fire mapping images generated by the main PCNNs to obtain the fused *** to wavelet transforms,Laplacian pyramids and traditional multi-PCNNs,fusion images based on our method have more information,rich details and clear edges.

关键词： infrared image image fusion dual band pulse coupled neural network(PCNN) feature extraction

OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 611-618页

作者： Jiangming Huang Mengxi Wu Yang Zhang Siyuan Kong mingqi liu Biyun Jiang Pengyuan Yang Weiqian Cao Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China The Fifth People’s Hospital Fudan Universityand the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyFudan UniversityShanghai 200032China NHC Key Laboratory of Glycoconjugates Research(Fudan University) Shanghai 200032China

Numerous studies on cancers, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the storage of and reference to emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was established in this *** was constructed with a collection of O-glycoprotein data from different sources. OGP contains 9354 O-glycosylation sites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it is the largest O-glycoprotein repository thus *** on the recorded O-glycosylation sites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-based website is already available(http://***/). The website comprises four specially designed and user-friendly modules:statistical analysis, database search, site prediction, and data submission. The first version of OGP repository and the website allow users to obtain various O-glycoprotein-related information, such as protein accession Nos., O-glycosylation sites,O-glycopeptide sequences, site-specific O-glycan structures, experimental methods, and potential O-glycosylation sites.O-glycosylation data mining can be performed efficiently on this website, which will greatly facilitate related studies. In addition, the database is accessible from OGP website(http://***/***).

关键词： O-glycosylation O-glycoprotein repository Site prediction O-glycoprotein related website Data mining

Effects of grain's shape-and size-polydispersities,orientation,and area fraction on tortuosity and permeability of 2D granular media

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Particuology 2024年第7期90卷 535-557页

作者： Ke Cao Huisu Chen Mohammad Iqbal Khan mingqi Li Lin liu Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Civil Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China College of Civil and Transportation Engineering Hohai UniversityNanjing210098China

The microstructure of granular media, including grain's shape- and size-polydispersities, orientation, and area fraction can potentially affect its permeability. However, few studies consider the coupling effects of these features. This work employs geometrical probability and stereology to establish quantitative relationships between the above microstructural features and the geometric tortuosity of the two-dimensional granular media containing superellipse, superoval, and polygon grains. Then the lattice Boltzmann method (LBM) is used to determine the permeabilities of these granular media. By combining the tortuosity model and the LBM-derived permeabilities, modified K–C equations are formulated to predict the permeability and the shape factor, considering the grain's shape- and size-polydispersities, orientation, and area fraction. The reliability of these methods can be verified by comparing them with both our simulations and available experimental, theoretical, and numerical data reported in the literature. The findings implicate that the tortuosity and permeability of the granular media are strongly correlated with the grain's shape, orientation, and area fraction but unaffected by the size polydispersity and spatial arrangement of grains. Only circularity is not enough to derive a unified formula for considering the impact of grain shape on tortuosity and permeability, other shape parameters need to be explored in the future.

关键词： Geometric tortuosity Konzey-Carman equation Shape and size ploydispersities Grain orientation Lattice Boltzmann method Granular media