检索结果-南通市图书馆

维普期刊数据库博看期刊

ACHIEVEMENT OF LOW-ENERGY HEAVY-ION BIOLOGY

在线全文

学校读者我要写书评

暂无评论

Bulletin of the Chinese Academy of Sciences 1996年第4期10卷 311-312页

作者： -Peng Dejian and liu junhong

Generally,the interaction of low-energy ions with matter used to attract less attention than that of high-energy *** the 1980s,when the study of ion beam modification of materials was prosperous both at home and abroad,a new biological effect caused by ion beam implantation was discovered by Prof. Yu Zengliang and his postgraduates at CAS institute of Plasma *** their research into the interaction between low energy ions and organism,they put forward and developed some new concepts,such as the bio damage model of mass-deposition and cell itching processing with ion *** they applied those principles in breeding new cultivars and made sig-

关键词： ACHIEVEMENT OF LOW-ENERGY HEAVY-ION BIOLOGY ION

基于代谢组学探讨中医肾虚证物质基础研究概况

在线全文

学校读者我要写书评

暂无评论

中国中医药信息杂志 2024年第5期31卷 172-177页

作者：苏海燕刘俊宏王柏清刘晓燕牛媛媛胡彦军苏怡琴甘肃中医药大学附属医院甘肃兰州730020 甘肃中医药大学甘肃兰州730000 临洮县中医院甘肃临洮730500

“证候”是中医学辨证论治的理论基石,证候的表型组学研究是回答中医药科学性问题的关键环节。肾虚证在临床各科疾病中极为常见,但其客观化研究仍存在物质基础认识模糊、评价标准不完备等难点。代谢组学符合中医学“整体观念”特征,为... 详细信息

“证候”是中医学辨证论治的理论基石,证候的表型组学研究是回答中医药科学性问题的关键环节。肾虚证在临床各科疾病中极为常见,但其客观化研究仍存在物质基础认识模糊、评价标准不完备等难点。代谢组学符合中医学“整体观念”特征,为揭示证候理论实质提供新视角,可较好地结合系统生物学与中医证候。本文梳理肾虚致病的复杂性、多样性与机体代谢网络失稳的相关性,认为氨基酸代谢、菌群代谢及能量代谢紊乱等是中医肾虚证的微观物质体现,且不同疾病的同一证型、同一证型不同表型间的内源性代谢产物均具备良好鉴别效应与诊断价值,可为进一步阐释中医证候学特征、肾虚证实质认识及客观评价研究提供参考。

关键词：代谢组学肾虚证生物标志物整体观念物质基础科学内涵

在线全文

学校读者我要写书评

暂无评论

山东农村居住建筑现状以及节能改造意愿调研

煤气与热力 2024年第2期44卷 21-25,42页

作者：徐振红刘俊红王好召李岳恩李申奥张钦渝张浩山东建筑大学热能工程学院山东济南250101

采用调查问卷形式,对山东农村既有居住建筑现状以及农村居民对建筑节能改造的意愿进行调研。调研结果显示,山东农村经济条件一般,房屋严重老龄化,围护结构保温性能不佳,能源利用缺乏科学合理性,节能改造程度低。农村居民对节能改造认识... 详细信息

采用调查问卷形式,对山东农村既有居住建筑现状以及农村居民对建筑节能改造的意愿进行调研。调研结果显示,山东农村经济条件一般,房屋严重老龄化,围护结构保温性能不佳,能源利用缺乏科学合理性,节能改造程度低。农村居民对节能改造认识不足,但有比较强烈的改造意愿。对山东农村居住建筑节能改造提出建议。

关键词：农村既有居住建筑节能改造调查研究

维普期刊数据库博看期刊

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第1期30卷 247-249页

作者： Xingjie Zhang Zhi Meng Zhiqiang Ma junhong liu Guiyan Han Fujia Ma Ningyang Jia Zhenyuan Miao Wannian Zhang Chunquan Sheng Jianzhong Yao Department of Medicinal Chemistry School of Pharmacy Second Military Medical University Department of Pharmacy 455th Hospital of Chinese People’s Liberation Army Department of Radiology Shanghai Eastern Hepatobiliary Surgery Hospital Second Military Medical University

Eight new water-soluble amino acid conjugates 6 a-h of chlorin p6 ethers(5 a-d) were synthesized and preliminarily investigated for their in vitro PDT antitumor activity and structure-activity relationship(SAR). The results showed that all compounds exhibited much higher phototoxicity against tumor cells than talaporfin. SAR analysis indicated that PDT antitumor effect enhanced with the increase of carbon chain length of alkoxyl ether bonds at 3~1-position, and L-aspartic acid was superior to L-glutamic acid. In particular, the IC_50 values of most phototoxic compound 6 d were 0.20 mmol/L against A549 cell and0.41υmmol/L against B16-F10 cell, which individually represented 31-and 24-fold increase of antitumor potency compared to talaporfin, suggesting that it was a promising candidate photosensitizer(PS) for PDT applications due to its strong absorption at long wavelength, high phototoxicity, low dark cytotoxicity and good water-solubility.

关键词： Photodynamic therapy (PDT) Photosensitizer Silkworm excrement Chlorin P6 Antitumor

在线全文

学校读者我要写书评

暂无评论

国医大师周信有辨治胆汁反流性胃炎经验

中国中医药信息杂志 2024年第8期31卷 162-166页

作者：牛媛媛汪龙德苏海燕刘俊宏刘晓燕陈怀霞胡彦军甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 临洮县中医院甘肃临洮730500

胆汁反流性胃炎是消化系统的常见病与多发病,病理兼夹多样。周信有教授临证指出,本病病位在胆、肝、胃,倡导分三期辨证认识其病因病机。初期胆腑失和,乖戾犯胃;中期肝胆郁滞,旺木克土;后期胃络受损,气虚血瘀。周信有教授临证遵从“复方... 详细信息

胆汁反流性胃炎是消化系统的常见病与多发病,病理兼夹多样。周信有教授临证指出,本病病位在胆、肝、胃,倡导分三期辨证认识其病因病机。初期胆腑失和,乖戾犯胃;中期肝胆郁滞,旺木克土;后期胃络受损,气虚血瘀。周信有教授临证遵从“复方多法、综合运用、整体调节”的诊疗思路,对于临床典型症候群,制定出“痛分新久,以通为用”“口苦心烦,泻热和胃”“治胆安胃,理气解郁”的治则治法,从而达到标本兼治、胆胃和调之功。

关键词：国医大师周信有胆汁反流性胃炎名医经验

Insights into effects of thermotolerant nitrifying and sulfur-oxidizing inoculants on nitrogen-sulfur co-metabolism in sewage sludge composting

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第10期144卷 76-86页

作者： Tingting Hou Yujie Zhou Rongchun Du Jiali liu Weiguang Li Shumei Zhang Muzi Li junhong Chu Liqiang Meng Institute of Microbiology Heilongjiang Academy of SciencesHarbin 150010China Hebei University of Environmental Engineering Hebei Key Laboratory of Agroecological SafetyQinhuangdao 066102China School of Environment Harbin Institute of TechnologyHarbin 150090China

In this study,high temperature thermotolerant nitrifying bacteria(TNB)and high temperature thermotolerant sulfide oxidizing bacteria(TSOB)were obtained from compost samples and inoculated into sewage sludge(SS)*** effects of inoculation on physical and chemical parameters,ammonia and hydrogen sulfide release,nitrogen form and sulfur compound content change and physical-chemical properties during nitrogen and sulfur conversion were *** results showed that inoculation of TNB and TSOB increased the temperature,pH,OM degradation,C/N ratio and germination index(GI)of *** with the control treatment(CK),the addition of inoculants reduced the release of NH3 and H2S,and transformed them into nitrogen and sulfur compounds,the hydrolysis of polymeric ferrous sulfate was promoted,resulting in relatively high content of sulfite and *** the same time,the physical and chemical properties of SS have a strong correlation with nitrogen and sulfur compounds.

关键词： Sewage sludge Composting Inoculation Thermotolerant nitrifying bacteria Thermotolerant sulfurized oxidizing bacteria

Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APPSWE/PS1DE9 Mouse:A Novel Therapeutic Intervention for Alzheimer’s Disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第7期40卷 857-871页

作者： Jun Zhang Yixin Chen Yarui Zhao Panpan Wang Hongbin Ding Cong liu junhong Lyu Weidong Le Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalian 116011China School of Physics Dalian University of TechnologyDalian 116024China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China Advanced Research Institute Chinese Academy of SciencesShanghai 201203China Department of Neurology and Institute of Neurology Sichuan Academy of Medical Sciences‑Sichuan Provincial HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by the deposition of amyloid-β(Aβ),neurofibrillary tangles,neuroinflammation,and neurodegeneration in the *** recent years,considering the unsatisfied benefits of pharmacological therapies,non-pharmacological therapy has become a research hotspot for AD ***(THz)waves with a range between microwave and infrared regions in the electromagnetic spectrum and high permeability to a wide range of materials have great potential in the bioengineering ***,its biological impacts on the central nervous system,under either physiological or pathological conditions,are poorly *** this study,we first measured the 0.14 THz waves penetration across the skull of a C57BL/6 mouse and found the percentage of THz penetration to be~70%,guaranteeing that THz waves can reach the relevant brain *** then exposed the APPSWE/PS1DE9 mouse model of AD to repeated low-frequency THz waves on the *** demonstrated that THz waves treatment significantly improved the cognitive impairment and alleviated AD neuropathology including Aβdeposition and tau hyperphosphorylation in the AD ***,THz waves treatment effectively attenuated mitochondrial impairment,neuroinflammation,and neuronal loss in the AD mouse *** findings reveal previously unappreciated beneficial effects of THz waves treatment in AD and suggest that THz waves may have the potential to be used as a novel therapeutic intervention for this devastating disease.

关键词： Alzheimer's disease Cognitive impairment Senile plaque Tau protein Terahertz

Assessment and Enhancement of FRC of Power Systems Considering Thermal Power Dynamic Conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1371-1383页

作者： Feng Hong Yalei Pang Weiming Ji Lu Liang Fang Fang junhong Hao Jizhen liu State Key Laboratory of Alternate Electric Power System with Renewable Energy Sources and School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Alternate Electric Power System with Renewable Energy Sources School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

Frequency stability and security have been a vital challenge as large-scale renewable energy is integrated into power *** contrast,the proportion of traditional thermal power units decreases during the decarbonization transformation process,resulting in poor frequency *** paper aims to explore the potential of frequency regulation support,dynamic assessment,and capacity promotion of thermal power plants in the transition *** the dynamic characteristics of the main steam working fluid under different working conditions,a nonlinear observer is constructed by extracting the main steam pressure and valve opening degree *** real-time frequency modulation capacity of thermal power units can provide a dynamic state for the power grid.A dynamic adaptive modification for primary frequency control(PFC)of power systems,including wind power and thermal power,is proposed and *** power dynamic allocation factor is adaptively optimized by predicting the speed droop ratio,and the frequency modulation capability of the system is improved by more than 11%under extreme ***,through the Monte Carlo simulation of unit states of the system under various working conditions,the promotion of the frequency regulation capacity with high wind power penetration(WPP)is verified.

关键词： Dynamic evaluation frequency regulation power system predictive modeling wind penetration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

线粒体在芥子气损伤中的作用研究进展

广西医科大学学报 2024年第5期41卷 780-785页

作者：王雨润张鑫月刘俊宏陈佳胜谢璐泽孙铭学孟文琪海军军医大学海军医学系防化医学教研室上海200433 郑州市疾病预防控制中心郑州450042

芥子气(SM)是一种难防难治的化学战剂,可引起多个组织器官不可逆转的损伤,包括皮肤、眼睛、肺和神经系统等,迄今为止SM的中毒机制尚不明确。已有SM中毒机制研究表明,氧自由基大量产生、谷胱甘肽耗竭、NAD^(+)的消耗、钙离子超载以及细... 详细信息

芥子气(SM)是一种难防难治的化学战剂,可引起多个组织器官不可逆转的损伤,包括皮肤、眼睛、肺和神经系统等,迄今为止SM的中毒机制尚不明确。已有SM中毒机制研究表明,氧自由基大量产生、谷胱甘肽耗竭、NAD^(+)的消耗、钙离子超载以及细胞凋亡等都与线粒体关系密切。本综述拟从线粒体形态、功能以及膜电位,氧化应激,线粒体DNA,NAD^(+),凋亡、自噬等方面对线粒体在SM损伤中的作用进行总结,并展望了未来的研究方向。

关键词：芥子气线粒体 NAD+消耗氧化应激凋亡