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STUDY ON DYNAMIC CURVING BEHAVIOR OF TILTING PASSENGER CARS

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Chinese Journal of Mechanical Engineering 2002年第4期15卷 360-365,371页

作者： liu Hongyou Zeng Jing National Traction Power Laboratory, Southwest Jiaotong University, chengdu 610031, china National Traction Power Laboratory Southwest Jiaotong University Chengdu 610031 China

By using tilting carbodies, train can negotiate at a higher speed withoutreducing the passenger's ride quality. This is a good method to allow a significant increase inspeed at existing track to improve the railway transportation capability, and to enhance thecompetition ability of railways with other transportation systems. With the increase of the curvenegotiation speed, the wheel-rail lateral forces and wheel-rail wear of the tilting train willincrease. The self-steering radial bogie is an effective way to solve the problem. The dynamic modelof the tilting passenger car with self-steering bogies is established in detail, and the curvingperformance of the car is investigated.

关键词： tilting passenger car self-steering bogie dynamic curving behavior wheel-rail interaction

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Design of a 400 N and 12 mm Mechanical Air Gap High Temperature Superconducting Linear Synchronous Motor

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稀有金属材料与工程 2011年第S3期40卷 319-321页

作者： Yen Fei1,2,3, Li Jing1,2,3, Zheng Shijun1,2,3, Jiang Donghui1,2,3, liu Lu1,2,3, liu Wei1,2,3, Ma Guangtong1,2,3, wang Jiasu1,3, wang Suyu1,3 1 Applied Superconductivity Laboratory, Southwest Jiaotong University, chengdu 610031, china 2 State Key Laboratory of Traction Power, Southwest Jiaotong University, chengdu 610031, china 3 National Laboratory for Rail Transit, chengdu 610031, china SW Jiaotong Univ Appl Superconduct Lab Chengdu 610031 Peoples R China SW Jiaotong Univ State Key Lab Tract Power Chengdu 610031 Peoples R China Natl Lab Rail Transit Chengdu 610031 Peoples R China

The static thrust output on a superconducting coated conductor coil at different excitation and alternating current suspended above a three phase alternating current long-stator comprised of copper coils is presented. Excitation current up to 45 A was applied through the superconducting coil acting as the excitation system of the superconducting linear synchronous motor (SLSM), alternating current up to 9 A was applied to the armature and magnetic air gaps of 10 and 15 mm were investigated for four different cases; coreless, with an iron core or yoke and both a core and yoke. By scaling up and converting the studied superconducting single pancake racetrack coil into a double pancake coil and connecting four of such coils in series, an SLSM prototype capable of generating 400 N of thrust output and 1 kW of power output with a 12 mm mechanical air gap operating at 77 K is proposed.

关键词： high temperature superconductivity linear synchronous motor long stator motor superconducting coil force measurements

Evolutionary Particle Swarm Optimization Algorithm Based on Collective Prediction for Deployment of Base Stations

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Computers, Materials & Continua 2025年第1期82卷 345-369页

作者： Jiaying Shen Donglin Zhu Yujia liu Leyi wang Jialing Hu Zhaolong Ouyang Changjun Zhou Taiyong Li School of Computer Science and Technology Zhejiang Normal UniversityJinhua321004China School of Future Technologies Jiangxi Institute of Applied Science and TechnologyNanchang330000China School of Computing and Artificial Intelligence Southwestern University of Finance and EconomicsChengdu611130China

The wireless signals emitted by base stations serve as a vital link connecting people in today’s society and have been occupying an increasingly important role in real *** development of the Internet of Things(IoT)relies on the support of base stations,which provide a solid foundation for achieving a more intelligent way of *** a specific area,achieving higher signal coverage with fewer base stations has become an urgent ***,this article focuses on the effective coverage area of base station signals and proposes a novel Evolutionary Particle Swarm Optimization(EPSO)algorithm based on collective prediction,referred to herein as *** a new strategy called neighbor-based evolution prediction(NEP)addresses the issue of premature convergence often encountered by *** also employs a strengthening evolution(SE)strategy to enhance the algorithm’s global search capability and efficiency,ensuring enhanced robustness and a faster convergence speed when solving complex optimization *** better adapt to the actual communication needs of base stations,this article conducts simulation experiments by changing the number of base *** experimental results demonstrate thatunder the conditionof 50 ormore base stations,ECPPSOconsistently achieves the best coverage rate exceeding 95%,peaking at 99.4400%when the number of base stations reaches *** results validate the optimization capability of the ECPPSO algorithm,proving its feasibility and *** ablative experiments and comparisons with other algorithms highlight the advantages of ECPPSO.

关键词： Particle swarm optimization effective coverage area global optimization base station deployment

Evaluation of Sustainable Land Management and Diagnosis of Obstacle at County Scale in Sichuan Basin:Taking Lezhi County as Example

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Wuhan University Journal of Natural Sciences 2006年第4期11卷 1046-1051页

作者： CHEN Guangjian 1, 2, 3 , liu Qing 1 1. chengdu Institute of Biology, Chinese Academy of Sciences, chengdu 610041, Sichuan,china 2. Graduate University of Chinese Academy of Sciences, Beijing 100049, china 3. Academy of Land Reconnaissance and Layout of Sichuan Province , chengdu 610031, Sichuan, china chengdu Institute of Biology Chinese Academy of Sciences 610041 Chengdu Sichuan China Graduate University of Chinese Academy of Sciences 100049 Beijing China Academy of Land Reconnaissance Layout of Sichuan Province 610031 Chengdu Sichuan China

This paper established sustainable land resources evaluating indicators fit for hilly area in Sichuan Basin, Southwest of china, and evaluated the case of sustainable land management of Lezhi County from 1990 to 2001. The result showed that the land resource sustainable utilization ability in Lezhi County is belong to Second level （better sustainable）. Secondly, this paper diagnosed some years obstacles of sustainable land management of Lezhi County from base period to goal period and compared the obstacles factors in the indicators system. There were 16 indexes orderly become major affect factor to land sustainable utilization of Lezhi county in indicator system, of which there are 8 obstacles indexes exist both in 1990 and 2001. The value of obstacles degree of five indicators exceeded 5 in 1990, but in 2001, only two indicators＇ values were more than 5.

关键词： land resources sustainable land management assessment indicators diagnosis of obstacle

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan wang Xin Xie Wei Huang B O liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. Our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

Evaluation on Glare Response to Car Headlight and Drivers′Visibilit

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Journal of Modern Transportation 1996年第2期13卷 93-97页

作者： Zhang Dianye wang wuhong Cao Qi School of Economics and Managment,Southwest Jiaotong University,chengdu 610031,china

This paper proposes an ideal set of glare rating scales,shows how it affects the vision legibility for driving,and simulates the situation in whic... 详细信息

This paper proposes an ideal set of glare rating scales,shows how it affects the vision legibility for driving,and simulates the situation in which cars are moving at the relative speed of 120 km/h and 180 km/h,and the light quantity change caused by the moving light sources affects vision *** will offer quantitative vision data for engineers.

关键词： man machine interface vision legibility glare response ergonomics evaluation

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue wang Qu Yue Taotao Gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Control of the Rendition Wavelength Shifts of Color Lippmann Holograms Recordedin Single-layer panchromatic Silver-halide Emulsion

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Chinese Journal of Lasers 2000年第2期9卷 155-160页

作者： ZHU Jianhua, GUO Lurong, LI Zuoyou, liu Zhenqing (Information Optics Institute, Sichuan University, chengdu 610064, china Institute of Southwest Find Physics, chengdu 610003, china ) 四川大学四川成都中国工程物理研究院西南流体物理所四川成都

Russian PFG-03C panchromatic ultra-high resolution silver-halide emulsion is regarded as the most successful material for the fabrication of color reflection holograms. But the lack of established and reliable processing sequences prevents its practical applications in business and everyday life. Though much attention is drawn upon the processing of PFC-03C color reflection holograms, the color desaturation is still a problem. The article describes the new processing of color holograms recorded in PFC- 03C plates which is demonstrated experimentally to have the capacity of controlling the rendition wavelength shifts and improving the color desaturation effectively. The rendition spectra of Red-Green-Blue (R. G. B. ) single-line reflection holographic gratify, and the color reflection hologram as well, are given in this paper.

关键词： color holography reflection holograms rendition wavelength color desaturation