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Jianpi Huazhuo Tiaozhi granules reduce oxidative stress injury in macrophages by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase/reactive oxygen species-nuclear transcription factor kappa B pathway

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Journal of Traditional Chinese Medicine 2020年第6期40卷 922-927页

作者： liu Yanwei liu zhongyong School of Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China Department of Cardiology Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China

OBJECTIVE:To assess the effect of Jianpi Huazhuo Tiaozhi granules(JHTG)on oxidative stress damage to macrophages and explore the relationship between the levels of this damage and the nicotinamide adenine dinucleotide phosphate oxidase(NOX)/reactive oxygen species(ROS)-nuclear transcription factor kappa B(NF-κB)signaling ***:Macrophages cultured in vitro were divided into seven groups:control,model control,inhibitor,positive control,2.5%JHTG,5%JHTG,and10%*** oxidative stress injury model was established by stimulating macrophages with oxidized low-density *** survival and apoptosis were detected by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide and flow cytometry assays,*** and superoxide dismutase levels were detected by enzyme-linked immunosorbent assays,while ROS levels were detected using a fluorescence *** and m RNAs associated with the NOX/ROS-NF-κB pathway,including NOX4,p22 phox,inhibitor of NF-κB kinase-α(IKK-α),inhibitor of NF-κB kinase-β(IKK-β),and NF-κB were detected by Western blot and PCR,***:After JHTG treatment,there were fewer damaged and apoptotic macrophages,while superoxide dismutase levels were *** JHTG-treated groups also showed reduced ROS *** molecular changes following JHTG treatment included decreased expression of NOX4 and p22 phox at the protein level and decreased IKK-α,IKK-β,and NF-κB expression at the m RNA *** of these effects were correlated with the JHTG ***:These results demonstrated that the molecular mechanism underlying the antioxidant activity of JHTG in macrophages is through inhibiting the NOX/ROS-NF-κB pathway.

关键词： Atherosclerosis Oxidative stress Macrophages NADPH oxidases Reactive oxygen species NF-kappa B Jianpi Huazhuo Tiaozhi granules

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Synthesis of porous hematite nanorods loaded with CuO nanocrystals as catalysts for CO oxidation

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Journal of Natural Gas Chemistry 2011年第6期20卷 669-676页

作者： Jianliang Cao Yan Wang Tianyi Ma Yuping liu zhongyong Yuan Institute of New Catalytic Materials science Key Laboratory of Advanced Energy Materials Chemistry （Ministry of Education） College of Chemistry Nankai University Tianjin 300071 China

Porous hematite （α-Fe2O3） nanorods with the diameter of 20-40 nm and the length of 80-300 nm were synthesized by a simple surfactant-assisted method in the presence of cetyltrimethylammonium bromide （CTAB）.The α-Fe2O3 nanorods possess a mesostructure with a pore size distribution in the range of 5-12 nm and high surface area,exhibiting high catalytic activity for CO *** nanocrystals were loaded on the surface of porous α-Fe2O3 nanorods by a deposition-precipitation method,and the catalysts exhibited superior activity for catalytic oxidation of CO,as compared with commercial α-Fe2O3 powders supported CuO *** enhanced catalytic activity was attributed to the strong interaction between the CuO nanocrystals and the support of porous α-Fe2O3 nanorods.

关键词： porous materials iron oxide nanostructures CuO supported nanocatalysts catalytic CO oxidation

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Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2020年第3期40卷 355-364页

作者： Fang Ting Li Qi Zhou Fanyuan liu Fushui liu zhongyong Zhao Meimei Chen Mei You Jianyu Jin Yuli Xie Jinmei Department of Acupotomy Chiropractors The Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China Jiangxi Normal University Nanchang 330022China College of Clinical Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China Department of Cardiovascular Medicine The Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China

OBJECTIVE: To evaluate the clinical efficacy and safety of acupotomy in treatment of knee osteoarthritis(OA).METHODS: Extensive literature searches were carried out in PubMed, EMBASE, Cochrane Library(Issue 5, 2017), Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database and Wanfang Database. All databases were retrieved from their inception until May 31, *** controlled trials incorporating acupotomy versus intra-articular sodium hyaluronate for knee osteoarthritis were included. According to Cochrane Reviews’ Handbook(5.2), two reviewers screened each article and extracted data independently and were blinded to the findings of each reviewer. Meta-analysis was performed by the Cochrane Collaboration’s RevMan 5.3 ***: We identified 12 studies involving 1150 patients aged between 40 and 78 years old. The pooled analysis indicated that acupotomy showed a significant improvement for short-term effect[cure rate: odds ratio(OR) = 2.04, 95% confidence interval(CI)(1.46, 2.85), P < 0.01;total effective rate:OR = 2.25, 95% CI(1.55, 3.28), P < 0.01;pain score:standard mean difference(SMD) =-1.02;95% CI(-1.72,-0.31);P = 0.005;Western Ontario and McMaster Universities Questionnaire(WOMAC) score:SMD =-0.74;95% CI(-1.11,-0.37);P < 0.01];and also for long-term effect [total effective rate:OR = 2.99, 95%CI(1.88, 4.76), Z = 4.64, P < 0.01;pain score: SMD =-1.68;95% CI(-2.14,-1.22);P <0.001;WOMAC score: SMD =-0.91;95% CI(-1.40,-0.41);P < 0.001]. In addition, there was no obvious difference between acupotomy group and control group in adverse events [OR = 2.13, 95% CI(0.14, 32.28), P = 0.58].CONCLUSION: Acupotomy is a safe and effective treatment for KOA. However, due to the methodological deficiency of the included studies, well-designed randomized controlled trials are required to further confirm the findings.

关键词： Osteoarthritis knee Hyaluronic acid Acupuncture therapy Review Meta-analysis

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刘中勇应用黄连温胆汤辨治心悸浅析

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中国民间疗法 2019年第12期27卷 8-9页

作者：胡悫刘中勇江西中医药大学江西南昌330000 江西中医药大学附属医院江西南昌330006

痰、火是心悸发生发展常见的病理因素。心为火之脏,痰火可直接影响心的正常功能,从而导致心悸的发生。黄连温胆汤有清火化痰之功,尤擅于治疗证属痰火扰心之心悸。该方选药精妙,配伍严谨,为历代医家治疗心悸的重要方剂之一。刘中勇认为... 详细信息

痰、火是心悸发生发展常见的病理因素。心为火之脏,痰火可直接影响心的正常功能,从而导致心悸的发生。黄连温胆汤有清火化痰之功,尤擅于治疗证属痰火扰心之心悸。该方选药精妙,配伍严谨,为历代医家治疗心悸的重要方剂之一。刘中勇认为此方具有清热泻火、宁心止悸、化痰安神之功,将本方加减用于治疗因痰火内扰导致的心悸病证,每获良效。

关键词：黄连温胆汤痰火扰心心悸刘中勇

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刘中勇运用五苓散辨治咳嗽经验

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国医论坛 2020年第1期35卷 50-52页

作者：胡悫刘中勇江西中医药大学江西南昌330000 江西中医药大学附属医院江西南昌330000

目的:总结刘中勇运用五苓散治疗咳嗽的经验。方法:跟师学习,记录医案,总结分析。结果:刘师认为,三焦气化失司,水道不利,水湿上干于肺,是咳嗽的常见病机;治疗上应用具有温阳化气、利水渗湿功效的五苓散并随症加减进行治疗,屡用屡效。结论... 详细信息

目的:总结刘中勇运用五苓散治疗咳嗽的经验。方法:跟师学习,记录医案,总结分析。结果:刘师认为,三焦气化失司,水道不利,水湿上干于肺,是咳嗽的常见病机;治疗上应用具有温阳化气、利水渗湿功效的五苓散并随症加减进行治疗,屡用屡效。结论:刘师治疗咳嗽的经验值得效法。

关键词：水湿五苓散咳嗽刘中勇名医经验

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刘中勇“气血并治”论治冠心病

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中医药临床杂志 2019年第6期31卷 1040-1042页

作者：胡悫刘中勇江西中医药大学江西南昌330000 江西中医药大学附属医院江西南昌330000

中医学认为冠心病属于“胸痹”范畴,病机要点为心脉痹阻。刘中勇教授从人体最基本的组成物质气血相关理论出发,认为人体气血不和导致心脉痹阻是冠心病发生的主要病机。根据冠心病不同阶段气血之间的虚实变化,临床总结“气滞血瘀”“气... 详细信息

中医学认为冠心病属于“胸痹”范畴,病机要点为心脉痹阻。刘中勇教授从人体最基本的组成物质气血相关理论出发,认为人体气血不和导致心脉痹阻是冠心病发生的主要病机。根据冠心病不同阶段气血之间的虚实变化,临床总结“气滞血瘀”“气虚血瘀”以及“气虚血弱”为冠心病的基本病机。在冠心病的治疗中,遵《素问·至真要大论》中“疏其血气,令其条达,而致和平”的治疗原则,倡导“气血并治”,以“理气活血”“益气活血”“补气生血”为冠心病基本治法,在冠心病的治疗和病人预后方面均取得了显著效果,其经验值得学习和借鉴。

关键词：气血并治冠心病中医药疗法临证经验

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