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Effectiveness of Lianhua Qingwen Granule and Jingyin Gubiao Prescription in Omicron BA.2 Infection and Hospitalization:A Real-World Study of 56,244 Cases in Shanghai,China

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Chinese Journal of Integrative Medicine 2025年第1期31卷 11-18页

作者： ZHANG Yu-jie liu Guo-jian ZHANG Han liu Chen CHEN zhi-qiang XIAN Ji-shu SONG Da-li liu zhi YANG Xue WANG Ju ZHANG Zhe ZHANG Lu-ying FENG Hua ZHANG Yan-qi TAN Liang Department of Basic Medicine Army Medical UniversityChongqing400038China Department of Radiology The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Pediatrics The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Neurosurgery The First Affiliated Hospital of the Army Medical UniversityChongqing400038China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR519000China Department of Health Statistics College of Military Preventive MedicineArmy Medical UniversityChongqing400038China Department of Critical Care Medicine The First Affiliated Hospital of the Army Medical UniversityChongqing400038China

Objective: To examine the effectiveness of Chinese medicine(CM) Lianhua Qingwen Granule(LHQW) and Jingyin Gubiao Prescription(JYGB) in asymptomatic or mild patients with Omicron infection in the shelter hospital. Methods: This single-center retrospective cohort study was conducted in the largest shelter hospital in Shanghai, China, from April 10, 2022 to May 30, 2022. A total of 56,244 asymptomatic and mild Omicron cases were included and divided into 4 groups, i.e., non-administration group(23,702 cases), LHQW group(11,576 cases), JYGB group(12,112 cases), and dual combination of LHQW and JYGB group(8,854 cases). The length of stay(LOS) in the hospital was used to assess the effectiveness of LHQW and JYGB treatment on Omicron infection. Results: Patients aged 41–60 years, with nadir cycle threshold(CT) value of N gene <25, or those fully vaccinated preferred to receive CM therapy. Before or after propensity score matching(PSM), the multiple linear regression showed that LHQW and JYGB treatment were independent influence factors of LOS(both P<0.001). After PSM, there were significant differences in LOS between the LHQW/JYGB combination and the other groups(P<0.01). The results of factorial design ANOVA proved that the LHQW/JYGB combination therapy synergistically shortened LOS(P=0.032). Conclusions: Patients with a nadir CT value <25were more likely to accept CM. The LHQW/JYGB combination therapy could shorten the LOS of Omicron-infected individuals in an isolated environment.

关键词： Lianhua Qingwen Granule Jingyin Gubiao Prescription Chinese medicine Omicron COVID-19

The Stereocomplex Crystallites Improve the Stability of Biodegradable Poly(L-lactic acid)/Poly(D-lactic acid) Melt-Blown Nonwovens

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 368-379页

作者： Yu, Jin-Shuo Huan, Yue-Wei Pan, Hong-Wei liu, zhi-Gang Zhao, Yan Tan, zhi-Yong Bian, Jun-Jia Yang, Hui-Li Zhang, Hui-Liang Chinese Acad Sci Changchun Inst Appl Chem Key Lab Polymer Ecomat Changchun 130022 Peoples R China Changchun Univ Technol Coll Mat & Engn Engn Res Ctr Synthet Resin & Special Fiber Sch Chem EngnMinist Educ Changchun 130012 Peoples R China Shandong Fufeng Fermentat Co Ltd Linyi 276600 Shandong Peoples R China Jilin COFCO Biochem Co Ltd Natl Engn Res Ctr Corn Deep Proc Changchun 130033 Peoples R China

Poly(lactic acid) (PLA) is a biodegradable and eco-friendly polymer that is increasingly being incorporated into various applications in contemporary society. However, the limited stability of PLA-based products remains a significant challenge for their broader use in various applications. In this study, poly(L-lactic acid)(PLLA)/poly(D-lactic acid) (PDLA) melt-blown nonwovens were prepared by melt spinning. The structure, thermal properties, thermal stability, biodegradability and crystalline morphology of the melt-blown nonwovens were investigated. DSC and WAXD confirmed the formation of stereocomplex (SC) crystallites in the PLLA matrix. The storage modulus (G '), loss modulus (G ''), and complex viscosity (divided by eta*divided by) of the PLLA/PDLA blend increased with an increase in SC crystallite content. The thermal degradation temperatures of PLLA/PDLA melt-blown nonwovens increased with the incorporation of SC crystallites, and the maximum rate of decomposition increased to 385.5 degrees C, thus enhancing the thermal stability. Compared with neat PLLA melt-blown nonwovens, the hydrophobicity of PLLA/PDLA melt-blown nonwovens was improved, and WCA increased to 139.7 degrees. The SC crystallites were more resistant to degradation by proteinase K compared to neat PLLA. However, the degradation rate of PLLA/PDLA melt-blown nonwovens remained at a high level. This work provides an effective strategy to obtain high-performance PLLA melt-blown nonwovens.

关键词： PLLA PDLA Melt-blown nonwovens Stereocomplex crystallites Thermal stability Enzymatic degradation

Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu liu zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na XIA Jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

Beyond the tumor region:Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer

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World Journal of Gastroenterology 2025年第8期31卷 49-65页

作者： zhi-Ying Liang Mao-Li Yu Hui Yang Hao-Jiang Li Hui Xie Chun-Yan Cui Wei-Jing Zhang Chao Luo Pei-Qiang Cai Xiao-Feng Lin Kun-Feng liu Lang Xiong Li-zhi liu Bi-Yun Chen Department of Radiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Imaging First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND The peritumoral region possesses attributes that promote cancer growth and ***,the potential prognostic biomarkers in this region remain relatively underexplored in *** To investigate the prognostic value and importance of peritumoral radiomics in locally advanced rectal cancer(LARC).METHODS This retrospective study included 409 patients with biopsy-confirmed LARC treated with neoadjuvant chemoradiotherapy and *** were divided into training(n=273)and validation(n=136)*** on intratumoral and peritumoral radiomic features extracted from pretreatment axial high-resolution small-field-of-view T2-weighted images,multivariate Cox models for progression-free survival(PFS)prediction were developed with or without clinicoradiological features and evaluated with Harrell’s concordance index(C-index),calibration curve,and decision curve *** stratification,Kaplan-Meier analysis,and permutation feature importance analysis were *** The comprehensive integrated clinical-radiological-omics model(ModelICRO)integrating seven peritumoral,three intratumoral,and four clinicoradiological features achieved the highest C-indices(0.836 and 0.801 in the training and validation sets,respectively).This model showed robust calibration and better clinical net benefits,effectively distinguished high-risk from low-risk patients(PFS:97.2%vs 67.6%and 95.4%vs 64.8%in the training and validation sets,respectively;both P<0.001).Three most influential predictors in the comprehensive ModelICRO were,in order,a peritumoral,an intratumoral,and a clinicoradiological ***,the peritumoral model outperformed the intratumoral model(C-index:0.754 vs 0.670;P=0.015);peritumoral features significantly enhanced the performance of models based on clinicoradiological or intratumoral features or their *** Peritumoral radiomics holds greater prognostic value than intratumoral radiomics for predicting PFS in L

关键词： Rectal cancer Peritumoral radiomics Intratumoral radiomics Prognosis analysis Variable importance analysis Tumor microenvironment

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土-水特征曲线的动态效应试验及模型研究

岩土力学 2025年第1期46卷 178-186,198页

作者：张高翔刘艳刘志强河北交通职业技术学院路桥工程系石家庄050091 北京交通大学城市地下工程教育部重点实验室北京100044 河北省季冻区公路服役安全与预警技术创新中心河北石家庄050091

室内测量土-水特征曲线(soil-water characteristic curve,简称SWCC)往往需要很长的平衡时间,而实际土体的变化可能并不满足平衡时间要求。当时间尺度较小时,SWCC可能未达到平衡,此时如果仍采用平衡条件下土-水特征曲线来建立非饱和土... 详细信息

室内测量土-水特征曲线(soil-water characteristic curve,简称SWCC)往往需要很长的平衡时间,而实际土体的变化可能并不满足平衡时间要求。当时间尺度较小时,SWCC可能未达到平衡,此时如果仍采用平衡条件下土-水特征曲线来建立非饱和土的方程,就会产生误差。为此,研究了在非平衡条件下土-水特征曲线的动态效应,基于现有理论给出了土-水特征曲线参数与饱和度变化率的关系,并利用动态参数建立了动态毛细滞回模型。自主设计SWCC快速测量装置,针对粗砂和细砂开展了不同饱和度变化率情况下的土-水特征曲线测定试验。试验研究表明:(1)土-水特征曲线参数具有明显的动态效应;(2)进气值和残余饱和度并非定值,随饱和度变化率的不同有所改变;(3)利用试验结果对模型进行了验证,动态模型的预测结果与试验结果吻合较好,说明了该模型的合理性。本研究为解决非饱和土变形、强度和渗流问题提供了更加贴合实际的理论基础。

关键词：土-水特征曲线吸力增量水力参数动态效应滞回模型

A Study on the Mechanisms by Which AGEs and RAG Promote Wound Healing in Patients with Second-Degree Burns undergoing Eschar Grinding Combined with Drug Therapy

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Modern Plastic Surgery 2025年第1期15卷 1-20页

作者： Weijie He zhi liu Lujun Yang Sitian Xie Zhan Ouyang Yao Lin Fuhua Huang Shijie Tang Second Affiliated Hospital of Shantou University Medical College Shantou China Shiquan County Hospital Ankang City Shaanxi Province Ankang China

Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, th

关键词： AGEs RAG Dermabrasion Second Degree Burns

基于功能化COFs材料的样品前处理技术在新兴污染物中的研究进展

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分析测试学报 2025年第1期44卷 12-24页

作者：潘自宇刘智敏许志刚昆明理工大学理学院云南昆明650500

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不... 详细信息

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不稳定污染物的分析准确性差等缺点,因此,亟需开发设计具有高选择性、高传质效率的新型材料作为前处理技术的吸附剂,以实现新兴污染物的高选择、高灵敏检测。共价有机骨架材料(COFs),特别是功能化的COFs材料,因具有比表面积大、结构可设计、稳定且构筑基元丰富等诸多优点而被广泛用于新兴污染物的富集。该文主要综述了近年来功能化COFs材料的合成策略及其作为样品前处理吸附剂在环境、食品和生物样品中新兴污染物中的分析应用,并对该类材料的未来发展趋势进行了展望。

关键词：新兴污染物功能化COFs材料样品前处理技术

表面印迹微球在水相介质样品前处理中的应用研究进展

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分析测试学报 2025年第1期44卷 61-72页

作者：王思涛刘智敏许志刚昆明理工大学理学院云南昆明650500

氢键通常是分子印迹聚合物识别模板分子的主要机制,由于水分子等诸多影响因素带来的干扰,有效识别水环境中的分析物一直是分子印迹技术面临的一大挑战。表面印迹微球具有比表面积大和易于修饰等特性,能够被灵活运用以满足各种水相样品... 详细信息

氢键通常是分子印迹聚合物识别模板分子的主要机制,由于水分子等诸多影响因素带来的干扰,有效识别水环境中的分析物一直是分子印迹技术面临的一大挑战。表面印迹微球具有比表面积大和易于修饰等特性,能够被灵活运用以满足各种水相样品前处理的需求,是克服水相识别困难的有效方法之一。该文综述了近年来水相识别表面印迹微球的各种制备策略及其代表性应用,包括不同基底、亲水性识别、非氢键的协同识别和基于特殊组件的表面印迹微球;从作用力和识别机制层面讨论了在水相介质中识别分子时的干扰因素及其调控策略,并进一步介绍了表面印迹微球在水相样品前处理中的应用;最后探讨了表面印迹微球在水相样品前处理领域面临的挑战及未来研究趋势。

关键词：表面印迹微球水相识别样品前处理制备策略

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-zhi liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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