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HiFAST:An H?data calibration and imaging pipeline for FAST

Science china(Physics,Mechanics & Astronomy) 2024年第5期Mechanics & Astronomy) .卷 186-203页

作者： Yingjie Jing Jie Wang Chen Xu Ziming liu Qingze Chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang huijie hu Chuan-Peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang Xu Kong Fujia Li Zerui liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu National Astronomical Observatories Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Astronomy and Space Science University of Chinese Academy of Sciences Guizhou Radio Astronomical Observatory Guizhou University Max Planck Institute for Extraterrestrial Physics Kavli Institute for Astronomy and Astrophysics Peking University Institute of Computational Cosmology Department of PhysicsUniversity of Durham CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of China School of Astronomy and Space Science University of Science and Technology of China Astrophysics Department of PhysicsUniversity of Oxford College of Earth Sciences Guilin University of Technology Department of Physics Anhui Normal University School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing University

The Five-hundred-meter Aperture Spherical radio Telescope（FAST） has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas（H?） in the *** present HiFAST（https://***）,a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square（RMS） noises of the calibrated spectra from all 19 beams were only slightly（～5%） higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps（0,1 and 2） of M33 agree well with the results from the Arecibo Galaxy Environment Survey（AGES） with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA（ALFALFA） survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1) is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H? in the universe.

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生物信息学和机器学习策略识别骨关节炎炎性衰老生物标志物与临床验证

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四川大学学报（医学版） 2024年第2期55卷 279-289页

作者：周巧刘健朱艳汪元王桂珍齐亚军胡月迪安徽中医药大学第二附属医院老年病一科合肥230061 安徽中医药大学第一临床医学院合肥230012 安徽中医药大学第一附属医院风湿病科合肥230031

目的本研究旨在识别骨关节炎(osteoarthritis, OA)中炎性衰老生物标志物。方法 GEO(Gene Expression Omnibus)数据库获得年轻OA和老年OA微阵列基因谱,人类衰老基因组资源数据库(human Aging Genome Resource,HAGR)获得衰老相关基因(agi... 详细信息

目的本研究旨在识别骨关节炎(osteoarthritis, OA)中炎性衰老生物标志物。方法 GEO(Gene Expression Omnibus)数据库获得年轻OA和老年OA微阵列基因谱,人类衰老基因组资源数据库(human Aging Genome Resource,HAGR)获得衰老相关基因(aging-related genes, ARGs)。筛选获得年轻OA与老年OA的差异基因,再与ARGs取交集得到OA衰老相关基因。富集分析揭示OA衰老相关标志物的潜在机制。3种机器学习方法识别OA核心衰老标志物,受试者工作特征(receiver operating characteristic curve, ROC)曲线评估其诊断OA炎性衰老的能力。收集临床OA患者外周血单核细胞验证衰老相关分泌表型(senescence-associated secretory phenotype, SASP)因子和衰老标志物的表达。结果总共获得45个衰老相关标志物,主要参与对细胞衰老、细胞周期、炎症反应等的调控。3种机器方法筛选得出5个核心衰老标志物(FOXO3、MCL1、SIRT3、STAG1和S100A13)。纳入20例正常组,40例OA患者,包括年轻组和老年组各20例。与年轻组相比,老年组OA中C反应蛋白(C-reactive protein, CRP)、白细胞介素(interleukin, IL)-6、IL-1β上升,IL-4水平下降(P<0.01);FOXO3、MCL1、SIRT3 mRNA表达下降,STAG1和S100A13 mRNA表达上升(P<0.01)。Pearson相关性分析表明选定的标志物与红细胞沉降率(erythrocyte sedimentation rate, ESR)、IL-1β、IL-4、CRP、IL-6指标相关。5个核心衰老基因ROC曲线下面积均大于0.8,列线图预测模型中校正曲线的C-index为0.755,模型校准能力较好。结论 FOXO3、MCL1、SIRT3、STAG1和S100A13可作为OA炎性衰老的新型诊断分子标志物和潜在治疗靶点。

关键词：骨关节炎炎性衰老衰老相关分泌表型机器学习生物标志物

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基于生成对抗网络的图像超分辨率改进模型

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黑龙江工业学院学报（综合版） 2024年第6期24卷 74-78页

作者：刘庆俞胡莹陈磊刘磊淮南师范学院计算机学院安徽淮南232038 淮南市职业教育中心安徽淮南232038

针对图像去噪处理后出现的细节模糊等问题,提出一种改进生成对抗网络的图像超分辨率模型。以Super Resolution Generative Adversarial Networks(SRGan)模型为基础,为充分提高其特征提取能力和重建能力,使用空间注意力机制改造残差模块... 详细信息

针对图像去噪处理后出现的细节模糊等问题,提出一种改进生成对抗网络的图像超分辨率模型。以Super Resolution Generative Adversarial Networks(SRGan)模型为基础,为充分提高其特征提取能力和重建能力,使用空间注意力机制改造残差模块,并在生成器网络中使用了空洞卷积层。在对抗损失、感知损失和L1损失函数的作用下,生成器和判别器子网络交替训练,逐步提高各自性能。训练数据集中的低分辨率图像添加了高斯噪声,使其更好地模拟真实场景。使用Set5、Set14和Urban100数据集进行测试。结果表明,超分辨率模型的重建效果较好,SSIM和PSNR两项指标均有明显提升。

关键词：生成对抗网络图像超分辨率残差注意力机制空洞卷积

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Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu huan Wang Chuang liu Yu-Ping Man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou Li Shang Zheng Chang Dong Bai-Lin Wang Yan-Xiang Sun hui-Qin Zhang Jie-Wei Li Quan-hui Mo Ying Zhang Xin Lou Hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo liu Lei Gao Jin-hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western china’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

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教师专业发展中的退缩现象及改善策略

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教育发展研究 2009年第10期29卷 70-73页

作者：余圆圆安徽师范大学教育科学学院硕士研究生芜湖241000

教师专业发展中的退缩现象,是指教师在日常的工作、生活中出现适应性困难时,倾向于从环境中退避出来,并出现情绪淡漠、人际关系紧张、对职业倦怠等症状。这种现象主要是由于教师专业发展水平的极值状态、教育内部环境的变迁以及社会转... 详细信息

教师专业发展中的退缩现象,是指教师在日常的工作、生活中出现适应性困难时,倾向于从环境中退避出来,并出现情绪淡漠、人际关系紧张、对职业倦怠等症状。这种现象主要是由于教师专业发展水平的极值状态、教育内部环境的变迁以及社会转型所致。为此,加强教师自我调适、完善教师管理激励机制、改进教师培训、开展员工帮助计划,是克服和改善这种退缩现象的可行策略。

关键词：教师专业发展退缩现象教师管理激励机制

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Variability of PM_(2.5) and O_(3) concentrations and their driving forces over Chinese megacities during 2018-2020

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Journal of Environmental Sciences 2023年第2期124卷 1-10页

作者： Tianyi Xu Chengxin Zhang Cheng liu Qihou hu School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China Key Laboratory of Precision Scientific Instrumentation of anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230026China

Recently,air pollution especially fine particulate matters(PM_(2.5))and ozone(O_(3))has become a severe issue in *** this study,we first characterized the temporal trends of PM_(2.5) and O_(3) for Beijing,Guangzhou,Shanghai,andWuhan respectively during *** annual mean PM2.5 has decreased by 7.82%-33.92%,while O_(3) concentration showed insignificant variations by-6.77%-4.65%during *** generalized additive models(GAMs)were implemented to quantify the contribution of individual meteorological factors and their gas precursors on PM_(2.5) and O_(3).On a short-term perspective,GAMs modeling shows that the daily variability of PM_(2.5) concentration is largely related to the variation of precursor gases(R=0.67-0.90),while meteorological conditions mainly affect the daily variability of O_(3) concentration(R=0.65-0.80)during *** impact of COVID-19 lockdown on PM_(2.5) and O_(3) concentrations were also quantified by using *** the 2020 lockdown,PM_(2.5) decreased significantly for these megacities,yet the ozone concentration showed an increasing trend compared to *** GAMs analysis indicated that the contribution of precursor gases to PM_(2.5) and O_(3) changes is 3-8 times higher than that of meteorological *** general,GAMsmodeling on air quality is helpful to the understanding and control of PM2.5 and O3 pollution in china.

关键词： Air pollution PM_(2.5)and O_(3)trends Meteorology COVID-19 lockdown

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Test of the Louis scheme and COARE algorithm for friction velocity in different wind-sea/swell regimes

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Acta Oceanologica Sinica 2005年第4期24卷 20-28页

作者： GAO Zhiqiu hu Wen liu Shaomin Chinese Academy of Meteorological Sciences Beijingl00081 China Jiangsu Province Key Laboratory of Meteorological Disaster and Environmental Variation Nanjing 210044 China anhui Meteorological Bureau Hefei 230061 China State Key Laboratory of Remote Sensing Science School of Geography Beijing Normal University Beijing 100875 China

The Louis scheme and the COARE algorithm （version 3.0） are tested against eddy covariance and inertial dissipation methods for friction velocity estimates in different wind-sea/swell regimes. Atmospheric forcing data, tabulated by Donelan et al. （1997.J Phys Oceanog, 27：2087-2099）, were collected from a mast on the foredeck of a SWATH （small water-plane area, twin hull） ship in deep sea off the State of Virginia during the surface wave dynamics experiment. These data are representative of low to moderate wind regimes. The aerodynamic roughness length is determined by using the Charnock relationship. The intercomparison shows that the Louis scheme and the COARE algorithm underestimate the friction velocity by 6% and 3% respectively under pure wind sea conditions, 15% and 13% respectively under cross swell conditions, and 21% and 17% respectively under counter swell conditions. The analysis shows that these underestimations were caused by the method chosen to determine the aerodynamic roughness length because it significantly underestimates the aerodynamic roughness length. It is especially true under the cross swell and counter swell conditions.

关键词： Louis scheme friction velocity sea surface

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基于网络教学平台高师体育院校学生语言表达能力培养的实验研究

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安徽体育科技 2024年第2期45卷 72-75,90页

作者：刘璇王彤胡宇弘山西师范大学体育学院太原山西030000

随着科技的进步与网络的发展,教学模式不断变革,基于网络教学平台教学,拓宽了教学渠道与学习平台,本文主要运用实验法、数理统计法等科学研究方法,基于网络教学平台对学生的语言表达能力进行培养,结果表明,基于网络教学平台,学生通过观... 详细信息

随着科技的进步与网络的发展,教学模式不断变革,基于网络教学平台教学,拓宽了教学渠道与学习平台,本文主要运用实验法、数理统计法等科学研究方法,基于网络教学平台对学生的语言表达能力进行培养,结果表明,基于网络教学平台,学生通过观看网络教学平台“教学评价视频库”中的视频,结合教师课堂教学讲解、即时点评;积极参与线上讨论等形式对学生语言表达能力的提高效果明显,实验后学生的语言表达能力明显高于实验前。

关键词：网络教学平台高师体育院校语言表达能力

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雄家鸽不同生长期血浆性激素和睾丸组织学变化

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四川动物 1995年第4期14卷 154-156页

作者：胡增高蒋斌安徽师范大学生物系

本文对雄家鸽不同生长期血浆性激素和睾丸组织学进行了研究，得到如下结果：童鸽性腺小，性激素含量低，切片没有看到各级生殖细胞。成鸽性腺大，性檄素含量高，切片见有各级生殖细胞，成熟精子活跃。老鸽生殖机能减退，性激素含量下降... 详细信息

本文对雄家鸽不同生长期血浆性激素和睾丸组织学进行了研究，得到如下结果：童鸽性腺小，性激素含量低，切片没有看到各级生殖细胞。成鸽性腺大，性檄素含量高，切片见有各级生殖细胞，成熟精子活跃。老鸽生殖机能减退，性激素含量下降，切片只见各级生殖细胞，管壁薄，管腔大，成熟精子少。

关键词：家鸽性激素睾丸性腺组织学

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Apoptosis of human umbilical vein endothelial cells(huVEC) induced by lgA1 isolated from Henoch-Schonlein purpura Children

Apoptosis of Human umbilical vein endothelial cells(HUVEC) i...

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中华医学会第十七次全国儿科学术大会

作者： liping yuan,ling lu,qin zhang,bo hu Department of Pediatrics,First affiliated hospital of anhui Medical university,Hefei,china

Aim HSP is a common immunoglobulin A(IgA),especially lgA1-mediated vasculitis in *** has been showed that apoptosis of vascular endothelial cells played an important role in the pathogenesis of *** this study,we investigated the apoptosis of vein endothelial cells in HSP patients. Methods lgA1 was isolated from sera at the acute stage of childhood HSP and the apoptosis rate of human umbilical vein endothelial cells(huVEC) induced by lgA1 was analyzed using flow cytometry and TUNEL ***-2,Bax and P53 mRNA and protein expression was determined by Real-time quantitative RT-PCR and western blotting methods. Results The results showed that isolated lgA1 markedly induced the apoptosis death of huVEC compared with normal control *** the bax and P53 expression was up-regulated and the Bcl-2 expression was down-regulated in huVEC co-cultured with lgA1 isolated from HSP patients for 24h. Conclusion These findings suggested that lgA1 isolated from HSP patients had an effect on the apoptosis of huVEC;moreover bax/bcl-2 and p53 signaling pathways played a key role in the process of apoptosis in huVEC induced by lgA1.

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