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Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis(Invited)

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激光与光电子学进展 2024年第6期61卷 260-271页

作者： liu zhen Wu Yang Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina

The last two decades have witnessed the invention and development of super-resolution microscopy(SRM)that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several nanometers.While SRM is widely used in biological studies,such as resolving subdiffraction structures,molecular mapping,tracking single molecules,probing protein-protein interactions,and observing organelle dynamics,its direct application in translational medicine,such as disease diagnosis,is still preliminary.Despite their small size,cilia play a crucial role as organelles in cell signaling and motility,with defects in cilia leading to ciliopathy.Similar to other miniature organelles and macromolecular complexes,cilia are ideal for super-resolution imaging.In this review,we will 1)introduce cilia and ciliopathy,2)show how SRM extends our knowledge of cilia,and 3)focus on how SRM improves the diagnosis of motile ciliopathies.

关键词： diagnosis limit spite

Data and Model Driven Task Offloading Strategy in the Dynamic Mobile Edge Computing System

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Journal of Systems Science & Complexity 2024年第1期37卷 351-368页

作者： DONG Hairong WU Wei SONG Haifeng liu zhen ZHANG Zixuan School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Electronic and Information Engineering BeiHang UniversityBeijing 100191China CRSC Research&Design Institute Group Co. Ltd.Beijing 100070China

Mobile Edge Computing(MEC)provides communication and computational capabilities for the industrial Internet,meeting the demands of latency-sensitive tasks.Nevertheless,traditional model-driven task offloading strategies face challenges in adapting to situations with unknown network communication status and computational capabilities.This limitation becomes notably significant in complex industrial networks of high-speed railway.Motivated by these considerations,a data and model-driven task offloading problem is proposed in this paper.A redundant communication network is designed to adapt to anomalous channel states when tasks are offloaded to edge servers.The link switching mechanism is executed by the train according to the attributes of the completed task.The task offloading optimization problem is formulated by introducing data-driven prediction of communication states into the traditional model.Furthermore,the optimal strategy is achieved by employing the informer-based prediction algorithm and the quantum particle swarm optimization method,which effectively tackle real-time optimization problems due to their low time complexity.The simulations illustrate that the data and model-driven task offloading strategy can predict the communication state in advance,thus reducing the cost of the system and improving its robustness.

关键词： Data driven model informer mobile edge computing quantum particle swarm optimization task offloading.

Experimental Study on Vortex-Induced Vibration of Rough Risers Coupling with Interference Effect in Tandem Arrangement

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China Ocean Engineering 2024年第3期38卷 394-407页

作者： HU Ze-bo liu zhen LI Peng GUO Hai-yan REN Xiao-hui HOU Hao HAO Lian-hong College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China

In order to study the response law of vortex-induced vibration(VIV)of marine risers under the combined action of roughness and interference effects,and to reveal the coupling mechanism of roughness and interference effects on the riser,a VIV experiment of rough risers in tandem arrangement was conducted in a wave−current combined flume.The experiment characterized the risers’roughness by arranging different specifications of attachments on the surface of the risers.Three rough risers with different roughness and smooth risers were arranged in tandem arrangement,with the rough risers arranged downstream.The experimental results indicate that the suppression of the attachments on the downstream risers’vibration are more significant both in the CF and IL directions as the reduced velocity increases.For the downstream riser,the amplitude response of rough riser is more significantly weakened compared with the smooth one at high reduced velocity.For the upstream risers,changes in the roughness and spacing ratio have an impact on their‘lock-in’region.When the roughness of downstream risers is relatively large(0.1300)and the spacing between risers is small(S/D=4.0),the reduced velocity range of‘lock-in’region in the CF direction of upstream risers is obviously expanded,and the displacement in the‘lock-in’region is severer.

关键词： marine riser vortex-induced vibration tandem arrangement roughness interference effect

Experimental Study on Vortex-Induced Vibration of Rough Risers with Coupling Interference Effect Under Side-by-Side Arrangement

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China Ocean Engineering 2024年第1期38卷 18-28页

作者： HU Ze-bo liu zhen LI Peng GUO Hai-yan WANG Shu-bing REN Xiao-hui HOU Hao WANG Ye-shuo College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China CHEC Dredging Co. LtdShanghai 200136China

A vortex-induced vibration(VIV)experiment of rough risers with coupling interference effect under a side-by-side arrangement was carried out in a wave-current combined flume.The roughness of the riser was characterized by arranging different specifications of surface attachments on the surface of the riser.Rough risers with three different roughnesses were arranged side by side with smooth risers to explore the VIV response of the riser under the combined action of roughness and interference effect,and to reveal the coupling mechanism between roughness and interference effect.The experimental results show that,compared with that of a smooth riser,the VIV of a rough riser under the coupling interference effect has a wider"lock-in"region,and the displacement decreases more significantly at a high reduced velocity,which is more likely to excite higher-order modes and frequency responses.In addition,the displacement response and frequency response of the smooth riser are not significantly affected by wake interference from the rough riser,which is caused by the decrease of the wake region due to the delay of the boundary layer separation point of the rough riser.

关键词： marine riser vortex-induced vibration side-by-side arrangement roughness interference effect

Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis（特邀）

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激光与光电子学进展 2024年第6期 270-281页

作者： liu zhen Wu Yang Division of Life Science The Hong Kong University of Science and Technology

The last two decades have witnessed the invention and development of super-resolution microscopy(SRM) that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several nanometers. While SRM is widely used in biological studies, such as resolving subdiffraction structures, molecular mapping, tracking single molecules, probing protein-protein interactions, and observing organelle dynamics, its direct application in translational medicine, such as disease diagnosis, is still preliminary. Despite their small size, cilia play a crucial role as organelles in cell signaling and motility, with defects in cilia leading to ciliopathy. Similar to other miniature organelles and macromolecular complexes, cilia are ideal for super-resolution imaging. In this review, we will 1) introduce cilia and ciliopathy, 2) show how SRM extends our knowledge of cilia, and 3) focus on how SRM improves the diagnosis of motile ciliopathies.

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Neural network study of the nuclear ground-state spin distribution within a random interaction ensemble

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Nuclear Science and Techniques 2024年第3期35卷 216-227页

作者： Deng liu Alam Noor A zhen-zhen Qin Yang Lei School of Mathematics and Physics Southwest University of Science and TechnologyMianyang 621010China School of Nuclear Science and Technology Southwest University of Science and TechnologyMianyang 621010China

The distribution of the nuclear ground-state spin in a two-body random ensemble(TBRE)was studied using a general classification neural network(NN)model with two-body interaction matrix elements as input features and the corresponding ground-state spins as labels or output predictions.The quantum many-body system problem exceeds the capability of our optimized NNs in terms of accurately predicting the ground-state spin of each sample within the TBRE.However,our NN model effectively captured the statistical properties of the ground-state spin because it learned the empirical regularity of the ground-state spin distribution in TBRE,as discovered by physicists.

关键词： Neural network Two-body random ensemble Spin distribution of nuclear ground state

Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： zhen-Hang He Guang-Feng liu Ze-Kun Zhou zhen liu Yi-Shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

Efficacy and safety of Nafamostat mesylate in patients with endstage renal failure

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World Journal of Clinical Cases 2024年第1期12卷 68-75页

作者： Kun liu zhen-Hua Li Department of Critical Care Medicine The Third People's Hospital Of Hubei ProvinceWuhan 430030Hubei ProvinceChina Department of Critical Care Medicine General Hospital of The Yangtze River ShippingWuhan Brain HospitalWuhan 430015Hubei ProvinceChina

BACKGROUND Recent studies on dialysis anticoagulation therapy in patients with renal failure have shown that Nafamostat mesylate,a broad-spectrum potent serine protease inhibitor,has strong anticoagulation and anti-fiber activity.AIM To evaluate the efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure.METHODS Seventy-five patients with end-stage renal failure who received hemodialysis at our hospital between January 2020 and August 2021 were selected and divided into the observation group(Nafamostat mesylate for injection,n=33)and control group(heparin sodium injection,n=32).General patient data,indicators of clinical efficacy,dialyzer hemocoagulation parameters,coagulation function indices,and hemoglobin concentration and platelet count before and after treatment,and the occurrence of adverse reactions after treatment were compared between the two groups.RESULTS The two groups showed no significant differences in general patient data(P>0.05).The post-treatment effectiveness rate in the control group was lower than that in the observation group(P0.05),while the number of patients in grade 0 was lower in the control group,and the number of patients in grades II and III was higher in the control group(P0.05).The total number of post-treatment adverse reactions in the observation group was lower than that in the control group(P<0.05).CONCLUSION Treatment of patients showing end-stage renal failure with Nafamostat mesylate can significantly improve therapeutic efficacy and ha

关键词： End-stage renal failure Nafamostat mesylate Effectiveness Safety study Chronic kidney diseases

Sobolev Mapping of the Bergman Projections on Generalized Hartogs Triangles

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Acta Mathematica Sinica,English Series 2024年第2期40卷 451-466页

作者： Hong Yan liu zhen Han TU School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we investigate Sobolev mapping properties of the Bergman projection.Th domain we focus on is defined byΩm/n:={(z,w)∈C^(1+N):|w1|<|z|m1/n1<1,…|wN|<|z|/m_(N)/n_(N)<1},where m=(m1,…mN)∈(Z^(+))^(N),n=(n1,…nN)∈(Z^(+))N,N∈Z^(+).Sobolev irregularity of the Bergman projections on 2 is shown.We also prove some Sobolev regularity results of the Bergman projections onΩm/n for m=(1,…1).

关键词： Bergman projections generalized Hartogs triangles Sobolev spaces